What does latuda mean

Lurasidone (Latuda) | NAMI: National Alliance on Mental Illness

Brand name: Latuda®

Oral tablet: 20 mg, 40 mg, 60 mg, 80 mg, 120 mg

Generic name: Lurasidone (loo RAS I done)

All FDA black box warnings are at the end of this fact sheet. Please review before taking this medication.

What is lurasidone and what does it treat?

Lurasidone is a medication that works in the brain to treat schizophrenia. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Lurasidone rebalances dopamine and serotonin to improve thinking, mood, and behavior.

Symptoms of schizophrenia include:

Hallucinations – imagined voices or images that seem real
Delusions - beliefs that are not true (e.g., other people are reading your thoughts)

Disorganized thinking or trouble organizing your thoughts and making sense
Little desire to be around other people
Trouble speaking clearly
Lack of motivation

Lurasidone may help some or all of these symptoms.

Lurasidone is also FDA approved for the treatment of depressive phases of bipolar disorder.

This medication sheet will focus primarily on schizophrenia. You can find more information about bipolar disorder here.

Lurasidone may also be helpful when prescribed “off-label” for major depressive disorder or other mental health conditions. “Off-label” means that it has not been approved by the Food and Drug Administration for this condition. Your mental health provider should justify his or her thinking in recommending an “off-label” treatment. They should be clear about the limits of the research around that medication and if there are any other options.

What is the most important information I should know about lurasidone?

Schizophrenia requires long-term treatment. Do not stop taking lurasidone, even when you feel better.

With input from you, your health care provider will assess how long you will need to take the medication.

Missing doses of lurasidone may increase your risk for a relapse in your symptoms.

Do not stop taking lurasidone or change your dose without talking with your health care provider first.

For lurasidone to work properly, it should be taken every day as ordered by your health care provider.

Are there specific concerns about lurasidone and pregnancy?

If you are planning on becoming pregnant, notify your health care provider to best manage your medications. People living with schizophrenia who wish to become pregnant face important decisions. This is a complex decision since untreated schizophrenia has risks to the fetus, as well as the mother. It is important to discuss the risks and benefits of treatment with your doctor and caregivers.

Antipsychotic use during the third trimester of pregnancy has a risk for abnormal muscle movements (extrapyramidal symptoms [EPS]) and/or withdrawal symptoms in newborns following delivery. Symptoms in the newborn may include agitation, feeding disorder, hypertonia, hypotonia, respiratory distress, somnolence, and tremor; these effects may be self-limiting or require hospitalization.

Caution is advised with breastfeeding since it is not known if lurasidone passes into breast milk.

What should I discuss with my healthcare provider before taking lurasidone?

Symptoms of your condition that bother you the most
If you have thoughts of suicide or harming yourself
Medications you have taken in the past for your condition, whether they were effective or caused any adverse effects
If you ever had muscle stiffness, shaking, tardive dyskinesia, neuroleptic malignant syndrome, or weight gain caused by a medication
If you experience side effects from your medications, discuss them with your provider. Some side effects may pass with time, but others may require changes in the medication.
Any psychiatric or medical problems you have, such as heart rhythm problems, long QT syndrome, heart attacks, diabetes, high cholesterol, or seizures
If you have a family history of diabetes or heart disease
All other medications you are currently taking (including over the counter products, herbal and nutritional supplements) and any medication allergies you have
Other non-medication treatment you are receiving, such as talk therapy or substance abuse treatment. Your provider can explain how these different treatments work with the medication.
If you are pregnant, plan to become pregnant, or are breastfeeding
If you smoke, drink alcohol, or use illegal drugs

How should I take lurasidone?

Lurasidone is usually taken 1 time per day with food (at least 350 calories).

Typically patients begin at a low dose of medication and the dose is increased slowly over several weeks.

For schizophrenia, the dose usually ranges from 40 mg to 160 mg. Only your health care provider can determine the correct dose for you.

For acute treatment of depressive episodes of bipolar disorder (when used alone or with lithium or valproate), the dose usually ranges from 20 mg to 120 mg. Only your health care provider can determine the correct dose for you.

Use a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication. You may also ask a family member or a friend to remind you or check in with you to be sure you are taking your medication.

What happens if I miss a dose of lurasidone?

If you miss a dose of lurasidone, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your health care provider. Do not double your next dose or take more than what is prescribed.

What should I avoid while taking lurasidone?

Avoid drinking alcohol or using illegal drugs while you are taking lurasidone. They may decrease the benefits (e.g., worsen your confusion) and increase adverse effects (e.g., sedation) of the medication.

What happens if I overdose with lurasidone?

If an overdose occurs call your doctor or 911. You may need urgent medical care. You may also contact the poison control center at 1-800-222-1222.

A specific treatment to reverse the effects of lurasidone does not exist.

What are possible side effects of lurasidone?

Common side effects

Extrapyramidal symptoms, drowsiness, restlessness, insomnia, increased glucose, cholesterol abnormalities, nausea

Rare/serious side effects

Lurasidone may increase the blood levels of a hormone called prolactin. Side effects of increased prolactin levels include females losing their period, production of breast milk and males losing their sex drive or possibly experiencing erectile problems. Long term (months or years) of elevated prolactin can lead to osteoporosis, or increased risk of bone fractures.

Some people may develop muscle related side effects while taking lurasidone. The technical terms for these are “extrapyramidal symptoms” (EPS) and “tardive dyskinesia” (TD). Symptoms of EPS include restlessness, tremor, and stiffness. TD symptoms include slow or jerky movements that one cannot control, often starting in the mouth with tongue rolling or chewing movements.

Temperature regulation: Impaired core body temperature regulation may occur; caution with strenuous exercise, heat exposure, and dehydration.

Second generation antipsychotics (SGAs) increase the risk of weight gain, high blood sugar, and high cholesterol. This is also known as metabolic syndrome. Your health care provider may ask you for a blood sample to check your cholesterol, blood sugar, and hemoglobin A1c (a measure of blood sugar over time) while you take this medication.

Information on healthy eating and adding exercise to decrease your chances of developing metabolic syndrome may be found at the following sites:
- https://www.helpguide.org/articles/healthy-eating/healthy-eating.htm
- http://www.helpguide.org/home-pages/exercise-fitness.htm

SGAs have been linked with higher risk of death, strokes, and transient ischemic attacks (TIAs) in elderly people with behavior problems due to dementia.

All antipsychotics have been associated with the risk of sudden cardiac death due to an arrhythmia (irregular heart beat). To minimize this risk, antipsychotic medications should be used in the smallest effective dose when the benefits outweigh the risks. Your doctor may order an EKG to monitor for irregular heartbeat.

Neuroleptic malignant syndrome is a rare, life threatening adverse effect of antipsychotics which occurs in <1% of patients. Symptoms include confusion, fever, extreme muscle stiffness, and sweating. If any of these symptoms occur, contact your health care provider immediately.

All antipsychotics can cause sedation, dizziness, or orthostatic hypotension (a drop in blood pressure when standing up from sitting or lying down). These side effects may lead to falls which could cause bone fractures or other injuries. This risk is higher for people with conditions or other medications that could worsen these effects. If falls or any of these symptoms occur, contact your health care provider.

Are there any risks for taking lurasidone for long periods of time?

Tardive dyskinesia (TD) is a side effect that develops with prolonged use of antipsychotics. Medications such as lurasidone have been shown to have a lower risk of TD compared to older antipsychotics, such as Haldol® (haloperidol). If you develop symptoms of TD, such as grimacing, sucking, and smacking of lips, or other movements that you cannot control, contact your health care provider immediately. All patients taking either first or second generation antipsychotics should have an Abnormal Involuntary Movement Scale (AIMS) completed regularly by their health care provider to monitor for TD.

Second generation antipsychotics (SGAs) increase the risk of diabetes, weight gain, high cholesterol, and high triglycerides. (See “Serious Side Effects” section for monitoring recommendations).

What other medications may interact with lurasidone?

The following medications may increase the levels and effects of lurasidone: diltiazem (Cardizem®), erythromycin (Ery-Tab®), and fluconazole (Diflucan®). Grapefruit juice may also increase levels of lurasidone.

The following medications may decrease the levels and effects of lurasidone: carbamazepine (Tegretol®) and phenobarbital.

How long does it take for lurasidone to work?

It is very important to tell your doctor how you feel things are going during the first few weeks after you start taking lurasidone. It will probably take several weeks to see big enough changes in your symptoms to decide if lurasidone is the right medication for you.

Antipsychotic treatment is generally needed lifelong for persons with schizophrenia. Your doctor can best discuss the duration of treatment you need based on your symptoms and illness.

Hallucinations, disorganized thinking, and delusions may improve in the first 1-2 weeks

Sometimes these symptoms do not completely go away
Motivation and desire to be around other people can take at least 1-2 weeks to improve
Symptoms continue to get better the longer you take lurasidone
It may take 2-3 months before you get the full benefit of lurasidone

Summary of FDA Black Box Warnings

Increased Mortality in Elderly Patients with Dementia Related Psychosis

Both first generation (typical) and second generation (atypical) antipsychotics are associated with an increased risk of mortality in elderly patients when used for dementia related psychosis.
Although there were multiple causes of death in studies, most deaths appeared to be due to cardiovascular causes (e.g., sudden cardiac death) or infection (e. g., pneumonia).
Antipsychotics are not indicated for the treatment of dementia-related psychosis.

Suicidal Thoughts or Actions in Children and Adults

Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide.
Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking medications. This risk may persist until significant remission occurs.
Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient’s prescriber or health care professional.
All patients being treated with this medication for depression should watch for and notify their health care provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment

Provided by

(November 2022)

©2022 The College of Psychiatric and Neurologic Pharmacists (CPNP) and the National Alliance on Mental Illness (NAMI). CPNP and NAMI make this document available under the Creative Commons Attribution-No Derivatives 4.0 International License. Last Updated: January 2016.

This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists. This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein.

Latuda oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

See also Warning section.

Drowsiness, dizziness, lightheadedness, nausea, shaking, weight gain, mask-like facial expression, inability to keep still, and agitation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Your doctor may order another medication to lessen these effects.

This medication may cause a serious drop in blood pressure, especially when starting this medication. Dizziness and lightheadedness can increase the risk of falling. Get up slowly when rising from a sitting or lying position.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these serious side effects occur: drooling/trouble swallowing, fainting, interrupted breathing during sleep.

Rarely, this medication may cause face/muscle twitching and uncontrollable movements (tardive dyskinesia). In some cases, this condition may be permanent. Tell your doctor right away if you develop any uncontrollable movements such as lip smacking, mouth puckering, tongue thrusting, chewing, or unusual arm/leg movements.

This drug may rarely make your blood sugar rise, which can cause or worsen diabetes. Weight gain from this drug may increase the risk of this side effect. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. If you already have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This medication may also cause a rise in your blood fat levels (cholesterol and triglycerides). These increases, along with diabetes and weight gain, may increase your risk for developing heart disease. Discuss the risks and benefits of treatment with your doctor.

In rare cases, lurasidone may increase your level of a certain substance made by the body (prolactin). For females, this increase in prolactin may result in unwanted breast milk, missed/stopped periods, or difficulty becoming pregnant. For males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. If you develop any of these symptoms, tell your doctor right away.

Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur.

Get medical help right away if this serious side effect occurs: seizure.

This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, signs of kidney problems (such as change in the amount of urine).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

90,000 ITCI opinion of American colleagues. Those who are too worried about the approval not coming today

rostov1

December 18, 2021 at 5:35 am

$ITCI opinion of American colleagues. Those who are too worried about the approval not coming today. At the moment, we have 3 drugs approved for the treatment of bipolar depression, namely Symbiax, Seroquel and Latuda. Symbyax is nothing but a combination of zyprexa and Prozac. When was the patent ran out of pharma giant Lily came out with symbyax.All 3 drugs from Lily.Zyprexa and cause weight gain leading to diabetes, high cholesterol, and insulin resistance, i.e. your body still produces insulin, but it is not effective blood glucose control & Prozac cause all sorts of sexual side effects, including lack of desire or inability to get or maintain an erection erection and lack orgasm. So someone can tell who wants to take these drugs, but Prozac and Zyprexa have been blockbuster drugs in the past. The 2nd drug, seroquel, also has the main side effects of weight gain and excessive sleepiness, but it also brought in good returns. Then comes lauda, which was first approved for the treatment of schizophrenia & has been approved for the treatment of bipolar depression for about 20 months. Caplite has also been approved for the treatment of schizophrenia and will now be approved for the treatment of bipolar 1 disorder and bipolar depression on Monday. Chemically, lauda and caplita have more in common than differences. zyprexa, seroquel, ability latuda, caplyta and rexulti, are in the broad category of 2nd generation antipsychotics, but I consider latuda, ability, rexulti and caplyta 3rd generation antipsychotics/mood stabilizers because they don't make you gain as much weight how many antipsychotics 2nd generation.I forgot include geodon in the 2nd generation group, which is the only drug in this broad category, does not make you gain weight, but may help you lose a few pounds. The nice thing about caplita is that it only comes in one dosage, which is 42mg, so no titration is required. Psychiatry is still in its infancy as a science, and we're not 100% sure why these drugs work. All of these antipsychotics/mood stabilizers are supposed to correct dopamine and serotonin imbalances. Caplyta is already being used by some physicians to treat bipolar depression. More sales representatives have already been hired & leading psychiatrists/educators are already trained to go out into the community for education/marketing. All longs will be happy on Monday. Caplita is following the same roadmap that Latuda followed, which is to get permission for schizophrenia and then move on for indications for bipolar depression. I am very confident that this approval will be announced on Monday morning around 7.30 am Central Time. This is not an educated guess. Enjoy the close. nine0003

Doctors reported a shortage of more than 80 drugs in pharmacies

Andrey Gordeev / Vedomosti

Russian doctors faced a shortage of more than 80 drugs in their practice, follows from a survey of 3317 doctors conducted from March 14 to 21 by the professional community "DoctorsRF". The results of the study are at the disposal of Vedomosti.

In the course of the survey, doctors spoke about problems with anti-inflammatory (children's Nurofen), gastroenterological (Ursofalk), antiepileptic, anticonvulsant drugs (Finlepsin, Depakin, Diazepam, Carbamazepine, Latuda 56), as well as antidepressants (paroxetine, Anafranil) and antipsychotics (Rispolept ). nine0003

Their patients also have difficulty finding combined oral contraceptives, menopausal hormone therapy drugs (femoston, estrogel, angelik, divina, climonorm, divigel, yarina, utrogestan), insulins (levemir, novorapid, apidra, trulicity), drugs for the treatment of diabetes diabetes (ozempic, saxenda, metformins, jardins, trajent, januvia), thyroid and parathyroid glands (euthyrox, L-thyroxine, triiodothyronine, vigantol), etc.

Vedomosti separately studied the situation with 20 drugs prescribed by doctors for cardiovascular diseases and oncology. Mortality from these diseases in 2020, according to Rosstat, amounted to more than half of all cases (almost 44% and 14% of the total number of deaths). The analysis also included drugs from the group of glucocorticosteroids used to treat many diseases - from rheumatoid arthritis and bronchial asthma to cancer and hepatitis. nine0003

In 2021, pharmacies sold 83.92 million packs of medicines containing the active ingredient found in these 20 medicines, according to the DSM Group. More than a third (37.4%) were sales of drugs, which are now difficult.

Vedomosti requested statistics on the balance of these drugs in Russian pharmacies from the operator of the drug labeling system - the Center for the Development of Advanced Technologies (CRPT), the Ministry of Health and Roszdravnadzor. But at the time of publication, the data was not provided. nine0003

The representative of the Ministry of Health reminded about the existence of analogues for most drugs with the same active ingredient in various dosage forms, both Russian and foreign. The reduction in the supply of certain foreign drugs to Russia or their suspension is not associated with sanctions restrictions, representatives of the Ministry of Health and the Ministry of Industry and Trade assure.

Of the 12 foreign medicines used for hypertension and arrhythmia (espiro, prestans, lokren, norvask, betalok, sotahexal, propanorm, cordarone, etc.) missing from pharmacies, two have no direct analogues for the active substance - coaprovel from Sanofi and edarbi from Stada. Many patients have to take antihypertensive and antiarrhythmic drugs for a long time, sometimes for life, explains Albert Akhobekov, a cardiologist at the Doctis online consultation service. For example, people with hypertension take medications their entire lives to avoid a stroke, myocardial infarction, or heart failure. nine0003

All these drugs have been used in cardiology for a long time and have several generic versions that have proven themselves well, says Akhobekov, the main thing is to choose the right dosage. For example, 17 companies produce analogues of the antihypertensive Diovan from Novartis, including the Icelandic Actavis Group (Valz) and the Russian Vertex and Alium (Valsartan), follows from the state register of medicines. A cardiologist will be able to replace coaprovel and edarbi with other drugs from other groups at an equivalent dose with the same efficacy and safety profile, Akhobekov added. nine0003

Prior to the rush demand, antihypertensive prestance was available in at least 80% of pharmacies throughout Russia, but now it is rather difficult to estimate its real quantity on pharmacy shelves, says Yana Rostovtseva, Managing Director of Servier in Russia. The company's Moscow plant continues to operate as usual, the drug is in stock in all dosages. Prestans, like the rest of the Russian portfolio, is shipped to distributors in accordance with orders, Rostovtseva added. The supply of edarbi, which is indicated for essential hypertension, is also continuing, a spokesman for Stada said. From the beginning of the year to March 20, 2022, the company shipped twice as much drug to distributors compared to the same period last year. In addition, Stada intends to localize edarbi production in Russia in 2022, he added. nine0003

Yury Mochalin, director of corporate communications at Sanofi in the Eurasian region, connects the possible absence of cordarone (used to prevent recurrence of life-threatening ventricular arrhythmias) with the rush demand and the purchase of the drug for the future. According to him, cordarone is available from distributors and pharmacy chains. But with coaprovel, things are different: since 2020, technical problems have continued in the production of the substance irbesartan, so the production of the drug has been reduced, but not stopped, says Mochalin. Coaprovel (12.5 mg + 150 mg) was delivered in March 2022, and shipments of the drug in dosages of 12.5 mg + 300 mg and 25 mg + 300 mg are scheduled for the second quarter of 2022.

Of the two antitumor drugs (Fulvestrant, Fareston), one has no direct analogue - Fareston from the Finnish Orion Corporation. Among the five drugs of the group of glucocorticosteroids (seretide multidisk, pulmicort, cortef, solu-cortef, cortineff), two cannot be replaced - cortef and solu-cortef from Pfizer. But drugs with the international non-proprietary name (INN) "methylprednisolone", according to the survey, are not sold under any brand.

All drugs, with the exception of Solu-Cortef, entered the Russian market from January 2021 to March 2022, commented a representative of the Ministry of Industry and Trade, referring to the register of drugs introduced into civil circulation, Roszdravnadzor. As a Pfizer representative explained, Solu-Cortef, according to preliminary data, will return to the market in the first half of 2023. Until then, the company will import the drug as part of charitable assistance, he added. Cortef and Medrol are available for sale and deliveries are regular, a Pfizer spokesman said. Two domestic pharmaceutical companies are also going through the stage of registration of an injectable form of methylprednisolone for further organization of its production, a representative of the Ministry of Industry and Trade said. Methylprednisolone in tablets is packaged in Russia by Pharmacor Production, he added. nine0003

As a top manager of one of the Russian pharmacy chains explained to Vedomosti, the most stressful period with the supply of medicines was observed until February 28th. Now, according to him, there are no 79 of the top 800 commodity items (they generate two-thirds of sales), if you combine all the distributors with whom the company works. Individual suppliers of these 800 commodity items may lack from 278 to 394 items. The situation with the supply of medicines is slowly but surely returning to normal, says Nikolai Bespalov, director of development at the analytical company RNC Pharma.

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