Latuda weight gain reviews
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Most voted positive review
90 People found this comment helpful
Simply put: Latuda is the most positive game changer of 20-25 med combinations my doctor and I have tried. He stopped my mirtazipine(Remeron)and replaced it with Latuda. Wow. What a difference for all the right reasons. Latuda is the very best drug I have been on during the five years I have been treated for "basic" depression, horrid nightmares, lack of focus (ADHD), chronic pain from two failed ...
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Most voted negative review
9 People found this comment helpful
I am in lots of pain.
Shared reviews and ratings
SORT BYCondition: Bipolar Depression
Overall rating 4. 0
I didn't get any side effects on this medicine except from akatishia. It stopped when I stopped taking it together with food. I used it for 2 years. I didn't get any side effects when I stopped taking it.
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Fill 3Created with Sketch.Condition: Bipolar Depression
Overall rating 1.0
EffectivenessEase of UseSatisfactionIt stopped my obsessive suicidal ideation but made me emotionally numb so I was disconnected from loved ones, I barely spoke, had no motivation, didn't go anywhere, didn't take care of myself or the house, didn't cook, had no appetite, lost my creativity and connection to music, sex drive, had trouble thinking and remembering.
I've been off over a year and am better but I'm not the same. I'm not sure what's worse being suicidal or this version of myself.
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Fill 3Created with Sketch.Condition: Other
Overall rating 2.0
EffectivenessEase of UseSatisfactionThe weight gain of 30 lbs in 2 months isn't worth this drug. Suicidal thoughts gone but can barely function due to the weight gain. 5'2 at 200 lbs. Not. Good luck to everyone.
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Fill 3Created with Sketch.Condition: Schizophrenia With Mood Changes
Overall rating 4.
3
I haven't been using Latuda for very long. My experience is positive. I have zero negative side effects. I am having more dreams than usual, not nightmares, just very vivid and long. I have a bit more energy and my moods have stabilized. I do not take additional meds with it. I think I found the right medication.
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Fill 3Created with Sketch.Condition: Bipolar Depression
Overall rating 2.7
EffectivenessEase of UseSatisfactionI took latuda for two years for bipolar 2. The side effects for me were nausea, tardive dyskinesia, and when my psychiatrist took me from 40mg to 60mg I developed akathesia.
I HAD to take another medication such as Clonidine to counteract the tardive dyskinesia, it was unbearable. I also simply could not tolerate a larger dose from 40mg. Overall, I would rate this drug fair to poor. I haven’t had a severe depressive episode for a few years which is great because my last one had me unable to get out of bed for 30 days. I still suffer from mild to moderate depression, though. I also have some suicidal thoughts still. As for the hypomanic episodes, they have not gone away and have still made my life a little unmanageable. I sometimes feel like a shell of a person and have a low mood most of the time. I have tried a lot of different antipsychotics and even antidepressants and I have not tolerated anything other than Latuda, though. Since I still have hypomanic episodes, suicidal thoughts, and moderate depression, my psychiatrist is switching me from latuda to vraylar next week. Hopefully that drug works and I don’t have to suffer anymore. I don’t think I would take this medication again.
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Fill 3Created with Sketch.Condition: Other
Overall rating 2.0
EffectivenessEase of UseSatisfactionI was prescribed this medication after a recent increase in my MDD and severe anxiety/panic attacks. I was previously on Cipralex 20mg for 8 years that worked really well, along with Quetiapine 25mg for the anxiety. I was prescribed 20mg of Latuda. I’ve been taking it only 3 days and feel like a complete zombie. I feel dizzy when I stand up, still had an anxiety attack today and get no joy out of anything. I feel like I have no personality, when I normally have a very loud and animated personality. It’s a complete shift and I hate it.
Went to a clinic today, after describing my side effects was told to skip my dose tonight since it’s only been 3 days. Speaking with my doctor tomorrow to discuss switching meds.Read More Read Less
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Fill 3Created with Sketch.Condition: Other
Overall rating 1.7
EffectivenessEase of UseSatisfactionI was sleepy all the time and small things made not even angry but furious
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Fill 3Created with Sketch.Condition: Bipolar Depression
Overall rating 1.
0
I started taking Latuda after my new psych suspected I might have bipolar depression. I had been on Prozac 20mgs for about three years and was doing fine, but I trusted her judgement. It seemed to be working fine for the first month(took it for around 4 months), until I started with horrible episodes of akathisia. I would fall into horrible dread and felt like world was coming to an end. My depression worsened horribly and I was having thoughts of suicide. Around this time I got a new doctor and she began trying to wean me off the medication, going from 40mgs to 20mgs..this was a mistake because I suddenly gained insomnia, completely lost my appetite and would suffer from horrible bouts of panic and anxiety, not to mention the diarrhea and vomiting. Because the withdrawal symptoms were so horrible and strong I decided to go back on the pill at 40mgs but none of these symptoms improved, in fact they got worse.
I became so suicidal that the doctor ordered me to lower the dose to 10mgs for 5 days before weaning off completely. Within those those 5 days of taking 10 mgs I began to see improvement. I recognize that this medication might work for some, but it was not the drug for me. Read More Read Less
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Fill 3Created with Sketch.Condition: Bipolar Depression
Overall rating 1.0
EffectivenessEase of UseSatisfactionThis medicine caused so many seizures I have permanent brain damage. Don't make the same mistake I did, there are better medicines out there.
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Condition: Bipolar Depression
Overall rating 4.7
EffectivenessEase of UseSatisfactionI started Latuda after a severe manic episode that led to an arrest. I haven’t felt so good in years. I feel stable and happy. My sleeping pattern is normal for the first time I can remember. I’m no longer making the impulsive decisions, no more depression, or suicidal ideations. I still experience anxiety which hasn’t become worse or better but is still the same. One thing I noticed on the medication though is if I do not go to bed when I feel tired, then I end up restless and cannot sleep at night. My doctor recommended I start taking the medication at night about an hour before bed and that did the trick. I’m so happy I found this medication. Also, side note: If you do not have Bipolar or other chemically imbalanced me STL health issues this drug will not work for you and it will cause adverse effects so keep that in mind when reading other negative reviews.
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Fill 3Created with Sketch.Condition: Bipolar Depression
Overall rating 4.7
EffectivenessEase of UseSatisfactionIt has been a good drug for me. I am a very noncompliant patient usually because I had drugs that numb me but I have not been sedated by Latuda. I feel pretty stable on it usually. The only thing is that I get a little insomnia from it. I am using it in combination with low dosed propranolol which may combat the anxiety other people are experiencing. I am in a doctorate program and haven't had any loss of concentration. As a matter of fact, I think it may help my concentration a little.
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Fill 3Created with Sketch.Condition: Bipolar Depression
Overall rating 2.7
EffectivenessEase of UseSatisfactionAwful experience. I feel incredibly restless, yet constantly exhausted at the same time. My body isn't tired, but my head is, and I feel like I can't think or do anything at all. All I can muster is laying in bed hoping for this feeling to go away. I want to be productive and move around, but I can't, because of this drug, and I hate it.
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Fill 3Created with Sketch.Condition: Bipolar Depression
Overall rating 1.
0
Panic attacks. Trouble catching my breath and expanding my lungs. Excessive sweating day and night. Muscle pain and cramping. Muscle spasms in pelvic area. Dizzy. Nauseous. No change in mood. This drug will kill people
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Fill 3Created with Sketch.Condition: Bipolar Depression
Overall rating 2.7
EffectivenessEase of UseSatisfactionThis was my first experience taking any type of antipsychotic/mood stabilizing medication, I honestly think it was too intense for me, I have GAD and was diagnosed Bipolar II with Major Depression. I feel like this medication did help with the overall “bipolar” issues but I had major side effect problems, the first was is what I would describe as a “foggy brain” I got confused when driving and totally disoriented which is not typical of me I am only in my twenties and I could not for the life of me figure out where or how to get home which was scary.
The second was this medication made me physically sick, I was nauseas and even threw up a few times. However the worst side effect was the intense restlessness this medication made me feel, I was crawling out of my skin and so uncomfortable, I was literally crying because I felt so uncomfortable in my own body which was absolutely awful. After a month I quit taking it and found a good therapist and haven’t had any medication since, could I probably use some meds to help with my depression? Yes, but I have managed to find coping skills and more help from therapy to keep me in a good place, I have my ups and downs and if I ever need to, I will try meds again, but as of now I am having children and breast feeding so I’m staying away from the meds for now. Read More Read Less
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Fill 3Created with Sketch.Condition: Bipolar Depression
Overall rating 1.
0
My psychiatrist, if you could call her that, prescribed me Latuda during my most recent massive depressive episode (that started around October of last year). She figured I had bipolar depression and immediately told me to go on Latuda and being a complete fool I listened to her (she's recommended a myriad of medications for every little problem that I've come to her with, everything from benzodiazapine for sleeping to anti seizure medication for sweating). My depression got progressively worse over the next few months and I could not sleep at all. I couldn't even get into bed without having massive panic attacks. It got so bad that I had to sleep in my clothes (like jeans and a sweater) on the couch in my living room because the thought of my bed made me disgusted. This was when my doctor told me to take benzos to knock me out at night which I of course did not do. I kept taking Latuda and she kept raising the dosage to try and get me out of my depression but It wasn't working.
Finally one night I snapped and couldn't take the depression anymore. I was suicidal and took matters into my own hands. My course of action was to change my life situation and go off of the medication. I moved back home and weened myself off of the Latuda. I rebounded really well and am feeling much better. My doctor was skeptical and kept trying to convince me that I was bipolar, she would call me and my parents and make me question my sanity. I stopped talking to her recently and decided to go off of all my medication because I have no faith in the established psychiatry field anymore. TLDR Latuda is a massive waste of time. Read More Read Less
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Fill 3Created with Sketch.Condition: Other
Overall rating 1.0
EffectivenessEase of UseSatisfactionThis drug has been a living nightmare for our teenage son who struggles with mood disorder due to severe ODD.
We had hoped to take him off of Abilify even though it has worked for years because Latuda works as a mood stabilizer PLUS an anti depressant. Our 15 yr old son has been on Latuda for just over a month. Started on 10mg and worked up to 30mg. Just 2 weeks into it he started experiencing nightmares that always ended in him committing suicide (which he never had prior). Then I had to abruptly pull him off of it this past weekend because he blacked out which also has never happened before. While he was blacked out he had visions of him murdering his father and all he could do after he came to was cry to me and ask what was happening to him. Within the next hour he was in full hives so we took him straight to the ER. They agreed on taking him off of it immediately which I had already planned on. We will transition him back to Abilify however that does not help with depression. Read More Read Less
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Fill 3Created with Sketch.Condition: Bipolar Depression
Overall rating 1.7
EffectivenessEase of UseSatisfactionI have neither had a good experience or a bad one. I simply do not believe latuda does anything. I'd be better off with a placebo.
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Fill 3Created with Sketch.Condition: Bipolar Depression
Overall rating 4.7
EffectivenessEase of UseSatisfactionFirst you all I have Bipolar & Anxiety was on sequoia & Zanax ER for years They had to change my Sequoia to put me on another blood thinner.
I didn’t realize that my brain was frogged over the many years that I was on Sequoia. But since I’ve been on Latuda my brain is more alive than it has been for years. I will tell but for me this is a life changer. I’m 62 years old & my husband didn’t know when I would I would go crazy. I really believe n this medicine but I know that when we get to draw Medicare it probably won’t cover it. It’s so freaking SAD what we do to older Americans!!!!!Read More Read Less
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Fill 3Created with Sketch.Condition: Bipolar Depression
Overall rating 5.0
EffectivenessEase of UseSatisfactionAfter trying different antipsychotics to treat Bipolar Disorder and Substance Use Disorder, Latuda (120mg) was the most effective medication I have taken so far.
My mood swings are much better, I can focus again and do not need ADHD medication, and my cravings for drugs and alcohol have substantially gone away. I began taking this medication when I was 26 years of age. Today, I am 29 years old, clean and sober, and doing much better because of Latuda.
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Fill 3Created with Sketch.Condition: Schizophrenia With Mood Changes
Overall rating 5.0
EffectivenessEase of UseSatisfactionI am taking this medicine for schizoaffective bipolar type, at first it seemed really bad but once it balanced itself I was very sharp. I was allergic to captyla and Seroquel but this is a related family but not in the same family. You will need to takea stimulant to produce dopamine.
Alot of uneducated schizophrenics think just take one antipsychotic and get a horrible doctor. No. No. NO. Get A STIMULANT W/ this medication.
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The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions.
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Latuda (Lurasidone) Reviews | Everyday Health
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1 Stars
Posted 2 months ago (3/5/2023) 1
Rated for Bipolar Disorder Report
It Made me emotionally numb therefore disconnected from my loved ones, I barely spoke, had no motivation so I didn't take care of myself or the house, I didn't cook or go anywhere, I lost my creativity, emotional connection to music, sex drive, I had trouble thinking and remembering.
I've been off over a year and am somewhat better but I lost years of my life and aspects of my personality I'm not sure I'll ever get back. Sure I'm not suicidal but I'm not sure it was worth it.
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3 Stars
Posted 5 months ago (11/8/2022) 3
Rated for Bipolar Disorder Report
I started on 40mg of latuda after major depression with suicidal thoughts. Raised to 80 mg in two months. Felt very edgy, like skin crawling and could barely keep my eyes open. Doctor raised it to 120mg. Been at this dosage for a few months. Tiredness became worse and was unbearable. Decided to start taking it in the evening instead of mornings which helped tremendously with the sleepiness during the day. Wake up easily in the mornings now. Moods are less drastic. The twitching is very annoying when in bed. I currently have very anxious thoughts and feeling dissociated from myself and reality.
Not sure if the pros outweigh the cons. Going to talk to my doctor ASAP.
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3 Stars
Posted 7 months ago (9/11/2022) 3
Rated for Bipolar Disorder Report
Crazy Dreams Like watching movies all night Getting tired of that at first it was amusing now I'm over it. Knocks me out at night but crazy exhausting dreams. Depression pretty bad today Take 20 mg, 40 was too much Felt better for a while especially in morning more mild mannered but lately very down and want to stay in bed all day. I also take Prozac and Lamictal twice a day I've gained 30 lbs in a year. Lost a lof weight on Wellbutrin but too manic shaking, lip quivering Latuda worked for a while in the mix but not lately
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5 Stars
Posted 9 months ago (7/30/2022) 5
Rated for Bipolar Disorder Report
Worked for me when nothing else would.
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5 Stars
Posted 9 months ago (7/21/2022) 5
Rated for Bipolar Disorder Report
Have been taking 40mg Latuda for about 3 years now. It has dramatically changed my life. I suffered from major recurring depression (episode every 6 - 8 months for 20 years) and haven't experienced anything worse than just the occasional bad day since starting this medication. I sometimes get mildly nauseated after taking it, but gravol resolves this issue. It does make me sleepy, but I take it at night and so it can just help me sleep.
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1 Stars
Posted 10 months ago (6/9/2022) 1
Rated for Bipolar Disorder Report
I was diagnosed with having Bipolar 2 disorder by a psychiatrist who saw me for one and a half hours. His diagnosis made sense to me. He prescribed Latuda.
I forget the amount, sorry. It turned me into a suicidal zombie. I couldn't feel anything, no emotions, no feelings, no motivation. I couldn't laugh, cry, be angry, be happy or sad. That being said I was miserable. I couldn't see beauty, no response to the arts which I love. It was awful. My friends noticed easily, became seriously concerned for me. My doctor said I had to get off of it. I did what they tell you not to do, quit cold turkey and isolated myself. As you know Bipolar disorder is all the rage now. It is in fashion and drug companies are advertising their products for Bipolar with regularity on TV. This drug may be effective and good for some people. For me it was horrific. Please get multiple opinions on whatever you may decide to take. These medications have serious consequences for your life and health.
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5 Stars
Posted 11 months ago (6/2/2022) 5
Rated for Bipolar Disorder Report
I've been taking this a little over a month.
Still take adjunct low dose of lithium and 3 Depakote pills. Also, atomoxetine for ADD inattention. This combination seems (so far to be working phenomenally well). I've had a period of mania/hypomania, but the mood dives down into deep depression every week and a half to two weeks for my rapid cycling are gone. For the first time in over five years, while taking this medication, I've been consistently happy. Even the mania was more pleasant, with much less irritability than I was previously dealing with. Its not going to work for everyone, but it sure is working for me so far. I'm so pleased. Don't give up trying to find the right meds for your bipolar . . . so worth it if you can figure that out with your doc. Good luck and God Bless!
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5 Stars
Posted 13 months ago (3/24/2022) 5
Rated for Bipolar Disorder Report
Best medication I’ve ever been put on for the bipolar.
I’m stable, clear headed, calm and less impulsive. It does still make me tired soon after I take it, but I wake up refreshed. I’ve been on it four years now at a dose of 60 mgs
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2 Stars
Posted 13 months ago (3/8/2022) 2
Rated for Bipolar Disorder Report
I tried Latuda for Bipolar depression related to bipolar type II. Prior to this, had been on Abilfy, which caused massive weight gain. I did lose weight on Latuda, however it made me EXTREMELY irritable and impatient; I didn't even like being around myself. This was after starting at 20mg and going up to 40mg. At 60mg I developed severe akathisia, which is a horribly uncomfortable feeling that you have to constantly move and just want to crawl out of your skin. That and the irritability were unbearable. I know some people say it works very well for them, and that is great, but I don't understand how it turned me into an extremely irritable person who wanted to crawl out of my skin? I will never take this again.
I tried it a second time after Vraylar helped my depression but also caused me to gain back all the weight I lost after stopping Abilify, so tried Latuda again and my irritability was absolutely horrible. Within 3 days of going off the med I was starting to feel so much better. I will never take this medication again.
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5 Stars
Posted 17 months ago (11/21/2021) 5
Rated for Schizophrenia Report
Latuda is a very comfortable drug it really helped me with my condition. Gave me the sleep at night the best sleep I ever had. I did experience some weight gain but it was a combination of invega and abilify not that much latuda. I do get stiff muscles at night which is not too comfy. Overall is the best drug I had been on so far. My weight gain was twenty pounds.
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1 Stars
Posted 21 months ago (8/2/2021) 1
Rated for Schizophrenia Report
I hate this drug.
I’m taking 80mg for a month for I Don’t Know What. I’m on day 4 of a severe panic attack. I cut the dose in half as per the on-call psychiatrist. It’s still terrible. Don’t take this.
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1 Stars
Posted 22 months ago (6/22/2021) 1
Rated for Bipolar Disorder Report
This medication causes severe epilepsy in more than 50% of patients. I was lucky enough to get grand mal seizures from it and needed to be hospitalized. My life has been permanently ruined because of this worthless pill. It causes seizures in those who have not been previously diagnosed with them and the company that produces it in Japan has gone to court nonstop since its inception to avoid listing that common side effect. If you have bipolar disorder, depression or schizophrenia, please ask for anything else but this poison. I never recovered from my seizure. My psychiatrist was at first hesitant to blame latuda then confirmed it was the culprit, thereafter not prescribing it to any more of his patients.
No medication will have a 5 star review. Look closely at the most negative reviews first to see an honest experience of the medication. Don't make the mistake I made, your life will be ruined if you take this medication. I was at a low dose and it still caused paralyzing seizures.
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4 Stars
Posted 23 months ago (5/10/2021) 4
Rated for Bipolar Disorder Report
I had been on Geodon and Adderall for over 14 years. The Geodon knocked me out so had to take at night and the Adderall was taken in morning and non for ADHD. No matter what antidepressant I went on they made me suicidal. Starting last fall my new therapist slowly took me off Geodon and then started weaning me into latuda. I can't take the 60 mg of latuda at night cause then I can't sleep and I get restless legs. Talking it in the morning, I haven't noticed side effects. It's hard to say right now if it has lifted my mood significantly because my horse, my comfort cat and my working k9 have all been euthanized since starting the Latuda.
So my therapist doesn't want to increase or decrease Latuda until I get further through my grief process.
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3 Stars
Posted 23 months ago (5/9/2021) 3
Rated for Bipolar Disorder Report
I was diagnosed with bipolar type 1 in 2018 and ever since been trialing medications as none of them really stuck or made things better without triggering the other. I started on latuda a month ago roughly, it’s done wonders for my bipolar depression pulled me straight out so quickly. However, I’m now sleeping 12-13 hours a day about half an hour after I take the medication. The nausea is what gets me though, it’s shortly after taking latuda I feel so sick to my stomach I can’t eat after I’ve taken it. I’ve thrown up a few times because of the nausea. It’s also caused my liver enzymes to become really high.
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1 Stars
Posted 24 months ago (5/4/2021) 1
Rated for Bipolar Disorder Report
They gave this to my 16 year old daughter that had Bipolar II Disorder. She was immediately nauseous the first night, and could not sleep but about 2 hours. This went away in the morning, but that evening before she even had her second dose, she started feeling sick to her stomach again. She was outside and her legs gave way and she needed to be helped to her feet. She was slurring and then she'd stop for a second, and then start slurring again. She seriously was acting like she was drunk or on drugs, which she does not have a history of. I didn't smell any alcohol on her breath and she swore to me that she hadn't taken anything. I called the Doctor the next morning and they told me to go ahead and take her off of it, and that yes, it does sometimes have those side effects in teenagers. EEEEEK, so scary.
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3 Stars
Posted 24 months ago (4/23/2021) 3
Rated for Bipolar Disorder Report
I take latuda for bipolar disorder with psychosis. I take Latuda 40mg I switched from Invega to Latuda from a psychiatrist. The side effects are terrible twitchy movements and tongue clicking at night. I also sleep 12 hours I feel like this drug makes me very sedated. I usually take Latuda at night with food which helps but makes me twitchy sometimes in which I take benztropine to stop the twitchy side effects. Overall, my mood has been stable.
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1 Stars
Posted 24 months ago (4/22/2021) 1
Rated for Bipolar Disorder Report
I started this medication at 20mg, then increased to 40mg then 60mg. At 60mg, I started feeling very uncomfortable side effects. At night, I felt very short of breath along with rapid heartbeat. It got so bad that I had to go to the hospital. I literally felt like my next breath would be my last. Also severe panic, as you can imagine. I’m now tapering off Latuda and the feeling went away. I’m hoping my review will help someone who has the same symptoms.
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1 Stars
Posted 25 months ago (3/30/2021) 1
Rated for Bipolar Disorder Report
i feel down and hopeless when taking this. i get a bad feeling in the pit of my stomach and feel suicidal. i take it with prozac to help my bipolar depression and it just makes me miserable. i’m 17 and take 10 mg of prozac with 40 mg of latuda.
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4 Stars
Posted 25 months ago (3/20/2021) 4
Rated for Bipolar Disorder Report
I was diagnosed with Bipolar 2 last year and have since tried a number of meds. Lithium made me too “flat,” paired with Wellbutrin which made me hallucinate. I take 20Mg of Latuda and so far it has really helped. Started this med around thanksgiving (late Nov.) and so far it has been pretty good to, compared to all the other meds i’ve tried. I do shake a bit but my body seems to have adjusted over time and it really isn’t that bad. my skin has been breaking out some, but it’s been manageable. No weight gain or weight loss. I am able to sleep, which is very important to me. I work graves and also sometimes take Hydroxyzine 50mg to help me get to sleep.
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1 Stars
Posted 25 months ago (3/12/2021) 1
Rated for Schizophrenia Report
I started at 10 milligrams. When I went up to 30 milligrams my period stopped and I started getting the shakes. I also gained 10 pounds in a month. It has caused me to have severe acne.
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4 Stars
Posted 27 months ago (2/2/2021) 4
Rated for Bipolar Disorder Report
Akathesia horribly!! Now that I'm off of it, I can see how latuda was working! Taking it is just not an option for me anymore ??
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5 Stars
Posted 27 months ago (1/12/2021) 5
Rated for Schizophrenia Report
Schizoaffective Disorder - Schizophrenia and Bipolar. It's great. Am currently on Abilify, Latuda 80mg and Lithium. Was on Zyprexa 5mg instead of Latuda, gained a lot of weight, still had residual delusions. All delusions have gone and I think due to diarrhoea side effects during the transitional phase, have lost about five kilograms. Don't sleep much and I wake up early ready for the day despite a feeling of mild laziness. Strongly recommend.
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1 Stars
Posted 28 months ago (1/3/2021) 1
Rated for Bipolar Disorder Report
My 17 year old daughter took this after abilify was not working to help her depression. Latuda was started at 40mg. She became angry and irritable. Still could not get out of bed. No motivation to do schoolwork. Increased to 60mg, side effects were worse. She developed allergic rxn. Skin itched like crazy and she literally screamed from the rash. This drug was awful and did not work. She was only on it for a month. Hoping we find something to help her depression. Also she was prescribed .1mg clonidine to help her sleep.
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5 Stars
Posted 28 months ago (12/9/2020) 5
Rated for Bipolar Disorder Report
I have tried every anti depressant know to man with little to no help or I was what I call a fixture on the couch for days. I would have intrusive thoughts and cry all the time, My doctor had me on zoloft 50 mg and added Latuda 10mg. Let me express to you how much bettter my life is!! I feel alive again. I take it at 9pm and zoloft around noon, Somedays I am a little jittery but its controllable. I hope this may help someone because it did me. I was a little nauseous in the beginning but rarely now .
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5 Stars
Posted 29 months ago (11/16/2020) 5
Rated for Bipolar Disorder Report
I just started taking it about 2 weeks ago. I feel a big difference in my mood already. Normally the week before my period I get depressed but so far I’m able to let bad thoughts pass as soon as I think about them. Before I would dwell on them. It doesn’t help much with anxiety but can be paired with Gabapentin, a relatively safe antianxiety med that works GREAT! Causes extreme drowsiness. Plan to take a 2 hour nap a couple hours after taking Latuda.
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1 Stars
Posted 29 months ago (11/9/2020) 1
Rated for Bipolar Disorder Report
Latina is big old nothin’ for me. I’ve been on 40mg for a few weeks now and I notice no difference. Luckily, I don’t have any real bad side effects, but for me, it may as well be a placebo.
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5 Stars
Posted 31 months ago (9/16/2020) 5
Rated for Schizophrenia Report
80mg @ night, after dinner. Side affects, nausea! I sleep 6 good hours, so I have to watch what time I go to bed, I tend to get up real early & I don’t nap. My sexdrive drives my partner nuts, no pun! I’m also bipolar & I take another medication for that! I still have mania & even I notice & I still have bouts of DEEP SAD depression so I’m thinking I’m not medicated properly! But my loved ones love the Latuda 80mg (I did start @ 40mg, did that for a month, went up to 60mg, did that for a month been on 80mg for a year!) I get it, this is NOT for everyone with just ANY diagnosis!!
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5 Stars
Posted 31 months ago (9/8/2020) 5
Rated for Schizophrenia Report
Taking for Borderline Personality disorder. Love how I feel during the day now. But also I wake uo 830 am no matter how late I stay up. Sleep deprived and when I take the meds at night I feel awful.
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1 Stars
Posted 32 months ago (8/7/2020) 1
Rated for Bipolar Disorder Report
I have Bipolar Disorder and I am currently in a severe depressive state. I take Lamictal and Seroquel. My doctor added Latuda as an antidepressant and it has made my depression much worse. Total hopelessness and suicidal thoughts. Also terribly sedating, can't wake up in the morning. Sleep like 12 hours before I can get up. Horrible drug for me.
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3 Stars
Posted 33 months ago (7/13/2020) 3
Rated for Schizophrenia Report
I was put on latuda for schizophrenia and bipolar disorder and it hasn’t done anything for my mood but has stopped my hallucinations. I have been on latuda for 5 months now and I take it at night after dinner because it makes me very sick without food.
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1 Stars
Posted 33 months ago (7/12/2020) 1
Rated for Bipolar Disorder Report
Sadly I was misdiagnosed with Bipolar Disorder. I took Latuda for 2 years. I became a different person. I had no joy. I had no sadness. I could only do the minimal things to stay alive. I didn't want to shower. I hardly slept. At times I was completely disassociated with myself. It took me some time to realize I was not bipolar. I went on a board for people with bipolar and I could not relate at all. None of their issues were mine. I asked the psych about it, and she reviewed it and said I didn't have it. It has since taken me a solid 2 years to recover my brain to where it used to be. Dangerous drug.
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5 Stars
Posted 33 months ago (7/6/2020) 5
Rated for Bipolar Disorder Report
I've been on lurasidone now for about 4 months after being changed from aripriprozole (which sedated me) it has helped with my mood and motivation... hasn't been cured 100% got another review with my pd weather my lurasidone needs increasing
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3 Stars
Posted 34 months ago (6/25/2020) 3
Rated for Bipolar Disorder Report
i have only taken this drug once, yesterday, and it made me feel very out of it. i work at a call center and my job is to do chat customer service, but after taking this, i couldn’t even type on my keyboard. i don’t know if i couldn’t focus or if it made me just really out of it, or both. since i only have taken it the one time, im sure i haven’t given my body time to adjust to the meds, but if that’s how it’s going to make me feel every time i take it, i’ll stop now and ask for a different prescription...
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2 Stars
Posted 34 months ago (6/4/2020) 2
Rated for Bipolar Disorder Report
I’ve only been taking this for two weeksBut had to stop. My depression got so much worse. I was already feeling quite depressed but because of my bipolar diagnosis, my doc didn’t want to add another antidepressant (I already take 300 mg Wellbutrin) unless I was on a mood stabilizer or antipsychotic. We tried this primarily because it’s not supposed to cause weight gain. It does give me severe acid reflux soon after I take it, every time. But I had several days where I couldn’t get out of bed and had suicidal ideation. I couldn’t find any mention of these side effects anywhere but know it’s from the meds. I stoped it last night and didn’t have the acid and feel a little better today already. I was hoping for the miracle drug everyone talks about.
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3 Stars
Posted 35 months ago (6/3/2020) 3
Rated for Bipolar Disorder Report
so i didnt get nausea but i do have dizzy spells on 20mg. My doctor thought it would be good for my anxiety but i feel worse like i dont know how to deal with it on this drug. i do get tired but its tolerable except my depression is worse.
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Cariprazine use and likelihood of weight gain
- In clinical trials, weight gain in patients treated with cariprazine was comparable to weight gain with placebo 1 .
- Significant weight gain may occur in some patients while taking cariprazine and should be carefully monitored. 1 .
- Cariprazine is metabolically neutral: the incidence of hyperlipidemia, hyperglycemia and diabetes mellitus in clinical studies was comparable to the incidence of these events when using placebo 2-4 .
In this section:
Antipsychotics may cause weight gain
People with schizophrenia are more likely to be overweight or obese than the general population 5 . During therapy with antipsychotic drugs, most patients may experience a clinically significant increase in body weight. Weight gain is a problem for patients because it can contribute to the development of type 2 diabetes, dyslipidemia and hypertension, which increases the risk of cardiovascular events 6 .
Although diet and a sedentary lifestyle also contribute to weight problems in patients with schizophrenia, strong evidence suggests that antipsychotics are a key factor in weight gain 5. 7 . This side effect is different for each antipsychotic drug. But no remedy works equally for all treated patients 8 . The incidence of clinically significant weight gain (≥7%) associated with treatment with atypical antipsychotics has been reported in the range of 8.1% (aripiprazole) 9 up to 22.2% (olanzapine) 10 .
Advice for clinicians and patients on managing weight gain
Because antipsychotics, including cariprazine, may be associated with weight gain, weight should be monitored in all patients with schizophrenia 1 . Body mass index (BMI) is considered the accepted standard for deciding whether to correct overweight 5 .
The patient's waist circumference can also be an informative indicator of pathological weight gain. Women with a waist circumference ≥90 cm and men with a waist circumference ≥100 cm have an increased risk of high blood pressure, type 2 diabetes, dyslipidemia, and metabolic syndrome 11 .
| BMI 12.13 | Weights |
| 18.5-24.9 | Normal weight |
| Overweight | |
| 30 or more | Obesity |
the patient to a doctor within the first 6 months after starting therapy or changing the drug 5 . If values are stable, weight and BMI should be checked quarterly in normal weight patients and more frequently in overweight patients.
Patients who visit more than 1 month apart should be educated about weight management and asked to come in off-schedule if they begin to gain weight 5 .
If the patient is gaining weight, counsel on dietary changes, exercise choices, use of weight loss medications, and consider switching from an antipsychotic to an agent that is less likely to cause weight gain 14.15 .
Methods for preventing weight gain
As with other antipsychotics, weight gain has been observed in some patients with cariprazine 1 . Studies have shown that when taking cariprazine, a weight gain of 1 kg occurred, both in short-term and long-term treatment 1 . In a long-term study using dosages of 1.5 mg-6 mg/day, it was shown that weight gain was recorded in 9.0% of patients taking cariprazine 1 . Compared with the placebo group, an increase in body weight was recorded in 5.1% of patients receiving cariprazine and 1.5% of patients receiving placebo 16 .
In general, it can be said that cariprazine leads to a slight increase in body weight 1 .
| Placebo n=683 | Cariprazine 1.5-6 mg n=2048 | |
| Weight gain 1 | 0.9 kg | 1.1 kg |
| Weight gain ≥7% 1 | 7.1% | 9.8% |
Metabolic changes with cariprazine
Po- Cariprazine does not appear to have a clinically significant adverse effect on metabolic parameters.
Mean (SD) changes in metabolic characteristics from baseline with authorized doses of cariprazine were small and clinically insignificant 4 .
The number of patients who experienced adverse events associated with hyperlipidemia was approximately 1% in all treatment groups. The number of patients who experienced adverse events associated with hyperglycemia and diabetes mellitus was <1% in the cariprazine treatment group and 1% in the placebo group 16 .
In short-term studies, changes from normal to high lipid and glucose levels were generally comparable between placebo and cariprazine 2 .
In conclusion, the results of the study indicate that cariprazine may be considered an acceptable treatment option for patients with schizophrenia at risk of developing cardiovascular disease due to problems with excess weight or metabolic disorders 2-4 .
Instructions for medical use of Reagila® RU: LP-005405 dated 03/18/2019. The instructions can be found on the website: www.grls.rosminzdrav.ru.
Sources:
- Reagila SmPC. Instructions for medical use of Reagila® RU: LP-005405 dated 03/18/2019.
- Earley, W. et al. Safety and tolerability of cariprazine in patients with acute exacerbation of schizophrenia: A pooled analysis of four phase II/III randomized, double-blind, placebo-controlled studies. Int. Clin. Psychopharmacol. 32, 319–28 (2017).
- Leucht, S. et al. Sixty years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Systematic review, Bayesian meta-analysis, and meta-regression of efficacy predictors. Am. J. Psychiatry 174, 927–942 (2017).
- Citrome, L. Cariprazine in schizophrenia: Clinical efficacy, tolerability, and place in therapy. Adv. Ther. 30, 114–126 (2013).
- Marder, S. R. et al. Physical health monitoring of patients with schizophrenia. Am. J. Psychiatry 161, 1334–1349 (2004).
- Kapur, S. & Marques, T.
R. Dopamine, striatum, antipsychotics, and questions about weight gain. JAMA Psychiatry 73, 107–108 (2016).
- Padmavati, R., McCreadie, R. G. & Tirupati, S. Low prevalence of obesity and metabolic syndrome in never-treated chronic schizophrenia. Schizophr. Res. 121, 199–202 (2010).
- Musil, R., Obermeier, M., Russ, P. & Hamerle, M. Weight gain and antipsychotics: A drug safety review. Expert Opin. drug safe. 14, 73–96 (2015).
- Abilify [package insert]. Rockville, MD: Otsuka America Pharmaceutical, Inc https://www.otsuka-us.com/media/static/Abilify-PI.pdf (2018).
- Zyprexa [package insert]. Indianapolis, IN: Lilly USA, LLC https://pi.lilly.com/us/zyprexa-pi.pdf (2018).
- Janssen, I., Katzmarzyk, P. T. & Ross, R. Body Mass Index, Waist Circumference, and Health Risk. Arch. Intern. Med. 162, 2074–2079(2002).
- Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Heal. Organ. – Tech. Rep. Ser. (2000).
- National Heart Lung and Blood Institute & National Institutes of Health (NIH) National Heart, Lung, and Blood Institute, N. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. The Evidence Report, NIH Publication No. 98-4083. WMJ official publication of the State Medical Society of Wisconsin (1998) doi:10.1001/jama.2012.39.
- Aquila, R. Management of weight gain in patients with schizophrenia. J.Clin. Psychiatry 63, 33–36 (2002).
- Ball, M. P., Coons, V. B. & Buchanan, R. W. A program for treating olanzapine-related weight gain. Psychiatr. Serv. 52, 967–969 (2001).
- EMA. Reagila Assessment Report. https://www.ema.europa.eu/en/documents/assessment-report/reagila-epar-public-assessment-report_en.pdf.
Advances in Therapy
Treatment with cariprazine: clinical efficacy, tolerability
Citrome L.
Adv Ther. 2013; 30(2):114–26.
"Potential candidates for treatment with cariprazine may include adult patients with schizophrenia for whom the risk of metabolic or cardiovascular disease is a concern, as well as patients in whom weight gain should be minimized or prevented. "
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Mechanism of action of Reagila Mechanism of action of Reagila
(Reagila® RU: LP-005405 dated 03/18/2019) The therapeutic effect of cariprazine is provided by a combination of partial agonism in relation to dopamine D3- and D2-recLearn more about the mechanism of action of Reagila
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(Reagila® RU: LP-005405 dated 03/18/2019) patient, maintaining and returning self-service skills, social interaction
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Medicines that can make you gain weight
Taking medicines that your doctor prescribes for you for a particular reason may be accompanied by side effects that are not always desirable. Unfortunately, doctors do not always warn about what medications can lead to, and many would like to know what to expect from a course of medications.
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The fight against excess weight
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One of the most common drug side effects is weight gain. Let's make a reservation right away - this does not happen for everyone and not always, but you can be one of those "lucky ones" who really put on weight.
We talk about drugs that can cause weight gain. We are sure that it is better to know and take some steps in advance so as not to gain weight than to accidentally discover an extra 3-5, or even 10 kg, gained over several weeks of taking the drug.
In general, it would be absolutely useful to discuss with the doctor all the possible "side effects" that the prescribed medicine can cause in order to take timely action. This, however, applies to any side effects, and not just those associated with weight. In some cases, undesirable effects are inevitable, but there are situations when their occurrence can be completely avoided or at least made less pronounced.
Steroids
Steroid preparations can be prescribed for various diseases. They make it quite easy to achieve an improvement in the condition, but the treatment is often accompanied by an undesirable effect, including insomnia, increased appetite and swelling. All this is the perfect combo for those extra pounds to literally stick in strategic places. It is important that steroids are available in different forms - these can be ointments and creams, sprays, as well as tablets. The latter just cause weight gain the most. You can reduce your chances of gaining weight by choosing the lowest possible dose for you, as well as adjusting your diet and choosing the ideal sleep pattern for you.
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Antidepressants
Many people say that you can gain weight on antidepressants. Fortunately, not everyone is gaining it, although this, of course, is quite real. Selective serotonin reuptake inhibitors pose the greatest danger in this regard, so if you are taking drugs whose active ingredient belongs to this class of substances, be careful.
The fact is that such drugs not only improve your mood and help you feel less depressed, but also increase your appetite. And here the connection is quite obvious: you want to eat more - you eat more - your weight increases.
If you are prone to weight gain, then discuss with your doctor in advance that you are worried about the fact that he will become more - it is likely that he will be able to choose another suitable drug for you.
Birth control pills
Oral contraceptives have many side effects, some of which are quite pleasant and desirable. But, let's not hide, weight gain is not included in this list for everyone.
It works like this: progesterone, which is part of birth control pills, increases appetite, which causes women to eat more and gain weight. Another possible mechanism is that while taking contraceptives, the body begins to more actively retain water, and the weight also goes up because of this.
Antihistamines
Popular antihistamine-based allergy medications are most often not available by prescription. They can be prescribed by a doctor, but many people buy these drugs on their own initiative and choose the dosage on their own.
In addition to the fact that the selection of medicines still has to be handled by a specialist, there is another danger. All the same kilograms that you can gain. Taking allergy medications frequently can lead to weight gain. This happens more often in women than in men. If you notice that you are really gaining weight on the background of a course of antihistamines, but at least try to change the dosage form: the spray in this case will be much less dangerous than tablets.
Blood pressure medications
Medicines prescribed for hypertension, such as beta-blockers and angiotensin receptor blockers, also affect weight. Unfortunately, in the case of such drugs, the choice is not too rich. There is nothing to replace them and cancel, most likely, the doctor will not allow. And this means that in order to prevent gaining extra pounds, you will have to carefully monitor your lifestyle, adjust your diet and try to introduce at least a minimum of physical activity into your daily routine.
Migraine Medicines
The pain of migraine is terrible and excruciating, so finding that one medicine or another really helps with these nightmarish headaches is priceless. People who suffer from migraines are often ready to go to great lengths to improve their condition, and they may not even notice such "little things" as weight gain while taking medication.
However, in any case, for those who suffer from migraines, it is important to monitor their condition, minimize or completely eliminate the influence of triggers that can provoke a migraine attack.
