Sertraline name brand

Uses, how to take, side effects, and interactions

Sertraline belongs to a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs).

Sertraline is sold under the brand name Zoloft, and there are also generic versions. It is available at most pharmacies.

Healthcare professionals can prescribe over 30 medications intended to help with depression and improve a person’s quality of life.

Sertraline is sold under the brand name Zoloft, and there are also generic versions. It is available at most pharmacies.

Share on PinterestSertraline increases the amount of serotonin that is available in the brain.
Image credit:, 2012

Sertraline has the same mechanism of action as other SSRIs. It works by increasing the amount of serotonin that is available in the brain.

Serotonin is a neurotransmitter, or chemical messenger, that is involved in regulating many elements of a person’s daily life, including mood, sleep, rewards, learning, and memory.

Research has linked depression with low levels of serotonin.

Sertraline increases the amount of serotonin present in the brain, helping to reduce chemical imbalances and improve a person’s overall mood.

Other SSRIs include:

  • escitalopram (Lexapro)
  • citalopram (Celexa)
  • fluvoxamine (Luvox, Luvox CR)
  • fluoxetine (Prozac, Sarafem, Symbyax)
  • paroxetine (Paxil, Paxil CR, Pexeva)
  • vilazodone (Viibryd)

The Food and Drug Administration (FDA) note that people use sertraline to treat depression, anxiety, and other mood disorders.

The main use of sertraline is to treat depression, though healthcare providers also prescribe this drug to help treat other conditions, including:

  • obsessive compulsive disorder, or OCD
  • panic disorder
  • social anxiety disorder
  • post-traumatic stress disorder, or PTSD
  • premenstrual dysphoric disorder — to reduce bloating, mood swings, irritability, and breast tenderness

A doctor may prescribe sertraline to treat other issues, such as sexual dysfunction or headaches. Anyone interested in the range of uses should consult a doctor.

Sertraline is available as either an oral tablet or a liquid.

Typically, a person takes a dose in the morning or evening, once a day. People using it to treat premenstrual dysphoric disorder may take it every day or only on select days of the month.

According to the National Alliance on Mental Illness, sertraline comes in the following doses:

  • 25 milligram (mg) tablets
  • 50 mg tablets
  • 100 mg tablets
  • 20 milligrams per liter of liquid

A person taking sertraline should follow these general guidelines:

  • Take it at about the same time every day.
  • Take with or without food.
  • Follow all instructions on the prescription packaging and from the doctor.
  • If you miss a dose, take it as soon as you remember to, but do not double the dose the next day.
  • Take only the amount that the healthcare provider has prescribed.

When using the liquid, dilute it in a drink. According to the National Library of Medicine, a person should mix 4 ounces (half a cup) of medication with one of the following beverages, then drink it immediately:

  • water
  • lemon soda
  • orange juice
  • lemonade
  • ginger ale

However, the right dosage will vary, based on a person’s age and weight.

Typically, a healthcare provider will prescribe a low dose and increase the amount over time, but no more than once per week. It can take several weeks before a person feels any effects of sertraline.

People should not stop taking the drug without speaking to a doctor, even if they are feeling better. This may mean that the drug is working, and missing a dose can result in a return of symptoms.

Side effects can vary from person to person. Talk to a healthcare provider if severe side effects occur or if any side effects do not go away.

Common side effects of sertraline include:

  • nausea
  • diarrhea
  • headache
  • dry mouth
  • sweating
  • nervousness
  • feeling restless
  • fatigue
  • trouble sleeping
  • sexual dysfunction

These side effects usually go away after the first week or two. However, sexual dysfunction often does not reduce over time.

The package insert for Zoloft states that it and other antidepressants can increase the risk of suicidal thoughts or actions in people aged 24 years or younger.

Pay close attention to any new or sudden changes in mood, behavior, thoughts, or feelings, and speak to a healthcare provider about these changes.

Other severe side effects of sertraline may include:

  • serotonin syndrome
  • low sodium levels
  • eye problems such as angle-closure glaucoma
  • increased risk of bleeding, especially when a person is also taking blood thinners or nonsteroidal anti-inflammatory drugs

In children, sertraline can cause a loss of weight and appetite. The pediatrician will likely monitor their weight.

Share on PinterestIf a person stops taking sertraline abruptly they may experience sleep problems, tinnitus, or irritability.

Whenever possible, a person should come off sertraline gradually. Stopping the dosage suddenly can cause the following side effects:

  • tinnitus
  • irritability
  • agitation
  • anxiety
  • nausea
  • dizziness
  • tremors
  • confusion
  • sleep problems
  • seizures

Sertraline contains a warning for children, teens, and adults under 24 years of age. It states that sertraline may increase a person’s suicidal thoughts or actions.

Parents and caregivers should make doctors aware of any family history of suicide. It is also important to recognize possible signs of suicidal thoughts or actions.

Adults can also experience suicidal thoughts in the first month or two of taking sertraline, as well as when the doctor increases the dosage.

Look carefully for signs such as:

  • agitation
  • irritability
  • acting without thinking
  • difficulty falling asleep or staying asleep
  • new or worsening anxiety
  • new or worsening depression
  • aggressive behavior
  • severe restlessness
  • frenzied or unusual excitement
  • extreme worry
  • panic attacks
  • thoughts of self-harm
  • planning or trying to commit suicide

In addition, it is important to pay close attention to side effects. If any are severe or do not go away, talk to a doctor.

People using sertraline may test positive on certain drug tests. Before taking a drug test, ask a healthcare professional for advice.

When first taking sertraline, avoid using heavy machinery or driving immediately after a dose, until it becomes clear how the body will react. Some people continue to experience dizziness, tiredness, or other effects that can impair judgment after doses.

Avoid drinking alcohol while taking sertraline.

Certain medications can interact with sertraline. An interaction can cause unwanted side effects or cause medications to be more or less potent than intended.

People should not take any monoamine oxidase inhibitors — another type of antidepressant, commonly called MAOIs — while taking sertraline or up to 2 weeks after stopping.

Taking sertraline along with other drugs that affect serotonin can increase the risk of serotonin syndrome. This syndrome involves a range of symptoms, including agitation and loss of muscle coordination.

Some drugs that affect serotonin include:

  • migraine medications called triptans
  • certain other antidepressants
  • some pain medications, such as tramadol
  • an antibiotic called linezolid

People should not take pimozide while taking sertraline. Pimozide is an antipsychotic that helps treat Tourette’s syndrome.

Also, use caution when taking medications such as ibuprofen, warfarin, and aspirin. Sertraline can increase the risk of bleeding associated with these medications.

Sertraline is available in brand and generic forms. Most insurance plans and Medicare cover the cost of the generic version of sertraline. In this case, a person will pay only the associated medication cost of their insurance plan.

People who do not have insurance may be able to use coupons to reduce the cost of sertraline.

Share on PinterestA person should discuss their medication history with their doctor before starting sertraline.

Doctors generally consider sertraline to be the preferred medication for the treatment of depression.

There is some evidence that sertraline is preferable to other antidepressants. For example, a medical review determined, based on almost 60 studies, that sertraline was more effective than other antidepressants. However, the researchers acknowledged that the majority of the studies were of low quality.

Each individual is different, and what works well for one person may not for another. Before taking sertraline, a person should discuss their medication history and family history with the doctor, who should describe the potential side effects of the drug. For some people, another option is more appropriate.

Sertraline is an antidepressant that can help treat depression and other mood disorders.

Some people find that taking sertraline helps them manage their symptoms. Others can experience side effects that are not manageable. If this happens, see a healthcare provider who can recommend alternatives, before stopping the medication.

Like other drugs, sertraline can cause mild to severe side effects. As with any treatment, discuss the benefits and potential side effects with a doctor before taking the medication.

Prozac vs. Zoloft: What's the Difference?

Prozac vs. Zoloft: What's the Difference?
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Medically reviewed by Andrea Hodgson — By Ann Pietrangelo — Updated on September 28, 2018


Prozac and Zoloft are powerful prescription medications used to treat depression and other issues. They’re both brand-name drugs. The generic version of Prozac is fluoxetine, while the generic version of Zoloft is sertraline hydrochloride.

Both drugs are selective serotonin reuptake inhibitors (SSRIs). Serotonin is a naturally occurring chemical that produces a feeling of well-being. These drugs work by influencing serotonin levels in your brain. By balancing chemicals in your brain, these drugs will likely improve your mood and appetite. They can also enhance your energy levels and help you sleep better. Both medications can reduce anxiety, fear, and compulsive behaviors. For people who have major depression, they can dramatically improve quality of life.

However, these drugs do have some differences, including who they’re used for.

What they treat

Prozac and Zoloft have slightly different uses. The table below lists the conditions each drug is approved to treat.

To lower your chance of side effects, your doctor will start you on the lowest possible dosage. If your symptoms don’t improve at this dosage, your doctor may increase it. It may take some time to find the correct dosage and the best medication for you.

Both drugs cause many similar side effects. Common side effects can include:

  • nausea and vomiting
  • diarrhea
  • nervousness and anxiousness
  • dizziness
  • sexual problems, such as erectile dysfunction (trouble getting or keeping an erection)
  • insomnia (trouble falling or staying asleep)
  • weight gain
  • weight loss
  • headache
  • dry mouth

When it comes to side effect specifics, Zoloft is more likely than Prozac to cause diarrhea. Prozac is more likely to cause dry mouth and sleep problems. Neither drug causes drowsiness, and both medications are less likely to cause weight gain than older antidepressant drugs.

Antidepressants can also cause serious side effects. Prozac and Zoloft may cause suicidal thoughts in children, teenagers, and young adults. Talk to your doctor or your child’s doctor if this risk applies to you.

Both Prozac and Zoloft can interact with other drugs. Be sure to tell your doctor about all drugs and supplements you take, both prescription and over-the-counter. These include:

  • monoamine oxidase inhibitors (MAOIs)
  • methylene blue injection
  • pimozide
  • linezolid

Prozac or Zoloft can also cause problems if you’re pregnant or breastfeeding. In general, you should only use these medications in these cases if the potential benefit justifies the potential risk.

Both medications are available in most pharmacies. At the time this article was written, a 30-day supply of Prozac was about $100 more than a similar supply of Zoloft. To check the most current pricing, though, you can visit

Most health insurance plans likely won’t cover brand-name Prozac or Zoloft. This is because both drugs are also available as generic medications, and generics tend to cost less than their brand-name counterparts. Before covering the brand-name product, your health insurance company may need prior authorization from your doctor.

Prozac and Zoloft are both effective drugs. They work in the same way in your body and cause similar side effects. They treat some different conditions, though, so the drug your doctor chooses for you may depend largely on your diagnosis.

Talk to your doctor to learn which medication may be the best choice for you. Many people react differently to these types of medications. It’s hard to predict if one drug will work better for you than the other. It’s also impossible to know ahead of time which side effects you may have or how severe they will be. There are also other options available. To learn more, check out Healthline’s depression medication list.


Are these drugs addictive?

Anonymous patient


You should take either of these drugs exactly as prescribed, and you should never take them without a prescription. Antidepressants aren’t considered addictive, but it’s still possible to have unpleasant symptoms of withdrawal if you stop taking them suddenly. You’ll likely have to taper off of them slowly. Don’t stop taking your drug without your doctor’s supervision. For more information, read about the dangers of stopping antidepressants abruptly.

Answers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Last medically reviewed on August 10, 2016

How we reviewed this article:

Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  • Anderson, I. M., & Reid, I. C. (2003). Fundamentals of Clinical Pharmacology.  London, UK: Martin Dunitz, LTD.
  • Boynton Health Service, University of Minnesota. (n.d.). Common questions about antidepressants
  • Dean, L. (2011, May 16). Comparing antidepressants
  • Eli Lilly and Company. (2009). Medication guide: Prozac (PRO-zac) (fluoxetine hydrochloride) pulvule and weekly capsule. Indianpolis, IN. Retrieved from
  •  Mayo Clinic Staff. (2016, June 24). Selective serotonin reuptake inhibitors (SSRIs)
  • National Institute of Mental Health. (n.d.). Antidepressant medications for children and adolescents: Information for parents and caregivers shtml
  • Pfiezer. (2012, December). Medication guide: Zoloft (ZOH-loft) (sertraline hydrochloride) (tablets and oral concentrate (solution)). New York, NY
  • Prozac - fluoxetine hydrochloride capsule. (2016, June 8). Retrieved from
  • Zoloft - sertraline hydrochloride tablet, film coated; Zoloft - sertraline hydrochloride solution, concentrate. (2016, April 22). Retrieved from

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Current Version

Sep 29, 2018

Written By

Ann Pietrangelo

Aug 10, 2016

Medically Reviewed By

Andrea Hodgson

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Medically reviewed by Andrea Hodgson — By Ann Pietrangelo — Updated on September 28, 2018

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List of medicines with SERTRALINE - the active substance SERTRALINE in the drug guide Vidal

International name INN: Rec.INN

Single component preparations

trade names of preparations containing only the active substance SERTRALINE

Aleval nine0011

Tab, coated film coated, 25 mg: 14 and 28 pcs.

reg. No.: LSR-003615/10 from 30.04.10 nine0019

Tab, coated film-coated, 50 mg: 14 and 28 pcs.

reg. No.: LSR-003615/10 from 30.04.10

Tab, coated film coated, 100 mg: 14 and 28 pcs.

reg. No.: LSR-003615/10 from 30.04.10


Asentra ® nine0002 Tab. , coated film-coated, 50 mg: 28 pcs.

reg. No.: P N014474/01 dated 10.04.08 Re-registration date: 03/25/20

Tab., coated film-coated, 100 mg: 28 pcs.

reg. No.: P N014474/01 dated 10.04.08 Re-registration date: 03/25/20

KRKA (Slovenia)

Manufactured and packaged by: KRKA (Slovenia)

Packaging and release quality control: KRKA (Slovenia) or Krka-RUS (Russia)

Zoloft ® nine0002 Tab, cover film coated, 50 mg: 14 or 28 pcs.

reg. No.: P N013622/01 dated 18.07.08 Re-registration date: 07/14/22

Tab., coated film coated, 100 mg: 14 or 28 pcs.

reg. No.: P N013622/01 dated 18.07.08 Re-registration date: 07/14/22



Serenata nine0002 Tab, cover film-coated, 50 mg: 4, 30 or 50 pcs.

reg. No.: LS-000063 dated 05.02.10 Date of re-registration: 12/28/15

Tab, coated film coated, 100 mg: 4, 30 or 50 pcs.

reg. No.: LS-000063 dated 05.02.10 Date of re-registration: 12/28/15


Sirlift nine0011

Tab. , coated film coated, 50 mg: 10, 14, 28 or 30 pcs.

reg. No.: P N012258/01 from 24.12.07 Re-registration date: 11/20/18 nine0019

Tab., coated film coated, 100 mg: 10, 14, 28 or 30 pcs.

reg. No.: P N012258/01 from 24.12.07 Re-registration date: 11/20/18


Stimuloton ®

Tab, coated film coated, 100 mg: 14 or 28 pcs.

reg. No.: P N013940/01 dated 08.04.09Date of re-registration: 06.12.17

EGIS Pharmaceuticals (Hungary)

Stimuloton ®

Tab, coated film coated, 50 mg: 10 or 30 pcs.

reg. No.: P N013940/01 dated 08.04.09 Date of re-registration: 06.12.17
nine0002 EGIS Pharmaceuticals (Hungary)

Descriptions of drugs with invalid reg. beats or not supplied to the Russian market

Thorin ® nine0011

Tab, coated film coated, 100 mg: 30 pcs.

reg. No.: P N003379/01 from 17.03.09


Thorin ®

Tab, coated film coated, 50 mg: 14 or 28 pcs. nine0003 reg. No.: P N003379/01 from 17.03.09


Difference between Zoloft and Wellbutrin

There are various drugs available on the market for testing different types of deficiency disorders in the human body. Many medical experts advise these medicines for treatment and cure. nine0003



These medicines and/or drugs are available in a variety of forms such as patches and tablets. However, in order to cure depression, many medical experts suggest various medications. Two of them: 1. Zoloft and 2. Wellbutrin.

Zoloft vs Wellbutrin

The main difference between Zoloft and Wellbutrin is that Zoloft treats conditions such as Obsessive Compulsive Disorder or OCD, Social Anxiety Related Disorder, Premenstrual Dysphoric Disorder, etc. , on the other hand On the other hand, conditions that Wellbutrin treats include depression and/or anxiety disorder. nine0214

Zoloft is a brand name for sertraline. Used to treat several mental health disorders. It is used to treat and treat various medical conditions such as anxiety disorder, panic disorder, OCD, or obsessive compulsive disorder, and is also used in various therapies that are used to test for these disorders, such as cognitive behavioral therapy.

Wellbutrin is the brand name for bupropion. They are used to treat a variety of mental disorders, and many medical consultants also prescribe these medications for other disorders, such as smoking cessation. nine0011 Lustral Zyban Side effects Feeling tired, sleepy, insomnia, diarrhea, nausea, dry mouth, constipation, etc. Agitation, tinnitus, sexual side effects , lack of taste, increased sweating and urination, etc. Type Selective serotonin reuptake inhibitor Prescription drug Increased levels Serotonin Dopamine, norepinephrine.

What is Zoloft?

Zoloft is a brand name for Sertraline. In addition, brands such as lustral also refer to Zoloft. Apart from the general side effects, it also has sexual side effects.

If sertraline is consumed with monoamine oxidase inhibitors, the person is more likely to develop serotonin syndrome.

In the United States of America, sertraline was accepted and approved in 1991 year. After that, it became available as a generic. It was created by Pfizer.

This is an essential medicine and is on the World Health Organization's List of Essential Medicines. After its release, many psychiatrists prescribed it to their patients.

Along with monoamine oxidase inhibitors, if the patient has sertraline, disulfiram is contraindicated. Sertraline concentration contains alcohol in higher amounts.

Important drug information includes that patients with hepatic impairment should take sertraline with caution. Patients with impaired liver function are more likely to have higher sertraline exposure than normal patients. nine0003

There are some adverse and common side effects of sertraline use. There are sexual side effects, for example, a person may experience a decrease in sex drive.

The person may also experience nausea, increased sleepiness, sudden shaking, insomnia, restlessness, dry mouth, diarrhea, etc.

What is Wellbutrin?

Wellbutrin is usually prescribed for patients with higher borderline disorders, people with severe mental illness. Wellbutrin is the brand name for Bupropion. nine0003

Zyban is another brand name for the same drug. Many doctors prescribe Wellbutrin because it has comparatively fewer side effects.

This medicine is given by mouth. Wellbutrin controversy includes people with neurological disorders and disorders that cause seizures in patients who should be careful when using it.

These neurological disorders include epilepsy, eating disorders such as anorexia, bulimia, etc. In addition, a person suffering from alcohol withdrawal should also be careful when using Wellbutrin. nine0003

In addition to the treatment of mental disorders, Wellbutrin is also prescribed for the eradication of smoking, sexual dysfunction, obesity, psoriasis, intestinal inflammation, etc.

In the treatment of seasonal affective disorder, Wellbutrin has proven to be an effective drug. This prevents the general development of depression in these patients.

The patient is mainly prescribed Wellbutrin, since it does not affect the patient's weight. Instead, it is sometimes prescribed to treat obesity.

There are some common as well as serious side effects of consuming Wellbutrin. Some of the common side effects include dry mouth, severe constipation, insomnia, feeling nauseous, drowsiness, throbbing in the head, etc. while some adverse side effects include confusion when making decisions, vision changes, irregular heartbeat rhythm . skin rashes, convulsions, etc.

Women may also experience changes in the menstrual cycle. nine0003

Main differences between Zoloft and Wellbutrin

  1. Zoloft is a brand name for sertraline. On the other hand, Wellbutrin is the brand name for the drug bupropion.
  2. Zoloft does not affect dopamine and norepinephrine. On the other hand, Wellbutrin targets dopamine and norepinephrine.
  3. Wellbutrin is most commonly taken two or one time per day. On the other hand, most often Zoloft is taken once a day.
  4. Zoloft is available in liquid form. On the other hand, Wellbutrin is available in tablet form. nine0324
  5. Zoloft has comparatively more sexual side effects. On the other hand, Wellbutrin has comparatively fewer sexual side effects.
  6. Another brand of Zoloft is Lustral. On the other hand, another brand name for Wellbutrin is Zyban.
  7. Wellbutrin does not increase serotonin levels. On the other hand, Zoloft increases serotonin levels.


Mental health problems are as serious as the physical problems a person faces. Medicines such as Zoloft and Wellbutrin help to relieve the condition of patients suffering from mental disorders. nine0003

Zoloft and Wellbutrin also help treat other disorders such as obesity, sexual dysfunction, etc.

However, an overdose of these drugs can lead to serious side effects on the patient's health. It is important to know the exact amount of the dose that is supposed to be taken. You should also consult your doctor before taking these medicines.



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Sandeep has a bachelor's degree in Computer Science. He has been a software architect for 12 years. As a local teacher, he taught courses in computer programming, computer networks, computer graphics, and database systems at two schools.

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