What can you take for anxiety over the counter
What Are the Best Options- K Health
Everyone copes with anxiety differently. For some individuals, prescription medication is the best way to keep this condition from controlling their lives.
For others, therapy, lifestyle changes, and over-the-counter medications and herbal supplements may help manage anxiety.
However, not all OTC options have scientific evidence to show that they do anything to treat anxiety.
Since the research can be difficult to interpret, we looked at the studies for you.
In this article, first we’ll explain why anxiety medications are only available by prescription.
Then we’ll discuss seven OTC options that have been shown to provide relief for symptoms of anxiety.
We’ll also share lifestyle changes that can help improve symptoms, as well as when to see a doctor or mental health professional about anxiety.
Why Anxiety Medication Is Prescription Only
Prescription drugs approved by the U.S. Food and Drug Administration (FDA) for the treatment of anxiety disorders include:
- Selective serotonin reuptake inhibitors (SSRIs)
- Serotonin norepinephrine reuptake inhibitors (SNRIs)
- Buspirone (Buspar)
These anti-anxiety medications work to affect neurotransmitters in the brain that can become unbalanced, leading to symptoms of anxiety.
They require a prescription because they can cause serious side effects and must be taken under the supervision of a medical provider.
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OTC Anxiety Medications
Some people prefer trying OTC anxiety medicines before moving to prescription treatment.
Although these may not work for everyone, the ones below have some level of evidence for their effectiveness.
Discuss OTC remedies with your healthcare provider before taking anything, as these can interact with foods, prescription medications, or supplements.
Also know that supplements are not regulated by the FDA and may not contain the ingredients or doses they advertise, or could contain other unlisted ingredients.
Most often used to treat allergies, antihistamines typically cause side effects of drowsiness or sedation.
Research has not found diphenhydramine (Benadryl) to be an effective anxiety treatment compared to anti-anxiety medications.
However, if anxiety symptoms interfere with sleep or are triggered by allergies, diphenhydramine or other antihistamines may help.
Older adults should be cautious with diphenhydramine since it can lead to dizziness or drowsy feelings, which could increase the risk for injury, falls, or confusion.
Diphenhydramine overdose can be fatal, so never take more than the dose listed on the package.
A prescription antihistamine, hydroxyzine (Vistaril), has been shown to be effective when taken as needed for anxiety.
Your healthcare provider can determine if that is a good treatment option for you.
5-HTP, sometimes called tryptophan, is a compound found naturally in the body.
It is used to make several neurotransmitters, including serotonin.
Anti-anxiety medications often work by helping the brain recycle or increase levels of serotonin.
5-HTP is thought to be beneficial for anxiety by helping provide the materials the body needs to make more serotonin.
However, quality studies have not proven that it increases the amount of serotonin available to the brain or positively impacts mood.
Taking 5-HTP with other medications that influence brain chemicals could cause interactions.
Do not take 5-HTP with the following:
- Anti-anxiety medications
- Muscle relaxers
Magnesium is a mineral required for many bodily functions, including muscle contraction, blood pressure and blood sugar regulation, and, possibly, mood balance and helping to alleviate feelings of anxiety.
While magnesium is found in many foods, nearly half the U.S. population does not consume enough.
The recommended daily intake is 310-420 milligrams (mg), depending on age and biological sex.
Too much magnesium from food does not pose risks, but high doses of magnesium supplements can cause diarrhea and other side effects.
Don’t take more than 350 milligrams of magnesium as a supplement.
Cannabidiol, or CBD, provides the calming properties of cannabis without the psychoactive component.
It may help treat different anxiety disorders, but more research is necessary to prove its safety and effectiveness.
Additionally, CBD products are not regulated by the FDA for dosage consistency, purity, or safety.
Many contain inconsistent amounts of CBD and may contain some psychoactive substances from marijuana or other contaminants.
So buy CBD products from trustworthy brands. Cannabidiol can also interact with medications.
Ashwagandha is an herb that may support balanced cortisol levels.
The body produces this hormone during times of stress.
Some clinical trials have found that ashwagandha has anti-anxiety properties, however, more research is needed to determine if this herbal remedy has effects in larger groups.
Kava, sometimes called kava kava, is a root sold as a dietary supplement.
A small study found that kava may help improve anxiety symptoms compared to a placebo.
Use caution with kava supplements, as they may cause liver damage that can be permanent and even fatal.
Valerian root is commonly used for sleep problems.
One clinical trial found that this supplement led to improvements in the area of the brain associated with anxiety.
But not all studies show that valerian has anxiety-relief benefits, and if you take it regularly, you may notice withdrawal symptoms if you stop.
It also may have the potential to increase the risk of liver damage.
If you are interested in natural remedies to reduce anxiety, consider the following lifestyle changes:
- Aromatherapy: Lavender essential oil is known for its soothing and calming effects. Diffuse it in a room or make a linen spray to use in your sleeping space or on your shirt. Never ingest essential oils or apply them directly to your skin.
- Meditation and mindfulness: Meditation, deep breathing exercises, and mindfulness practices can help with anxiety symptom relief, especially when paired with psychotherapy and other methods of treatment.
- Regular physical activity: In anxiety, it is thought that the HPA axis (a network of three glands) is hyperactive, causing the body to be stuck in “fight or flight” response for too long. Exercise can improve the function of the HPA axis and in turn improve mood, decrease stress, and modulate anxiety. Yoga in particular may provide anxiety relief.
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When to See a Doctor or Mental Health Professional
If you experience symptoms of anxiety, speak with a healthcare provider about lifestyle changes and OTC options.
They can recommend supplements and other treatments that are likely to be better for you, considering your overall health and specific symptoms.
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Frequently Asked Questions
Are there any stress or anxiety medications available OTC?
The only FDA-approved treatments for anxiety require a prescription. However, some OTC medications and supplements may help address anxiety symptoms. Talk to a healthcare provider about your best options.
What are the strongest over-the-counter anti-anxiety medications?
Some dietary supplements (such as ashwagandha, CBD, valerian root, kava, and magnesium) may be helpful in easing anxiety but have not been proven to be safe or effective. In addition, supplements are not FDA-regulated and may not contain the advertised ingredients or doses.
K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.
K Health has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references.
Cannabidiol (CBD). (2022).
Cannabidiol as a Potential Treatment for Anxiety Disorders. (2015).
The Effect of Yoga on Stress, Anxiety, and Depression in Women. (2018).
Effects of Aromatherapy on Anxiety: A Meta-Analysis of Randomized Controlled Trials. (2020).
Exercise for Mental Health. (2006).
GABA-Modulating Phytomedicines for Anxiety: A Systematic Review of Preclinical and Clinical Evidence. (2018).
Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. (2016).
An Investigation Into the Stress-Relieving and Pharmacological Actions of an Ashwagandha (Withania Somnifera) Extract. (2019).
Kava in the Treatment of Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled Study. (2013).
Kava Kava - LiverTox. (2018).
Mindfulness-Based Interventions for Anxiety and Depression. (2018).
Pharmacodynamic Response Profiles of Anxiolytic and Sedative Drugs. (2017).
Role of Magnesium Supplementation in the Treatment of Depression: A Randomized Clinical Trial. (2017).
Subclinical Magnesium Deficiency: A Principal Driver of Cardiovascular Disease and a Public Health Crisis. (2018).
Treatment of Anxiety disorders. (2017).
Use of Cannabidiol in Anxiety and Anxiety-Related Disorders. (2019).
The Unexpected Identification of the Cannabimimetic, 5F-ADB, and Dextromethorphan in Commercially Available Cannabidiol E-liquids. (2018).
Valerian - LiverTox. (2020).
Valerian Extract Alters Functional Brain Connectivity: A Randomized Double‐Blind Placebo‐Controlled Trial. (2019).
What You Need to Know (And What We're Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD. (2020).
Are There Any Over-The-Counter Anxiety Medications?
Anxiety medications are controlled substances for a reason. It all comes down to anxiety’s action within the brain.
Chronic anxiety (and panic attacks) can influence your central nervous system, causing your brain to release stress hormones such as adrenaline and cortisol more frequently than normal. This can result in various symptoms of anxiety, including depression, headaches, and dizziness.
Adrenaline and cortisol are extremely helpful when you’re in a threatening situation - they’re an essential component of your body’s fight-or-flight response, the reaction you have when exposed to dangerous situations. However, when you are responding to imagined threats (as is common with anxiety disorders), your brain is continually releasing stress hormones unnecessarily.
Therefore, to treat anxiety, treatment methods need to focus on preventing this neurological reaction. And anything powerful enough to affect the brain in this way you should only use after professional medical advice from a doctor.
And it’s important to ask yourself, “would I want over-the-counter medication for my anxiety?” Anxiety is not a disease that can be cured by taking some medication for a week. Instead, it’s a condition affecting the way you think and feel.
Medication dulls anxiety but it doesn't cure it. You'd have to take medication for the rest of your life, and that can lead to difficulties such as dependency, side effects, and a reduction in effectiveness over time. It may also prevent you from seeking further methods that could reduce your anxiety.
To truly combat anxiety, you need to understand why you’re anxious in the first place. You may need to speak to a mental health professional such as a therapist for this - more on that topic later!
Still, medications can help with the emotional distress and physical symptoms anxiety causes. So, why are there no over-the-counter treatment options?
Reason #1 Potential for Abuse
Taken in certain ways, anti-anxiety medications can cause significant mental impairment, and the concern is that if they were available over the counter, many people would be taking these drugs off-label. That's too dangerous.
Remember, these are drugs that affect your brain directly. They alter your body's production and reception of neurotransmitters. That can be useful for reducing anxiety but can cause significant side effects and be extremely dangerous if more is taken than directed. They also interact with numerous other medications, alcohol, and more. These medications simply cannot be sold over the counter without posing a significant risk to the community.
Reason #2 Side Effects
Even over-the-counter medications can elicit harmful side effects. And, without a doctor’s supervision, this could have serious repercussions. One example of this is Benadryl.
In the past, many people have used Benadryl to manage their anxiety symptoms because it’s fast-acting and convenient - taking just 15 - 30 minutes to kick in and lasting for several hours. Yes, it reduces anxiety symptoms temporarily, but Benadryl was never intended for long-term use. It comes with various side effects, including:
And these are just the most commonly reported. Other, more severe side effects, include:
- Lower red blood cell levels
- Irregular heart rhythm
- Rapid heartbeat
- Memory loss
With other medications, you may suffer from a decreased appetite, weight loss, and other adverse effects impacting your health. Without the assistance of a doctor, these side effects may be deadly. These can be particularly troublesome if you’re in a vulnerable group, such as pregnant women, the elderly, and young children.
Reason #3 Hands-Off Approach
In the short term, these medicines may provide some relief. But unfortunately, if you use these medicines for so long without any additional coping tips, your brain will start to depend on them as the only way to cope with stress.
As anxiety symptoms ease, you may feel a natural pull away from coping mechanisms you previously used to reduce your anxiety, reading to dependence on over-the-counter medication as your sole treatment approach.
So when you stop taking these medicines, you'll have lost some of your natural coping skills which, if you suffer from anxiety, may already have been struggling with. That's a significant risk without alternative treatments and a doctor's supervision.
Will Anxiety Medications Ever Be Available Over the Counter?
There may be a day when an over-the-counter anxiety medication is a viable option. Some medications, like Buspirone, are less powerful (while still useful for mild anxiety) and have fewer side effects.
It is possible that a medication like Buspirone may someday be released with a primary focus on easing anxiety symptoms, but given that it can also take several days for the medications to start working, and they are not as powerful as benzodiazepines and other prescription medications, it still may not be the right choice.
Someday there will be an over-the-counter anxiety medicine, but as of yet, there are no medications that meet the criteria that would make them viable as an over-the-counter option.
Alternatives to Over-the-Counter (OTC) Anxiety Medications
Until OTC medications become available, there are several effective alternatives that you could try. Let’s look at each option in turn.
Talk therapy has proven a highly effective method for managing anxiety symptoms. One of the most common forms of therapy for anxiety disorders is Cognitive Behavioral Therapy (CBT).
In CBT, you work with a therapist to identify the factors contributing to your anxiety, focusing on problem-solving rather than digging deep into the past, unlike other therapy approaches such as psychodynamic and humanistic.
Researchers extensively study the benefits of exercise on mental health and well-being. One of the positive effects of regular exercise is that it reduces anxiety. It does this in several ways:
Exercise provides a welcome distraction from anxious thoughts and the physical symptoms associated with chronic anxiety.
Reduces Muscle Tension
Exercise gets your muscles active, which can help to reduce muscle tension and other anxiety effects on your muscles.
Increases Heart Rate
Exercise makes your heart beat faster, which alters your brain chemistry, encouraging the release of anxiolytic (anxiety-reducing) neurochemicals such as GABA, serotonin, and BDNF.
Activates Specific Brain Regions
Your frontal brain regions are activated when you exercise. These areas are responsible for executive function, enhancing control over the amygdala, an area of the brain related to the stress response.
There are also several herbal ingredients that reduce anxiety. This includes:
- Kava. Kava is an herbal supplement that some studies have shown may be as effective as several anxiety medications. Kava should still be used under the supervision of a doctor since it can interact with other medicines and alcohol, but as it is an herb that is available without a prescription, it may be worth trying. Passionflower and valerian may also be beneficial, although they are not believed to be as powerful.
- CBD oil. CBD oil is an extract of the cannabis plant (known as Cannabidiol). It is usually taken from industrial hemp, which contains very little THC (the drug that causes the high), and even then any remaining THC is completely removed. Although we cannot recommend CBD oil yet due to a lack of research and questionable legality, there are studies showing that this extract may have stress relief benefits. Talk to your doctor about the risks and benefits of CBD.
- 5-HTP, L-Tryptophan, or Sam-e. Although many neurotransmitter imbalances have been linked to anxiety, serotonin is the one that has the strongest connection for most people. In theory, increasing serotonin levels in the brain should be able to decrease anxiety symptoms. According to natural health promoters, 5-HTP, L-Tryptophan, and Sam-e are three supplements that increase serotonin levels. It is not clear that they work in the research, but they are available over the counter for those interested in trying it.
- Water and Magnesium. In some cases, anxiety may be caused or exacerbated by a lack of important nutrients. So drinking a lot of water and taking magnesium supplements may help some people reduce their anxiety and find some degree of relief, even if it doesn't cure the anxiety altogether.
To learn more, read our article on natural remedies for anxiety.
None of these are guaranteed immediate cures, but they can be a tremendous help. If you're someone that benefits from relaxation exercises like deep breathing, progressive muscle relaxation, and visualization, then you should try those as well.
You should never self-medicate with alcohol, or with any drug not designed for anxiety. Self-medication has the same effect as anxiety medicines - use them when you're feeling anxious, and you start to depend on them and lose your ability to cope any other way.
Next Steps for Anxiety
Anxiety isn’t a quick fix. You need to work on it regularly and learn the skills necessary to reduce anxiety, as well as figure out the cause of your anxiety in the first place.
While many consider taking medication a short-term solution, it can often turn into a long-term problem, especially if consumption isn’t supervised by a doctor.
However, there are some approaches you can take to manage anxiety yourself, such as talking therapy, exercise, and herbal remedies. But be sure to speak to your healthcare provider to identify the best course of action for you.
There are no OTC medications for anxiety since any medication that affects the brain needs to be carefully monitored; that’s why they tend to be prescription medication only.
Medication is not the only treatment a person should take as it can lead to dependency, unpleasant side effects, and reliance as the only coping strategy.
Luckily, there are other natural remedies for treating anxiety, including talk therapy, exercise, and herbal products. Ultimately, more research is needed to uncover a truly effective over-the-counter medication for anxiety.
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Good sedatives without a prescription - article on the site Aptechestvo, Nizhny Novgorod
Insomnia, apathy, anxiety - these and other symptoms of stress appear when the nervous system is shaken up. In such a state, the quality of life decreases: fatigue and weakness dominate the desire to do something, and lack of sleep provokes unreasonable aggression and anxiety. To overcome the symptoms of stress, good sedatives without prescriptions, which can be bought at the pharmacy, will help. nine0003
Nature of stress
Stress is a set of non-specific adaptive (normal) reactions of the body to the impact of various adverse factors. Difficulties in the team, moving, the upcoming exam are just a small part of what can affect the nervous system, causing insomnia, anxiety and other manifestations of stress.
The nature of such a condition can be chronic, acute or short-term, which is important for the selection of treatment. So, if the disorder is not associated with serious mental disorders, sedative drugs without prescriptions are enough. For chronic and severe stress, prescription drugs prescribed by a doctor are required. nine0003
How stress manifests itself
Human reactions are controlled by processes occurring in the nervous system - excitation and inhibition. With normal psychological health, they are balanced, but in the event of a nervous shock, this balance is disturbed.
Depending on which process is activated more strongly, the following appear:
anxiety attacks, irritability, aggression;
- nine0002 sleep disorders;
frequent and abrupt mood swings;
memory and concentration disorders;
nervous excitement and other signs of stress.nine0020
Over-the-counter sedative pills restore this balance. The cumulative effect of taking them prevents disruptions in mental health, including during periods of a break between courses.
Effect of sedatives
Fast-acting sedative pills without prescriptions reduce the excitability of nerve cells. As the concentration of active substances in the body increases, nervous tension disappears, healthy sleep is restored, and other symptoms of stress disorder are suppressed. nine0003
An over-the-counter herbal sedative should be taken in cases of unreasonable anxiety, sleep problems and unstable mood.
Suppression of irritability is facilitated by preparations based on magnesium carbonate and vitamin B6. Capsules Motherwort Forte Evalar and Stressovit have proven themselves, the main substances of which are linden, motherwort and hops.
Types of antidepressants
All antidepressant drugs are divided into groups: nine0003
neuroleptics - suppress psychomotor agitation;
tranquilizers - are an adjuvant when taking antipsychotics, they stop nervous excitement;
psychostimulants - return activity and vigor;
antidepressants - applicable in the treatment of depression and other mental disorders; nine0003
normothymic drugs - effective in depression associated with chronic affective diseases.
These are prescription drugs that are selected exclusively by a specialist. The list of over-the-counter soothing pills includes amino acids, as well as herbal preparations based on St. John's wort, valerian, motherwort, mint, and chamomile.
The best sedatives without prescriptions
For mild psychosomatic disorders, it is useful to take sedatives for the nervous system of an adult without prescriptions. Herbal components and amino acids in the composition of such preparations can quickly relieve psycho-emotional stress, reduce anxiety, increase mental activity, restore healthy sleep without night awakenings.
The list of sedatives without prescriptions includes preparations with lemon balm and valerian - Dormiplant, Persen, Novo-Passit. nine0003
Certain drugs for nervous tension are suitable for suppressing anxiety attacks and treating nocturnal enuresis in children.
Use of tablets for nervous tension
In the event of a nervous breakdown, psycho-emotional health is helped to keep sedatives from nerves without prescriptions. When taken, the body does not react so sharply to emotional stimuli, reduces aggressiveness and irritability. At night, it is easier for a person to relax and fall asleep. The quality of rest also improves: insomnia and intermittent sleep disappear. nine0003
Sedative drugs reduce excitability, help to relax, normalize sleep, and prevent neuroses. The tablets have a cumulative effect and are gentle on the body, which distinguishes them from most potent prescription drugs for this purpose.
top-5 rating according to the KP version
Everyone knows the phrase “all diseases are from nerves”. Indeed, prolonged stress undermines our health, reduces immunity. As a result of constant failures, diseases to which a tendency has been observed develop. For example, if you have relatives with hypertension, you have a high risk of developing the disease after prolonged stressful conditions. nine0003
Short-term stress and emotional outbursts are usually not harmful. Much more dangerous is the sluggish nervous tension that often occurs among residents of megacities. Lack of sleep, city noise, worries at work lead to prolonged, but unnoticed depression, fatigue, mood and sleep disorders. This can drag on for years, until the person "breaks loose", falling into a panic or aggressive state.
Many people unknowingly develop bad habits, start smoking and drinking alcohol to relieve stress. Toxic substances exacerbate the situation. nine0003
You can keep your nervous system healthy in other ways. Go in for sports, walk in the fresh air, consult a psychotherapist, take supportive drugs. Light drugs are not addictive and act on the brain quite gently. Therefore, you can buy the best pills for stress and nerves without prescriptions.
Top 5 rating according to KP version
Combined herbal medicine. It has anxiolytic and anti-stress activity. It is produced in Vietnam, so its recipe contains components that are widely used in traditional oriental medicine. It consists of extracts of seeds and embryos of the walnut lotus, seeds of thuja orientalis and Chinese dates, rhizomes of Dioscorea, mulberry leaves and erythrina, as well as the fruits of euphoria longana. nine0003
Components of Lotusonic reduce irritation and tension, which are manifested in mental fatigue and neurasthenia. When taking other sedative, hypnotic drugs, as well as antihypertensive and analgesics, the dosage should be adjusted, since the drug enhances their effect. The effect of Lotusonic is cumulative, as with most herbal preparations.
natural herbal composition based on recipes of traditional oriental medicine; indicated for increased excitability, irritability, fatigue; additionally, with insomnia, it helps to restore normal sleep; not addictive; low price. nine0003
not allowed under 18; can not be pregnant and lactating; allergic reactions are possible; during the period of treatment should refrain from driving.
Helps fight stress manifestations
Combination medicine Lotusonic has anti-stress activity and helps to cope with irritation and tension. It contains herbal ingredients used in traditional oriental medicine*
Get priceView ingredients
* THERE ARE CONTRAINDICATIONS. CONSULT WITH A SPECIALIST
Advertisement. DOMINANTA-SERVICE JSC. Photo: market.yandex.ru
This drug is usually prescribed as an additional support for the brain with constant overstrain: stressful work, difficult studies. Tablets regulate metabolism and improve the processes of inhibition in the central nervous system. This reduces tension and aggression.
Also, the drug reduces the consequences after brain injuries, after alcohol or drug poisoning.
improves mental performance; improves sleep; no side effects; possible during pregnancy and children; low price
cumulative effect, not effective immediately
3. Novo-Passit solutionNovo-Passit. Photo: TEVA
Herbal preparation, consists of a complex of valerian, hops, lemon balm and others. The herbal complex has a calming effect, effective not only with anxiety, but also with more severe disorders. For example, with itching, migraines, intestinal diseases, bouts of neurasthenia, which are caused by psychological stress. nine0003
The product contains ethanol - alcohol, which should be taken into account. During pregnancy, the drug is not recommended to be taken, but according to certain indications, they are at risk. For convenience, there is also a form of tablets, but the solution is absorbed and acts faster.
natural composition; fights many nervous diseases; improves sleep; palatable
possible side effects; recommended to stop driving; not allowed under 12 years of age; not for breastfeeding mothers; inconvenient form of reception; not compatible with certain medications; high price
4. AfobazoleAfobazole tab. Photo: market.yandex.ru
This drug is one of the most “strong” in our ranking of the best pills for stress and nerves, it belongs to tranquilizers and antidepressants. It is used for anxiety, anxiety attacks, sleep disorders. It also facilitates the course of many diseases: asthma, hypertension, arrhythmias.
The drug is especially indicated for vulnerable, suspicious people, prone to tearfulness or irritability. Taking pills makes it easier to endure premenstrual syndrome, as well as the "withdrawal syndrome" with a sharp rejection of bad habits, smoking and alcohol. nine0003
protects nerve cells; eliminates anxiety; relieves depression; fights many nervous diseases; does not cause lethargy and addiction; practically no side effects.
not allowed under 18; not during pregnancy and lactation; cumulative effect, does not appear immediately; high price.
5. Motherwort forteMotherwort forte tab. Photo: market.yandex.ru
In fact, it is not a medicine, but a dietary supplement, a source of vitamins, magnesium and flavones. Their accumulation has a very mild calming effect and is suitable for minor anxiety as an additional support for the body. With severe stress and its physical manifestations, the drug may not work immediately. Sometimes you have to take pills for more than a week before the effect appears. nine0003
natural composition; reduces the level of anxiety; no side effects; does not cause addiction and drowsiness; low price.