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Prozac cause weight loss


Changes in weight during a 1-year trial of fluoxetine

Clinical Trial

. 1999 Aug;156(8):1170-6.

doi: 10.1176/ajp.156.8.1170.

D Michelson  1 , J D Amsterdam, F M Quitkin, F W Reimherr, J F Rosenbaum, J Zajecka, K L Sundell, Y Kim, C M Beasley Jr

Affiliations

Affiliation

  • 1 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. [email protected]
  • PMID: 10450256
  • DOI: 10.1176/ajp.156.8.1170

Clinical Trial

D Michelson et al. Am J Psychiatry. 1999 Aug.

. 1999 Aug;156(8):1170-6.

doi: 10.1176/ajp.156.8.1170.

Authors

D Michelson  1 , J D Amsterdam, F M Quitkin, F W Reimherr, J F Rosenbaum, J Zajecka, K L Sundell, Y Kim, C M Beasley Jr

Affiliation

  • 1 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. [email protected]
  • PMID: 10450256
  • DOI: 10.1176/ajp.156.8.1170

Abstract

Objective: Fluoxetine has been associated with weight loss during acute treatment, but no controlled studies of weight change during long-term treatment with fluoxetine or other selective serotonin reuptake inhibitors have been reported. Weights were assessed for patients whose depressive symptoms had disappeared with acute fluoxetine treatment. Patients were then randomly assigned to continuation treatment with fluoxetine or placebo.

Method: Patients whose illness had remitted after 12 weeks of treatment with fluoxetine, 20 mg/day, were randomly assigned to receive up to 38 weeks of treatment with fluoxetine or placebo. Weight was assessed at each visit. Change in weight was analyzed during the initial 12 weeks of acute treatment and after 14, 26, and 38 weeks. Relationships between weight change and body mass index and between weight change and appetite change were assessed.

Results: During the initial 4 weeks of therapy, a mean absolute weight decrease of 0.4 kg was observed for all patients. Among patients who completed 50 weeks of therapy, the mean absolute weight increase during continuation treatment was similar for both the placebo- and fluoxetine-treated groups. Weight increase was not related to initial body mass index but was related to both poor appetite at study entry and to improvement in appetite after recovery. No patients discontinued therapy because of weight gain.

Conclusions: Acute therapy with fluoxetine is associated with modest weight loss. After remission of depressive symptoms, weight gain for patients taking fluoxetine for longer periods is not different from that for patients taking placebo and is most likely related to recovery from depression.

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Is Fluoxetine an Effective Therapy for Weight Loss in Obese Patients?

JOHN EPLING, M.D., State University of New York Upstate, Medical University, Syracuse, N. Y.

Searchable Question

In patients who are obese, are selective serotonin reuptake inhibitors (SSRIs) more effective than placebo or other therapies for weight loss?

Evidence-Based Answer

Fluoxetine (Prozac) use may result in an average, short-term weight loss of up to 3.3 kg (7 lb, 4 oz) in obese patients, but the longterm effects and maintenance of weight loss after discontinuation of the drug have not been well studied. No evidence concerning other SSRIs was found. [Strength of recommendation: B, based on low-quality systematic reviews of randomized controlled trials (RCTs)]

Evidence Summary

Safety concerns have curbed the use of many weight loss medications, notably appetite suppressants. SSRIs, initially approved for the treatment of depression, are being studied now for use in obesity treatment.

A systematic review1 of 11 studies of fluoxetine in the treatment of obesity was weakened by a failure to evaluate the quality of the included articles and by its reliance on effect size as a reported outcome. The review did use a reasonably comprehensive search strategy and a sound meta-analytic process. In the 11 studies, fluoxetine was used for an average of 28 weeks and resulted in an average weight loss of 3.3 kg. [Evidence level 2a] No long-term follow-up data were available in this review.

Another review2 reported the same information but noted, in 10 to 15 percent of cases, an occurrence of minor side effects (e.g., anxiety, diarrhea, dry mouth), and “uncommon but serious” adverse events (e.g., bleeding, granulocytopenia, seizures, hyponatremia, hepatotoxicity, serotonin syndrome, extrapyramidal effects). [Evidence level 2a]

A 1999 systematic review3 of RCTs and prospective cohort trials looked at existing treatment options for obesity. A single RCT of fluoxetine was included in the review of eight RCTs of drug therapy in combination with dietary management and appetite suppressants. Fluoxetine had no significant benefit over placebo in bringing about weight loss in the 12-month study. All of the RCTs reported that any weight lost with medication use generally was regained 12 months after discontinuation of therapy. [Evidence level 1a: systematic review]

The Agency for Health Care Research and Quality is preparing a health technology assessment on the topic of pharmacologic therapy for obesity.

Recommendations from Others

The Obesity Education Initiative guidelines4 from the National Heart, Lung, and Blood Institute do not address SSRIs in the pharmacologic management of obesity, presumably because SSRIs are not approved by the U.S. Food and Drug Administration for this use. [Evidence level 5: evidence-linked consensus guideline]

Clinical Commentary

One of the consistent “concomitant therapies” in all pharmacologic weight loss studies is a program of rigorous diet and exercise. Evaluating SSRIs as weight loss therapy is a good idea, given the extent of obesity in our society. However, as safer weight loss medications are brought to the market, we must resist the temptation to concentrate solely on the numbers on the scale and continue to promote a healthy lifestyle of diet and exercise as the primary method of achieving weight control and preventing obesity.

Clinical Inquiries provides answers to questions submitted by practicing family physicians to the Family Physicians Inquiries Network (FPIN). Members of the network select questions based on their relevance to family medicine. Answers are drawn from an approved set of evidence-based resources and undergo peer review. The strength of recommendations and the level of evidence for individual studies are rated using criteria developed by the Evidence-Based Medicine Working Group (https://www. cebm.net).

The complete database of evidence-based questions and answers is copyrighted by FPIN. If interested in submitting questions or writing answers for this series, go to https://www.fpin.org or email: [email protected].

This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor.

A collection of FPIN’s Clinical Inquiries published in AFP is available at https://www.aafp.org/afp/fpin.

Fluoxetine for weight loss

fluoxetine for weight loss " rel="nofollow"nofollow" title="Permanent Link to Fluoxetine for Weight Loss" target="_blank">

Girls today are willing to go to great lengths to get a slender and beautiful body. Some, in search of a new weight loss remedy, find a medical drug such as Fluoxetine. But it must be remembered that such experiments cannot be carried out without certain knowledge. Before using Fluoxetine for weight loss, you need to learn about the features of its use, and most importantly, about contraindications.

Product Description

Fluoxetine is available as hard opaque capsules. They are either white or white with green. The drug is used to treat depression, bulimia, anorexia, schizophrenia and other psychological problems. The active substance of the capsules is Fluoxetine hydrochloride, which is a white powder that is poorly soluble in water. The drug is absorbed in the gastrointestinal tract.

Fluoxetine is available in white or white/green oblong capsules

Fluoxetine is available at any pharmacy, but only with a doctor's prescription. The drug can be used for three years from the date of manufacture, but the storage temperature should not exceed 25 about C.

Principle of action and effectiveness in weight loss

capture of serotonin. Thus, the drug is able to eliminate anxiety, excessive feelings of fear and even depressive states. One of the additional effects of fluoxetine is a decrease in appetite. It is due to this that the capsules help with weight loss. Taking the drug, a person practically ceases to want to eat.

When taking Fluoxetine, there is a decrease in appetite, due to which a person loses excess weight. This leads to a gradual decrease in body fat. After two weeks of taking the drug, you can lose three kilograms. Of course, it all depends on the initial data of losing weight. In one case, this figure will be more, in the other - less.

Taking weight loss medication

It should be noted that Fluoxetine is not intended for weight loss. The antidepressant has a noticeable effect on brain activity, due to which the person who is losing weight improves mood and reduces appetite. Take the remedy daily. The minimum course of fluoxetine use is three weeks. The duration of administration and dosage is prescribed by the attending physician, but the drug should not be taken for more than two months. In case of an overdose, symptoms such as nausea, weakness, and convulsions may be noticed. In such a situation, you should immediately consult a doctor and do a gastric lavage.

When taking Fluoxetine, you should eat only wholesome foods, as this will enhance the effect of the drug.

If you are taking Fluoxetine for weight loss, you should be more careful about your diet. Drink more water, eliminate sweets and fatty foods from your diet, replace high-calorie coffee drinks with green tea with ginger. Try to move more: walk, climb stairs and walk the dog more often. It is not at all necessary to go to the gym, but daily activity must be present. If you do not adhere to proper nutrition and move little, then the effect of taking the drug will not bring the desired result.

During the period of use of fluoxetine for weight loss, it is necessary to adhere to a daily caloric intake equal to 1400 units for women and 1800 for men.

Contraindications

  1. Individual intolerance to the active substance. If a few days after you start taking Fluoxetine, you notice symptoms such as nausea, dizziness and redness on the skin, stop using the drug immediately.
  2. Renal failure.
  3. Liver failure.
  4. Epilepsy. Taking fluoxetine in this case can aggravate the disease.
  5. Suicidal tendencies. According to statistics, taking the drug in 3% of cases ends in suicide.
  6. Diabetes mellitus.
  7. Parkinson's disease.
  8. Pregnancy. Taking fluoxetine in this case can provoke premature birth and birth defects of the fetus.
  9. Lactation period.
  10. Physical exhaustion. The drug should not be taken by people whose weight does not correspond to the norm, since one of the actions of Fluoxetine is a decrease in appetite.
  11. Prostate hypertrophy.
  12. Early age. Persons under the age of 18 should never take Fluoxetine.
  13. Taking MAO inhibitors.
  14. Lactose intolerance.

Even if you did not find any contraindications for yourself in this list, you should still consult with your doctor before taking the drug.

Side effects

Fluoxetine has many side effects.

First of all, the drug has a strong effect on the central nervous system and sensory organs. Long-term use may cause symptoms such as:

  • severe headaches;
  • dizziness;
  • nightmares in sleep;
  • fatigue;
  • emotional instability;
  • loss of visual acuity;
  • tinnitus;
  • conjunctivitis;
  • hallucinations;
  • constant causeless anxiety;
  • violation of concentration.

In addition, fluoxetine has a negative effect on the cardiovascular system. Long-term use of the drug can provoke the following health problems:

  • tachycardia;
  • cardiac arrest;
  • myocardial infarction;
  • heart failure;
  • thrombus formation;
  • anemia;
  • ischemic heart disease;
  • leukocytosis.

It is also worth noting that the constant use of the drug has a negative effect on the respiratory system. The following symptoms may occur:

  • swelling of the lungs;
  • cough;
  • hiccups;
  • swelling of the larynx and nasal cavity;
  • nasal congestion;
  • hypoxia;
  • chest pains.

Fluoxetine is absorbed from the gastrointestinal tract. Of course, the drug also has a certain effect on this system. The following problems may occur here:

  • dry mouth;
  • excessive salivation;
  • aphthous stomatitis;
  • gastritis;
  • internal gastrointestinal bleeding;
  • pancreatitis;
  • hepatitis;
  • flatulence;
  • diarrhea;
  • constipation;
  • gastric ulcer;
  • duodenal ulcer;
  • nausea.

An overdose of fluoxetine can also provoke the appearance of such ailments as impotence, diabetes mellitus, gout, hypokleemia, furunculosis, urinary tract infections, severe pain during menstruation, skin ulcers, acne, eczema, rash, excessive sweating and many other diseases .

Remember that no amount of weight lost is worth the sacrifice. If you are not sure that you have no contraindications and will be able to stop in time, then it is better not to start taking the drug. In addition, fluoxetine is addictive, so be sure to consult a specialist before using it.

Fluoxetine analogues and peculiarities of drug choice

  1. Apo Fluoxetine.
  2. Deprex.
  3. Deprenon.
  4. Portal.
  5. Prodep.
  6. Prozac.
  7. Profluzak.
  8. Floxat.
  9. Fluval.
  10. Fluxonil.
  11. Flunisan.
  12. Fluoxetine HEXAL.
  13. Fluoxetine Lannahe.
  14. Fluoxetine Nycomed.
  15. Fluoxetine OBL.
  16. Fluoxetine Canon.
  17. Fluoxetine hydrochloride.
  18. Framex.

When choosing Fluoxetine, you should not pay attention to the manufacturer, since the quality of the active substance is the same everywhere. Listen to your doctor. Take the drug advised by your specialist. If you are on a budget, then buy the cheapest capsules. The effect of this will not change.

Interactions of fluoxetine with other drugs

  1. Do not drink alcohol while using the drug, as this combination leads to unwanted side effects.
  2. Fluoxetine enhances the effect of drugs such as Alprozoalam, Diazepam and other drugs that lower blood sugar levels.
  3. The drug increases the concentration in the blood of drugs such as: Phenytoin, tricyclic antidepressants and Trazodone. In this case, it is worth consulting with your doctor and adjusting the dosage of Fluoxetine.
  4. It is strictly forbidden to take the drug simultaneously with MAO inhibitors, since these substances enhance the negative effects of Fluoxetine on the body.
  5. Do not start taking the drug if you are using drugs that have an increased degree of protein binding. This combination will enhance the negative impact of Fluoxetine on the internal organs.

Doctors' opinions

I’ll make a reservation right away that Fluoxetine is an antidepressant and, of course, a doctor should prescribe it. Unfortunately, in our pharmacies without a prescription you can buy almost everything ... I lament like a doctor. And as a patient, I am happy. I drink as part of the complex therapy of chronic migraine, in addition to which there is a combination of such "joy" as irritability, nervousness, tearfulness, anxiety. As a side effect of these pills is a decrease in appetite. The truth is, I want to eat much less, I lost 3 kilos (

Heartbeat

http://irecommend.ru/content/uspokoites-poveseleete-i-pokhudeete

I prescribed fluoxetine myself, as I am a doctor. I had absolutely no adverse reactions. I didn't notice any significant loss of appetite, maybe just a little. The mood has greatly improved and returned to normal. The mood swings have stopped. Crazy behavior before menstruation disappeared altogether.

Sasha Dragonfly

http://irecommend.ru/content/khorosho-uspokoil-nervy-i-pomog-s-pms-foto

Weight loss testimonials

I've been on fluoxetine since August and I'm fine! Over the past month there have been only 3 bulimic breakdowns, I am learning to eat normally, slowly but surely losing weight. I don't think about food 24/7, I feel free from food. There were some other interests, except how to fill the stomach.

Gingerbread

http://irecommend.ru/content/bilet-v-zhizn-bez-bulimii-zamknutyi-krug-fluoksetin-spasitel-mega-otzyv-prismotrites-k-flu-n

I have been taking fluoxetine (alsi) for two years now. Lost 10kg in the first 2 months. There were side effects, but after a couple of weeks everything went away.

Guest

http://www. woman.ru/health/diets/thread/4508094/

In a week I lost 3 kg of weight with the help of Apo-Fluoxetine, I didn’t follow a special diet, I almost don’t want to eat. A week later, the pills began to act differently, the mood is stable, average, but with vision, something happens, in the evening the eyes are very tense.

Guest

http://www.woman.ru/health/diets/thread/4508094/2/

Photo gallery: results of those who lost weight on Fluoxetine

fluoxetine for weight loss foto-zhenshchiny-do-i-postle-priema-fluoksetina-v-celyah-snizheniya-vesa-jpg/" rel="nofollow" target="_blank"> From the photo of a woman, you can see that taking Fluoxetine really has a positive effect on the figure. fluoxetine for weight loss devushka-do-i-posle-pohudeniya-s-pomoshchyu-fluoksetina-jpg/" rel="nofollow" target="_blank"> Photo proves that fluoxetine is effective in weight loss fluoxetine for weight loss zhenshchina-do-i-postle-ispolzovaniya-fluoksetina-v-celyah-pohudeniya-jpg/" rel="nofollow" target="_blank"> The photo of the woman shows that thanks to Fluoxetine, you can achieve a good result in weight loss.
Fluoxetine for weight loss fotografiya-devushki-do-i-posle-priema-fluoksetina-jpg/" rel="nofollow" target="_blank"> As you can see from the photo, fluoxetine really helps to get rid of excess body fat.

Fluoxetine can really help those who lose weight achieve the desired result. But at what cost? If you have contraindications, then in no case do not use the drug for weight loss. Of course, before you start taking Fluoxetine, you should always consult with your doctor, since the side effects of the capsules are quite significant.

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Antidepressant Prozac 20mg - "Lose weight? Hardly.

Deal with depression? Maybe."

Greetings to all who have looked into my review

Well, my reviews of diet sweets have been replaced by reviews of antidepressants and antipsychotics.0009 Prozac (with the active ingredient called fluoxetine ). A little more about my treatment and recovery from urinary tract infections can be found in the review on Quetiapine.

Initially I was on another antidepressant for about 4 months (I should write a review about it later). But in the end, my psychiatrist decided that it would be more effective to replace him with another one. He prescribed me fluoxetine.

General description : antidepressant

Manufacturer : Patéon France S.A.S.

Country of origin : France

Dosage form - capsules: opaque green/cream, hard gelatin (size 3), imprinted with the LILLY logo and identification code 305 capsules white .

Composition:

Active substance fluoxetine hydrochloride equivalent to 20 mg fluoxetine;
Excipients: starch 205.64 mg, dimethicone 2.0 mg;
Composition of the capsule shell: dye patent blue V 3.0 mcg; iron dye yellow oxide 67.0 µg; titanium dioxide 800.0 µg; gelatin q.s. up to 50 mg; food grade ink (for identification printing) traces.

Indications

Depression of various etiologies

Bulimia nervosa

Obsessive-compulsive disorder

Premenstrual dysphoric disorder

I have been depressed for a long time, as I suspected. Since the beginning of this year. But when I came to a psychiatrist (in June), I thought that depression was gone, only bulimia nervosa remained, but it turned out that it seemed to me. When I started treatment, I saw a difference.

I have been taking fluoxetine since September and I think that I can already draw conclusions.

I'll start with the side effects:

  • In the first two weeks I periodically felt dizzy - and not only during sharp bending over or getting out of bed, it could be spinning even at the moment when I lay down and tried to sleep, but these " helicopters "notably interfered with me.
  • Sleepiness in the morning and throughout the day is a common thing, sometimes I yawned so that my jaw cracked (the condition lasted about a month, then it disappeared).
  • Reduced libido - what is this sex of yours?
  • The emergence of suicidal thoughts, which I did not have for a very, very long time (fortunately, these are just thoughts that I controlled. Without the desire to act)

I did not get the desired effect of losing weight per cent. To be honest, because I have been on treatment for a long time, I didn’t really need it (the value of weight has decreased for me), so I wasn’t upset.

On the positive side, I can say that the drug still works. Of the 4 side effects, only 1 remained, the most harmless of all, I calmly get along with her (we are talking about libido). I feel better on this drug compared to my previous antidepressant, but I'm still not completely satisfied. Most often, my mood is 5 out of 10, or it decreases even more, but it rarely grows and for a very short time. In addition to taking pills, I, of course, work with a psychologist. There is progress, and a lot, but the methods of supporting myself do not really help me. I already have a list of what brings me pleasure and can lift my spirits. When I do something on this list, I get a little better only for the time that I do the chosen activity. Then the mood falls again and I continue to live in a low or very mediocre mood mode. To be honest, this is very tired, especially when the depression has been going on for almost a year. Pharmacological support really helps me a lot and helps, without it there would be no such effect from psychotherapy, but what can I say, I would not even have the strength to go to her (I am well aware of the state when you sit at home for months, just eat, sleep and suffer, not understanding what is happening and how to deal with it). Therefore, I want the drug to be as suitable as possible and give the expected results. For this, there is a therapy adjustment. I don't know if they will keep this drug for me, but they will change the dosage, or transfer me to something else, or add some other drug - all this will become clear at the next visit to the psychiatrist.

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