Trintellix dosage guide

Dosing & Administration | TRINTELLIX (vortioxetine)

TRINTELLIX^® (vortioxetine) is indicated for the treatment of Major Depressive Disorder (MDD) in adults.

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Individual results may vary.

Dosing &
Administration

How does dosing fit into the story?

Tablets shown not actual size.

The recommended starting dose of TRINTELLIX is 10 mg administered orally once daily, without regard to meals¹
Dosage should then be increased ‌to 20 mg once daily, as tolerated¹
- The efficacy and safety of doses above 20 mg/day have not been evaluated in controlled clinical trials
- 5 mg/day may be considered for patients who do not tolerate higher doses

Prior to initiating treatment with TRINTELLIX, screen patients for personal or family history of bipolar disorder, mania, or hypomania¹

Although patients can abruptly discontinue therapy with TRINTELLIX, it is recommended that doses of 15 mg/day or 20 mg/day be reduced to 10 mg/day for one week prior to full discontinuation if possible¹
- In placebo-controlled trials, some patients experienced transient adverse reactions such as headache and muscle tension following abrupt discontinuation

The maximum recommended dose is 10 mg/day in known CYP2D6 poor metabolizers¹
Concomitant administration of TRINTELLIX and strong CYP2D6 inhibitors or strong CYP inducers may require a dose adjustment of TRINTELLIX¹

For additional dosing information, please see the Full Prescribing Information.

Drug interactions

Clinically important drug interactions with TRINTELLIX¹

Drug Class

Clinical Impact & Recommendations

Monoamine Oxidase Inhibitors

selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue

CONCOMITANT USE WITH TRINTELLIX MAY INCREASE THE RISK OF SEROTONIN SYNDROME

MAOIs for psychiatric disorders are contraindicated with TRINTELLIX or within 21 days of stopping TRINTELLIX.

TRINTELLIX is contraindicated within 14 days of stopping MAOIs for psychiatric disorders.

Starting TRINTELLIX in patients on linezolid or IV methylene blue is also contraindicated.

Other Serotonergic Drugs

SNRIs, SSRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, buspirone, amphetamines, tryptophan, St. John’s Wort

CONCOMITANT USE WITH TRINTELLIX MAY INCREASE THE RISK OF SEROTONIN SYNDROME

Monitor for serotonin syndrome when TRINTELLIX is coadministered with other serotonergic drugs.

If serotonin syndrome occurs, discontinue TRINTELLIX and other serotonergic drugs, and initiate supportive treatment.

Strong CYP2D6 Inhibitors

bupropion, fluoxetine, paroxetine, quinidine

CONCOMITANT USE WITH TRINTELLIX MAY INCREASE TRINTELLIX PLASMA LEVELS

Reduce the TRINTELLIX dose by half.

When discontinuing a strong CYP2D6 inhibitor, increase TRINTELLIX to its original dose.

Strong CYP Inducers

rifampin, carbamazepine, phenytoin

CONCOMITANT USE WITH TRINTELLIX DECREASES TRINTELLIX PLASMA LEVELS

Consider increasing the dose of TRINTELLIX when coadministered for more than 14 days.

The maximum TRINTELLIX dose should not be greater than three times the original TRINTELLIX dose.

When discontinuing a strong CYP inducer, reduce TRINTELLIX within 14 days to its original dose.

Antiplatelet Drugs and Anticoagulants

aspirin, NSAIDs, clopidogrel, heparin, warfarin

CONCOMITANT USE WITH TRINTELLIX MAY POTENTIATE BLEEDING RISK

Inform patients of increased bleeding risk.

For patients on warfarin, monitor INR carefully when initiating, titrating or discontinuing TRINTELLIX.

Drugs Highly Bound to Plasma Protein

warfarin

CONCOMITANT USE WITH TRINTELLIX MAY INCREASE FREE TRINTELLIX PLASMA LEVELS OR OTHER HIGHLY PROTEIN-BOUND DRUG LEVELS

Monitor for adverse reactions.

Reduce dosage of TRINTELLIX or other highly protein-bound drugs as needed.

Note: Class examples do not include all possible class members.

Abbreviations: INR, International Normalized Ratio; IV, Intravenous; MAOIs, Monoamine oxidase inhibitors; NSAIDs, Nonsteroidal anti-inflammatory drugs; SNRIs, Serotonin-norepinephrine reuptake inhibitors; SSRIs, Selective serotonin reuptake inhibitors.

For additional Drug Interactions information, please see the Full Prescribing Information.

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Trintellix Dosage Guide - Drugs.com

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Generic name: VORTIOXETINE HYDROBROMIDE 10mg
Dosage form: tablet, film coated
Drug class: Miscellaneous antidepressants

Medically reviewed by Drugs. com. Last updated on Jan 5, 2023.

Recommended Dosage

The recommended starting dose is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated. The efficacy and safety of doses above 20 mg/day have not been evaluated in controlled clinical trials. A dose decrease down to 5 mg/day may be considered for patients who do not tolerate higher doses [see Clinical Studies (14)].

Screen for Bipolar Disorder Prior to Starting TRINTELLIX

Prior to initiating treatment with TRINTELLIX or another antidepressant, screen patients for personal or family history of bipolar disorder, mania, or hypomania [see Warnings and Precautions (5.4)].

Discontinuing Treatment

Although TRINTELLIX can be abruptly discontinued, in placebo-controlled trials patients experienced transient adverse reactions such as headache and muscle tension following abrupt discontinuation of TRINTELLIX 15 mg/day or 20 mg/day. It is recommended that the dose be decreased to 10 mg/day for one week before full discontinuation of TRINTELLIX 15 mg/day or 20 mg/day [see Warnings and Precautions (5. 5) and Adverse Reactions (6)].

Switching a Patient to or From a Monoamine Oxidase Inhibitor (MAOI) Intended to Treat Psychiatric Disorders

At least 14 days must elapse between discontinuation of a MAOI intended to treat psychiatric disorders and initiation of therapy with TRINTELLIX to avoid the risk of Serotonin Syndrome [see Warnings and Precautions (5.2)]. Conversely, at least 21 days must elapse after stopping TRINTELLIX before starting an MAOI intended to treat psychiatric disorders [see Contraindications (4)].

Use of TRINTELLIX in Known CYP2D6 Poor Metabolizers or in Patients Taking Strong CYP2D6 Inhibitors

The maximum recommended dose of TRINTELLIX is 10 mg/day in known CYP2D6 poor metabolizers. Reduce the dose of TRINTELLIX by one-half when patients are receiving a CYP2D6 strong inhibitor (e.g., bupropion, fluoxetine, paroxetine, or quinidine) concomitantly. The dose should be increased to the original level when the CYP2D6 inhibitor is discontinued [see Drug Interactions (7. 1), Use in Specific Populations (8.6)].

Use of TRINTELLIX in Patients Taking Strong CYP Inducers

Consider increasing the dose of TRINTELLIX when a strong CYP inducer (e.g., rifampin, carbamazepine, or phenytoin) is coadministered for greater than 14 days. The maximum recommended dose should not exceed three times the original dose. The dose of TRINTELLIX should be reduced to the original level within 14 days, when the inducer is discontinued [see Drug Interactions (7.1)].

Frequently asked questions

Does Trintellix (vortioxetine) cause weight gain or loss?
How long does it take for Trintellix (vortioxetine) to start working?
Is Trintellix (vortioxetine) good for anxiety?
Shall I take Trintellix (vortioxetine) in the night or morning?
Can I take Cymbalta (duloxetine) and Trintellix (vortioxetine) together?
Is Trintellix the same as Brintellix?

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Trintellix Dosage Guide – Drink-Drink

Overview

If you are considering treatment options for depression, your doctor may suggest thrintellix (vortioxetine).

Trintellix is a prescription medicine used to treat major depressive disorder in adults.

Trintellix comes as a tablet that you take by mouth. It contains the active drug vortioxetine and belongs to a class of drugs called antidepressants. (A drug class is a group of drugs that work in a similar way.)

This article describes the dosages of Trintellix, including its form, strengths, and how to take the drug. To learn more about Trintellix, see this detailed article.

This article discusses the typical Trintellix dosages provided by the drug manufacturer. But when using Trintellix, always take the dosage your doctor prescribes.

What is the dosage of Trintellix?

Trintellix is approved for the treatment of major depressive disorder in adults with depression.

In what form is Trintellix available?

Trintellix comes as a tablet that you take by mouth.

What are the strengths of Trintellix?

Trintellix tablets are available in three strengths: 5 milligrams (mg), 10 mg and 20 mg.

Typical doses of Trintellix (10mg, 15mg or 20mg)

The information below describes dosages that are commonly used or recommended. However, be sure to take the dose your doctor has prescribed for you. Your doctor will determine the best dosage for your needs.

Common doses of Trintellix are 10 mg, 15 mg and 20 mg taken daily. People who cannot tolerate higher doses of Trintellix may need to take the drug at a dose of 5 mg.

The usual dosage range for Trintellix is 10 to 20 mg per day. Your doctor may increase your dosage to help relieve symptoms of depression. If you have side effects from this medication, your doctor may decrease your dosage. For more information on side effects that Trintellix may cause, you can read this detailed article.

According to the manufacturer's dosing guideline, the typical dosing schedule for Trintellix is once daily, with or without food. You should take your medicine at about the same time every day.

Your doctor will likely prescribe the lowest dose of Trintellix for your condition. They will then adjust your medication over time to reach the correct dosage for you. Your doctor will ultimately prescribe the lowest dosage that provides the desired effect.

Has Trintellix been used for a long time?

Yes, Trintellix is usually used for long-term treatment. If you and your doctor decide that Trintellix is safe and effective for you, it is likely that you will be using it for a long time.

Dosage Adjustment

Certain conditions may affect how your body reacts to Trintellix. Your doctor may reduce your dosage if your body is slowly breaking down an enzyme called CYP2D6.

Some medicines can cause you to have too much or too little Trintellix in your body. Some drugs that affect the CYP2D6 enzyme may interact with Trintellix. To learn more about drugs that may interact with Trintellix, see this article.

It is important to talk to your doctor about all medications you are taking. So they can increase or decrease your dosage as needed.

Some people experience suicidal thoughts or behavior while taking Trintellix. If you or a loved one who is taking Trintellix has thoughts of suicide, call your doctor right away or 911.

If you have thoughts of suicide while using Trintellix, your doctor may need to adjust your dosage of Trintellix. Or they may transfer you to another treatment.

What factors can affect my dosage?

The dose of Trintellix prescribed to you may depend on several factors. This includes:

the type and severity of the condition you are using Trintellix to treat
other medicines you are taking
other conditions you may have (see "Dose Adjustment" in the "What is the dosage of Trintellix?" section above)

Frequently Asked Questions

Here are some answers to a few frequently asked questions about Trintellix.

Can I get Trintellix 30 mg or 40 mg per day?

Yes, your doctor may prescribe any of these dosages.

The typical maximum (highest) dose for most people is 20 mg. But for people taking certain medicines that interact with Trintellix, a dosage increase may be necessary.

Tell your doctor about all the medicines you take. This helps them prescribe the correct Trintellix dosage for your condition.

If I am already taking an antidepressant, what is the equivalent dosage of Trintellix?

If you start taking Trintellix, your dosage will depend on the types and dosages of other medicines you are taking. If you are already taking antidepressants, your doctor will decide what dose of Trintellix you should start with.

Will I get side effects if I miss a dose of Trintellix?

You will usually not experience any side effects if you miss one dose of Trintellix.

If you suddenly stop taking Trintellix, you may experience serious side effects. This includes:

Headache
dizziness
moodiness
nausea
restlessness
insomnia
seizures

If you decide to stop taking Trintellix, talk to your doctor about the best way to do this.

For tips on remembering to take your dose on time, see What if I miss a dose? section below.

What to do in case of an overdose?

Do not take more Trintellix than your doctor has told you to. Using more can lead to serious side effects.

Overdose symptoms

Overdose symptoms may include:

Nausea and vomiting
Dizziness
DIOLS
Drumstick
stomach Disorders
Itching
Redness (temporary heat, redness or increased skin reinforcement)

What if they took too many tritelliks 9000 call your doctor if you think you have taken too much Trintellix. You can also call 800-222-1222 to contact the American Association of Poison Control Centers or use their online resource.

However, if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

What if I miss a dose?

If you miss a dose of Trintellix, take it as soon as you remember. If it's almost time for the next dose, don't take two doses to make up for the missed one. Just take your next dose as usual.

If you have questions about when to take a missed dose, talk to your doctor or pharmacist.

If you need help remembering to take your dose of Trintellix on time, try using the Medication Reminder. This may include setting an alarm, downloading a reminder app, or setting a timer on your phone. A kitchen timer can also work.

How to take Trintellix?

Trintellix comes in tablet form that you swallow and most likely take once a day. The tablet can be taken with or without food.

Try to take Trintellix around the same time each day. This helps to maintain a constant level of the drug in the body so that it can work effectively.

Trintellix and withdrawal and addiction

Trintellix is non-addictive. But you should not abruptly stop taking Trintellix. This can cause serious side effects, including withdrawal (withdrawal of antidepressants). Symptoms may include:

Headache
dizziness
moodiness
nausea
restlessness
insomnia
seizures

Talk to your doctor if you want to stop taking Trintellix. They will recommend a treatment plan to help you safely stop taking this drug. Typically, your doctor will gradually reduce your dosage over time until you can stop treatment completely.

What should I ask the doctor?

The sections above describe typical dosages provided by the drug manufacturer. If your doctor recommends Trintellix for you, he will prescribe the appropriate dosage for you.

Remember that you should not change the dosage of Trintellix without your doctor's permission. Only take Trintellix exactly as directed. Talk to your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you can ask your doctor:

If I get side effects from Trintellix, will I need to lower my dosage?
I have been taking Trintellix for a while but I still have depressive symptoms. Do I need to adjust my dosage?
Can Trintellix interact with other medicines I take?

For advice about depression and personal stories from others with the condition, subscribe to the Drink Drink depression newsletter and join the Bezzy Depression community.

Ask a pharmacist

Q:

I'm worried about Thrintellix's suicide warning. Are there certain signs that I may see in a loved one starting treatment with this drug?

Anonymous

A:

You should talk to your loved one often when they start taking Trintellix. If you notice that he is having suicidal thoughts or behavior that could be dangerous for him, contact your doctor immediately.

Suicidal warning signs may include:

threats or comments about self-harm
increased use of alcohol or drugs
aggressive, reckless or impulsive behavior
withdrawal from social relationships (friends, family, community)
talking, writing or thinking about death

If you or someone you know is having suicidal thoughts, a prevention hotline can help. The National Suicide Helpline is available 24 hours a day at 24-800-273. During a crisis, people who are hard of hearing can call 8255-800-799.

The answers represent the opinions of our medical experts. All content is for informational purposes only and should not be considered medical advice.

Registration data: Drink-Drink has made every effort to ensure that all information is accurate, complete and up to date. However, this article should not be used as a substitute for the knowledge and experience of a licensed healthcare professional. You should always check with your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or side effects. The absence of warnings or other information for a given medicinal product does not mean that the drug or combination of drugs is safe, effective, or suitable for all patients or for all specific uses.

Trintellix side effects and how to avoid them | SingleCare - Product Information

Home >> Medication Information >> Trintellix Side Effects, Interactions and How to Avoid Them

Information about the drug

Trintellix (active ingredient: vortioxetine) is a brand name prescription drug that treats major depressive disorder (MDD). Vortioxetine, the active ingredient in Trintellix, balances serotonin in the brain, which may help improve mood, memory, and cognitive function in those suffering from depression. Trintellix is an effective medication but may not be suitable for everyone due to possible side effects.

Drowsiness is not a common side effect of vortioxetine. Instead, vortioxetine may improve sleep cycles and help reduce daytime sleepiness.

Weight changes Trintellix

Antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), are known to be associated with: weight gain, but whether they actually cause weight gain is far from certain. On the other hand, Trintellix has a minimal effect on body weight. In clinical studies, Trintellix, then called Brintellix, had no significant effect on body weight. After a year of training, however, patients were shown to gain an average of one (1) pound while taking Trintellix. About 18% of study participants who took Trintellix gained or lost 7% of their original weight at the start of the study. Thus, Trintellix has less of an effect on weight than other antidepressants, but weight changes are possible and will vary from person to person.

Withdrawal of Trintellix

Like all drugs that affect serotonin in the brain, Trintellix should not be stopped abruptly. Although the drug is not habit-forming, the dose should be gradually reduced over several weeks before discontinuation to prevent withdrawal symptoms. The most common symptoms of withdrawal from Trintellix are:0062

Anxiety

Confusion

Insomnia

Withdrawal symptoms may take several hours to three days to appear and may persist for one or two weeks. These symptoms usually resolve without treatment within one to two weeks.

Serious side effects Trintellix

Trintellix may cause serious side effects including:

Suicidal thoughts and behavior
Serotonin syndrome
Bleeding problems
Mania or hypomania in patients with bipolar disorder
Angle-closure glaucoma
Low sodium
Severe allergic reactions, including anaphylaxis or angioedema.

Suicide

Trintellix comes with an FDA black box warning that children, adolescents and young adults are at increased risk for suicidal thoughts and behavior. When taking Trintellix, younger patients should be carefully monitored. Signs of suicidality such as:

Thoughts or comments on suicide
attempts to commit suicide
Unusual mood swings
Anges, irritability or aggression
Exception or anxiety
New or aggravating depress
new or increasing anxiety 9001 New or enhancing anxiety, new or increasing anxious anxiety
. behavior
Risky behavior or dangerous impulses

Serotonin syndrome

Antidepressants such as vortioxetine can cause serotonin syndrome, a potentially dangerous condition caused by too much serotonin in the brain. Stop taking Trintellix immediately and seek medical attention if you experience any of the following signs of serotonin syndrome, such as:

Agitation
Hallucinations
Loss of coordination
Muscle twitching

1 Stiff muscles

0062
High or low blood pressure
sweatiness
Farms
Nausea or vomiting
Consciousness Change Changes
DREAM
cramps

, maybe the low -level of the blood is the same as the bloods

cause SIADH, a problem with the hormone that controls the elimination of water and electrolytes from the body. SIADH, in turn, can cause a decrease in salt (sodium) levels in the blood, a condition called hyponatremia. Low blood sodium can be a serious and potentially life-threatening condition, so seek medical attention if you have signs of hyponatremia, including:

Eye pain
Vision changes
Red or swollen eyes
Headache

People with narrow angles between the iris and cornea are most at risk of developing angle-closure glaucoma. Narrow angles can be diagnosed during a routine eye examination. Narrow angles are amenable to surgical treatment.

How long do the side effects of Trintellix last?

The most common side effects of Trintellix are temporary and usually resolve within a few days after the medication is stopped. However, serious side effects may take longer to resolve. Mild cases of serotonin syndrome usually resolve within two to three days after stopping the medication, but severe cases require immediate medical attention. In symptomatic cases of low blood sodium levels, Trintellix should be discontinued and a doctor should be consulted. In severe cases, low blood sodium levels may require hospitalization.

Contraindications and warnings Trintellix

Trintellix may not be the right medicine for everyone. For various reasons, some people may not be able to take the medication, while others may need to be careful before starting it.

Allergies

People who are severely allergic to Trintellix should not take this medicine.

MAO inhibitors

People taking monoamine oxidase inhibitors (MAOIs), a class of drugs that includes certain types of antidepressants, antibiotics, or drugs that treat Parkinson's disease, will not be given Trintellix until they have stopped taking the MAOIs for at least minimum 14 days.

Poor metabolisers

Some people do not break down vortioxetine well. The drug then lingers longer in the body at higher concentrations, increasing the risk of side effects. Fortunately, people can be genetically tested. Weak metabolizers will be limited to a maximum daily dose of 10 milligrams (mg).

Children

Trintellix is FDA approved for use in adults 18 years of age and older. Trintellix has not been determined to be safe or effective in children.

Elderly

In clinical trials, Trintellix has been shown to be effective and safe in patients over 65 years of age. Dose adjustment is not required.

Pregnancy and lactation

There are not enough studies or information to determine that Trintellix is safe to take during pregnancy. People who are pregnant or planning to become pregnant should consult their doctor before starting or stopping Trintellix.

Similarly, there is not enough research or information on whether Trintellix passes into breast milk or affects a nursing baby. Medicines and Breastfeeding Database (National Library of Medicine) Before mothers taking Trintellix should switch to alternative medicines before breastfeeding. Another alternative is to find another way to feed the baby.

Trintellix interactions

Trintellix has several drug interactions that can cause many side effects.

Trintellix and MAO inhibitors

Trintellix should not be taken with monoamine oxidase inhibitors (MAOIs). The combination of Trintellix with an MAO inhibitor may cause serotonin syndrome. These drugs include:

Parnat (trailcypromine)
Marplan (Izokarboxazid)
Nardil (radio) Fenelzin)
Zivivkas (linenesolid)
Silezolid
EMSE (CELLIGILI)
Methylene blue injection

Trintellix and serotonergic drugs

Drugs that increase serotonin levels are called serotonergic drugs. Some of these drugs have a strong effect on serotonin, while others do not. The risk of serotonin syndrome is very low, but increases when two or more serotonergic drugs are taken concomitantly. For this reason, the combination of other serotonergic drugs with Trintellix should be avoided. This includes:

Medicines for Parkinson's disease

lithium
Herbal additives such as St. John's wort, triptophanes or yochimba

Trintelliks (anticoagulants), and so the tests are required by the bloodstream taking anticoagulants such as warfarin or Plavix (clopidogrel). Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen also interfere with blood clotting, so they should be used with caution while taking Trintellix. Some anticancer drugs also increase the risk of bleeding when taken with Trintellix. Finally, steroids can cause gastrointestinal bleeding. The risk of bleeding problems is increased when these medicines are taken with Trintellix.

Many people are unaware that some popular dietary and herbal supplements interfere with blood clotting, so these should also be used with caution when taking Trintellix. These include:

Garlic
Ginkgo
Krill oil
Saw palmetto
Willow bark

Trintellix and diuretics

Trintellix increases the risk of low blood levels of sodium. Diuretics (water tablets) can exacerbate the problem by increasing sodium excretion. It may be necessary to monitor or change diuretic therapy. Sulfonylureas given to control blood sugar in patients with type 2 diabetes will also increase the risk of low sodium in people taking Trintellix.

Drugs that reduce the effectiveness of Trintellix

Some drugs speed up the metabolism of vortioxetine in the body, reducing its effectiveness. This includes:

in Antibiotics rifampin, rifepentin, rifamicin, rifaxine and rifabutin
Certain types Anti -illegal drugs

Antiviral drugs

Barbibratures0062

When taking these drugs, you may need to increase the dose of Trintellix.

Drugs that increase the side effects of Trintellix

Some drugs slow down the metabolism of vortioxetine in the body, increasing the frequency and severity of possible side effects. This includes:

Some antidepressants like Wellbutrin (bupropion), Paxil (paroxetine) or Prozac (fluoxetine)

Some drugs that treat irregular heart rate such as quinidine

Your doctor may need to cut your Trintellix dose in half while taking these medicines.

Trintellix and alcohol

There is no evidence that drinking alcohol will cause additional problems when taking vortioxetine. However, the manufacturer recommends that people avoid drinking alcohol while taking Trintellix.

How to avoid the side effects of Trintellix

Not everyone who takes Trintellix will experience side effects. For those who do, the side effects will often be minimal. However, there are several ways to reduce the risk of side effects:

1.
Take Trintellix as directed.
Take the prescribed dose, usually 5 to 20 mg once a day. Do not take extra medicine, reduce your dose, or skip a day or two. Trintellix can be taken with food or on an empty stomach.

2. Do not stop taking Trintellix suddenly.

Try not to stop taking Trintellix immediately. Possible side effects. If the medicine doesn't work or the side effects are hard to take, talk to your doctor, pharmacist, or other healthcare professional about changing your dose or switching to a new medicine. If it is agreed that the medication should be discontinued, the best course of action is to gradually reduce the dose as instructed by your healthcare professional.

3. Don't skip doses

Like all antidepressants, people get less benefit from a medication if they miss a dose. If you skip too many doses in a row, the symptoms of the disease may return. It is helpful to keep a medication diary, use a medication app, set a seven-day pill, or set an alarm for your daily dose.

4. Tell your doctor about all medical conditions.

Providing a complete medical history can help prevent side effects. Before you start Trintellix, tell your doctor if you have had any of the following:

History of seizures

Any low sodium problems

Any bleeding problems

Mania or bipolar disorder

Glaucoma

Also be sure to tell your doctor if you are pregnant, breastfeeding, or are planning to breastfeed.

5. Tell your doctor about all medications you are taking.

Trintellix has several side effects due to drug interactions. Tell your doctor about all medicines and supplements you take, in particular:

Medicines that treat mood, anxiety, psychosis or other mental disorders.

MAO inhibitors

Blood thinners

Diuretics

Migraine medicines

Painkillers such as opioids or NSAIDs.

Anticonvulsants

Rifampicin

Quinidine

All over-the-counter drugs, supplements, and herbs you take, especially St.
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