Zoloft for men
Can Zoloft Cause ED?
Can Zoloft Cause ED?Medically reviewed by Lindsay Slowiczek, PharmD — By Ann Pietrangelo — Updated on August 15, 2018
Overview
Zoloft (sertraline) is a selective serotonin reuptake inhibitor (SSRI). It’s used to treat a range of psychological conditions, including depression and anxiety. These conditions can cause erectile dysfunction (ED). Zoloft may also cause ED, however.
Read on to learn more about the relationships among ED, Zoloft, and mental health.
SSRIs such as Zoloft work by increasing the amount of the neurotransmitter serotonin that is available in your brain. While increased serotonin can help relieve your symptoms of depression or anxiety, it can also cause problems for your sexual function. There are several theories for how antidepressants such as Zoloft cause ED. Some of them suggest that these drugs can do the following:
- decrease feeling in your sexual organs
- reduce the action of two other neurotransmitters, dopamine and norepinephrine, which reduces your levels of desire and arousal
- block the action of nitric oxide
Nitric oxide relaxes your muscles and blood vessels, which allows enough blood to flow to your sexual organs. Without enough blood being sent to your penis, you can’t get or maintain an erection.
The severity of sexual problems caused by Zoloft varies from person to person. For some men, side effects decrease as the body adjusts to the medication. For others, the side effects don’t go away.
If your ED is caused by depression or anxiety, it may improve after Zoloft starts to take effect. If you haven’t been taking Zoloft very long, wait a few weeks to see if things improve.
Talk to your doctor if you think your ED is due to Zoloft. If they agree, they may adjust your dosage. A lower dosage may reduce the drug’s effects on your sexual function. Your doctor may also suggest that you try a different type of antidepressant instead of an SSRI. Finding the right treatment for depression, anxiety, and similar disorders takes time. It often requires several adjustments of medication and dosage before settling on the right ones.
Your doctor may suggest other remedies if you find that your ED is not caused by depression or Zoloft. For instance, you may be able to take another medication to treat your ED symptoms.
Zoloft, depression, and anxiety are only a few of the things that can cause ED. Normal sexual function involves many parts of your body, and they all need to work together correctly to cause an erection. An erection involves your blood vessels, nerves, and hormones. Even your mood can play a part.
Other factors that can affect your sexual function include:
Age
Studies show that ED tends to increase with age. By age 40, about 40 percent of men have experienced ED at some point in their lives. By age 70, this number goes up to about 70 percent. Sexual desire can also decrease with age.
Erectile dysfunction and your age: Is it inevitable? »
Health conditions
Certain health conditions put you at increased risk of developing ED. Examples of these conditions include:
- diabetes
- heart disease
- high blood pressure
- Peyronie’s disease
- multiple sclerosis
- Parkinson’s disease
- spinal cord injury or injuries that damage nerves and arteries involved in erections
Medications
Certain medications can also cause ED. These include:
- other SSRIs such as citalopram (Celexa) and fluoxetine (Prozac)
- the antihistamine cimetidine
- diuretics such as chlorothiazide and chlorthalidone
- pain medications such as opioids
Learn more about medications that can cause ED »
Lifestyle
Lifestyle factors can also affect your ability to have an erection. Smoking, drinking, and drug use can be part of the problem. Stress and obesity can also add to sexual dysfunction.
If you and your doctor think lifestyle issues are the cause of your ED, make changes accordingly. If you smoke, try to quit. Cut down on alcohol use. And if you have a substance abuse problem, seek help. Also, make time for some physical activity every day. It helps with blood flow, weight control, and stress reduction.
Keep reading: 5 natural treatments for erectile dysfunction »
There are many possible causes for ED, and if you’re taking Zoloft, it may be the culprit. The only way to know for sure is to talk to your doctor. They can help find the cause of your problem and help you resolve it. They can also answer any questions you may have, such as:
- Is there another antidepressant that might work better for me?
- If Zoloft isn’t causing my ED, what do you think is?
- Are there lifestyle changes I should make that might improve my sexual function?
Q:
What antidepressants are least likely to cause sexual side effects?
Anonymous patient
A:
Any antidepressant can cause sexual problems. However, two drugs in particular have been shown to have slightly less risk of problems such as ED. These drugs are bupropion (Wellbutrin) and mirtazapine (Remeron).
Answers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
Last medically reviewed on January 4, 2017
How we vetted this article:
Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
- Erectile dysfunction. (2014, March)
familydoctor.org/condition/erectile-dysfunction/ - Erectile dysfunction. (2016, March 15)
my.clevelandclinic.org/health/articles/erectile-dysfunction-overview - Hellerstein, D. (n.d.). Why do SSRI antidepressants cause sexual side effects? Retrieved from
asp.cumc.columbia.edu/psych/asktheexperts/ask_the_experts_inquiry.asp?SI=226 - Lakin, M., & Wood, H. (2012, November). Erectile dysfunction
clevelandclinicmeded.com/medicalpubs/diseasemanagement/endocrinology/erectile-dysfunction/ - Mayo Clinic Staff. (2016, June 24). Selective serotonin reuptake inhibitors (SSRIs)
mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825 - Sertraline hydrochloride- sertraline hydrochloride tablets. (2008, May)
dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a8b2ad71-cfdc-4a29-8194-deefea138b16 - Sertraline (Zoloft). (2015, October)
nami.org/Learn-More/Treatment/Mental-Health-Medications/Sertraline-(Zoloft) - Zoloft - sertraline hydrochloride tablet, film coated; Zoloft - sertraline hydrochloride solution, concentrate. (2016, November 7)
dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fe9e8b7d-61ea-409d-84aa-3ebd79a046b5
Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.
Share this article
Medically reviewed by Lindsay Slowiczek, PharmD — By Ann Pietrangelo — Updated on August 15, 2018
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Can Zoloft Cause ED?
Can Zoloft Cause ED?Medically reviewed by Lindsay Slowiczek, PharmD — By Ann Pietrangelo — Updated on August 15, 2018
Overview
Zoloft (sertraline) is a selective serotonin reuptake inhibitor (SSRI). It’s used to treat a range of psychological conditions, including depression and anxiety. These conditions can cause erectile dysfunction (ED). Zoloft may also cause ED, however.
Read on to learn more about the relationships among ED, Zoloft, and mental health.
SSRIs such as Zoloft work by increasing the amount of the neurotransmitter serotonin that is available in your brain. While increased serotonin can help relieve your symptoms of depression or anxiety, it can also cause problems for your sexual function. There are several theories for how antidepressants such as Zoloft cause ED. Some of them suggest that these drugs can do the following:
- decrease feeling in your sexual organs
- reduce the action of two other neurotransmitters, dopamine and norepinephrine, which reduces your levels of desire and arousal
- block the action of nitric oxide
Nitric oxide relaxes your muscles and blood vessels, which allows enough blood to flow to your sexual organs. Without enough blood being sent to your penis, you can’t get or maintain an erection.
The severity of sexual problems caused by Zoloft varies from person to person. For some men, side effects decrease as the body adjusts to the medication. For others, the side effects don’t go away.
If your ED is caused by depression or anxiety, it may improve after Zoloft starts to take effect. If you haven’t been taking Zoloft very long, wait a few weeks to see if things improve.
Talk to your doctor if you think your ED is due to Zoloft. If they agree, they may adjust your dosage. A lower dosage may reduce the drug’s effects on your sexual function. Your doctor may also suggest that you try a different type of antidepressant instead of an SSRI. Finding the right treatment for depression, anxiety, and similar disorders takes time. It often requires several adjustments of medication and dosage before settling on the right ones.
Your doctor may suggest other remedies if you find that your ED is not caused by depression or Zoloft. For instance, you may be able to take another medication to treat your ED symptoms.
Zoloft, depression, and anxiety are only a few of the things that can cause ED. Normal sexual function involves many parts of your body, and they all need to work together correctly to cause an erection. An erection involves your blood vessels, nerves, and hormones. Even your mood can play a part.
Other factors that can affect your sexual function include:
Age
Studies show that ED tends to increase with age. By age 40, about 40 percent of men have experienced ED at some point in their lives. By age 70, this number goes up to about 70 percent. Sexual desire can also decrease with age.
Erectile dysfunction and your age: Is it inevitable? »
Health conditions
Certain health conditions put you at increased risk of developing ED. Examples of these conditions include:
- diabetes
- heart disease
- high blood pressure
- Peyronie’s disease
- multiple sclerosis
- Parkinson’s disease
- spinal cord injury or injuries that damage nerves and arteries involved in erections
Medications
Certain medications can also cause ED. These include:
- other SSRIs such as citalopram (Celexa) and fluoxetine (Prozac)
- the antihistamine cimetidine
- diuretics such as chlorothiazide and chlorthalidone
- pain medications such as opioids
Learn more about medications that can cause ED »
Lifestyle
Lifestyle factors can also affect your ability to have an erection. Smoking, drinking, and drug use can be part of the problem. Stress and obesity can also add to sexual dysfunction.
If you and your doctor think lifestyle issues are the cause of your ED, make changes accordingly. If you smoke, try to quit. Cut down on alcohol use. And if you have a substance abuse problem, seek help. Also, make time for some physical activity every day. It helps with blood flow, weight control, and stress reduction.
Keep reading: 5 natural treatments for erectile dysfunction »
There are many possible causes for ED, and if you’re taking Zoloft, it may be the culprit. The only way to know for sure is to talk to your doctor. They can help find the cause of your problem and help you resolve it. They can also answer any questions you may have, such as:
- Is there another antidepressant that might work better for me?
- If Zoloft isn’t causing my ED, what do you think is?
- Are there lifestyle changes I should make that might improve my sexual function?
Q:
What antidepressants are least likely to cause sexual side effects?
Anonymous patient
A:
Any antidepressant can cause sexual problems. However, two drugs in particular have been shown to have slightly less risk of problems such as ED. These drugs are bupropion (Wellbutrin) and mirtazapine (Remeron).
Answers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
Last medically reviewed on January 4, 2017
How we vetted this article:
Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
- Erectile dysfunction. (2014, March)
familydoctor.org/condition/erectile-dysfunction/ - Erectile dysfunction. (2016, March 15)
my.clevelandclinic.org/health/articles/erectile-dysfunction-overview - Hellerstein, D. (n.d.). Why do SSRI antidepressants cause sexual side effects? Retrieved from
asp.cumc.columbia.edu/psych/asktheexperts/ask_the_experts_inquiry.asp?SI=226 - Lakin, M., & Wood, H. (2012, November). Erectile dysfunction
clevelandclinicmeded.com/medicalpubs/diseasemanagement/endocrinology/erectile-dysfunction/ - Mayo Clinic Staff. (2016, June 24). Selective serotonin reuptake inhibitors (SSRIs)
mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825 - Sertraline hydrochloride- sertraline hydrochloride tablets. (2008, May)
dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a8b2ad71-cfdc-4a29-8194-deefea138b16 - Sertraline (Zoloft). (2015, October)
nami.org/Learn-More/Treatment/Mental-Health-Medications/Sertraline-(Zoloft) - Zoloft - sertraline hydrochloride tablet, film coated; Zoloft - sertraline hydrochloride solution, concentrate. (2016, November 7)
dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fe9e8b7d-61ea-409d-84aa-3ebd79a046b5
Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.
Share this article
Medically reviewed by Lindsay Slowiczek, PharmD — By Ann Pietrangelo — Updated on August 15, 2018
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Antidepressant Zoloft in the practice of a general practitioner
Choosing an antidepressant. Focus on the needs of the patient Top page topics
12/29/2016
Antidepressant Zoloft in the practice of a therapist The work of a doctor of any profile has its own characteristics. The specifics of the work of a general practitioner is determined by a wide range of his diagnostic and therapeutic activities, sometimes without clear boundaries. In the diagnosis and treatment of diseases of the cardiovascular system, the therapist interacts (collaborates, and sometimes competes) with a cardiologist, in the treatment of diseases of the digestive system - with a gastroenterologist, in the treatment of kidney diseases - with a nephrologist and urologist, etc. Therapists along with traumatologists and rheumatologists often treat patients with osteochondrosis, arthrosis and arthritis. It is the therapist who can be the main doctor for patients with several concomitant diseases, since he has to put into practice the principle “to treat not the disease, but the patient” and sometimes draw up the final comprehensive treatment plan, taking into account the appointments of narrow specialists.The therapist is rightly called the “primary link” of the health care system and the “family doctor”, since he has to deal with the issues of primary diagnosis and treatment of many diseases. Many patients, regardless of the identified pathology, remain under his supervision, and the treatment of the rest (referring to narrow specialists) can subsequently be carried out with his participation. And of course, for each patient, the therapist should ideally be a personal psychotherapist. In his work, the therapist often encounters certain manifestations of depression, which are detected in many patients with a therapeutic profile. According to statistics, 80% of all patients with depressive disorders first turn to a therapist, which is due to both objective and subjective reasons. Among the objective reasons, one can single out the mutual influence of the pathogenetic mechanisms of mental disorders and organic diseases (including internal diseases).
On the one hand, depression can create conditions for the formation of organic diseases, aggravate and change their course. This is mediated through a variety of neuroendocrine and immunological mechanisms, regarding the interaction of which there is no consensus today. However, it is believed that they are realized through significant violations of autonomic functions, which leads to the formation of "organ neuroses". Pathological enhancement of sympathoadrenal influences may be accompanied by the formation of persistent arterial hypertension, hyperthyroidism, reduced glucose tolerance, and an increase in the content of inflammatory enzymes in the synovial fluid.
Parasympathetic pathological influences contribute to the formation of bronchospastic syndrome and hypersecretion of gastric juice. On the other hand, the pathogenesis of long-term chronic somatic diseases involves the formation of certain psychological changes that create prerequisites for the development of depression. The so-called psychosomatic disorders include not only organ neuroses (syndrome of "irritable stomach", "irritable intestines", "irritated bladder" and other "irritated" organs, functional coprostasis, esophageal achalasia), but also angina attacks that occur as a conditioned reflex , bronchospasm, etc. Such disorders are often accompanied by phobias (fear of gas incontinence, inability to use the toilet) and psychoreactive states (neurotic syndromes, affective and pathocharacterological reactions).
Thus, one group of patients with depression at the therapist's appointment is made up of "dispensary" patients who have new symptoms, and the other is new patients who turned to the therapist with somatic manifestations of depression. It should be noted that in these difficult conditions, the timely diagnosis of depressive disorders largely depends on the qualifications of the doctor: the appearance of somatic symptoms in a patient with depression is often mistakenly perceived as vegetative manifestations of psychogenic disorders, and the addition of symptoms of depression to the clinic of a somatic disease is considered as astheno-vegetative or " hypochondriacal "syndrome (as part of the clinic of the underlying disease).
The diagnostic principle of searching for one disease that explains the fullness of the symptoms in a particular patient (correct in most cases) often plays a cruel joke with the doctor when diagnosing depression. In addition, the primary appearance of depressive symptoms or its addition to somatic pathology significantly reduces the patient's adherence to treatment. As for the subjective reasons for such a high frequency of patients with depression visiting a therapist, it can be noted that a significant part of patients, even suspecting the nature of their condition, under the influence of subjective factors, prefers to seek help not from a psychiatrist (some fear publicity about the fact of observation by a psychiatrist and related social restrictions, others the alleged negative side effects of psychotropic drugs).
The specificity of the medical activity of a general practitioner also determines the features of the choice of drugs. As their own observations show, general practitioners prefer to start treatment with broad-spectrum drugs with a proven therapeutic effect, without pronounced side effects and adverse interactions with other drugs, which have a positive effect on the most common comorbidities, which have a convenient mode of administration - then There are first-line drugs that are safe and effective in most patients. Thus, in the treatment of arterial hypertension, we often begin therapy with the use of modern calcium antagonists (amlodipine) or angiotensin-converting enzyme inhibitors (quinapril, lisinopril). When choosing antibiotic therapy, we often start treatment with broad-spectrum antibiotics. Selective serotonin reuptake inhibitors (SSRIs), in particular sertraline (Zoloft, Phizer), occupy such a place in the arsenal of a general practitioner for the treatment of depressive conditions.
As a characteristic representative of the SSRI group, Zoloft has all the main advantages of this group of antidepressants. From other drugs used in the treatment of depression, SSRIs differ in fewer and less severe side effects. They do not increase the effect of alcohol and tranquilizers when taken at the same time. The drugs of this group, unlike sulpiride, do not affect the level of prolactin. If you look at the list of side effects of SSRIs, then it becomes uncomfortable (for both the doctor and the patient): anxiety, sleep disturbances, vision, gait, digestive disorders, sexual function and endocrine system organs are possible. However, in our clinical practice, only parasympathicotonic effects of SSRIs were encountered: sweating, hypotension and dizziness, dry mouth, and the frequency of these effects was rather low.
Indications for the appointment of Zoloft are depression (including accompanied by a sense of anxiety) with or without a history of mania; obsessive-compulsive disorders (OCD) in adults and children; panic disorder, with or without agoraphobia; post-traumatic stress disorder; social phobia (social anxiety disorder). With a satisfactory result of treatment, continuation of sertraline therapy is an effective means of preventing recurrence of the initial episode of depression and its development in the future; recurrence of the initial episode of obsessive-compulsive disorder; panic disorder, initial episode of post-traumatic stress disorder, social phobia.
Sertraline does not cause drug dependence; does not have the stimulating and disturbing effects characteristic of D-amphetamine, or the sedative effect and psychomotor disturbances characteristic of alprazolam; does not have a stimulating, sedative or anticholinergic effect, and also does not show a cardiotoxic effect in the experiment. A wide range of indications and significant therapeutic possibilities, high and predictable efficacy, ease of administration (reception and control), an insignificant frequency of side effects determine the choice of Zoloft as a treatment for depression, as well as concomitant psychogenic and autonomic disorders in general therapeutic practice.
Medical newspaper "Health of Ukraine 21 stories" No. 3 (232), February 2010
- Current topic:
- Choice of antidepressant. Focus on the needs of the patient
Zoloft - customer reviews and experience
Zoloft reviews
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Thinks it's great
Pros: Everyone
Cons: Prescription.
Comment: In general, everything becomes indifferent, everything and everything, life is beautiful))
Thinks that the product is good
Advantages: I have been taking it for 3 months already, side effects disappeared after the first 2 weeks (headache, lethargy, vision problems), the drug stabilized my condition. It stabilized, did not awaken in me the joy of life and good mood - I just felt normal (probably, it should be so)
Faults: Most likely increased the alarm But so, a good and not sharp drug. It affects me, but not much, although the dosage is not small
He thinks that the product is excellent
Advantages: Positive effect, good result, excellent price
Disadvantages: the drug is not for everyone, a selection of drugs is needed
Comment: Approached right away and had positive dynamics0002 Thinks the product is excellent
Advantages: The drug works, anxiety disorder cured in 2 months. Psychosomatics passed on the 3rd week. The dosage was 25 mg, half a tablet. Take the original drug, you will not regret it!
Disadvantages: It must be understood that the drug is psychotropic, in the first 1-2 weeks there will be side effects, anxiety may increase, panic attacks, loose stools, but you need to endure, it's worth it, don't stop taking it!
Thinks the product is excellent
I had depression for two years and I got so used to this condition that I considered it normal. Everyday tears for no reason, apathy, unwillingness to live and work. Then overeating and bulimia were superimposed on all this, I tried to seize emotions and look for joy in food. I think I would have died if I had not sought help from a therapist earlier. He just prescribed Zoloft + teraligen. Together they began to help me 1.5 months after taking it. I can’t explain the state I’m in, but I can say with certainty that before that I lived in depression. Now I get up early, I do everything much faster, I have more strength and a good mood, my relationship with people in general has improved. I am satisfied with the drug and definitely recommend it to people with depression. Do not be afraid to talk about your problems and do not belittle their significance, otherwise you will ruin your life, as I almost ruined it.
Thinks the product is terrible
I take Zoloft for 2 weeks. So far it's only getting worse! Of the side effects: dry mouth, everyday nausea (weight loss in 2 weeks 6 kg), which I don’t need at all (from 54 to 48), I don’t feel like eating anything! I can hardly force myself !!! also: fussiness, increased tearfulness, anxiety, tics and shudders of the whole body, lethargy, mental confusion, headache! The doctor says that everything will go away soon, but every day it only gets worse. I don't want to take this drug again!
Thinks the product is excellent
I have been taking it for 2 days now, constant yawning, dizziness is rare .. lethargy is present, appetite disappeared as soon as I started drinking, apparently I need to get used to the drug
He thinks that the product is excellent
I have taken Zoloft more than once in my life. In general, the drug is not bad. The effect of taking is felt quite quickly, after about 1-1.5 weeks. Easy to use, as you need to drink only 1 time per day. For me personally, this is a huge plus, since I do not like drugs that need to be taken 10 times a day strictly by the hour. It's very difficult. But the body must get used to Zoloft. At first, it makes you a little sick, and you don’t want to eat anything at all. Therefore, be prepared for the fact that you will definitely throw off a couple of kilograms. For me, the end result is important. And after taking Zoloft, he is worthy. He completes his assigned task. Therefore, despite all the shortcomings, I am satisfied with the drug.
Thinks the product is terrible
I could not get out of depression for a long time, so I had to see a doctor. The doctor prescribed me Zoloft at a dosage of 100 mg. The first 2-3 days of taking everything was fine, and then I started having severe panic attacks. I felt terrible. It was so bad that I even had to call an ambulance. The ambulance doctor said something because the dosage was too high. But I won't drink this crap anymore. It only gets worse from him.
Thinks the product is excellent
There are times in life when everything comes crashing down at once. And sometimes these periods of the “black streak” are so prolonged that it is simply impossible to do without the help of drugs. That happened to me once too. Circumstances drove me into a severe depression. When I realized that a little more and I would break down, I turned to a doctor I knew. He advised me Zoloft.