Is zoloft better than lexapro
Which medication is better for you?
If you are struggling with anxiety or depression, remember that with the right treatment plan in place, relief is possible. Medication is often an important part of treating both generalized anxiety disorder (GAD) and major depressive disorder (MDD).
You and your doctor or prescribing nurse may want to begin by narrowing your search to one specific category of medication frequently used to treat depression or anxiety—such as the selective serotonin reuptake inhibitors (SSRIs). Two SSRIs that you might consider are Lexapro and Zoloft.
Whether this is your first time taking one of these medications or you are thinking about switching from Lexapro to Zoloft (or switching from Zoloft to Lexapro), this
Minded Medication Guide will take a closer look at Lexapro vs Zoloft to help you understand which medication might be the better choice for you. This information can be helpful to you when talking with your doctor, prescribing nurse, or Minded provider in choosing the medication used in your treatment plan.
Read on to learn more about these two medications, including:
- An introduction to Lexapro and Zoloft
- A closer look at Lexapro vs Zoloft
- Dosage information
- How long it takes for each medication to work
- Side effects and warnings for Lexapro and Zoloft
- Similarities and differences between Lexapro and Zoloft
- Lexapro side effects vs Zoloft side effects
- Zoloft vs Lexapro for depression
- Lexapro vs Zoloft for anxiety
- Lexapro vs Zoloft: weight gain
- Switching from Lexapro to Zoloft (or switching from Zoloft to Lexapro)
Minded Medication Guides, including Zoloft vs Prozac and Wellbutrin vs Lexapro, are intended as educational aids only. They are not intended as medical advice for individual conditions or treatment.
They are not a substitute for a medical exam, nor do they replace the need for services provided by medical professionals. Talk to your doctor, nurse, or pharmacist before taking any prescription medication or following any treatment or regimen.
Antidepressant medications are typically grouped by how and which neurotransmitters (tiny molecules in the brain that relay messages from nerve to nerve) they primarily affect in order to relieve depression symptoms. As mentioned above, both Lexapro and Zoloft are selective serotonin reuptake inhibitors (SSRIs), a type of antidepressant medication that also may be used to treat anxiety.
As their name implies, SSRIs affect the levels of serotonin (a neurotransmitter) in your brain. Serotonin helps to keep your mood balanced and plays a role in feelings of contentment, optimism, and satisfaction, as well as your overall sense of well-being. SSRIs increase the serotonin levels in your brain by preventing serotonin from being reabsorbed into the neurons (nerves in your brain) and thus inactivated.
When looking at Lexapro vs Zoloft, both are SSRI medications, but that does not mean they are exactly the same. Looking more closely at each of these medications can help you determine which medication might be a better choice for your treatment plan.
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Lexapro is the brand name of the generic drug escitalopram. It is used to treat generalized anxiety disorder (GAD) and major depressive disorder (MDD).
Lexapro may also sometimes be prescribed for “off-label” uses. “Off-label” use means taking a medication for a condition that it has not been approved by the FDA to treat. This is a common and acceptable medical practice. Lexapro may be used “off-label” to help treat obsessive-compulsive disorder (OCD), eating disorders (including binge eating disorder or bulimia nervosa), panic disorder, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).
Lexapro (escitalopram) is available in tablet and liquid forms:
Lexapro tablet
- 5 mg
- 10 mg
- 20 mg
Lexapro liquid
- 1 mg/ml
The recommended starting dose for Lexapro—whether you are taking it for depression or anxiety—is typically 10 mg taken once a day.
Your doctor or prescribing nurse may gradually increase the dosage over the course of several weeks, if necessary. The maximum recommended dose is 20 mg, though some people need higher doses to achieve symptom relief.
Lexapro is taken once a day, with or without food. It can be taken in the morning or the evening, whichever is more convenient for you.
If you miss a dose of Lexapro, you will want to either take the missed dose as soon as you remember, or if it is closer to the time when you would take your next dose, just take the next dose.
How long does it take for Lexapro to work?
As with most SSRIs, you may notice that your sleep, energy, and/or appetite begins to improve within the first two weeks of starting Lexapro. However, it may take up to 6 to 8 weeks (or longer) before the improvement of symptoms such as depressed mood or decreased interest in activities become noticeable.
Lexapro side effects
Common side effects of Lexapro include:
- Appetite loss
- Constipation or diarrhea
- Difficulty performing sexually or decreased sex drive
- Difficulty sleeping or feeling unusually sleepy
- Dizziness
- Dry mouth
- Feeling anxious
- Infection
- Nausea
- Shaking
- Sweating
- Weakness
- Yawning
Some Lexapro side effects may improve over the first week or two as you continue to take the medication.
However, sexual side effects may not decrease over time.
Talk to your doctor or Minded provider if you experience any of these or other side effects.
Rare or serious side effects of Lexapro include:
- Angle-closure glaucoma (symptoms of this could include: pain in your eye, vision changes, or swelling or redness in or around your eye)
- Low sodium levels in your blood (symptoms of this could include: headaches, feeling weak, or having a hard time concentrating or remembering things)
- Seizures
- Serotonin Syndrome (symptoms of this could include: shivering, diarrhea, confusion, severe tightness in your muscles, fever, or seizures). Serotonin Syndrome is a very serious condition and can be fatal if not recognized and treated.
- Teeth grinding
SSRI antidepressant medications—like Lexapro—may also put you at an increased risk for potentially life-threatening bleeding, especially when they are taken with medications such as aspirin, nonsteroidal anti-inflammatories (NSAIDs—like ibuprofen or naproxen), and warfarin (an anticoagulant medication), or other anticoagulants.
Lexapro taken with any single or combination of these medications could cause your gums, nose, stomach, or intestines to bleed more easily.
Seek medical attention right away if you experience any of these (or other) serious side effects.
Warnings
Lexapro comes with an FDA “Black Box” warning, which means that the FDA has identified certain serious safety risks from taking it. While these are serious safety warnings, the actual risk may be very low, or even rare.
The Black Box warning for Lexapro states that children, adolescents, and young adults who are taking antidepressants may be at an increased risk for suicidal thoughts or behaviors. Lexapro is not approved for use in children younger than 12 years of age. There is no upper age limit for its use.
Lexapro and pregnancy
It is important to discuss your depression medication with your doctor if you are planning on becoming pregnant because taking SSRIs—like Lexapro—during pregnancy or while breastfeeding may impact your baby.
Lexapro and alcohol
Drinking alcohol is not recommended if you are taking Lexapro or other antidepressant medications, for several reasons. While alcohol may seem to improve your mood in the short term, it may actually worsen anxiety or depression symptoms in the long run. Alcohol can decrease the benefits of antidepressant medications and increase their negative side effects, such as sedation. There is also a risk of accidentally overdosing on Lexapro if it is taken with alcohol.
Symptoms of an overdose of Lexapro may include:
- Convulsions
- Coma
- Dizziness
- Drowsiness/sleepiness
- Hypotension (low blood pressure)
- Insomnia
- Irregular heartbeat
- Nausea and/or vomiting
Because SSRIs like Lexapro must be taken regularly to be effective (and to avoid withdrawal symptoms), you should not skip doses of Lexapro in order to drink alcohol.
Lexapro withdrawal symptoms
If you need to stop taking Lexapro for any reason, work with your doctor or prescribing nurse to develop a plan to do so gradually and carefully to avoid withdrawal symptoms. While antidepressant medication withdrawal symptoms may sometimes be mild and last only a week or two, in some cases, withdrawal symptoms may last weeks or even months.
Lexapro withdrawal symptoms may include:
- Dizziness
- Headache
- Irritability
- Nausea
- Nightmares
- Paresthesias (a prickling and/or tingling sensation on your skin)
- Vomiting
Always let your provider know about any other medications (and supplements, often called nutraceuticals) you are taking to determine if Lexapro might have any negative interactions with them.
Wondering if Lexapro is right for you?
Get a free assessment
Zoloft is the brand name of the generic drug sertraline.
It is used to treat major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder.
Zoloft is also sometimes used “off-label” for generalized anxiety disorder (GAD), binge eating disorder, and bulimia nervosa.
Zoloft (sertraline) is available in tablet and liquid forms:
Zoloft tablet
- 25 mg
- 50 mg
- 100 mg
Zoloft liquid
- 20 mg/mL
At first, your doctor or prescribing nurse may have you start out on a lower dose of Zoloft—such as 25 or 50 mg per day. They may then gradually increase your dosage over the course of several weeks, if necessary. The maximum recommended dose is typically no more than 200 mg daily, though some people need higher doses for symptom relief.
Zoloft is taken one time per day (usually in the morning or evening), with or without food.
If you miss a dose of Zoloft, you will want to either take the missed dose as soon as you remember or, if it is closer to the time when you would take your next dose, just take the next dose.
How long does it take for Zoloft to work?
As with Lexapro, when you first begin taking Zoloft, you may notice your sleep, energy, and/or appetite improve within the first two weeks. However, it may take 6 to 8 weeks (or longer) for the improvement of other common depression symptoms (such as low mood or decreased interest in activities) to become noticeable.
Zoloft side effects
Common Zoloft side effects include:
- Decreased appetite
- Decreased sex drive and/or difficulty performing sexually
- Diarrhea
- Excessive sweating (hyperhidrosis)
- Indigestion (dyspepsia)
- Nausea
- Tremor
Like Lexapro, some of these side effects may decrease over the course of the first few weeks of taking Zoloft.
However, others—such as lowered sex drive or difficulty performing sexually—might not improve over time.
Talk to your doctor or prescribing nurse or the experts at Minded if you experience any of these or other side effects.
Rare or serious Zoloft side effects include:
- Angle-closure glaucoma (symptoms of this could include: pain in your eye, vision changes, or swelling or redness in or around your eye)
- Low sodium levels in your blood (symptoms of this could include: headaches, feeling weak, or having a hard time concentrating or remembering things)
- Seizures
- Serotonin Syndrome (symptoms of this could include: shivering, diarrhea, confusion, severe tightness in your muscles, fever, or seizures). Serotonin Syndrome is a very serious condition and can be fatal if not detected and treated.
- Teeth grinding
And because it is an SSRI like Lexapro, Zoloft may also increase your risk for potentially life-threatening bleeding in your gums, nose, stomach, or intestines.
This risk is increased if you are also taking medications such as aspirin, nonsteroidal anti-inflammatories (NSAIDs—like ibuprofen or naproxen), and warfarin, or other anticoagulant drugs.
You should seek medical attention right away if you experience any of these (or other) serious side effects.
Warnings
Like Lexapro, Zoloft comes with an FDA “Black Box” warning. The Black Box warning for Zoloft says that antidepressant medications may increase the risk of suicidal thoughts or behaviors in children and young adults under 25 years old.
Zoloft and pregnancy
Zoloft is an SSRI that can affect your baby during pregnancy and while breastfeeding. Be sure to discuss your depression or anxiety treatment plan with your doctor if you are pregnant or breastfeeding, or are planning to do so.
Zoloft and alcohol
As with Lexapro, you should not drink alcohol while taking Zoloft. Alcohol may temporarily appear to improve your mood, but it can actually worsen depression and anxiety symptoms long-term.
Alcohol can also decrease the benefits of medications like Zoloft and increase their negative side effects (such as sedation). And there is a risk of accidentally overdosing on Zoloft if it is taken with alcohol.
Symptoms of an overdose of Zoloft may include:
- Agitation
- Coma
- Convulsions
- Delirium and/or hallucinations
- Dizziness
- Drowsiness/sleepiness
- Hypertension (high blood pressure)
- Hypotension (low blood pressure)
- Irregular heartbeat
- Nausea and/or vomiting
- Serotonin syndrome
- Syncope (fainting)
- Tremor
Because SSRIs like Zoloft must be taken regularly to be effective (and to avoid withdrawal symptoms), you should not skip doses of Zoloft in order to drink alcohol.
Zoloft withdrawal symptoms
Like Lexapro, if you need to stop taking Zoloft, you will want to work with your doctor to come up with a plan to do so carefully and gradually to avoid withdrawal symptoms. In some cases, antidepressant medication withdrawal symptoms are mild and last only a week or two. However, in other cases, withdrawal symptoms may last weeks or even months.
Zoloft withdrawal symptoms may include:
- Dizziness
- Headache
- Irritability
- Nausea
- Nightmares
- Paresthesias (a prickling and/or tingling sensation on your skin)
- Vomiting
Always let your doctor or a Minded professional know about any other medications and/or supplements you are taking to determine if Zoloft might have any negative interactions with them.
Wondering if Zoloft is right for you?
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Lexapro vs Zoloft: Which works faster?
Both Lexapro and Zoloft can take several weeks for improvement in your depression or anxiety symptoms to become noticeable.
Because neither medication has a lead over the other in this area, it usually is not a factor in decision-making when choosing between these two medications.
In general, you might notice your sleep, energy, and appetite get better within the first two weeks of starting Lexapro or Zoloft. It can take 6 to 8 weeks for other symptoms—such as depressed mood or lack of interest in day-to-day activities—to improve as well.
Zoloft vs Lexapro for depression
Lexapro and Zoloft are similarly effective in terms of treating major depressive disorder (MDD). One study found that people on Lexapro and people on Zoloft reported similar levels of improvements in their depression symptoms. It also found that very few people discontinued treatment due to negative side effects (only 2% of people on Lexapro and 4% of people on Zoloft).
Zoloft vs Lexapro for anxiety
Zoloft and Lexapro have also been found to be effective treatment options for anxiety disorders.
According to a 2018 study published in the Expert Opinion on Pharmacotherapy, both medications reduced anxiety symptoms compared to placebos, and both were well tolerated in terms of side effects.
Lexapro side effects vs Zoloft side effects
While Lexapro and Zoloft have some possible side effects in common, they each come with their own more common side effects to keep an eye out for and bring to your doctor’s attention.
Lexapro vs Zoloft: weight gain
Weight gain is a common concern about antidepressant medications. While some of these medications may have a higher rate of weight gain compared to others, in some cases, weight gain is not directly caused by the medication itself.
For example, sometimes people lose weight when they are depressed before they have started treatment. When their appetite returns as their depression is treated effectively, they may begin to gain back the weight they lost. But this is not necessarily caused by the medication itself.
Instead, it is actually a result of an improvement in depression symptoms.
That being said, a 2015 study published in General Hospital Psychiatry found that both Lexapro and Zoloft—as well as other antidepressant medications—could lead to weight gain.
While head-to-head comparisons for Zoloft vs Lexapro are not available, studies suggest that both can cause weight gain when taken long-term.
A study published in the Journal of Clinical Medicine in 2016, for example, found that people taking Zoloft over a two-year period gained an average of 10.5 pounds.
While a 2011 study in the International Journal of Neuropsychopharmacology found that people taking Lexapro over a 12-week period (i.e., short-term) gained an average of less than a pound, a 2007 study in Current Medical Research and Opinion found that people taking Lexapro over an 8-month period gained an average of 4 pounds.
Can you take Lexapro and Zoloft together?
Lexapro and Zoloft should not be taken together.
Because both medications are SSRIs, taking them together can lead to dangerously high levels of serotonin collecting in your body. This is called serotonin syndrome, and it can be fatal.
Switching from Lexapro to Zoloft (or switching from Zoloft to Lexapro)
You may consider switching medications if you have been on Lexapro or Zoloft at the right dose (determined by you and your doctor or nurse practitioner) for six or more weeks and have not seen a noticeable improvement in your depression or anxiety symptoms or are experiencing side effects you that find too difficult to tolerate.
Another reason you may want to consider switching antidepressant medications is if you have been on one of these medications for a while and no longer find it as effective as it initially was. In some cases, switching to a different medication can be exactly what is needed to get your treatment plan back on track.
Lexapro and Zoloft can both cause withdrawal symptoms if you stop taking them suddenly.
When switching or stopping these types of medications, work with your doctor or a Minded professional to develop a plan to do so carefully and gradually. The plan may involve tapering down the dose of the medication you are currently taking and then starting the new medication.
Both Lexapro and Zoloft are worthy of consideration when you are developing your depression or anxiety treatment plan. Keep in mind that each of these medications comes with its own pros and cons. And while they are similar in many ways, there are some key differences as well.
For instance, Lexapro is approved to treat generalized anxiety disorder (GAD) and major depressive disorder (MDD). Zoloft is approved to treat depression, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder—though it is also used “off-label” to treat generalized anxiety disorder (GAD).
While both medications are similarly effective in treating both MDD and anxiety, one study found that slightly more people stopped using Zoloft because of side effects compared to Lexapro (4% compared to 2%).
However, it is also important to keep in mind that not everyone who takes a medication will experience the possible side effects of that medication—and some people find the side effects of one medication more tolerable than the side effects of another medication.
Seeking medical advice from your doctor, prescribing nurse or the experts at Minded can help you understand and choose which medication might be the better option for you.
Lexapro vs. Zoloft: What’s the difference?
With all the different depression and anxiety medications on the market, it can be hard to know which drug is which. Lexapro and Zoloft are two of the more commonly prescribed medications for mood disorders such as depression.
These medications are a type of antidepressant called selective serotonin reuptake inhibitors (SSRIs). SSRIs work by increasing levels of serotonin, a substance in your brain that helps maintain your mood.
Read on to learn more about the similarities and differences between Lexapro (escitalopram) and Zoloft (sertraline).
Lexapro is prescribed to treat depression and generalized anxiety disorder. Zoloft is prescribed to treat depression, obsessive-compulsive disorder, and several other mental health conditions.
The table below compares the conditions each drug is approved to treat.
| Condition | Zoloft | Lexapro |
|---|---|---|
| depression | X | X |
| generalized anxiety disorder | X | |
| obsessive-compulsive disorder (OCD) | X | |
| panic disorder | X | |
| post-traumatic stress disorder (PTSD) | X | |
| social anxiety disorder | X | |
| premenstrual dysphoric disorder (PMDD) | X |
The table below compares other key aspects of Zoloft and Lexapro.
| Brand name | Zoloft | Lexapro |
|---|---|---|
| What is the generic drug? | sertraline | escitalopram |
| What forms does it come in? | oral tablet, oral solution | oral tablet, oral solution |
| What strengths does it come in? | tablet: 25 mg, 50 mg, 100 mg; solution: 20 mg/mL | tablet: 5 mg, 10 mg, 20 mg; solution: 1 mg/mL |
| Who can take it? | people 18 years and older* | people 12 years and older |
| What is the dosage? | determined by your doctor | determined by your doctor |
| What is the typical length of treatment? | long-term | long-term |
| How do I store this drug? | room temperature away from excess heat or moisture | room temperature away from excess heat or moisture |
| Is there a risk of withdrawal from this drug? | yes† | yes† |
*Except for treating OCD
† If you’ve been taking this drug for longer than a few weeks, do not stop taking it without talking with your doctor.
They’ll guide you in tapering off the drug slowly to avoid withdrawal symptoms.
Both medications are available in most pharmacies in brand-name and generic versions. Generics are generally cheaper than brand-name products. At the time this article was written, the prices for the brand-name and generic versions of Zoloft were slightly cheaper than those of Lexapro, according to GoodRx.com.
Health insurance plans typically cover antidepressant medications such as Lexapro and Zoloft but may prefer you take the generic forms.
The charts below list examples of side effects of Lexapro and Zoloft. Because Lexapro and Zoloft are both SSRIs, they share many of the same side effects.
| Common side effects | Lexapro | Zoloft |
|---|---|---|
| nausea | X | X |
| sleepiness | X | X |
| weakness | X | X |
| dizziness | X | X |
| anxiety | X | X |
| sleeping trouble | X | X |
| sexual problems | X | X |
| sweating | X | X |
| shaking | X | X |
| loss of appetite | X | X |
| dry mouth | X | X |
| constipation | X | |
| respiratory infections | X | X |
| yawning | X | X |
| diarrhea | X | X |
| indigestion | X | X |
| Serious side effects | Lexapro | Zoloft |
|---|---|---|
| suicidal actions or thoughts | X | X |
| serotonin syndrome* | X | X |
| severe allergic reactions | X | X |
| abnormal bleeding | X | X |
| seizures or convulsions | X | X |
| manic episodes | X | X |
| weight gain or loss | X | X |
| low sodium (salt) levels in the blood | X | X |
| eye problems** | X | X |
*Serotonin syndrome is a condition that can occur when the levels of serotonin, a chemical produced by your body, become too high.
Serotonin syndrome can be life threatening.
**Eye problems can include blurry vision, double vision, dry eyes, and pressure in the eyes.
Keep reading: Managing sexual side effects from antidepressants
A concern that many people have about taking antidepressants is weight gain. It’s true that many antidepressants can cause weight gain, but some drugs are thought to cause less weight gain than others. Lexapro and Zoloft are two antidepressants that may cause less weight gain. If you’re concerned about this effect of taking an antidepressant, talk with your doctor.
The drug interactions of Lexapro and Zoloft are very similar. Before starting Lexapro or Zoloft, tell your doctor about all medications, vitamins, or herbs you take, especially if they’re listed below. This information can help your doctor prevent possible interactions.
The chart below compares examples of drugs that can interact with Lexapro or Zoloft.
| Interacting drugs | Lexapro | Zoloft |
|---|---|---|
| monoamine oxidase inhibitors (MAOIs) such as selegiline and phenelzine | X | X |
| pimozide | X | X |
| blood thinners such as warfarin and aspirin | X | X |
| nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen | X | X |
| lithium | X | X |
| antidepressants such as amitriptyline and venlafaxine | X | X |
| anti-anxiety drugs such as buspirone and duloxetine | X | X |
| medications for mental illness such as aripiprazole and risperidone | X | X |
| antiseizure drugs such as phenytoin and carbamazepine | X | X |
| medications for migraine headaches such as sumatriptan and ergotamine | X | X |
| sleeping medications such as zolpidem | X | X |
| metoprolol | X | X |
| disulfiram | X* | |
| medications for irregular heartbeat such as amiodarone and sotalol | X | X |
*interacts if you’re taking the liquid form of Zoloft
Conditions of concern
Lexapro and Zoloft contain many of the same warnings for use with other medical conditions.
For example, you should talk with your doctor if you’re pregnant or planning to become pregnant.
Research in animals has shown adverse effects on the fetus if you take either of these drugs. There haven’t been enough studies in humans to be certain of how Lexapro or Zoloft might affect the fetus. You should only take these drugs if the potential benefit justifies the potential risk.
The chart below lists other medical conditions you should discuss with your doctor before taking Lexapro or Zoloft.
| Medical conditions to discuss with your doctor | Lexapro | Zoloft |
|---|---|---|
| Liver problems | X | X |
| seizure disorder | X | X |
| bipolar disorder | X | X |
| kidney problems | X |
Risk of suicide
Both Lexapro and Zoloft raise the risk of suicidal thinking and behavior in children, adolescents, and young adults.
In fact, Zoloft is not approved by the Food and Drug Administration (FDA) for treatment in children younger than 18 years, except for OCD treatment. Lexapro is not approved for use in children younger than 12 years.
For more information, read about antidepressant use and the risk of suicide.
Possible withdrawal
You should not suddenly stop treatment with an SSRI such as Lexapro or Zoloft. Stopping these medications suddenly can cause withdrawal symptoms, which can include:
- flu-like symptoms
- agitation
- dizziness
- confusion
- headache
- anxiety
- sleeping trouble
If you need to stop one of these medications, talk with your doctor. They will slowly decrease your dosage to help prevent withdrawal symptoms.
For more information, read about the dangers of abruptly stopping an antidepressant.
To learn more about how Lexapro and Zoloft are alike and different, talk with your doctor. They’ll be able to tell you if one of these drugs, or a different drug, could help you with your mental health condition.
Some questions that might be helpful to ask your doctor include:
- How long will it take before I feel the benefits of this medication?
- What is the appropriate time of day for me to take this medication?
- Which side effects should I expect from this medication, and will they go away?
You and your doctor can work together to find a drug that’s right for you. To learn about other medication options, check out this article on the different types of antidepressants.
Lexapro Zoloft: What's the difference? - Your Body's Health
Contents
Introduction
With all the different drugs for depression and anxiety on the market, it can be difficult to know which drug it is. Lexapro and Zoloft are the two most commonly prescribed drugs for mood disorders such as depression.
These drugs are a type of antidepressant called selective serotonin reuptake inhibitors (SSRIs). SSRIs work by increasing levels of serotonin, a substance in your brain that helps keep you in the mood.
Read on to find out more about the similarities and differences between Lexapro and Zoloft. nine0003
Drug features
Lexapro is indicated for the treatment of depression and generalized anxiety disorder. Zoloft is prescribed for the treatment of depression, obsessive-compulsive disorder and a number of other mental illnesses. The table below compares the conditions under which each drug is approved for treatment.
Condition Zoloft LexaprodepressionXX Generalized Anxiety DisorderX Sexual Compulsive Disorder (OCD) Panic DisorderX Post Traumatic Stress Disorder (PTSD) Social Anxiety DisorderX Menstrual Dysphoric Disorder (PMDD) X
The table below compares other key aspects of Zoloft and Lexapro.
Brand name Zoloft LexaproWhat is a generic? Sertraline escitalopram Which forms are included: oral tablet, oral solution tablet, oral solution What strengths does it show? Tablet: 25 mg, 50 mg, 100 mg; solution: 20 mg/ml tablet: 5 mg, 10 mg, 20 mg; solution: 1 mg/ml Who can take it? persons 18 years of age and older * persons 12 years of age and older What is the dosage? The doctor's prescription is determined by your doctor.
What is the typical duration of treatment? Long term and long term How to store this medicine? at room temperature away from excessive heat or moisture at room temperature away from excessive heat or humidity Is there a risk of withdrawal symptoms while taking this medicine? yes † yes † * In addition to handling CSOs
† If you have been taking this medicine for more than a few weeks, do not stop taking it without talking to your doctor. You will need to gradually taper down the dose of the medication to avoid withdrawal symptoms.
Cost, availability and insurance
Both drugs are available in most pharmacies in branded and generic versions. Generic drugs are usually cheaper than brand name drugs. At the time of writing, Lexapro and Zoloft brand and generic prices were the same. GoodRx.com.
Health plans usually cover antidepressants such as Lexapro and Zoloft, but they prefer to use generic forms.
Nuspoyave
The figures below show examples of the side effects of Lexapro and Zoloft.
Since Lexapro and Zoloft are both SSRIs, they have many of the same side effects.
Zajedničke strane effectsLexaproZoloftnauseaXXsleepinessXXweaknessXXdizzinessXXanxietyXXsleeping troubleXXsexual problemsXXsweatingXXshakingXXloss od appetiteXXdry mouthXXconstipationXrespiratory infectionsXXyawning XXdiarrheaXXindigestionXX ozbiljnih sporednih djelovanja ili effectsLexaproZoloftsuicidal thoughtsXXserotonin sindrom * XXsevere alergijski reactionsXXabnormal bleedingXXseizures ili convulsionsXXmanic episodesXXweight dobitak ili lossXXlow natrij (sol) razina u problemima bloodXXeye ** XX * Serotonin sindrom je stanje koje se može pojaviti kad razine Serotonin, a chemical produced by your body, gets too high. Serotonin syndrome can be life-threatening. nine0019 ** Eye problems may include blurred vision, double vision, dry eyes, and eye pressure.
Continue reading: Managing the sexual side effects of antidepressants »
Many people's concern about taking antidepressants is related to weight gain.
It is true that many antidepressants can cause weight gain, but some drugs are thought to cause less weight gain than others. Lexapro and Zoloft are two antidepressants that may cause less weight gain. If you're worried about taking antidepressants, talk to your doctor. nine0003
drug interactions
The interactions between Lexapro and Zoloft are very similar. Before you start using Lexapro or Zoloft, tell your doctor about any medications, vitamins, or herbs you are taking, especially if they are listed below. This information can help your doctor prevent possible interactions.
The table below compares examples of drugs that may affect Lexapro or Zoloft.
Interakciji inhibitori drugsLexapro Zoloftmonoamine oksidaze (MAOI), kao što su selegilin i phenelzinexxpimozidexxblood razrjeđivača, kao što su varfarin i aspirinxxnonsteroidal protuupalnih lijekova (NSAID), kao što su ibuprofen i naproxenxxlithiumxxantidepressants kao što je amitriptilin i venlafaxinexxanti anksioznosti lijekovima kao što je buspiron i duloxetinexxmedications za mental illness such as aripiprazole and risperidone, anticonvulsants such as phenytoin and carbamazepinex, migraine medications such as suptriptan and ergotamine, sleeping pills such as zolpidemxx, metoprolol, disulfiramx* medicines for heart failure, such as heart failure if you are taking the liquid form of Zololox.
nine0003
Warnings
Conditions of concern
Lexapro and Zoloft contain many of the same warnings for use in other conditions. For example, both drugs are in pregnancy category C. This means that if you are pregnant, you should only use these medicines if the benefits outweigh the risks to your pregnancy.
The table below lists other health conditions you should discuss with your doctor before taking Lexapro or Zoloft. nine0003
Medical conditions requiring medical attention.
Risk of suicide
Both Lexapro and Zoloft increase the risk of suicidal thoughts and behavior in children, adolescents and young adults. In fact, Zoloft is not approved by the Food and Drug Administration (FDA) for the treatment of children under 18, with the exception of children with ASO. Lexapro is not approved for use in children under 12 years of age.
Read about antidepressant use and risk of suicide for more information. nine0003
Possible conclusion
Do not abruptly stop treatment with SSRIs such as Lexapro or Zoloft.
Stopping these drugs right away can cause withdrawal symptoms. It can be:
- CREVED SYMENTS
- Excitement
- Dizziness
- Confusion
- Headache
- Anxio
- Problems with sleep
If you need to stop taking any of these drugs, talk to your doctor. This will slowly reduce the dosage to prevent withdrawal symptoms. For more information, read about the dangers of abruptly stopping antidepressants. nine0003
Talk to your doctor
To learn more about the similarities and differences between Lexapro and Zoloft, talk to your doctor. They will be able to tell you if any of these or any other medications can help you with your mental state. Here are some questions you might find helpful to ask your doctor:
- How long will it take before I feel the benefits of this medicine?
- What is the best time of day to take this medicine? nine0068
- What side effects should I expect from this drug and will it go away?
Together you and your doctor can find the right medicine for you.
To learn more about other options, see this article on the different types of antidepressants.
Q:
Which is better for treating OCD or anxiety - Lexapro or Zoloft?
A:
Zoloft, not Lexapro, is approved for the relief of symptoms of obsessive compulsive disorder or OCD. CSOs are a common and long-term condition. This provokes uncontrollable thoughts and again and again prompts certain actions. In regards to anxiety, Zoloft is approved for the treatment of social anxiety disorder and is sometimes used without treatment to treat generalized anxiety disorder (GAD). Lexapro is approved for the treatment of GAD and can be used off-label for the treatment of social anxiety disorder and panic disorder. If you have obsessive-compulsive disorder or anxiety, talk to your doctor about what medication might be best for you. nine0003
Healthline Medical TeamAnswers represent the opinions of our medical experts. All content is for informational purposes only and should not be construed as medical advice.
Lexapro Zoloft: What's the difference? - Your Body's Health
Contents
Introduction
With all the different drugs for depression and anxiety on the market, it can be difficult to know which drug it is. Lexapro and Zoloft are the two most commonly prescribed drugs for mood disorders such as depression. nine0003
These drugs are a type of antidepressant called selective serotonin reuptake inhibitors (SSRIs). SSRIs work by increasing levels of serotonin, a substance in your brain that helps keep you in the mood. Read on to find out more about the similarities and differences between Lexapro and Zoloft.
Product Features
Lexapro is indicated for the treatment of depression and generalized anxiety disorder. Zoloft is prescribed for the treatment of depression, obsessive-compulsive disorder and a number of other mental illnesses. The table below compares the conditions under which each drug is approved for treatment. nine0003
Condition Zoloft LexaprodepressionXX Generalized Anxiety DisorderX Sexual Compulsive Disorder (OCD) Panic DisorderX Post Traumatic Stress Disorder (PTSD) Social Anxiety DisorderX Menstrual Dysphoric Disorder (PMDD) X
The table below compares other key aspects of Zoloft and Lexapro.
Brand name Zoloft LexaproWhat is a generic? Sertraline escitalopram Which forms are included: oral tablet, oral solution tablet, oral solution What strengths does it show? Tablet: 25 mg, 50 mg, 100 mg; solution: 20 mg/ml tablet: 5 mg, 10 mg, 20 mg; solution: 1 mg/ml Who can take it? persons 18 years of age and older * persons 12 years of age and older What is the dosage? The doctor's prescription is determined by your doctor. What is the typical duration of treatment? Long term and long term How to store this medicine? at room temperature away from excessive heat or moisture at room temperature away from excessive heat or humidity Is there a risk of withdrawal symptoms while taking this medicine? yes † yes † * In addition to handling CSOs
† If you have been taking this medicine for more than a few weeks, do not stop taking it without talking to your doctor. You will need to gradually taper down the dose of the medication to avoid withdrawal symptoms.
Cost, availability and insurance
Both drugs are available in most pharmacies in branded and generic versions.
Generic drugs are usually cheaper than brand name drugs. At the time of writing, Lexapro and Zoloft brand and generic prices were the same. GoodRx.com.
Health plans usually cover antidepressants such as Lexapro and Zoloft, but they prefer to use generic forms.
Nuspoyave
The figures below show examples of the side effects of Lexapro and Zoloft. Since Lexapro and Zoloft are both SSRIs, they have many of the same side effects.
Zajedničke strane effectsLexaproZoloftnauseaXXsleepinessXXweaknessXXdizzinessXXanxietyXXsleeping troubleXXsexual problemsXXsweatingXXshakingXXloss od appetiteXXdry mouthXXconstipationXrespiratory infectionsXXyawning XXdiarrheaXXindigestionXX ozbiljnih sporednih djelovanja ili effectsLexaproZoloftsuicidal thoughtsXXserotonin sindrom * XXsevere alergijski reactionsXXabnormal bleedingXXseizures ili convulsionsXXmanic episodesXXweight dobitak ili lossXXlow natrij (sol) razina u problemima bloodXXeye ** XX * Serotonin sindrom je stanje koje se može pojaviti kad razine Serotonin, a chemical produced by your body, gets too high.
Serotonin syndrome can be life-threatening. nine0019 ** Eye problems may include blurred vision, double vision, dry eyes, and eye pressure.
Continue reading: Managing the sexual side effects of antidepressants »
Many people's concern about taking antidepressants is related to weight gain. It is true that many antidepressants can cause weight gain, but some drugs are thought to cause less weight gain than others. Lexapro and Zoloft are two antidepressants that may cause less weight gain. If you're worried about taking antidepressants, talk to your doctor. nine0003
drug interactions
The interactions between Lexapro and Zoloft are very similar. Before you start using Lexapro or Zoloft, tell your doctor about any medications, vitamins, or herbs you are taking, especially if they are listed below. This information can help your doctor prevent possible interactions.
The table below compares examples of drugs that may affect Lexapro or Zoloft.
Interakciji inhibitori drugsLexapro Zoloftmonoamine oksidaze (MAOI), kao što su selegilin i phenelzinexxpimozidexxblood razrjeđivača, kao što su varfarin i aspirinxxnonsteroidal protuupalnih lijekova (NSAID), kao što su ibuprofen i naproxenxxlithiumxxantidepressants kao što je amitriptilin i venlafaxinexxanti anksioznosti lijekovima kao što je buspiron i duloxetinexxmedications za mental illness such as aripiprazole and risperidone, anticonvulsants such as phenytoin and carbamazepinex, migraine medications such as suptriptan and ergotamine, sleeping pills such as zolpidemxx, metoprolol, disulfiramx* medicines for heart failure, such as heart failure if you are taking the liquid form of Zololox.
nine0003
Warnings
Conditions of concern
Lexapro and Zoloft contain many of the same warnings for use in other conditions. For example, both drugs are in pregnancy category C. This means that if you are pregnant, you should only use these medicines if the benefits outweigh the risks to your pregnancy.
The table below lists other health conditions you should discuss with your doctor before taking Lexapro or Zoloft. nine0003
Medical conditions requiring medical attention.
Risk of suicide
Both Lexapro and Zoloft increase the risk of suicidal thoughts and behavior in children, adolescents and young adults. In fact, Zoloft is not approved by the Food and Drug Administration (FDA) for the treatment of children under 18, with the exception of children with ASO. Lexapro is not approved for use in children under 12 years of age.
Read about antidepressant use and risk of suicide for more information. nine0003
Possible conclusion
Do not abruptly stop treatment with SSRIs such as Lexapro or Zoloft.
Stopping these drugs right away can cause withdrawal symptoms. It can be:
- CREVED SYMENTS
- Excitement
- Dizziness
- Confusion
- Headache
- Anxio
- Problems with sleep
If you need to stop taking any of these drugs, talk to your doctor. This will slowly reduce the dosage to prevent withdrawal symptoms. For more information, read about the dangers of abruptly stopping antidepressants. nine0003
Talk to your doctor
To learn more about the similarities and differences between Lexapro and Zoloft, talk to your doctor. They will be able to tell you if any of these or any other medications can help you with your mental state. Here are some questions you might find helpful to ask your doctor:
- How long will it take before I feel the benefits of this medicine?
- What is the best time of day to take this medicine? nine0068
- What side effects should I expect from this drug and will it go away?
Together you and your doctor can find the right medicine for you.
