Lexapro ocd dosage


What is the optimal dose of escitalopram for the treatment of obsessive-compulsive disorder? A naturalistic open-label study

Comparative Study

. 2011 Sep;26(5):284-90.

doi: 10.1097/YIC.0b013e32834a5c09.

Geumsook Shim  1 , Hye Youn Park, Joon Hwan Jang, Euitae Kim, Hye Yoon Park, Jae Yeon Hwang, Sung Nyun Kim, Go-Eun Jang, Jun Soo Kwon

Affiliations

Affiliation

  • 1 Department of Psychiatry, Seoul National University, College of Medicine, Seoul, Korea.
  • PMID: 21829108
  • DOI: 10.1097/YIC.0b013e32834a5c09

Comparative Study

Geumsook Shim et al. Int Clin Psychopharmacol. 2011 Sep.

. 2011 Sep;26(5):284-90.

doi: 10.1097/YIC.0b013e32834a5c09.

Authors

Geumsook Shim  1 , Hye Youn Park, Joon Hwan Jang, Euitae Kim, Hye Yoon Park, Jae Yeon Hwang, Sung Nyun Kim, Go-Eun Jang, Jun Soo Kwon

Affiliation

  • 1 Department of Psychiatry, Seoul National University, College of Medicine, Seoul, Korea.
  • PMID: 21829108
  • DOI: 10.1097/YIC.0b013e32834a5c09

Abstract

This study explored the efficacy and tolerability of very high doses (maximum dose of >40 mg/day), high doses (maximum dose of 25-40 mg/day), and standard doses (maximum dose of ≤20 mg/day) of escitalopram (ESC) as an anti-obsessive-compulsive disorder treatment in a naturalistic clinical setting. We reviewed the medical records of all patients with obsessive-compulsive disorder (n=246) who had taken ESC between May 2006 and September 2009, and assigned Clinical Global Impression (CGI) scores, retrospectively. Of the total sample, 24.4, 38.2, and 37.4% patients received very high, high, and standard doses of ESC, and the mean daily maximum doses of ESC were 57.3±12.0 mg, 33.9±5.4 mg, and 13.4±5.8 mg, respectively. The CGI-Severity scores in each group decreased significantly after treatment with ESC, as evidenced by response rates (i.e. CGI-Improvement scores of 1 or 2) of 46.3, 43.2, and 26.2%, respectively. Although some adverse events increased in a dose-dependent manner, most could be managed with an ESC dose adjustment. These results imply that doses less than or equal to 40 mg/day ESC are sufficient for symptomatic improvement with good tolerability for most patients. Very high doses of ESC, on the other hand, can be considered for patients with inadequate therapeutic responses to the administration of 40 mg/day ESC.

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Examining The Use Of Lexapro In The Treatment Of OCD

Content
  • Overview
  • What is obsessive-compulsive disorder?
  • Is Lexapro used as a treatment for OCD?
  • Lexapro dosage in the treatment of OCD
  • What are the side effects of Lexapro?
  • How long does Lexapro take to work for OCD?
  • Conditions to discuss with your health care provider before taking Lexapro
  • The lowdown

Lexapro is an antidepressant belonging to the class of medicines known as selective serotonin reuptake inhibitors (SSRIs). Lexapro works by regulating serotonin levels in the brain. It is available as 5 mg, 10 mg, or 20 mg tablets, as well as liquid drops. The generic name for Lexapro is escitalopram.

Doctors typically prescribe Lexapro to treat anxiety and depression, especially anxiety and depression associated with generalized anxiety disorder (GAD) and major depressive disorder (MDD). Physicians can, in some situations, prescribe Lexapro to treat obsessive-compulsive disorder (OCD).

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Obsessive-compulsive disorder (OCD) is a mental illness characterized by recurrent unpleasant thoughts or feelings (obsessions) or a strong need to repeat a behavior (compulsions). Many people with OCD are aware that their thoughts or actions are irrational.

However, they engage in these recurrent and repetitive behaviors not because they enjoy it but because they cannot stop.

Some examples of obsessive thoughts are worrying about people getting hurt or being constantly aware of your breathing, blinking rate, or other physical sensations. Examples of compulsive habits include:

  • Performing tasks in a certain order

  • Needing to count items such as bottles or steps

  • Being afraid of shaking hands, using public restrooms, touching doorknobs, etc.

Not all routines or habits are compulsions. Everyone double-checks things once in a while. However, people with OCD cannot control their thoughts or behaviors, and they will spend at least an hour a day on these obsessions or compulsions.

While people with OCD do not enjoy their compulsive habits or rituals, doing them may temporarily relieve the anxiety generated by their obsessive thoughts.

Few studies¹ have assessed the use of escitalopram (Lexapro) for OCD; however, studies² have found that escitalopram has good efficacy in treating several OCD symptoms.   Several indicators show that escitalopram has significant potential in treating OCD in adults. 

These indicators include:

  • Lexapro is an SSRI, similar to other medicines used as first-line therapy for OCD

  • Among the SSRIs, escitalopram is the most selective 5HT reuptake inhibitor

  • Escitalopram has been proven effective in treating other anxiety disorders, such as generalized anxiety disorder, panic disorder, and social anxiety disorder

  • Escitalopram³ was found to be superior to placebo in one double-blind, placebo-controlled trial of escitalopram in OCD

A study⁴ was done to determine the efficacy and tolerability of escitalopram in obsessive-compulsive disorder (OCD), using paroxetine — another SSRI, as a reference. 

The study showed that escitalopram, 20 mg/day, was linked with improved functioning, higher response and remission rates, and better tolerability than paroxetine. Escitalopram should, therefore, be regarded as one of the first-line medications in the long-term treatment of OCD.

The dosage of Lexapro for OCD varies depending on the patient's symptoms, medical history, and sensitivity to adverse effects. 

According to a 2014 study,⁵ SSRIs are more successful in treating OCD in high doses, often higher than the doses used to treat the major depressive disorder (MDD). According to the study, a 40 mg dose of escitalopram⁶ is commonly required to treat OCD symptoms. 

A 40 mg dose for OCD differs from other disorders, as escitalopram is prescribed in doses ranging from 10 to 20 mg daily to treat depression and anxiety. The same study discovered that OCD patients on Lexapro — or another SSRI — take longer to respond to the medication and require more treatment time. 

Talking to your doctor before taking Lexapro for OCD is crucial because the FDA does not specify a precise Lexapro dosage for OCD.

The effects of Lexapro, like any other medication, will vary from person to person. The most common adverse effects of Lexapro include:

  • Nausea

  • Fatigue

  • Diarrhea

  • Headache

  • Constipation

  • Drowsiness

  • Dry mouth

  • Increased sweating

  • Restlessness

  • Insomnia

These side effects will often improve over the first week or two as you continue to take the medication. Contact your doctor if the symptoms persist or worsen.

In rare circumstances, Lexapro has been known to cause serious side effects, such as:

  • Low levels of sodium in the blood

  • The onset of manic episodes

  • Changes in appetite 

  • Unexplained weight gain

  • Vision problems

  • An increase in suicidal thoughts or actions

  • Violent behavior

  • New or worsening depression, anxiety, or panic attacks

There is always the possibility of side effects with any drug. However, Lexapro is a safe and effective medication when taken as directed. 

The physiological effects of Lexapro start almost immediately, and many people notice a difference quickly. Even though the drug starts to work from the first day it is taken, different people will experience the effects at different periods.

Most people say they start to feel the effects of their medication after four to eight weeks of taking it consistently.

Before you start taking Lexapro, there are a few things you need to talk to your doctor about. First, inform them if you are allergic to escitalopram, citalopram, or other medications. Other conditions you should discuss include:

  • Other medications you are currently taking

  • Whether you are breastfeeding, pregnant, or plan to get pregnant

  • If you drink alcohol or use drugs

  • Whether you have suicidal thoughts

It's important to ensure your doctor knows whether you have any medical issues, such as liver disease. The liver is principally responsible for the metabolism of selective serotonin reuptake inhibitors (SSRIs), so patients with liver disease may have difficulties metabolizing Lexapro. 

Even though escitalopram appears to be effective in various anxiety disorders, little research has been done on its efficacy in OCD. However, several case studies imply that escitalopram may be beneficial for disorders with obsessive features or conditions linked to OCD. More clinical studies need to be done to confirm the role of escitalopram in the treatment of OCD.

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Used the services of an online pharmacy for more than 5 years, I was always satisfied: almost all drugs could be purchased, of good quality, everything was always available, at a relatively affordable price, now everything has changed: what drug you don’t ask for is not available

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Go away About $17. 10 per month About $83.83 per month (without insurance) or $30.31 (with insurance). Type of drug SSRI SSRI Dosage Common cash Yes Yes Pregnancy safe Not contemplated for third trimester Not established

Medical Applications

Celexa is approved for treatment of depression and anxiety disorder, dysmorphic disorder OPMDD, and telepathic disorder There may be significant symptoms of premature ejaculation and pathological crying followed by a stroke.

Lexapro is currently approved for the treatment of depression and is officially recognized for the treatment of generalized anxiety disorder. Might as well get out of the etiquette for OCD and panic disorder.

Use for use

Celexa is not approved for use.

Lexapro is SAS approved. Some teachings both suggest that the couple are not safe and that Lexapro is not associated with an increase in the suicidal idea of ​​children and young men.

Mechanism

Both Celexa and Lexapro are selective serotonin reverse signal inhibitors (SSRI). These prevent the re-uptake of the neurotransmitter serotonin in nerve cells by releasing it, somehow leading up to more serotonin in the brain. See how SSRI works (YouTube video)

Dosage

Taken as a single dose Celexa, with or without storage. Yadenetmu from the store can help for preventing on the bastard, the page effect is often crossed. Offered in 10, 20 and 40 mg tablets and 5 ml solution. The usual starting dose is 20 mg.

Lexapro used to take kato 10 mg a day. You can increase it to 20 mg every week, but higher doses may not be effective for depression. Mozhe yes ce reception with or without storage.

Effects page

Worry-for-reactions to Celexa sa bad breath, dryness in fatigue, puffiness, sweating, headache, trembling, drowsiness, sexual dysfunction and inability to sleep. Between 1 in 6 and 1 in 5 souls will not have a single page effect. Celexa has dealt with an increase in suicidal thoughts and behavior in children and young men with depression.

The most undesirable reaction to Lexapro is sa vzbuda, blurred vision, diarrhoea, sleeplessness, drowsiness, dryness in the tired, elevated temperature, chest urinirane, headache, losho hranosmilane, gadena, promyana in appetite, sexual dysfunction and promyana on tegloto.Lexapro The story is connected with the increase in suicidal thoughts and the behavior of a child and a young man with depression.

Warnings

Celexa and Lexapro are not allowed to be taken with MAO inhibitors. If combined with aspirin, they can increase the likelihood of kervene from gornat often in the gynecological tract.


Pregnancy

Presented on Celexa in the third trimester may cause complications.

Safety on Lexapro has not been set in time for pregnancy.

Efikasnost

Some studies have found that Lexapro is usually effective in the treatment of depression from Celexa, but it is not.


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