What is the lowest dose of xanax xr
Xanax, Niravam (alprazolam) dosing, indications, interactions, adverse effects, and more
alprazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and alfentanil both increase sedation. Use Caution/Monitor.
alprazolam and amitriptyline both increase sedation. Use Caution/Monitor.
amobarbital will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
amobarbital and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam and amoxapine both increase sedation. Use Caution/Monitor.
alprazolam and apomorphine both increase sedation. Use Caution/Monitor.
aprepitant will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and aripiprazole both increase sedation. Use Caution/Monitor.
armodafinil will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
artemether/lumefantrine will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
atazanavir will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor.
alprazolam will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
azelastine and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam and baclofen both increase sedation. Use Caution/Monitor.
alprazolam and belladonna and opium both increase sedation. Use Caution/Monitor.
belzutifan will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. If unable to avoid coadministration of belzutifan with sensitive CYP3A4 substrates, consider increasing the sensitive CYP3A4 substrate dose in accordance with its prescribing information.
alprazolam and benperidol both increase sedation. Use Caution/Monitor.
alprazolam increases and benzphetamine decreases sedation.
Effect of interaction is not clear, use caution. Use Caution/Monitor.
bosentan will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
brexanolone, alprazolam. Either increases toxicity of the other by sedation. Use Caution/Monitor.
brompheniramine and alprazolam both increase sedation. Use Caution/Monitor.
budesonide will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam and buprenorphine both increase sedation. Use Caution/Monitor.
alprazolam and buprenorphine buccal both increase sedation. Use Caution/Monitor.
alprazolam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely.
Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.
alprazolam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases.
In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.
butabarbital will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
butabarbital and alprazolam both increase sedation. Use Caution/Monitor.
butalbital will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
butalbital and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam and butorphanol both increase sedation. Use Caution/Monitor.
alprazolam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
carbinoxamine and alprazolam both increase sedation.
Use Caution/Monitor.
alprazolam and carisoprodol both increase sedation. Use Caution/Monitor.
cenobamate will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate.
cenobamate, alprazolam. Either increases effects of the other by sedation. Use Caution/Monitor.
alprazolam and chloral hydrate both increase sedation. Use Caution/Monitor.
alprazolam and chlordiazepoxide both increase sedation. Use Caution/Monitor.
chlorpheniramine and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam and chlorpromazine both increase sedation. Use Caution/Monitor.
alprazolam and chlorzoxazone both increase sedation. Use Caution/Monitor.
cinnarizine and alprazolam both increase sedation. Use Caution/Monitor.
clemastine and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).
alprazolam and clomipramine both increase sedation. Use Caution/Monitor.
alprazolam and clonazepam both increase sedation. Use Caution/Monitor.
clonidine, alprazolam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.
alprazolam and clorazepate both increase sedation. Use Caution/Monitor.
alprazolam and clozapine both increase sedation. Use Caution/Monitor.
alprazolam and codeine both increase sedation. Use Caution/Monitor.
conivaptan will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
cortisone will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
crizotinib increases levels of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A.
crofelemer increases levels of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed.
cyclizine and alprazolam both increase sedation.
Use Caution/Monitor.
alprazolam and cyclobenzaprine both increase sedation. Use Caution/Monitor.
cyclosporine will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
cyproheptadine and alprazolam both increase sedation. Use Caution/Monitor.
dabrafenib will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.
alprazolam and dantrolene both increase sedation. Use Caution/Monitor.
alprazolam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
darifenacin will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor.
darunavir will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
dasatinib will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
deferasirox will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
desflurane and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam and desipramine both increase sedation. Use Caution/Monitor.
alprazolam and deutetrabenazine both increase sedation. Use Caution/Monitor.
dexamethasone will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
dexchlorpheniramine and alprazolam both increase sedation.
Use Caution/Monitor.
alprazolam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and dexmedetomidine both increase sedation. Use Caution/Monitor.
alprazolam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and dextromoramide both increase sedation. Use Caution/Monitor.
DHEA, herbal will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam and diamorphine both increase sedation. Use Caution/Monitor.
alprazolam and diazepam both increase sedation.
Use Caution/Monitor.
diazepam intranasal, alprazolam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.
alprazolam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
difelikefalin and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam and difenoxin hcl both increase sedation. Use Caution/Monitor.
alprazolam increases levels of digoxin by unknown mechanism. Use Caution/Monitor.
diltiazem will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor for increased alprazolam side effects including drowsiness or fatigue, nausea, vomiting, diarrhea or constipation.
dimenhydrinate and alprazolam both increase sedation. Use Caution/Monitor.
diphenhydramine and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.
alprazolam and dipipanone both increase sedation. Use Caution/Monitor.
disulfiram increases levels of alprazolam by decreasing metabolism. Use Caution/Monitor.
alprazolam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and dosulepin both increase sedation.
Use Caution/Monitor.
alprazolam and doxepin both increase sedation. Use Caution/Monitor.
alprazolam and doxylamine both increase sedation. Use Caution/Monitor.
dronedarone will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam and droperidol both increase sedation. Use Caution/Monitor.
duvelisib will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. will increase the level or effect of
efavirenz will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
elagolix will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.
Elagolix is a weak-to-moderate CYP3A4 inducer. Monitor CYP3A substrates if coadministered. Consider increasing CYP3A substrate dose if needed.
elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP3A4 inhibitor; consider benzodiazepine dose reduction.
encorafenib, alprazolam. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents.
alprazolam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam increases and epinephrine decreases sedation.
Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
esketamine intranasal, alprazolam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.
eslicarbazepine acetate will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam and estazolam both increase sedation. Use Caution/Monitor.
alprazolam and ethanol both increase sedation. Use Caution/Monitor.
ethinylestradiol will increase the level or effect of alprazolam by Mechanism: decreasing metabolism. Use Caution/Monitor. Ethinyl estradiol may inhibit the clearance of benzodiazepines that undergo oxidation, thereby increasing serum concentrations of concomitantly administered benzodiazepines.
etomidate and alprazolam both increase sedation. Use Caution/Monitor.
etravirine will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
fedratinib will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP3A4 substrates as necessary.
alprazolam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor serum potassium during initiation and dosage adjustment of either finererone or moderate CYP3A4 inhibitors. Adjust finererone dosage as needed.
alprazolam and flibanserin both increase sedation.
Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.
fluconazole will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
fludrocortisone will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam and fluphenazine both increase sedation. Use Caution/Monitor.
alprazolam and flurazepam both increase sedation. Use Caution/Monitor.
fluvoxamine will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fosamprenavir will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor.
fosphenytoin will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
gabapentin, alprazolam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
gabapentin enacarbil, alprazolam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
alprazolam and ganaxolone both increase sedation. Use Caution/Monitor.
grapefruit will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor.
griseofulvin will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam and haloperidol both increase sedation. Use Caution/Monitor.
hyaluronidase, alprazolam. Other (see comment). Use Caution/Monitor. Comment: Drug combination has been found to be incompatible.
hydrocortisone will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam and hydromorphone both increase sedation. Use Caution/Monitor.
hydroxyzine and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam and iloperidone both increase sedation. Use Caution/Monitor.
iloperidone increases levels of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4.
alprazolam and imipramine both increase sedation. Use Caution/Monitor.
indinavir will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
isoniazid will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
istradefylline will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.
ketamine and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
lapatinib will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
lasmiditan, alprazolam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
alprazolam will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Modify Therapy/Monitor Closely. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. See drug monograph for specific dosage modification.
lemborexant, alprazolam. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.
letermovir increases levels of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will increase the level or effect of alprazolam by decreasing metabolism. Use Caution/Monitor. Ethinyl estradiol may inhibit the clearance of benzodiazepines that undergo oxidation, thereby increasing serum concentrations of concomitantly administered benzodiazepines.
alprazolam and levorphanol both increase sedation. Use Caution/Monitor.
alprazolam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and lofepramine both increase sedation. Use Caution/Monitor.
alprazolam increases levels of lofepramine by decreasing metabolism. Use Caution/Monitor.
alprazolam and lofexidine both increase sedation. Use Caution/Monitor.
alprazolam increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lomitapide dose should not exceed 30 mg/day.
alprazolam and loprazolam both increase sedation. Use Caution/Monitor.
alprazolam and lorazepam both increase sedation. Use Caution/Monitor.
lorlatinib will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor.
alprazolam and lormetazepam both increase sedation. Use Caution/Monitor.
alprazolam and loxapine both increase sedation. Use Caution/Monitor.
alprazolam and loxapine inhaled both increase sedation. Use Caution/Monitor.
lumefantrine will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
lurasidone, alprazolam. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.
alprazolam and maprotiline both increase sedation. Use Caution/Monitor.
marijuana will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor.
alprazolam and marijuana both increase sedation. Use Caution/Monitor.
alprazolam and melatonin both increase sedation. Use Caution/Monitor.
alprazolam and meperidine both increase sedation. Use Caution/Monitor.
alprazolam and meprobamate both increase sedation. Use Caution/Monitor.
alprazolam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and metaxalone both increase sedation. Use Caution/Monitor.
alprazolam and methadone both increase sedation. Use Caution/Monitor.
alprazolam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and methocarbamol both increase sedation. Use Caution/Monitor.
alprazolam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
methylprednisolone will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
metronidazole will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
miconazole vaginal will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam and midazolam both increase sedation. Use Caution/Monitor.
alprazolam will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation.
midazolam intranasal will increase the level or effect of alprazolam by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
alprazolam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
mifepristone will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam and mirtazapine both increase sedation. Use Caution/Monitor.
mitotane decreases levels of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.
alprazolam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and morphine both increase sedation. Use Caution/Monitor.
alprazolam and motherwort both increase sedation. Use Caution/Monitor.
alprazolam and moxonidine both increase sedation. Use Caution/Monitor.
alprazolam and nabilone both increase sedation. Use Caution/Monitor.
alprazolam and nalbuphine both increase sedation. Use Caution/Monitor.
nelfinavir will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
nevirapine will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
nifedipine will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor.
nilotinib will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
nirmatrelvir/ritonavir will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Consider lowering alprazolam dosing when coadministered with nirmatrelvir/ritonavir
alprazolam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and nortriptyline both increase sedation. Use Caution/Monitor.
alprazolam and olanzapine both increase sedation. Use Caution/Monitor.
oliceridine, alprazolam.
Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered.
Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Consider decreasing alprazolam dose based on clinical response
alprazolam and opium tincture both increase sedation. Use Caution/Monitor.
alprazolam and orphenadrine both increase sedation. Use Caution/Monitor.
alprazolam and oxazepam both increase sedation. Use Caution/Monitor.
oxcarbazepine will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor.
alprazolam and oxycodone both increase sedation. Use Caution/Monitor.
alprazolam and oxymorphone both increase sedation. Use Caution/Monitor.
alprazolam and paliperidone both increase sedation. Use Caution/Monitor.
alprazolam and papaveretum both increase sedation. Use Caution/Monitor.
alprazolam and papaverine both increase sedation. Use Caution/Monitor.
alprazolam and pentazocine both increase sedation. Use Caution/Monitor.
pentobarbital will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital and alprazolam both increase sedation. Use Caution/Monitor.
perampanel and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam and perphenazine both increase sedation.
Use Caution/Monitor.
alprazolam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
phenobarbital will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
phenobarbital and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
phenytoin will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor.
alprazolam and pholcodine both increase sedation. Use Caution/Monitor.
alprazolam and pimozide both increase sedation. Use Caution/Monitor.
alprazolam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
posaconazole will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
prednisone will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pregabalin, alprazolam.
Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation._ALP_1mg_1__43127_zoom__16664_zoom.jpg)
primidone will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
primidone and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam and prochlorperazine both increase sedation. Use Caution/Monitor.
promethazine and alprazolam both increase sedation. Use Caution/Monitor.
propofol and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and protriptyline both increase sedation. Use Caution/Monitor.
alprazolam and quazepam both increase sedation. Use Caution/Monitor.
alprazolam and quetiapine both increase sedation. Use Caution/Monitor.
quinupristin/dalfopristin will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor.
alprazolam and ramelteon both increase sedation. Use Caution/Monitor.
remimazolam, alprazolam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
ribociclib will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
rifapentine will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam and risperidone both increase sedation. Use Caution/Monitor.
ritonavir will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Use Caution/Monitor.
rucaparib will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP3A4 substrates, if clinically indicated.
rufinamide will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and scullcap both increase sedation. Use Caution/Monitor.
secobarbital will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
secobarbital and alprazolam both increase sedation. Use Caution/Monitor.
sevoflurane and alprazolam both increase sedation. Use Caution/Monitor.
alprazolam and shepherd's purse both increase sedation. Use Caution/Monitor.
sofosbuvir/velpatasvir increases levels of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Velpatasvir inhibits CYP3A4. Caution if coadministered with drugs with narrow therapeutics indexes.
stiripentol, alprazolam. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. CYP3A4 substrates may require dosage adjustment.
stiripentol, alprazolam. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
alprazolam and sufentanil both increase sedation.
Use Caution/Monitor.
suvorexant and alprazolam both increase sedation. Modify Therapy/Monitor Closely. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary
alprazolam and tapentadol both increase sedation. Use Caution/Monitor.
tazemetostat will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
tecovirimat will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tecovirimat is a weak CYP3A4 inducer. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered.
teduglutide increases levels of alprazolam by Other (see comment). Use Caution/Monitor.
Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary.
alprazolam and temazepam both increase sedation. Use Caution/Monitor.
alprazolam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam and thioridazine both increase sedation. Use Caution/Monitor.
alprazolam and thiothixene both increase sedation. Use Caution/Monitor.
topiramate will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam and topiramate both increase sedation. Modify Therapy/Monitor Closely.
alprazolam and tramadol both increase sedation. Use Caution/Monitor.
alprazolam and trazodone both increase sedation.
Use Caution/Monitor.
alprazolam and triazolam both increase sedation. Use Caution/Monitor.
alprazolam and triclofos both increase sedation. Use Caution/Monitor.
alprazolam and trifluoperazine both increase sedation. Use Caution/Monitor.
alprazolam and trimipramine both increase sedation. Use Caution/Monitor.
triprolidine and alprazolam both increase sedation. Use Caution/Monitor.
verapamil will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
voriconazole will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alprazolam increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
zafirlukast will increase the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
alprazolam and ziconotide both increase sedation. Use Caution/Monitor.
alprazolam and ziprasidone both increase sedation. Use Caution/Monitor.
alprazolam and zotepine both increase sedation. Use Caution/Monitor.
Side effects, dosage, uses, interactions, and more
Xanax is a brand-name prescription medication. It’s FDA-approved to treat the following anxiety disorders in adults:
- generalized anxiety disorder
- panic disorder, with or without agoraphobia (fear of being in places where it may be hard to leave)
Drug details
Xanax is a type of drug called a benzodiazepine, and it contains the active drug alprazolam.
Xanax comes as an oral tablet. It’s available in four strengths: 0.25 milligrams (mg), 0.5 mg, 1 mg, and 2 mg.
Is Xanax a controlled substance?
Yes, Xanax is classified as a Schedule IV controlled substance. This means the medication has an accepted medical use, but it also has a risk of misuse and dependence.*
With misuse, a drug is taken for a purpose or in a way that a doctor has not prescribed. Misuse can lead to addiction, which is when you’re unable to stop taking a drug, even though it may be causing harm. With dependence, your body becomes reliant on a drug to function as usual. Dependence can lead to withdrawal symptoms if you suddenly stop taking a drug.
There are special rules around prescribing and supplying of schedule IV controlled drugs. Your doctor or pharmacist can tell you more about this.
* Xanax has boxed warnings from the Food and Drug Administration (FDA) for the risk of misuse and addiction and the risk of dependence and withdrawal.
A boxed warning is the most serious warning from the FDA. To learn more, see the “Xanax misuse and addiction” and “Xanax dependence and withdrawal” sections below.
Xanax vs. Xanax XR
Another form of Xanax is available. It’s called Xanax XR, and it’s approved to treat only panic disorder.
Xanax tablets are immediate-release, which means all the medication is released as soon as the tablet dissolves. Xanax XR tablets are extended-release (XR). This means the drug is released slowly over time.
To treat panic disorder, you’ll likely take Xanax three times per day. Xanax XR works over about 24 hours, so you’ll likely take a dose once per day. Your doctor may prescribe Xanax XR if once-daily dosing is more convenient for you. They may also prescribe this form if your panic disorder symptoms come back or worsen between doses of immediate-release Xanax.
This article focuses just on Xanax. To learn more about Xanax XR, talk with your doctor.
Effectiveness
For information about the effectiveness of Xanax, see the “Xanax uses” section below.
Xanax is a brand-name drug that contains the active drug alprazolam. This active drug is also available as a generic medication. A generic drug is an exact copy of the active drug in a brand-name medication.
Generic alprazolam comes as a tablet, extended-release tablet, orally-disintegrating tablet, and oral liquid concentrate.
The generic is considered to be as safe and effective as the original drug. Generics tend to cost less than brand-name drugs.
If you’re interested in the generic form of Xanax, talk with your doctor. They can tell you if it comes in forms and strengths that can be prescribed for your condition.
Xanax can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Xanax. These lists do not include all possible side effects.
For more information about the possible side effects of Xanax, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may concern or bother you.
Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with Xanax, you can do so through MedWatch.
Mild side effects
Mild side effects* of Xanax can include:
- memory loss
- constipation
- hypotension (low blood pressure)
- dry mouth
- drowsiness
- dizziness or lightheadedness
- problems with balance or coordination
- trouble concentrating
- trouble speaking clearly
- changes in sex drive
- changes in appetite
- weight changes
- mild allergic reaction†
Most of these side effects may go away within a few days to a couple of weeks. However, if they become more severe or do not go away, talk with your doctor or pharmacist.
* This is a partial list of mild side effects of Xanax. To learn about other mild side effects, talk with your doctor or pharmacist, or view Xanax’s prescribing information.
† For additional information about allergic reaction, see “Allergic reaction” below.
Serious side effects
Serious side effects from Xanax are not common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
Serious side effects and their symptoms can include:
- Reduced ability to drive safely or perform other potentially dangerous activities. Symptoms can include:
- sleepiness
- dizziness or lightheadedness
- reduced alertness
- trouble concentrating
- slowed reaction times
- Liver problems. Symptoms can include:
- abdominal pain
- nausea and vomiting
- increased levels of liver enzymes (types of proteins)
- jaundice
- Seizures. Symptoms can vary depending on the type of seizure but may include:
- shaking or jerking movements
- stiffness or floppiness
- confusion
- Hallucinations (sensing things that are not really there).
Symptoms can include:- hearing something that’s not present, such as a voice talking to you
- seeing something that’s not real, such as lights or people
- Risk of misuse and addiction.*†
- Risk of dependence and withdrawal.*‡
- Risk of severe harm or death if taken with opioids.*§
- Severe allergic reaction.¶
* Xanax has a boxed warning for this side effect. This is a serious warning from the FDA.
† To learn more, see the “Xanax misuse and addiction” section below.
‡ For more information, see the “Xanax dependence and withdrawal” section below.
§ For details, see the “Xanax precautions” section below.
¶ For additional information about allergic reaction, see “Allergic reaction” below.
Allergic reaction
As with most drugs, some people can have an allergic reaction after taking Xanax. This side effect was not reported in clinical trials of this drug but has occurred since the drug was approved.
Symptoms of a mild allergic reaction can include:
- skin rash
- itchiness
- flushing
A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:
- swelling under your skin, typically in your eyelids, lips, hands, or feet
- swelling of your tongue, mouth, or throat
- trouble breathing
Call your doctor right away if you have an allergic reaction to Xanax, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
The Xanax dosage your doctor prescribes will depend on several factors. These include:
- the condition you’re taking Xanax to treat and its severity
- your age
- the form of Xanax you take*
- your liver function
- other medical conditions you may have
- other medications you may take
- side effects you may have with Xanax
Xanax doses are not determined by weight.
Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.
The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.
* Xanax also comes in form called Xanax XR. To learn more, see the “What is Xanax?” section above.
Xanax form and strengths (0.25 mg, 0.5 mg, 1 mg, and 2 mg)
Xanax comes as an oral tablet that’s available in four strengths: 0.25 milligrams (mg), 0.5 mg, 1 mg, and 2 mg.
Xanax tablet colors: White, peach, blue, and white
The color and shape of Xanax tablets vary by strength:
- 0.25 mg: white, oval
- 0.5 mg: peach, oval
- 1 mg: blue, oval
- 2 mg: white, rectangle with rounded corners
Xanax also comes as a long-acting form called Xanax XR (extended-release).
Xanax XR tablets come in the following strengths, colors, and shapes:
- 0.5 mg: white, pentagon
- 1 mg: yellow, square
- 2 mg: blue, round
- 3 mg: green, triangle
To learn more about dosages of Xanax XR, talk with your doctor.
Dosage for generalized anxiety disorder
To treat generalized anxiety disorder (GAD) in adults, the typical starting dosage of Xanax is 0.25 mg to 0.5 mg, three times per day.
It’s possible that your doctor will adjust your dose every 3 to 4 days until you’re taking the dose that’s right for you. This depends on how you respond to the starting dosage.
The maximum recommended dosage for GAD is 4 mg per day, split into three doses.
Dosage for panic disorder
To treat panic disorder in adults, the recommended starting dosage of Xanax is 0.5 mg three times per day.
It’s possible that your doctor will adjust your dose every 3 to 4 days until you’re taking the dose that’s right for you.
This depends on how you respond to the starting dosage. Your dose should be increased by no more than 1 mg per day.
The average dosage for panic disorder is 5 mg to 6 mg per day, split into three doses. However, some people may need up to 10 mg per day, split into three doses.
What if I miss a dose?
If you miss a dose of Xanax, take it as soon as you remember. But if it’s nearly time for your next dose, skip the missed dose and just take your next dose as scheduled. You should not take a double or extra doses to make up for missing a dose. Doing so can cause serious side effects. (For more information about side effects, see the “Xanax side effects” section above.)
To help make sure that you do not miss a dose, try using a medication reminder. This can include setting an alarm or using a timer. You could also download a reminder app on your phone.
Will I need to take this drug long term?
Xanax is not meant to be a long-term treatment. Your doctor will typically prescribe it for as short a time as possible.
It’s unknown if it’s safe or effective to take Xanax for longer than 4 months for GAD. And it’s unknown if it’s safe or effective to take the drug for longer than 10 weeks for panic disorder.
When you and your doctor agree that you should stop taking Xanax, your doctor will reduce your dose slowly. This helps avoid withdrawal symptoms you may have if you suddenly stop treatment.*
* Xanax has a boxed warning about the risk of dependence and withdrawal. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). To learn more about this, see the “Xanax dependence and withdrawal” section below.
You may wonder how Xanax compares with other medications that are prescribed for similar purposes. To find out how Xanax compares with Ativan, see this article.
Here are answers to some frequently asked questions about Xanax.
Would my doctor prescribe Xanax for depression, sleep problems, or other conditions?
Maybe.
Xanax is approved to treat only generalized anxiety disorder and panic disorder. However, your doctor might sometimes prescribe Xanax off-label for certain other uses. These include short-term treatment of temporary anxiety symptoms. For example, Xanax might be prescribed off-label for anxiety associated with:
- depression
- fear of flying
- pain
- obsessive-compulsive disorder (OCD)
- post-traumatic stress disorder (PTSD)
Xanax may also sometimes be prescribed off-label for sleep problems. The medication works quickly, so it can help you fall asleep if you have trouble doing so. However, doctors prescribe Xanax only in certain circumstances because your sleep problems may come back when you stop taking the drug.
If you have additional questions about an off-label use of Xanax, talk with your doctor.
Is Xanax a narcotic?
No, Xanax is not a narcotic. Xanax is a type of drug called a benzodiazepine.
Narcotics are opioids, which are drugs related to the opium poppy.
Examples include strong prescription pain relievers, such as morphine (MS Contin) and oxycodone (Oxycontin, Xtampza ER, Oxaydo, others).
Xanax has a boxed warning about the risk of severe harm or death if taken with opioids. For details, see the “Xanax precautions” section below.
Your doctor and pharmacist can help answer other questions you have.
Is it safe to take Xanax with Adderall?
Xanax is not known to interact with amphetamine/dextroamphetamine (Adderall). However, taking these medications together may not be safe.
Adderall is a stimulant medication that’s for the treatment of attention deficit hyperactive disorder (ADHD). Doctors may sometimes prescribe Xanax with Adderall for people with ADHD who also have anxiety. Taking these medications together for this purpose as prescribed by a doctor is not known to be harmful.
However, both Xanax and Adderall have a risk of misuse.* Misuse refers to taking a drug for a purpose or in a way that a doctor has not prescribed.
If Xanax is misused with Adderall, this may increase the risk of serious outcomes. These may include serious side effects, overdose, and addiction. (For more information about side effects, see the “Xanax side effects” section above.)
You should take Xanax with Adderall only if your doctor has prescribed them. They can tell you more.
* Xanax has a boxed warning about the risk of misuse and addiction. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). To learn more about this, see the “Xanax misuse and addiction” section below.
Can I take a pain reliever such as Tylenol during Xanax treatment?
Yes, it’s typically safe to take a mild pain reliever, such as acetaminophen (Tylenol) or ibuprofen (Advil, Motrin), while you’re taking Xanax.
However, not all pain relievers are safe to take with Xanax. For example, pain relievers that contain opioids can cause severe side effects and, in rare cases, death if taken with Xanax.
* Examples of opioids include codeine, hydrocodone, and oxycodone.
It’s important to note that some pain-relieving drugs contain acetaminophen in combination with an opioid. Examples include:
- acetaminophen/oxycodone (Percocet, Oxycet)
- acetaminophen/hydrocodone (Anexsia)
- acetaminophen/dihydrocodeine (Trezix)
You should not take pain relievers that contain an opioid with Xanax unless your doctor has approved it. If you need a pain reliever during Xanax treatment, ask your doctor or pharmacist to recommend a suitable medication.
* Xanax has a boxed warning about the risk of severe harm or death if taken with opioids. A boxed warning is the most serious warning from the FDA. For more details, see the “Xanax precautions” section below.
What’s a half-life chart, and does Xanax have one?
A half-life chart can show you the amount of a dose that may still be in your system after a certain amount of time. Your doctor or pharmacist may be able to describe what a half-life chart for Xanax would look like.
The half-life of a drug is the length of time it takes for half a dose of the drug to be removed from your body. It typically takes between four and five half-lives for a drug to fully leave your system.
Xanax has a half-life of about 11 hours. This means it takes about 2.5 days for Xanax to be fully removed from your body. However, the exact amount of time you’ll have Xanax in your system depends on various factors. These include your age, liver function, and other medications you may take.
You can reach out to your doctor or pharmacist if you have additional questions.
Can stopping Xanax treatment cause a hangover-like feeling?
It might. Stopping Xanax treatment can sometimes cause withdrawal symptoms* as the effects of the medication wear off. This can cause symptoms similar to those you might have with an alcohol hangover. For example, you may have a headache, nausea, or vomiting. You may also feel anxious or irritable.
You’re more likely to have withdrawal symptoms after stopping Xanax treatment if you’ve been taking the drug for a long time or at a high dose.
However, these symptoms can also affect anyone who stops taking Xanax.
To help reduce your risk of withdrawal symptoms, your doctor will gradually reduce your dose when you stop taking Xanax. If you have hangover-like symptoms when stopping Xanax treatment, talk with your doctor. They can recommend ways to help ease the symptoms.
* Xanax has a boxed warning about the risk of dependence and withdrawal. A boxed warning is the most serious warning from the FDA. To read more about this, see “Xanax dependence and withdrawal” below.
The Food and Drug Administration (FDA) approves prescription drugs such as Xanax to treat certain conditions. Xanax may also be used off-label for other conditions. Off-label drug use is when an FDA-approved drug is prescribed for a purpose other than what it’s approved for.
Xanax for generalized anxiety disorder
Xanax is FDA-approved for the short-term treatment of generalized anxiety disorder (GAD) in adults.
Generalized anxiety disorder explained
GAD is a mental health condition that can affect your daily life and impact your relationships with others.
It’s common to have anxiety about the stresses of everyday life. However, with GAD, you have ongoing anxiety about everyday life that’s excessive and out of proportion.
Symptoms of GAD may include:
- excessive, uncontrollable, long lasting worries or fears
- intrusive thoughts or trouble concentrating
- trouble sleeping
- restlessness
- fatigue
- irritability
- tense muscles
- nausea
- diarrhea
- heart palpitations
- sweating
Xanax is a benzodiazepine drug that has a calming and relaxing effect. Doctors usually prescribe it for short periods of time. It’s typically used to help ease the symptoms of anxiety while other treatments for GAD, such as antidepressants, are taking effect.
Effectiveness for generalized anxiety disorder
Xanax is an effective medication for relieving anxiety.
To find out how the drug performed in clinical studies, see Xanax’s prescribing information.
Benzodiazepines such as Xanax are included in guidelines for managing GAD. The drugs are recommended for short-term treatment to help ease anxiety symptoms.
You can learn more about your condition in our anxiety hub and mental health hub.
Xanax for panic disorder
Xanax is FDA-approved to treat panic disorder, with or without agoraphobia, in adults.
Panic disorder explained
Panic disorder is a common mental health condition that can affect your daily life and impact your relationships with others. It’s a type of anxiety disorder.
With panic disorder, you have unexpected and recurrent panic attacks. A panic attack is an intense feeling of fear that comes on suddenly. It may cause symptoms such as:
- shaking
- dizziness
- nausea
- pounding heartbeat
- chest pain
- sweating
- trouble breathing
- choking sensation
With panic disorder, you become afraid of having more panic attacks.
This can make you avoid situations or places you feel may trigger a panic attack. This can lead to agoraphobia.
Agoraphobia is an intense and irrational fear of situations where you think you might have trouble leaving or getting help if you have a panic attack. For example, you may be afraid of being in a crowd or in open or enclosed spaces. You may also be afraid of using public transportation or leaving your home alone.
Xanax is a benzodiazepine drug that has a calming and relaxing effect. Doctors usually prescribe it for short periods of time. Xanax is typically used to help ease panic attacks while other treatments for panic disorder, such as antidepressants, take effect.
Effectiveness for panic disorder
Xanax is an effective medication for reducing the number of panic attacks you have. To find out how the drug performed in clinical studies, see Xanax’s prescribing information.
Benzodiazepines such as Xanax are included in guidelines for managing panic disorder.
The drugs are recommended for short-term treatment to help reduce the frequency of panic attacks.
You can learn more about your condition in the MNT anxiety hub and mental health hub.
Xanax and children
Xanax is not FDA-approved for any use in children. It’s unknown if Xanax is safe or effective in children.
Your doctor may prescribe Xanax with other drugs for generalized anxiety disorder or panic disorder.
Xanax is typically prescribed for short periods of time to relieve anxiety symptoms while other treatments, such as antidepressants, are taking effect. Antidepressants can take about 4 to 6 weeks to start working for anxiety disorders.
Examples of antidepressants that may be prescribed with Xanax include:
- selective serotonin reuptake inhibitors (SSRIs), such as:
- escitalopram (Lexapro)
- fluoxetine (Prozac)
- paroxetine (Paxil)
- sertraline (Zoloft)
- serotonin noradrenaline reuptake inhibitors (SNRIs), such as:
- duloxetine (Cymbalta)
- venlafaxine (Effexor XR)
Xanax can interact with several other medications.
It can also interact with certain supplements as well as certain foods.
Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe. Drug-condition interactions can also cause certain effects. For information about these interactions, see the “Xanax precautions” section below.
Xanax and other medications
Below is a list of medications that can interact with Xanax. This list does not contain all drugs that may interact with Xanax.
Before taking Xanax, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also, tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Types of drugs that can interact with Xanax include:
- Opioids.
Opioids are powerful drugs that are also known as opiates or narcotics. They include strong prescription pain relievers and certain illegal drugs. Taking Xanax with opioids can lead to severe harm and, in rare cases, death.* Due to these risks, doctors will typically not prescribe Xanax with opioids unless there are no other suitable treatment options. Examples of opioids include:- buprenorphine (BuTrans, Sublocade, Belbuca)
- buprenorphine/naloxone (Suboxone, Zubsolv)
- fentanyl (Subsys, Lazanda, Fentora, others)
- heroin†
- hydrocodone (Hysingla ER)
- methadone
- morphine (MS Contin)
- oxycodone (Oxycontin, Xtampza ER, Oxaydo, others)
- oxycodone/acetaminophen (Oxycet, Percocet)
- tramadol (Ultram, Conzip)
- Strong CYP3A inhibitors. Taking Xanax with drugs that are strong cytochrome P450 3A (CYP3A) inhibitors can increase the risk of side effects from Xanax.
‡ Due to this risk, doctors typically will not prescribe Xanax with strong CYP3A inhibitors, except ritonavir (Norvir). Examples of these drugs include:- clarithromycin
- ketoconazole
- itraconazole (Sporanox, Tolsura)
- Weak or moderate CYP3A inhibitors. Taking Xanax with drugs that are weak or moderate CYP3A inhibitors can increase the risk of side effects from Xanax.‡ If you need to take Xanax with one of these medications, your doctor will likely prescribe a Xanax dosage that’s lower than usual. Examples of weak or moderate CYP3A inhibitors include:
- cimetidine (Tagamet HB)
- erythromycin (Eryc, Ery-Tab, others)
- fluvoxamine (Luvox)
- nefazodone
- Strong CYP3A inducers. Taking Xanax with drugs that are CYP3A inducers can make Xanax less effective. Examples of these drugs include:
- carbamazepine (Tegretol, Carbatrol, Equetro, others)
- phenytoin (Dilantin)
- Ritonavir.
Ritonavir (Norvir) is a drug used to treat HIV. Ritonavir can affect the breakdown of Xanax in your body. Your doctor may adjust your Xanax dosage if you take the drug with ritonavir. - Digoxin. Digoxin (Lanoxin) is a heart medication. Taking Xanax with digoxin may cause digoxin to build up in your body. Your doctor may monitor your digoxin level and reduce your digoxin dosage if needed.
- CNS depressants. Xanax is a type of drug called a central nervous system (CNS) depressant. Taking Xanax with other CNS depressants may cause excessive sleepiness and breathing problems. If you need to take Xanax with one of these drugs, your doctor will likely prescribe a Xanax dosage that’s lower than usual. Examples of CNS depressants include:
- certain antidepressants, such as amitriptyline, trazodone, and mirtazapine (Remeron)
- certain antipsychotics, such as haloperidol (Haldol) and risperidone (Risperdal)
- certain seizure medications, such as gabapentin (Neurontin) and topiramate (Topamax)
- certain muscle relaxants, such as carisoprodol (Soma) and cyclobenzaprine (Amrix)
- sedating antihistamines, such as chlorpheniramine and promethazine
- sleeping pills, such as zolpidem (Ambien) and zaleplon (Sonata)
* Xanax has a boxed warning about this risk.
A boxed warning is the most serious warning from the Food and Drug Administration (FDA). To learn more about this interaction, see the “Xanax precautions” section below.
† Heroin is illegal for personal use in the United States, and Medical News Today does not support taking illegal substances. However, we do support access to important health information. This interaction is mentioned to help you stay safe during Xanax treatment.
‡ For more information about side effects, see the “Xanax side effects” section above.
Xanax and herbs and supplements
Here’s some information about herbs, supplements, and Xanax treatment. Be sure to talk with your doctor before taking any herbs or supplements with Xanax.
St. John’s wort
Taking Xanax with the herb St. John’s wort may lower the level of Xanax in your body. This could make Xanax less effective than usual.
St. John’s wort is often used to treat depression. If you’re taking this herb, talk with your doctor.
They can advise you on the right treatments for you.
Cannabis
Cannabis is often known as marijuana or “weed.” Taking Xanax with cannabis could increase the risk of side effects from Xanax, especially sleepiness. Due to this interaction, doctors will typically advise that you do not take Xanax with cannabis.
For more information about side effects of Xanax, see the “Xanax side effects” section above. To learn more about cannabis and the drug, talk with your doctor.
Xanax and foods
Consuming grapefruit or grapefruit juice while taking Xanax could increase your risk of side effects from Xanax. It’s best to avoid consuming grapefruit products while taking Xanax.
For more information about side effects of Xanax, see the “Xanax side effects” section above. If you have questions about consuming other foods with Xanax, talk with your doctor.
It’s best to avoid drinking alcohol while taking Xanax. Alcohol and Xanax can reduce the activity of your central nervous system (CNS).
So consuming alcohol with Xanax can lower the activity further.
The CNS refers to the brain and spinal cord. This system helps regulate breathing, actions, thinking, and more.
Drinking alcohol with Xanax can increase your risk of side effects such as:
- drowsiness
- dizziness or lightheadedness
- problems with balance or coordination
- trouble concentrating
- trouble speaking clearly
- memory loss
- slowed reaction time
- breathing problems
- coma
Consuming alcohol during Xanax treatment can also increase your risk of an overdose from Xanax and, in rare cases, death. If you feel you need help avoiding alcohol while taking Xanax, talk with your doctor.
Xanax has a boxed warning for the risk of misuse and addiction. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). The warning alerts doctors and patients to side effects that may be dangerous.
Misuse refers to taking a drug for a purpose or in a way that a doctor has not prescribed.
People often misuse drugs to produce a pleasurable, calm, or high feeling. Misuse can lead to addiction, which is when you’re unable to stop taking a drug, even though it may be causing harm.
Symptoms of Xanax misuse or addiction may include:
- taking Xanax more often or in higher doses than prescribed
- craving Xanax
- spending a lot of time trying to obtain Xanax
- having health, personal, social, work, or relationship problems due to Xanax
Xanax misuse and addiction can lead to serious side effects, including breathing problems, seizures, paranoia, and suicidal thoughts or actions. Xanax misuse and addiction can also lead to overdose and, in rare cases, death. This is especially the case if Xanax is taken with alcohol, illegal drugs, or other medications (especially opioids*).
If you’ve had problems with drug or alcohol misuse or addiction in the past, you may have an increased risk of these problems with Xanax. Your doctor will assess your risk of misuse and addiction before determining whether Xanax is right for you.
You should take Xanax exactly as prescribed by your doctor. It’s important that you do not increase your dose or take more than prescribed unless you first talk with your doctor. Also, be sure to see your doctor as soon as possible if you have any symptoms of misuse or addiction, or any concerns about them.
* Xanax has a boxed warning about the risk of severe harm or death if taken with opioids. To learn more, see the “Xanax precautions” section below.
Other drugs like Xanax are available that can treat your condition. Some may be a better fit for you than others. If you’re interested in finding an alternative to Xanax, talk with your doctor. They can tell you about other medications that may work well for you. This could include other benzodiazepines. (Xanax is a type of drug called a benzodiazepine.)
Note: Some of the drugs listed here are used off-label to treat these specific conditions. Off-label drug use is when a drug that’s approved by the Food and Drug Administration (FDA) is prescribed for a purpose other than what it’s approved for.
Alternatives for generalized anxiety disorder
Examples of other drugs that a doctor may prescribe for generalized anxiety disorder include:
- buspirone (Buspar)
- pregabalin (Lyrica)
- other benzodiazepines such as:
- clonazepam (Klonopin)
- diazepam (Valium)
- lorazepam (Ativan)
- SSRI antidepressants, such as:
- escitalopram (Lexapro)
- paroxetine (Paxil)
- sertraline (Zoloft)
- SNRI antidepressants, such as:
- venlafaxine (Effexor XR)
- duloxetine (Cymbalta)
- tricyclic antidepressants, such as:
- amitriptyline
- imipramine (Tofranil)
Alternatives for panic disorder
Examples of other drugs that may be prescribed for panic disorder include:
- other benzodiazepines such as:
- clonazepam (Klonopin)
- lorazepam (Ativan)
- SSRI antidepressants such as:
- fluoxetine (Prozac)
- fluvoxamine (Luvox)
- paroxetine (Paxil)
- sertraline (Zoloft)
- SNRI antidepressants such as:
- venlafaxine (Effexor XR)
- tricyclic antidepressants such as:
- amitriptyline
- imipramine (Tofranil)
You may wonder how Xanax compares with other medications that are prescribed for similar purposes.
To find out how Xanax compares with Valium, see this article.
You may be curious about how Xanax compares with other drugs that are prescribed for similar purposes. To see how Xanax is similar to and different from clonazepam, you can refer to this article.
Xanax has a boxed warning for the risk of dependence and withdrawal. A boxed warning is the most serious warning from the Food and Drug Administration. It alerts doctors and patients to side effects that may be dangerous.
With dependence, your body becomes reliant on a drug to function as usual. Dependence can lead to withdrawal symptoms if you suddenly stop taking a drug.
Symptoms of withdrawal
Suddenly “coming off” Xanax can cause serious or even life threatening withdrawal symptoms. These may include:
- withdrawal seizure
- hallucinations (seeing or hearing things that are not really there)
- psychosis (loss of touch with reality)
- mania (state of heightened energy)
- suicidal thoughts or actions
Other withdrawal symptoms associated with coming off Xanax may include:
- headache
- anxiety
- depression
- irritability
- problems with thinking, understanding, or memory
- dizziness
- fatigue
- insomnia
- nausea and vomiting
- diarrhea
- muscle twitching
- tremor
- tingling or burning sensations
- hearing problems such as increased sensitivity to noise or ringing in your ears
Certain withdrawal symptoms may sometimes last for several weeks or months.
You may have an increased risk of dependence and withdrawal if you take more than 4 milligrams (mg) of Xanax per day. You may also have an increased risk if you take Xanax for a long period of time. However, these problems are also possible with lower doses and after taking the drug for a short time.
Talking with your doctor
To help avoid withdrawal symptoms, do not stop taking Xanax unless you first talk with your doctor. You should not stop your treatment suddenly. When you and your doctor agree that you should stop taking Xanax, they’ll reduce your dose slowly over time. This can help prevent withdrawal symptoms.
If you have withdrawal symptoms after your doctor has reduced your dose or had you stop treatment with Xanax, talk with them. Your doctor may increase your dosage again and then reduce it more slowly. However, if you have serious withdrawal symptoms, see your doctor right away. If your symptoms feel life threatening, call 911 or your local emergency number immediately.
Suicide prevention
If you know someone at immediate risk of self-harm, suicide, or hurting another person:
- Ask the tough question: “Are you considering suicide?”
- Listen to the person without judgment.
- Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
- Stay with the person until professional help arrives.
- Try to remove any weapons, medications, or other potentially harmful objects.
If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988.
Click here for more links and local resources.
Whether Xanax is safe to take while pregnant may depend on how far along the pregnancy is. Clinical trials did not find an increased risk of congenital anomalies or pregnancy loss when Xanax was taken during early pregnancy.
(Congenital anomalies are commonly known as birth defects.)
However, if Xanax is taken in the third trimester (weeks 29 to 40) or during labor or delivery, it may cause harm. The newborn may experience problems such as:
- excessive sleepiness
- floppiness
- breathing problems
- feeding problems
- withdrawal symptoms, such as irritability, restlessness, tremor, and prolonged crying
If you’re pregnant or planning to become pregnant, talk with your doctor about the possible risks and benefits of taking Xanax.
Pregnancy exposure registry
If your doctor prescribes Xanax during pregnancy, they may want you to sign up with the pregnancy exposure registry for the drug. This registry monitors the health of people who are pregnant and take Xanax, and their babies. It aims to help healthcare professionals find out how safe psychiatric medications such as Xanax are during pregnancy. To find out more, talk with your doctor.
Whether Xanax is safe to take during pregnancy may depend on how far along the pregnancy is.
If you’re sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while you’re taking Xanax.
For more information about taking Xanax during pregnancy, see the “Xanax and pregnancy” section above.
Breastfeeding is not recommended while taking Xanax.
Xanax passes into breast milk and may have harmful effects in a child who is breastfed. These effects may include excessive sleepiness and withdrawal symptoms. The withdrawal symptoms can include irritability, sleeping problems, and vomiting. Diarrhea, muscle twitching, and tremor are other possible symptoms.
If you’re breastfeeding or planning to breastfeed, talk with your doctor about other treatment options. If you’re prescribed Xanax, talk with your doctor about how to feed your child while taking the medication.
You should take Xanax according to the instructions your doctor gives you.
Xanax comes as an oral tablet.
When to take
You’ll usually take Xanax three times per day.
For example, in the morning, after lunch, and in the evening. If you have anxiety that prevents you from falling asleep at night, your doctor may recommend taking your last dose of Xanax before going to bed.
Try to stick to the same times each day. Taking the medication around the same times of day helps keep a steady level of the drug in your body. This helps Xanax work effectively.
To help make sure that you do not miss a dose, try using a medication reminder. This can include setting an alarm or using a timer. You could also download a reminder app on your phone.
Accessible labels and containers
If your prescription label is hard to read, talk with your doctor or pharmacist. Some pharmacies offer labels that have large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy does not have these options, your doctor or pharmacist may be able to direct you to one that does.
If you have trouble opening medication bottles, ask your pharmacist if they can put Xanax in an easy-open container.
They also may be able to recommend tools that can make it simpler to open lids.
Taking Xanax with food
You can take Xanax on an empty stomach or after eating. And you can take the medication with or without food.
Can Xanax be crushed, split, or chewed?
Xanax tablets are scored and can be split if your doctor or pharmacist advises this. However, Xanax is not meant to be crushed or chewed. The manufacturer does not provide information on taking Xanax this way. If you have trouble swallowing Xanax, talk with your doctor or pharmacist.
As with all medications, the cost of Xanax can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.
Before approving coverage for Xanax, your insurance company may require you to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the prior authorization request and decide if the drug will be covered.
If you’re not sure if you’ll need to get prior authorization for Xanax, contact your insurance company.
Financial assistance
If you need financial support to pay for Xanax, help is available.
A savings card is available for Xanax. For more information and to find out if you’re eligible for support, call 855-854-4535 or visit the program website.
To learn more about saving money on prescriptions, check out this article.
Generic version
Xanax is available in a generic form called alprazolam. A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug. And generics tend to cost less than brand-name drugs. To find out how the cost of alprazolam compares to the cost of Xanax, visit GoodRx.com.
If your doctor has prescribed Xanax and you’re interested in taking alprazolam instead, talk with your doctor. They may have a preference for one version or the other.
You’ll also need to check your insurance plan, as it may only cover one or the other.
When you get Xanax from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. This date is typically 1 year from the date they dispensed the medication.
The expiration date helps guarantee that the medication is effective during this time. The current stance of the Food and Drug Administration (FDA) is to avoid taking expired medications. If you have unused medication that has passed the expiration date, talk with your pharmacist about whether you might still be able to take it.
Storage
How long a medication remains good can depend on many factors, including how and where you store the medication.
You should store Xanax tablets at room temperature in a tightly sealed container. Avoid storing this medication in areas where it could get damp or wet, such as bathrooms.
Disposal
If you no longer need to take Xanax and have leftover medication, it’s important to dispose of it safely.
This helps prevent others, including children and pets, from taking the drug by accident. It also helps keep the drug from harming the environment.
This article provides several useful tips on medication disposal. You can also ask your pharmacist for information about how to dispose of your medication.
Xanax is prescribed for generalized anxiety disorder and panic disorder.
Xanax is a type of drug called a benzodiazepine. It eases anxiety by boosting the effect of GABA, a type of neurotransmitter in your brain. GABA is short for gamma-aminobutyric acid.
Neurotransmitters are chemicals that help pass messages between nerve cells in your brain. GABA helps pass nerve messages that have a calming effect on your brain.
By boosting the effect of GABA, Xanax helps reduce nervous tension and feelings of anxiety. The drug makes you feel more relaxed.
How long does it take to work?
Xanax starts working about 30 minutes to 1 hour after taking a dose.
This drug comes with several precautions.
These are considered drug-condition interactions.
FDA warnings
This drug has boxed warnings. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous.
Risk of misuse and addiction. Xanax has a risk of misuse and addiction. With misuse, a drug is taken for a purpose or in a way that a doctor has not prescribed. Misuse can lead to addiction, which is when you’re unable to stop taking a drug, even though it may be causing harm. To learn more, see the “Xanax misuse and addiction” section above.
Risk of dependence and withdrawal. Xanax has a risk of dependence and withdrawal. With dependence, your body becomes reliant on a drug to function as usual. Dependence can lead to withdrawal symptoms if you suddenly stop taking the drug. For more information, see the “Xanax dependence and withdrawal” section above.
Risk of severe harm or death if taken with opioids.
Taking Xanax with an opioid may cause severe side effects. These can include excessive sleepiness, breathing problems, coma, and in rare cases, death. Due to these risks, doctors will typically not prescribe Xanax with an opioid unless no other treatment options are suitable.
Opioids are powerful drugs that are also known as opiates or narcotics. They include strong prescription pain relievers, such as hydrocodone (Hysingla ER) and certain illegal drugs. For more examples, see the “Xanax interactions” section above.
If your doctor does prescribe Xanax with an opioid, they’ll prescribe the lowest possible dosage of both medications for the shortest possible time.* Be sure to tell sure people you live with, your caregiver, and people close to you that you’re taking these medications together. You or another person should call 911 right away if:
- you become very sleepy or unresponsive
- your breathing becomes slow and shallow
- your breathing stops altogether
Also, you should not drive or perform other potentially dangerous activities, such as operating machines, until you know how the drug combination affects you.
For more information about this boxed warning, talk with your doctor.
* Your doctor may advise you to have naloxone (Narcan) nasal spray on hand to help treat a known or suspected opioid overdose. They can prescribe the drug, or you can request it at a pharmacy. To learn more, talk with your doctor or pharmacist.
Other precautions
Before taking Xanax, talk with your doctor about your health history. Xanax may not be right for you if you have certain medical conditions or other factors affecting your health. These include:
- Allergic reaction. If you’ve ever had an allergic reaction to Xanax or any of its ingredients, your doctor will likely not prescribe Xanax. Also, if you’ve ever had an allergic reaction to other benzodiazepine drugs, such as diazepam (Valium) or lorazepam (Ativan), your doctor will likely not prescribe Xanax. (Xanax is a benzodiazepine drug.) Taking Xanax could cause another allergic reaction.
You can ask your doctor what other medications may be better options for you. - Older age. If you’re ages 65 years or older, you may have an increased risk of side effects with Xanax. These include sleepiness, dizziness, and problems with coordination that may raise your risk of falls. Due to these risks, your doctor will likely prescribe a dosage of Xanax that’s lower than usual.
- Liver problems. Your liver breaks down Xanax in your body. If you have a liver problem, such as alcoholic liver disease, Xanax may build up in your body. This can increase your risk of side effects. Due to this risk, your doctorwill likely prescribe a dosage of Xanax that’s lower than usual.
- Kidney problems. Your kidneys help remove Xanax from your body. If you have a kidney problem, such as kidney failure, you may have an increased risk of side effects with Xanax. Your doctor may prescribe a Xanax dosage that’s lower than usual.
- Breathing problems.
Xanax can cause breathing problems, such as slowed breathing. If you have a lung or breathing problem, such as chronic obstructive pulmonary disease (COPD) or sleep apnea, Xanax could make your condition worse. You can talk with your doctor about whether Xanax is right for you. - Depression or bipolar disorder. Xanax may worsen depression or cause episodes of mania in people with depression. If you have a history of depression or bipolar disorder, talk with your doctor about whether Xanax is right for you.
- Pregnancy. Whether Xanax is safe to take during pregnancy may depend on how far along the pregnancy is. For more information, see the “Xanax and pregnancy” section above.
- Breastfeeding. Breastfeeding is not recommended while taking Xanax. For more information, see the “Xanax and breastfeeding” section above.
Note: For more information about the potential negative effects of Xanax, see the “Xanax side effects” section above.
Using more than the recommended dosage of Xanax can lead to serious side effects and, in rare cases, death. Do not take more Xanax than your doctor recommends. (For information on the recommended dosages of Xanax, see the “Xanax dosage” section above.)
Overdose symptoms
Symptoms of an overdose can include:
- sleepiness
- confusion
- problems with coordination and balance
- reduced reflexes
- coma
What to do in case of overdose
If you think you’ve taken too much of this drug, call your doctor. You can also call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. However, if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional.
You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Xanax is a lethal sedative for teenagers
Drug addiction is a disease that can overtake any person. Unfortunately, addictions don't take long to develop. Yes, and highly addictive drugs may seem at first glance, safe drugs. Xanax is such a drug. The drug, designed to help in the fight against insomnia, is easy to buy in pharmacies. Xanax is a medicine that has hidden possibilities. Often it is he who is chosen by drug addicts in pursuit of an inexpensive and affordable buzz.
Even if Xanax is prescribed by a doctor and bought with a prescription, you should not forget that the treatment can cause serious consequences.
The strongest sedative quickly causes addiction and should be taken under the strict supervision of a doctor and only in the doses indicated by a specialist. Exceeding the dosage or increasing the number of doses can become addictive.
Xanax is a form of benzodiazepine that helps with anxiety and insomnia. The drug slows down the nervous system, helps relieve anxiety, a sense of threat. The person calms down, his life rhythm is getting better. But only if you follow all the rules and recommendations for taking the medicine.
In addition to dealing with anxiety, Xanax helps to cope with alcohol addiction. When refusing alcohol, a person experiences feelings of anxiety, panic attacks and other problems, the solution of which is the drug prescribed by the doctor. For medical purposes, Xanax is also used in the treatment of seizures. This is really one of the most effective and effective psychoactive substances, for which drug addicts choose it.
Xanax as a drug can radically change a person's life.
Even the slightest overdose causes addiction, and with the systematic use of the drug without the supervision of a specialist, the consequences can be fatal.
Xanax: how the drug works
Treatment with Xanax rarely leads to addiction if done correctly. But the development of drug addiction due to medical care happens infrequently. Much more often, drug addicts deliberately begin to take pills of the drug.
The human brain is a receptacle for a huge number of gamma receptors (neurons). They are responsible for anxiety, restlessness, a sense of danger and other symptoms, which are eliminated with the help of Xanax. With severe anxiety, the activity of neurons increases excessively, and the drug helps to “extinguish” it. Xanax acts very quickly - anxiety and panic disappear almost immediately after taking the pill. But addiction develops quickly. Under the supervision of a doctor, the drug is quickly canceled, replacing it with other methods of treatment. With drug addiction, withdrawal does not occur.
Reviews for Xanax vary. For some patients, this medicine helps to cope with the disease. In other people, it causes serious health problems and addiction, which can be felt even between doses prescribed by a doctor.
Xanax is a drug, and if taken the way drug addicts take it, anyone can become addicted. As a result, there is a feeling of euphoria, lightness, mental activity becomes dull, the body relaxes, mood improves. A long period of Xanax use leads to dementia, mental disorders, poor coordination. With each new dose of the drug, the condition will worsen, the doses of the drug will increase, the risks to life will increase. If you have been prescribed Xanax for treatment, keep the tablets out of the reach of children and strangers. Carefully monitor your condition and be sure to visit your doctor regularly.
How to understand that a person needs help
Xanax is the effect of calmness and carelessness. But it also has a lot of side effects. Symptoms of dependence on Xanax are easy enough to recognize:
- rapid onset of fatigue, severe fatigue;
- a person is confused in his thoughts, judgments;
- the addict's speech is confused, slurred;
- severe headaches appear;
- increases sensitivity to noise;
- tremor of hands and whole body develops;
- mood changes abruptly;
- insomnia develops;
- emotions disappear;
- increased sweating;
- may experience numbness of the extremities, vomiting, nausea;
- weight changes dramatically.
Dependence on Xanax also has external manifestations. The skin may turn red and develop a rash. The face swells, becomes puffy, swelling may occur in other parts of the body, including the throat, tongue. Speech in this case becomes difficult, the voice changes.
Taking Xanax also affects the state of the gastrointestinal tract. Drug addicts experience stomach pain, diarrhea or constipation. Cardiac activity is disturbed, as a result of which an aggravated feeling of cold appears, a person shakes, freezes even in the heat. Over time, the feeling of euphoria is replaced by increased anxiety, suicidal thoughts, fears appear. This condition cannot last long - a person either goes to a specialized clinic for treatment, or dies.
The active substance of Xanax is alprazolam. The consequences of taking it can only be eliminated by specialists, so dealing with the problem on your own is not an option.
Xanax is a powerful drug, but what effect should be expected from its correct use? When treated with Xanax, the patient may experience a feeling of lethargy, slight fatigue, but such manifestations do not entail serious consequences.
Report any changes in your condition to your doctor immediately! After the abolition of Xanax, anxiety, panic attacks can develop, a person can harm himself and others. Therefore, the drug is not canceled just like that - a replacement is selected for it, the intake of which is also strictly controlled by a specialist. Cancellation of the drug takes place in stages.
| 💊 Ingredients of Xanax ® ✅ Use of Xanax ® Keep for yourself Search for analogues ⚠️ The state registration of this drug has been canceled Description of the active ingredients of the preparation Xanax ® (Xanax ® ) The scientific information provided is general and cannot be used to make decisions. Update date: 2020.11.07 Marketing authorization holder:PHARMACIA, NV/SA (Belgium) ATX code: N05BA12 (Alprazolam) Active substance: alprazolam (alprazolam) Rec.INN WHO registered Dosage form
Release form, packaging and composition Xanax®
10 pcs. - cellular contour packings (3) - packs of cardboard. Clinical and pharmacological group: Anxiolytic (tranquilizer) Pharmacotherapeutic group: Anxiolytic agent (tranquilizer) Pharmacological action Anxiolytic agent (tranquilizer), triazolo-benzodiazepine derivative. It has an anxiolytic, sedative, hypnotic, anticonvulsant, central muscle relaxant effect. The mechanism of action is to enhance the inhibitory effect of endogenous GABA in the CNS by increasing the sensitivity of GABA receptors to the mediator as a result of stimulation of benzodiazepine receptors located in the allosteric center of postsynaptic GABA receptors of the ascending activating reticular formation of the brainstem and intercalary neurons of the lateral horns of the spinal cord; reduces the excitability of the subcortical structures of the brain (limbic system, thalamus, hypothalamus), inhibits polysynaptic spinal reflexes. Pronounced anxiolytic activity (reduction of emotional stress, weakening of anxiety, fear, restlessness) is combined with a moderately pronounced hypnotic effect; shortens the period of falling asleep, increases the duration of sleep, reduces the number of night awakenings. The mechanism of hypnotic action is to inhibit the cells of the reticular formation of the brain stem. Reduces the impact of emotional, vegetative and motor stimuli that disrupt the mechanism of falling asleep. PharmacokineticsAfter oral administration, alprazolam is rapidly and completely absorbed from the gastrointestinal tract. C max in plasma is achieved within 1-2 hours. Plasma protein binding is 80%. Metabolized in the liver. T 1/2 averages 12-15 hours. Alprazolam and its metabolites are excreted mainly by the kidneys. Indications of the active substances of the drug Xanax® Anxiety, neurosis, accompanied by a sense of anxiety, danger, restlessness, tension, worsening sleep, irritability, and somatic disorders; mixed anxiety-depressive states; neurotic reactive-depressive states, accompanied by a decrease in mood, loss of interest in the environment, anxiety, loss of sleep, loss of appetite, somatic disorders; anxiety states and neurotic depressions that have developed against the background of somatic diseases; panic disorder with and without phobia symptoms. Open list of ICD-10 codes
Dosing regimenThe route of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed. Individual. It is recommended to use the minimum effective dose. The dose is adjusted during treatment, depending on the effect achieved and tolerability. If it is necessary to increase the dose, it should be increased gradually, first in the evening, and then in the daytime. The initial dose is 250-500 mcg 3 times / day, if necessary, a gradual increase to 4.5 mg / day is possible. For elderly or debilitated patients, the initial dose is 250 mcg 2-3 times / day, maintenance doses - 500-750 mcg / day, if necessary, taking into account tolerability, the dose can be increased. Cancel or reduce the dose of alprazolam should be carried out gradually, reducing the daily dose by no more than 500 micrograms every 3 days; sometimes even slower cancellation may be needed. Side effectsFrom the side of the central nervous system: at the beginning of treatment (especially in elderly patients) drowsiness, fatigue, dizziness, decreased ability to concentrate, ataxia, disorientation, unsteady gait, slowing mental and motor reactions; rarely - headache, euphoria, depression, tremor, memory loss, impaired coordination of movements, depressed mood, confusion, dystonic extrapyramidal reactions (uncontrolled movements, including the eyes), weakness, myasthenia gravis, dysarthria; in some cases, paradoxical reactions (aggressive outbursts, confusion, psychomotor agitation, fear, suicidal tendencies, muscle spasm, hallucinations, agitation, irritability, anxiety, insomnia). From the digestive system: possible dry mouth or salivation, heartburn, nausea, vomiting, loss of appetite, constipation or diarrhea, impaired liver function, increased activity of liver transaminases and alkaline phosphatase, jaundice. On the part of the hematopoietic system: possible leukopenia, neutropenia, agranulocytosis (chills, hyperthermia, sore throat, excessive fatigue or weakness), anemia, thrombocytopenia. From the urinary system: Urinary incontinence, urinary retention, impaired renal function, decreased or increased libido, dysmenorrhea are possible. On the part of the endocrine system: possible changes in body weight, libido disorders, menstrual cycle disorders. From the side of the cardiovascular system: possible decrease in blood pressure, tachycardia. Allergic reactions: possible skin rash, itching. Contraindications for use Coma, shock, myasthenia gravis, angle-closure glaucoma (acute attack or predisposition), acute alcohol poisoning (with weakening of vital functions), opioid analgesics, hypnotics and psychotropic drugs, chronic obstructive airways disease with initial manifestations of respiratory insufficiency, acute respiratory failure, severe depression (suicidal tendencies may occur), pregnancy (especially the first trimester), lactation, children and adolescents under 18 years of age, hypersensitivity to benzodiazepines. Use during pregnancy and lactationAlprazolam has a toxic effect on the fetus and increases the risk of congenital malformations when used in the first trimester of pregnancy. Chronic use during pregnancy can lead to physical dependence with the development of withdrawal syndrome in the newborn. Reception in therapeutic doses in later stages of pregnancy can cause depression of the central nervous system of the newborn. Use immediately before or during labor may cause respiratory depression, decreased muscle tone, hypotension, hypothermia, and poor suckling (poor neonatal sucking syndrome) in the neonate. Benzodiazepines may be excreted in breast milk, which may make the newborn drowsy and make feeding difficult. experimental studies show that alprazolam and its metabolites are excreted in breast milk. Use in hepatic impairmentAlprazolam should be used with caution in patients with hepatic impairment. Use in Impaired Renal Function Alprazolam should be used with caution in patients with impaired renal function. Use in childrenContraindication: children and adolescents under 18 years of age. Use in elderly patientsFor elderly or debilitated patients, the initial dose is 250 mcg 2-3 times / day, maintenance doses - 500-750 mcg / day, if necessary, taking into account tolerability, the dose can be increased. Special instructionsIn endogenous depression, alprazolam can be used in combination with antidepressants. When using alprazolam in patients with depression, there have been cases of the development of hypomanic and manic states. Alprazolam should be used with caution in patients with hepatic and/or renal impairment. In patients who have not previously taken drugs that affect the central nervous system, alprazolam is effective at lower doses compared with patients who received antidepressants, anxiolytics or suffering from chronic alcoholism. With long-term use in high doses, the development of addiction and the formation of drug dependence is possible, especially in patients prone to drug abuse. With rapid dose reduction or abrupt withdrawal of alprazolam, a withdrawal syndrome occurs, the symptoms of which can range from mild dysphoria and insomnia to a severe syndrome with abdominal and skeletal muscle cramps, vomiting, increased sweating, tremors and convulsions. The withdrawal syndrome is more common in individuals who have received alprazolam for a long time (more than 8-12 weeks). Other tranquilizers should not be co-administered with alprazolam. The safety of alprazolam in children and adolescents under 18 years of age has not been established. Children, especially at a younger age, are very sensitive to the inhibitory effect of benzodiazepines on the central nervous system. Avoid drinking alcohol during treatment. Influence on the ability to drive vehicles and mechanisms During the period of treatment, one should refrain from engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions (driving vehicles or working with mechanisms). Drug interactionsWith the simultaneous use of psychotropic, anticonvulsants, drugs and ethanol, an increase in the inhibitory effect of alprazolam on the central nervous system is observed. With simultaneous use of blockers of histamine H 2 receptors reduce the clearance of alprazolam and increase the inhibitory effect of alprazolam on the central nervous system; macrolide antibiotics - reduce the clearance of alprazolam. With simultaneous use of hormonal contraceptives for oral administration increase T 1/2 alprazolam. With the simultaneous use of alprazolam with dextropropoxyphene, more pronounced CNS depression is observed than in combination with other benzodiazepines, tk. it is possible to increase the concentration of alprazolam in the blood plasma. Simultaneous intake of digoxin increases the risk of developing intoxication with cardiac glycosides. Alprazolam increases the plasma concentration of imipramine.    Copyright © · The Wright Initiative · Articles · Site Map 
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