How long for rexulti to work
Mental Health Medications | NAMI: National Alliance on Mental Illness
Brand name: Rexulti®
- Oral tablet: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg
Generic name: brexipiprazole (breks PIP ray zole)
All FDA black box warnings are at the end of this fact sheet. Please review before taking this medication.
What is Brexpiprazole and what does it treat?
Brexpiprazole is a medication that works in the brain to treat schizophrenia. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Brexpiprazole rebalances dopamine and serotonin to improve thinking, mood, and behavior.
Symptoms of schizophrenia include:
- Hallucinations — imagined voices or images that seem real
- Delusions — beliefs that are not true (e.g., other people are reading your thoughts)
- Disorganized thinking or trouble organizing your thoughts and making sense
- Little desire to be around other people
- Trouble speaking clearly
- Lack of motivation
Brexpiprazole may help some or all of these symptoms.
Brexpiprazole is also FDA approved for the following indications:
- Adjunctive treatment of major depressive disorder. This means brexpiprazole is used in addition to an antidepressant to help treat depression.
This medication sheet will focus primarily on schizophrenia. You can find more information about depression here.
This medication may be prescribed for other uses; ask your health care provider for more information.
What is the most important information I should know about Brexpiprazole?
Schizophrenia requires long-term treatment. Do not stop taking brexpiprazole, even when you feel better.
With input from you, your health care provider will assess how long you will need to take the medication.
Missing doses of brexpiprazole may increase your risk for a relapse in your symptoms.
Do not stop taking brexpiprazole or change your dose without talking with your health care provider first.
For brexpiprazole to work properly, it should be taken every day as ordered by your health care provider.
Are there specific concerns about Brexpiprazole and pregnancy?
If you are planning on becoming pregnant, notify your healthcare provider to best manage your medications. People living with schizophrenia who wish to become pregnant face important decisions. This is a complex decision since untreated schizophrenia has risks to the fetus, as well as the mother. It is important to discuss the risks and benefits of treatment with your doctor and caregivers.
Antipsychotic use during the third trimester of pregnancy has a risk for abnormal muscle movements (extrapyramidal symptoms [EPS]) and/or withdrawal symptoms in newborns following delivery. Symptoms in the newborn may include agitation, feeding disorder, hypertonia, hypotonia, respiratory distress, somnolence, and tremor; these effects may be self-limiting or require hospitalization.
Caution is advised with breastfeeding since brexpiprazole has been shown to pass into animal milk. No studies have been conducted to assess for brexpiprazole in breastfed infants or how this medicine may affect milk production.
What should I discuss with my health care provider before taking Brexpiprazole?
- Symptoms of your condition that bother you the most
- If you have thoughts of suicide or harming yourself
- Medications you have taken in the past for your condition, whether they were effective or caused any adverse effects
- If you ever had muscle stiffness, shaking, tardive dyskinesia, neuroleptic malignant syndrome, or weight gain caused by a medication
- If you experience side effects from your medications, discuss them with your provider. Some side effects may pass with time, but others may require changes in the medication.
- Any psychiatric or medical problems you have, such as heart rhythm problems, long QT syndrome, heart attacks, diabetes, high cholesterol, or seizures
- If you have a family history of diabetes or heart disease
- All other medications you are currently taking (including over the counter products, herbal and nutritional supplements) and any medication allergies you have
- Other non-medication treatment you are receiving, such as talk therapy or substance abuse treatment.
Your provider can explain how these different treatments work with the medication. - If you are pregnant, plan to become pregnant, or are breastfeeding
- If you smoke, drink alcohol, use or ever used recreational drugs, or ever used prescription medications
How should I take Brexpiprazole?
Brexpiprazole may help control your symptoms but will not cure your condition.
It may take two to three months before you feel the full effect of brexpiprazole.
Brexpiprazole tablets are usually taken once a day with or without food.
Typically, patients begin at a low dose of medication and the dose is increased slowly over several weeks. Only your health care provider can determine the correct dose for you.
The dose usually ranges from 0.5 mg to 4 mg. Only your health care provider can determine the correct dose for you.
Use a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication. You may also ask a family member or a friend to remind you or check in with you to be sure you are taking your medication.
What happens if I miss a dose of Brexpiprazole?
It is important to take your medication everyday as directed by your health care provider. Do not miss or skip a dose.
If you miss a dose of brexpiprazole, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your health care provider. Do not double your next dose or take more than what is prescribed.
What should I avoid while taking Brexpiprazole?
Avoid drinking alcohol or using illegal drugs while you are taking brexpiprazole. They may decrease the benefits (e.g. worsen your confusion) and increase adverse effects (e.g. sedation) of the medication.
What happens if I overdose with Brexpiprazole?
If an overdose occurs call your doctor or 911. You may need urgent medical care. You may also contact the poison control center at 1-800-222-1222.
A specific treatment to reverse the effects of brexpiprazole does not exist. Management of overdose should concentrate on supportive therapy, maintaining an adequate airway, oxygenation and ventilation, and management of symptoms.
What are possible side effects of Brexpiprazole?
This is not a complete list. Talk with your health care provider for more information.
Common side effects
Restlessness, weight gain, cholesterol abnormalities
Rare/serious side effects
Brexpiprazole may increase the blood levels of a hormone called prolactin. Side effects of increased prolactin levels include females losing their period, production of breast milk and males losing their sex drive or possibly experiencing erectile problems. Long term (months or years) of elevated prolactin can lead to osteoporosis, or increased risk of bone fractures.
Some people may develop muscle-related side effects while taking brexpiprazole. The technical terms for these are “extrapyramidal symptoms” (EPS) and “tardive dyskinesia” (TD). Symptoms of EPS include restlessness, tremor, and stiffness. TD symptoms include slow or jerky movements that one cannot control, often starting in the mouth with tongue rolling or chewing movements.
Temperature regulation: Impaired core body temperature regulation may occur; caution with strenuous exercise, heat exposure, and dehydration.
Second generation antipsychotics (SGAs) increase the risk of weight gain, high blood sugar, and high cholesterol. This is also known as metabolic syndrome. Your healthcare provider may ask you for a blood sample to check your cholesterol, blood sugar, and hemoglobin A1c (a measure of blood sugar over time) while you take this medication.
Information on healthy eating and adding exercise to decrease your chances of developing metabolic syndrome may be found at the following sites:
- http://www.helpguide.org/articles/healthy-eating/healthy-eating.htm
- http://www.helpguide.org/home-pages/exercise-fitness.htm
SGAs have been linked with higher risk of death, strokes, and transient ischemic attacks (TIAs) in elderly people with behavior problems due to dementia.
All antipsychotics have been associated with the risk of sudden cardiac death due to an arrhythmia (irregular heartbeat).
To minimize this risk, antipsychotic medications should be used in the smallest effective dose when the benefits outweigh the risks. Your doctor may order an EKG to monitor for irregular heartbeat.
Neuroleptic malignant syndrome is a rare, life threatening adverse effect of antipsychotics which occurs in <1% of patients. Symptoms include confusion, fever, extreme muscle stiffness, and sweating. If any of these symptoms occur, contact your healthcare provider immediately.
All antipsychotics can cause sedation, dizziness, or orthostatic hypotension (a drop in blood pressure when standing up from sitting or lying down). These side effects may lead to falls which could cause bone fractures or other injuries. This risk is higher for people with conditions or other medications that could worsen these effects. If falls or any of these symptoms occur, contact your health care provider.
Are there any risks for taking Brexpiprazole for long periods of time?
Tardive dyskinesia (TD) is a side effect that develops with prolonged use of antipsychotics.
The risk is greater in people with diabetes, older adults, especially older women, longer use or higher doses but may also occur after short term use with low doses. Medications such as brexpiprazole have been shown to have a lower risk of TD compared to older antipsychotics, such as Haldol® (haloperidol). If you develop symptoms of TD, such as grimacing, sucking, and smacking of lips, or other movements that you cannot control, contact your health care provider immediately. All patients taking either first- or second-generation antipsychotics should have an Abnormal Involuntary Movement Scale (AIMS) completed regularly by their health care provider to monitor for TD.
Second generation antipsychotics (SGAs) increase the risk of diabetes, weight gain, high cholesterol, and high triglycerides. (See "Serious Side Effects" section for monitoring recommendations).
What other medications may interact with Brexpiprazole?
Tell your health care provider about all medications that you take, have recently taken or plan to take including prescription and nonprescription medications, vitamins, herbal products, and nutritional supplements.
This medication may affect the way other medications work, and other medications may affect how this medication works.
The following medications may increase the levels and effects of brexpiprazole:
- The antibiotic clarithromycin (Biaxin®)
- Antidepressants, such as fluoxetine (Prozac®), paroxetine (Paxil®), and nefazodone
- Antifungals, such as fluconazole (Diflucan®), ketoconazole (Nizoral®), and itraconazole (Sporanox®)
- The antiarrhymia agent quinidine
- HIV medications, such as the protease inhibitors indinavir (Crixivan®), ritonavir (Norvir®), saquinavir (Fortovase®, Invirase®), and lopinavir/ritonavir (Kaletra®)
The following medications may decrease the levels and effects of brexpiprazole:
- Some seizure medications and mood stabilizers, such as carbamazepine (Tegretol®)
- Medications used to treat tuberculosis, such as rifampin (Rifadin®)
How long does it take for Brexpiprazole to work?
It is very important to tell your doctor how you feel things are going during the first few weeks after you start taking brexpiprazole.
It will probably take several weeks to see big enough changes in your symptoms to decide if brexpiprazole is the right medication for you.
Antipsychotic treatment is generally needed lifelong for persons with schizophrenia. Your doctor can best discuss the duration of treatment you need based on your symptoms and illness.
- Hallucinations, disorganized thinking, and delusions may improve in the first 1-2 weeks
- Sometimes these symptoms do not completely go away
- Motivation and desire to be around other people can take at least 1-2 weeks to improve
- Symptoms continue to get better the longer you take brexpiprazole
- It may take 2-3 months before you get the full benefit of brexpiprazole
Summary of FDA Black Box Warnings
Increased mortality in elderly patients with dementia-related psychosis
- Both first generation (typical) and second generation (atypical) antipsychotics are associated with an increased risk of mortality in elderly patients when used for dementia related psychosis.
- Although there were multiple causes of death in studies, most deaths appeared to be due to cardiovascular causes (e.g. sudden cardiac death) or infection (e.g. pneumonia).
- Antipsychotics are not indicated for the treatment of dementia-related psychosis.
Suicidal thoughts or actions in children and adults
- Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide.
- Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking medications. This risk may persist until significant remission occurs.
- Antidepressants increase the risk of suicidal thoughts and behaviors in patients aged 24 years and younger. Monitor for clinical worsening and emergence of suicidal thoughts and behaviors.
- Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient’s prescriber or health care professional.
- All patients being treated with this medication for depression should watch for and notify their health care provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
Provided by
(November 2022)
©2022 The College of Psychiatric and Neurologic Pharmacists (CPNP) and the National Alliance on Mental Illness (NAMI). CPNP and NAMI make this document available under the Creative Commons Attribution-No Derivatives 4.0 International License. Last Updated: January 2016.
This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists.
This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein.
REXULTI® (brexpiprazole) | Frequently Asked Questions & Answers
Taking REXULTI
® (brexpiprazole)Get answers to common questions about taking REXULTI by clicking on the options below. You can also visit the Talk to your doctor page for help on starting a conversation with your doctor.
REXULTI is taken once daily, and you can take it with or without food.
It’s important to follow the dosing schedule prescribed by your healthcare provider. Here are a few tips that may help you stay on schedule:
- Make taking your medication part of your daily routine
- Set a reminder on your phone or mark it on a to-do list
- Get a daily reminder from a family member or friend
- Keep your REXULTI pills in order with a weekly pillbox
Take REXULTI as your healthcare provider prescribed it.
- Your healthcare provider may change your dose if needed. Do not change the dose or stop taking REXULTI without first talking to your healthcare provider.
- Take REXULTI 1 time each day with or without food.
- Do not take REXULTI if you are allergic to brexpiprazole or any of the ingredients in REXULTI.
If you take too much REXULTI, call your healthcare provider or the Poison Control Center at 1-800-222-1222 right away or go to the nearest hospital emergency room.
Not everyone responds to medication the same way, and your body may need time to adapt.
Therefore, it is important to share how you are feeling with your healthcare provider, including any side effects. This way, he or she will better understand what effect your treatment may be having and adjust if necessary. Write down questions you have about your treatment and share them with your doctor. Always talk to your doctor before making any changes to your treatment.
Before taking REXULTI, tell your healthcare provider about all of your medical conditions, including if you:
- have or have had heart problems or a stroke
- have or have had low or high blood pressure
- have or have had diabetes or high blood sugar or a family history of diabetes or high blood sugar. Your healthcare provider should check your blood sugar before you start REXULTI and during treatment with REXULTI.
- have of have had high levels of total cholesterol, LDL cholesterol, or triglycerides, or low levels of HDL cholesterol
- have or have had seizures (convulsions)
- have or have had kidney or liver problems
- have or have had a low white blood cell count
- are pregnant or plan to become pregnant.
REXULTI may harm your unborn baby. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. - Tell your healthcare provider if you become pregnant or think you are pregnant during treatment with REXULTI.
- If you become pregnant during treatment with REXULTI, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by calling 1-866-961-2388 or visit http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/.
- are breastfeeding or plan to breastfeed. It is not known if REXULTI passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with REXULTI.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
REXULTI and other medicines may affect each other causing possible serious side effects. REXULTI may affect the way other medicines work, and other medicines may affect how REXULTI works.
Your healthcare provider can tell you if it is safe to take REXULTI with your other medicines. Do not start or stop any medicines during treatment with REXULTI without first talking to your healthcare provider.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
Possible side effects
Take note of any side effects you or your family member experience while on REXULTI, and report them to your healthcare provider, especially if they are new, worse, or worry you.
Do not take REXULTI if you are allergic to brexpiprazole or any of the ingredients in REXULTI.
Serious side effects may happen when you take REXULTI, including:
- Increased risk of death in elderly people with dementia-related psychosis.
REXULTI is not approved for the treatment of patients with dementia-related psychosis. - Increased risk of suicidal thoughts and actions. Antidepressant medicines may increase suicidal thoughts and actions in some children, adolescents, and young adults especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts or actions. REXULTI is not approved for use in people less than 18 years of age with MDD.
- Stroke (cerebrovascular problems) in elderly people with dementia-related psychosis that can lead to death.
- Neuroleptic malignant syndrome (NMS) is a serious condition that can lead to death.
Call your healthcare provider or go to the nearest hospital emergency room right away if you have some or all of the following signs and symptoms of NMS: high fever; changes in your breathing, heart rate, and blood pressure; stiff muscles; confusion; or increased sweating.
- Uncontrolled body movements (tardive dyskinesia)
REXULTI may cause movements that you cannot control in your face, tongue or other body parts, which may not go away. - High blood sugar (hyperglycemia) and diabetes
Increases in blood sugar can happen in some people who take REXULTI, and extremely high blood sugar can lead to coma or death. - Increased fat levels (cholesterol and triglycerides) in your blood
Your healthcare provider should check the fat levels in your blood before you start, or soon after you start REXULTI, and then periodically during treatment with REXULTI. - Weight gain
You and your healthcare provider should check your weight before you start and often during treatment with REXULTI. - Unusual and uncontrollable (compulsive) urges.
Some people taking REXULTI have had strong unusual urges, to gamble and gambling that cannot be controlled (compulsive gambling). Other compulsive urges include sexual urges, shopping, and eating or binge eating.
If you or your family members notice that you are having unusual strong urges, talk to your healthcare provider. - Low white blood cell count
Your healthcare provider may do blood tests during the first few months of treatment with REXULTI. - Decreased blood pressure (orthostatic hypotension)
You may feel lightheaded or faint when you rise too quickly from a sitting or lying position. - Falls
REXULTI may make you sleepy or dizzy, may cause a decrease in your blood pressure when changing position (orthostatic hypotension), and can slow your thinking and motor skills which may lead to falls that can cause fractures or other injuries. - Seizures (convulsions)
- Problems controlling your body temperature so that you feel too warm
Do not become too hot or dehydrated during treatment with REXULTI. - Difficulty swallowing
This may cause food or liquid to get into your lungs.
- Sleepiness, drowsiness, feeling tired, difficulty thinking and doing normal activities.
Do not drive a car, operate machinery, or do other dangerous activities until you know how REXULTI affects you. REXULTI may make you feel drowsy.
The most common side effects associated with REXULTI plus an antidepressant were weight gain and an inner sense of restlessness such as feeling like you need to move (akathisia), as reported during 6-week clinical studies* of adults with major depressive disorder (MDD).
You and your healthcare provider should check your weight regularly. In 6-week clinical studies of adults with MDD, 7% of patients taking REXULTI plus an antidepressant reported an increase in body weight, compared with 2% of patients taking an antidepressant plus a placebo (non-therapeutic pill).
In the same studies, akathisia was reported by 9% of patients taking REXULTI plus an antidepressant and by 2% of patients taking an antidepressant plus a placebo.
These are not all the possible side effects of REXULTI. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about your health or medicines, including side effects.
An increase in blood sugar (hyperglycemia) can happen in some people who take REXULTI. Extremely high blood sugar can lead to coma or death.
In a 6-week clinical trial,* adult patients with shifts in fasting blood sugar from normal (<100 mg/dL) to high (≥126 mg/dL) and borderline (≥100 and <126 mg/dL) to high were similar in patients treated with REXULTI and patients treated with placebo (non-therapeutic pill).
Call your healthcare provider if you have any of these symptoms of high blood sugar while taking REXULTI: You feel very thirsty; feel very hungry; feel sick to your stomach; need to urinate more than usual; feel weak or tired; feel confused, or your breath smells fruity.
An increase in the fat levels (cholesterol and triglycerides) in your blood may occur while taking REXULTI.
Before starting on REXULTI, discuss with your healthcare provider if you have high levels of cholesterol, triglycerides, LDL-cholesterol, or low levels of HDL cholesterol.
Your healthcare provider should check the fat levels in your blood before you start, or soon after you start REXULTI, and then periodically during treatment with REXULTI.
During two 6-week clinical trials,* changes in fasting total cholesterol, LDL-cholesterol, and HDL cholesterol were similar between adult patients taking REXULTI and patients taking a placebo (non-therapeutic pill).
Weight gain has been reported in people taking medicines like REXULTI, so you and your healthcare provider should check your weight before you start and often during treatment with REXULTI.
In two 6-week clinical trials* of adults with MDD, 7% of patients taking REXULTI plus an antidepressant reported an increase in body weight, compared with 2% of patients taking an antidepressant plus a placebo (non-therapeutic pill).
In two 6-week clinical trials,* 4% of adult patients who had REXULTI added to an antidepressant experienced drowsiness compared to 1% of patients taking an antidepressant plus a placebo (non-therapeutic pill).
Until you know how REXULTI affects you, do not drive, operate heavy machinery, or do dangerous activities.
About 3% of adult patients taking REXULTI plus an antidepressant reported feelings of restlessness during two 6-week clinical trials,* compared to 0% of patients taking placebo (non-therapeutic pill).
Overall, there was no difference seen in sexual function of patients as a result of taking REXULTI with an antidepressant compared to those taking an antidepressant alone.
During two 6-week clinical trials,* adult patients taking REXULTI plus an antidepressant reported their overall sexual function was similar to that of patients taking an antidepressant alone, as measured by the Massachusetts General Hospital Sexual Functioning Questionnaire.
*Researchers studied REXULTI in clinical trials
REXULTI was studied in two 6-week clinical trials of 1,054 patients aged 18-65 diagnosed with major depressive disorder (MDD).
The patients selected for the studies took an antidepressant for at least 8 weeks. Patients who then had ongoing symptoms of depression were randomly selected to receive 1 mg to 3 mg/day of REXULTI in addition to their antidepressant, while the rest continued taking their antidepressant alone. At the end of 6 weeks, some patients who added REXULTI to their current antidepressant experienced a greater improvement in their symptoms of depression than the patients who continued taking only their antidepressant.
Can REXULTI help?
Adding REXULTI was proven to reduce the symptoms of depression.
Paying for REXULTI
If you are commercially insured, you may be eligible for the REXULTI Savings Card.†
All About Rexulti - Brexpiprazole
Rexulti has box warnings. These are serious drug warnings from the Food and Drug Administration (FDA). Rexulti boxed warnings are described below.
Risk of death in older people with psychosis associated with dementia.
Rexulti should not be used in the elderly for the treatment of psychosis associated with dementia.
In psychosis, mental well-being may be impaired. Symptoms may include:
With dementia, you experience changes in your mental state. These changes may include:
The use of Rexulti for psychosis associated with dementia may increase the risk of death in this group of people.
Risk of suicidal thoughts or behavior. The use of antidepressants in people aged 24 years and younger may increase suicidal thoughts and behavior. Rexulti is not considered an antidepressant. But it is used to treat depression along with an antidepressant.
Rexulti is not recommended for use in people under 18 years of age.
If you have ever had thoughts of harming yourself, talk to your doctor before taking Rexulti. They can discuss the risks of using Rexulti with you.
It is not clear why Rexulti may increase the risk of death in older people with psychosis-related dementia.
Keep in mind that other factors may affect this risk. This includes having other medical conditions or taking other medications. If you are concerned about this risk, ask your doctor about the safety of taking Rexulti.
Rexulti may also increase the risk of suicidal thoughts or behavior. This risk is higher in people with mental illness. This may include depression or bipolar disorder.
Be sure to share your medical history with your doctor before taking Rexulti. Tell them about your medical history, including whether you have had suicidal thoughts or behavior in the past.
Suicide Prevention
If you think someone is at immediate risk of harming themselves or harming another person:
- Call 911 or your local emergency number.
- Stay with the person until help arrives.
- Remove all weapons, knives, medicines, and other items that could cause harm.
- Listen, but don't judge, argue, threaten or yell.
If you or someone you know is thinking about suicide, seek help from a crisis or suicide prevention hotline. Call the National Suicide Prevention Hotline at 800-273-8255.
Weight gain
It is possible to have weight gain while you are taking Rexulti. But how much weight you can gain with Rexulti may vary depending on:
- your metabolism (the chemical processes that take place inside your body)
- your diet
- how long you have been taking Rexulti
Studies have shown that weight gain is a common side effect of brexpiprazole, which is the active drug in Rexulti.
Talk to your doctor about weight changes that can happen with Rexulti and what you can expect from treatment.
If you are concerned about weight gain, ask your doctor about lifestyle changes that can help you maintain a healthy weight with Rexulti. If you are concerned about weight gain while taking this medicine, do not stop taking Rexulti abruptly.
This may worsen the symptoms for which you have been using the drug.
Anger or other change in your mood
Rexulti may cause changes in your mood, thoughts or behavior. Examples of possible changes include:
- anger
- anxiety
- feeling very agitated or irritated
- feeling depressed
- thoughts of suicide or self-harm
These side effects are rare with Rexulti.
Before taking Rexulti, ask your doctor about mood-related side effects that the drug may cause. Discuss the benefits and risks of using this medicine with your doctor.
If you have changes or worsening of your mood or behavior while taking Rexulti, call your doctor. But if you have serious mental health changes or have thoughts of hurting yourself, call 911 or your local emergency number right away.
Allergic reaction
Some people may have an allergic reaction to Rexulti. Although no allergic reaction has been reported in Rexulti studies, it can still occur.
Symptoms of a mild allergic reaction may include:
- skin rash
- itching
- redness (temporary warmth, redness or discoloration of the skin)
A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction may include swelling under the skin, usually on the eyelids, lips, hands, or feet. They may also include swelling of the tongue, mouth, or throat, which can make it difficult for you to breathe.
Call your doctor right away if you have an allergic reaction to Rexulti. But if you think you need a medical emergency, call 911 or your local emergency number.
How to take Rexulti?
Your doctor will tell you how to take Rexulti. They will also explain how much to take and how often. Be sure to follow your doctor's instructions. The following are commonly used dosages, but Always take the dosage prescribed by your doctor.
Taking Rexulti
Rexulti contains the active drug brexpiprazole and comes in the form of tablets to be swallowed.
It is available in the following strengths:
- 0.25 milligrams (mg)
- 0.5 mg
- 1 mg
- the condition you are taking Rexulti 9 for0037
- how well your body responds to the drug
- other medicines you may be taking
- any side effects you may have from Rexulti
- other medical conditions you have, such as liver or kidney problems, or how well your body breaks down certain drugs.
- parksetin (PAXIL)
- CERTRALIN (ZHLOFT)
- Venlafaxin (Effector)
- Vortoxetes 9004 9,000 2 duplicate (Cymbalta) duplicate (Cymbalta)
- What if I miss a dose of Rexulti? If you miss a dose of Rexulti, take it as soon as you remember.
But do not double the next dose. This may increase the side effects of Rexulti. If it is close to when you will take your next dose, just skip the missed dose. Then take your usual dose at the usual time. You can also try using the reminder tool to keep track of your doses. - Do I need to use Rexulti for a long time? There is no specific time frame for using Rexulti. You and your doctor will discuss a treatment plan. If Rexulti is working to reduce your symptoms, you can take it long term.
- Can Rexulti be chewed, crushed or divided? No, you must take Rexulti tablets whole. Crushing, chewing, or splitting tablets can change how they work in the body. If you have trouble swallowing pills, try these tips or talk to your pharmacist about suggestions for taking Rexulti.
- Should I take Rexulti with food? You can take Rexulti with or without food. Eating during the reception does not change the action of the drug in the body.
- How long does Rexulti last? It may take several days to several weeks before Rexulti starts to reduce your symptoms. How quickly the drug works depends on individual factors such as your condition and how your body reacts to Rexulti. Ask your doctor what you can expect from your treatment.
- Before the meeting, write down questions such as:
- How will Rexulti affect my body, mood, or lifestyle?
- Take someone with you to the meeting if it makes you feel more comfortable.
- If you don't understand something about your condition or treatment, ask your doctor to explain it to you.
- tablets, liquid solution, and dissolving tablets, taken by mouth
- solution, injected into the muscle
- Rexulti contains the active drug brexpiprazole.
- Vraylar contains the active drug cariprazine.
- Seroquel contains the active drug quetiapine.
- bipolar 1 depression
- bipolar 1 manic or mixed episodes
- schizophrenia
- obsessive thoughts
- Motor disorders
- hallucinations (see or hear things that are actually not)
- Agitation
- Problems with
- Rassultural speech
- Some antidepressants, such as:
- Bupropion (vellbutrin)
- Paroxetine (Paxil)
- Dulsetin (Cymbalta)
- some anti -tribeen drugs, such as flinazo, such as Fluconaz used to treat heart rhythm problems
- certain antibiotics such as clarithromycin (Biaxin)
- antibiotic rifampin
- convulsive drugs such as carbamazepine and phenytoin
- Liver problems. If you have liver problems or serious liver disease, your doctor may adjust your dose of Rexulti. Be sure to tell your doctor about any history of liver-related problems.
- Allergic reaction. If you have had an allergic reaction to Rexulti or any of its ingredients, you should not take Rexulti. Ask your doctor which other medicines are best for you.
- Metabolic disorders of certain drugs, including Rexulti.
Some people have problems metabolizing (breaking down) drugs such as Rexulti due to genetic factors. This means the drug can stay in their body longer and cause side effects. Your doctor will check to see if you have a bad Rexulti metabolism in your body. If necessary, the doctor can adjust the dose of the drug. - Kidney problems. If you have kidney disease, you may need a lower dose of Rexulti. Your doctor will check your kidney function to determine the best dose of Rexulti for you.
- Diabetes. Rexulti may increase blood sugar levels in some people. If you have diabetes, you may be at a higher risk for this side effect. Rexulti can raise blood sugar to dangerous levels and cause diabetic ketoacidosis and diabetic coma. In rare cases, this can lead to death. While using Rexulti, you may need to check your blood sugar levels more often than usual. If you have diabetes, ask your doctor if it is safe for you to take Rexulti.
- Heart or blood pressure problems. Rexulti can cause orthostatic hypotension (drop in blood pressure when you stand up or sit down from a lying position). This condition can cause dizziness or fainting. If you have heart or blood pressure problems, ask your doctor if Rexulti is safe for you to use. In addition, it is important to avoid dehydration (low fluid levels in the body) while taking the drug. Dehydration can increase the risk of low blood pressure.
- Seizures. Taking Rexulti may increase the risk of seizures. The risk is higher for people with a seizure disorder or the elderly. Talk to your doctor about your medical history to see if Rexulti is safe for you.
- Problems with cholesterol. Rexulti may increase lipid levels in people with high cholesterol or triglyceride levels. Your doctor may check your lipid levels before and during Rexulti treatment.
- Low white blood cell count.
Rexulti may cause leukopenia (low white blood cell count) or neutropenia (low certain white blood cell count). If you already have a low white blood cell count, you may be at higher risk. Symptoms of a low white blood cell count may include fever and infection. If necessary, your doctor will order blood tests for you before you start taking Rexulti. Check with your doctor to see if you need to check your blood cell levels. - Problems with body temperature regulation. Rexulti may make it difficult to regulate body temperature. For example, you may find it harder to cool down after a workout. If you already have a medical condition that causes problems with regulating body temperature, be sure to tell your doctor. They can help determine if Rexulti is a safe option for you.
- Dropping. Taking Rexulti can cause problems with blood pressure, which can lead to dizziness and falls. If you are already at risk for falls due to medications you take or medical conditions you have, you may be at higher risk.
Talk to your doctor about the risk of falls before taking Rexulti. - tremor
- difficulty breathing
- agitation
- drowsiness
- feeding problems
- Are there other treatments I should consider?
- Does Rexulti cause weight loss?
- Is Rexulti a type of drug called a selective serotonin reuptake inhibitor (SSRI)?
- Is it safe to take vitamins with Rexulti?
- How can I get help for depression?
- What medications help treat depression?
- How to deal with depression: 20 ways to try it
- Treatment for schizophrenia
- Complementary and alternative treatments for schizophrenia
- clarithromycin (Biaxin)
- erythromycin
- Headache
- Fatigue
- Heartburn
- Current until you know how the medicine affects you. Tell your doctor right away if you experience serious side effects, which may include shortness of breath, rash or hives, itching, sore throat, fever, confusion, sweating, neck or throat muscle tension, swelling, difficulty breathing or swallowing, uncontrolled body movements, or seizures.
People aged 24 and younger are also at an increased risk of developing suicidal thoughts and behavior. You can also report side effects to the FDA at 1-800-FDA-1088 or online. What are the potential long-term effects of taking Rexulti?
Your doctor should monitor the progression of potential long-term side effects, which may include tardive dyskinesia (TD). Atypical antipsychotics may also increase the risk of cardiovascular side effects, diabetes, low white blood cell counts, weight gain, and high cholesterol.
Is Rexulti safe for pregnant, pregnant or lactating women?
There have been no controlled studies of the effects of Rexulti on pregnancy in humans, but there is a risk of neonatal withdrawal symptoms when the mother takes the drug during the third trimester. It is not known if the drug can pass through breast milk and harm the baby. Therefore, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding before taking Rexulti.
Can symptoms occur after stopping Rexulti?
It is important not to stop taking the drug if you feel better. Keep in touch with your doctor and, if necessary, seek medical advice when stopping the drug. Talk to your doctor about ways to reduce potential withdrawal symptoms.
What should I do if I overdose on Rexulti?
Data on overdose symptoms is limited, so seek help immediately or call Poison Helpline at 1-800-222-1222 if you overdose.
Is Rexulti addictive?
Rexulti is not habit-forming, but it is not recommended to stop taking the drug before talking with your doctor, as withdrawal symptoms may occur.How much does Rexulti cost?
According to goodrx.com, 30 2mg Rexulti tablets cost about $1,000.
Are there any disadvantages of Rexulti?
how to get short-term disability due to depression
The biggest disadvantages of Rexulti are potential side effects and potential long-term side effects, which may include tardive dyskinesia, hyperglycemia, and weight gain, as well as potential suicidal thoughts and behavior in people 24 years of age and younger.
Learn more
For depression, you will take Rexulti once a day with another depression medicine.
Your doctor will prescribe you a low dose of Rexulti and monitor your body's response to treatment. After the first few weeks of treatment, your doctor will likely increase your Rexulti dosage.
The maximum dose of Rexulti for depression is 3 mg once daily.
For schizophrenia, you will take a low dose of Rexulti once a day from days 1 to 4 of treatment. Then your doctor will increase your daily dose from day 5 to day 7.
If necessary, he can increase your daily dose even more, starting from day 8.
The maximum dose for schizophrenia is 4 mg once daily.
To learn more about depression and schizophrenia and how Rexulti is used for them, see Is Rexulti Used for Depression? and "Is Rexulti used for other conditions?" sections below.
Taking Rexulti with other drugs
For depression, Rexulti is taken with an antidepressant.
Some examples of antidepressants that can be used with rexulti include:
Talk to your doctor about your treatment plan and recommended medications.
Questions about taking Rexulti
Here is a list of common questions about taking Rexulti.
Questions to ask your doctor
You may have questions about Rexulti and your treatment plan. It is important to discuss all your concerns with your doctor.
Here are some tips to help guide your discussion:
Remember that your doctor and other healthcare professionals are always available to help you.
And they want you to get the best possible care. So don't be afraid to ask questions or offer feedback about your treatment.
What should I know about Rexulti vs Abilify?
Rexulti and Abilify belong to a group of medicines called atypical antipsychotics. These are newer drugs that have fewer serious side effects than older antipsychotics (so-called first-generation antipsychotics).
Rexulti and Abilify have some similar uses and effects, but they also have some differences. For example, Rexulti contains the active drug brexpiprazole and Abilify contains the active drug aripiprazole.
Both Rexulti and Abilify are used to treat depression and schizophrenia. But Abilify is also used to treat other conditions.
Rexulti comes in the form of tablets that you swallow. Abilify, on the other hand, comes in several forms. These forms include:
To learn more about the two drugs, check out this side-by-side comparison.
And be sure to talk to your doctor if you want to know which drug is right for you.
What are the frequently asked questions about Rexulti?
Below are answers to some frequently asked questions about Rexulti.
Will I have withdrawal symptoms if I stop taking Rexulti?
No, you won't. Rexulti does not cause physical dependence, so discontinuation does not result in withdrawal. (In addiction, your body needs the drug to make you feel good.)
But abruptly stopping the drug can worsen the symptoms you were using the drug to treat. Therefore, you should not abruptly stop taking Rexulti.
If you have side effects or have other concerns about using Rexulti, talk to your doctor. They can recommend a treatment plan that is right for you.
Rexulti used for anxiety? If so, what is the dose for anxiety?
No, Rexulti is not approved for anxiety. The drug can be used off-label for anxiety, but there are other approved treatments for anxiety.
(When used off-label, the medicine is used to treat conditions other than those for which it was approved.)
You may also ask your doctor for information about using Rexulti for anxiety, including typical dosage.
Also, be aware that, in rare cases, Rexulti may cause anxiety as a side effect. If you have concerns with Rexulti, talk to your doctor. They can discuss options with you to help manage your anxiety.
Does Rexulti treat bipolar disorder?
No, Rexulti is not approved for the treatment of bipolar disorder. The drug can be used off-label to treat this condition, but there are other medications approved for bipolar disorder that may be better options. (When used off-label, the drug is used to treat conditions other than those for which it was approved.)
Your doctor can tell you more about how Rexulti works. They can also provide information about other treatment options for bipolar disorder.
How is Rexulti different from the alternative drugs Vraylar and Seroquel?
Rexulti, Vraylar and Seroquel do the same.
All of them belong to a group of drugs called atypical antipsychotics. These drugs are newer drugs that have fewer serious side effects than older antipsychotics (so-called first-generation antipsychotics).
Each of these three products contains a different active ingredient:
Rexulti is used to treat depression and schizophrenia. For depression, Rexulti is taken with an antidepressant. With schizophrenia, Rexulti can be taken separately. Rexulti comes in the form of tablets that you take by mouth.
Vraylar comes in the form of capsules that you take by mouth. It is used to treat:
Seroquel comes as a tablet you take by mouth. It is used to treat depression, bipolar disorder, and schizophrenia.
If you need more information about comparing these medicines to each other, talk to your doctor. They can discuss all of your treatment options and the benefits and risks of each drug.
What is the half-life of Rexulti? And how long does it stay on your system?
The active drug Rexulti brexpiprazole has a half-life of 91 hours. This means that it takes 91 hours to eliminate half the dose of brexpiprazole from the body.
In general, about four to five half-lives are required to completely eliminate a full dose of the drug from the body.
How long the medicine stays in your body may vary depending on personal factors. These include your genetic makeup and how well your liver and kidneys work. Rexulti may stay in your body for several days.
How does Rexulti work?
The exact mechanism of action of Rexulti is unknown. (The mechanism of action of a drug describes how it works.)
But this type of drug is thought to work by regulating certain neurotransmitters in your brain.
(Neurotransmitters are brain chemicals.)
In particular, Rexulti is thought to act on dopamine and serotonin. This drug is believed to balance dopamine and serotonin, helping to reduce symptoms of depression and schizophrenia.
Is Rexulti used to treat depression?
If you have been diagnosed with depression or schizophrenia, your doctor can discuss Rexulti with you. To learn more about its use for depression, read on. For information on the use of Rexulti in the treatment of schizophrenia, see the section immediately below.
Rexulti is used in adults with major depressive disorder (MDD), also commonly referred to as depression.
Short periods of sadness are natural to everyone. But when you are depressed, you have a constant strong feeling of sadness. These feelings affect your quality of life, sleep and other aspects of your life.
For MDD, Rexulti is given with an antidepressant. This is considered combination therapy.
Rexulti belongs to a group of medicines called second generation antipsychotics.
These are new drugs that have fewer serious side effects than older antipsychotics. Rexulti is believed to work for depression by helping to balance certain chemicals in your brain.
If you wish, talk to your doctor for more information about the pros and cons of using Rexulti for MDD.
Is Rexulti used for other conditions?
If you have been diagnosed with depression or schizophrenia, your doctor can discuss Rexulti with you. To learn more about its use for depression, see the section directly above. For information on the use of Rexulti in the treatment of schizophrenia, read on.
Rexulti is indicated for adults with schizophrenia, which is a complex mental health condition. Schizophrenia has various symptoms, including:
Studies show that people with schizophrenia have an imbalance in the brain called neurotransmitters.
Rexulti is believed to work by regulating the levels of two neurotransmitters: dopamine and serotonin.
Your doctor can give you more information about the benefits and risks of using Rexulti to treat schizophrenia.
How much does Rexulti cost?
The cost of prescription drugs can vary depending on many factors. These factors include what your insurance plan covers and which pharmacy you use. For current Rexulti tablet pricing in your area, visit GoodRx.com.
If you have questions about how to pay for a prescription, talk to your doctor or pharmacist. You can also visit the Rexulti manufacturer's website to see if they have support options.
What should I consider before taking Rexulti?
Talk to your doctor about all your medications and any other health conditions before starting treatment with Rexulti.
Tell your doctor if you have kidney or heart problems, diabetes, high cholesterol or triglycerides. And let them know if you've ever had seizures or any other health issues.
Also, tell your doctor if you are pregnant, plan to become pregnant, or plan to breastfeed while taking Rexulti. Antipsychotics such as Rexulti may increase certain risks when used during pregnancy.
These and other considerations are described below.
interactions
Taking medicines, vaccines, foods, and other things with a certain medicine can affect how it works. These effects are called interactions.
Be sure to tell your doctor about all medicines you are taking, including prescription and over-the-counter medicines, before taking Rexulti. Also describe any vitamins, herbs, or supplements you use. Your doctor or pharmacist can tell you about any interactions these items may cause with Rexulti.
Interactions with drugs or supplements
Rexulti may interact with several types of drugs. Rexulti is broken down in the liver by certain enzymes (types of proteins). If you are taking Rexulti drugs that are also broken down by these enzymes, the drugs may interact and cause side effects.
Some drugs may increase the effect of Rexulti. In this case, your doctor may need to lower your dose of Rexulti to reduce the risk of adverse reactions. Examples of such drugs include:
Some other drugs can reduce the effect of Rexulti by removing it from the body faster than usual. In this case, your doctor may need to increase your dose of Rexulti. Some examples of such drugs include:
This list does not contain all types of drugs that may interact with Rexulti. Your doctor or pharmacist can tell you more about these and any other interactions that you may experience while using Rexulti.
Other interactions
Rexulti may also interact with herbs and supplements.
For example, St. John's wort can reduce the effects of Rexulti. Do not take this herb with Rexulti. Tell your doctor if you have taken this herb before starting treatment with Rexulti.
Boxed warnings
Rexulti has boxed warnings. These are serious drug warnings from the Food and Drug Administration (FDA). Rexulti boxed warnings are described below.
Risk of death in older people with psychosis associated with dementia. Rexulti should not be used in the elderly (aged 65 years and over) for the treatment of psychosis associated with dementia. (In psychosis, you lose touch with reality. In dementia, you experience changes in your mental state.)
This is because Rexulti may increase the risk of death in older people with this condition.
Risk of suicidal thoughts or behavior. The use of antidepressants in people aged 24 years and younger may increase suicidal thoughts and behavior.
Rexulti is not considered an antidepressant. But it is used to treat depression along with an antidepressant.
Rexulti is not recommended for use in people under 18 years of age.
For more information about these warnings, see "What are the side effects of Rexulti?" section above.
Other warnings
Rexulti may not be right for you if you have certain medical conditions or other health conditions. Talk to your doctor about your medical history before taking Rexulti. Factors to consider include those listed in the list below.
Use with alcohol
Drinking alcohol with Rexulti may increase the risk of certain side effects.
For example, Rexulti may cause drowsiness and certain movement problems. And drinking alcohol can exacerbate these side effects. Taking Rexulti and drinking alcohol can also affect liver function.
If you plan to drink alcohol while taking Rexulti, ask your doctor if it is safe to do so.
Pregnancy and breastfeeding
There is no specific information on the risks of using Rexulti during pregnancy.
But some evidence suggests that similar drugs taken in the third trimester of pregnancy increase the risk of extrapyramidal symptoms in exposed infants. (Extrapyramidal symptoms are a specific movement disorder.)
Use of Rexulti during the third trimester of pregnancy may also increase the risk of withdrawal in exposed infants. Examples of withdrawal symptoms may include:
Your doctor can discuss the risks and benefits of taking Rexulti during pregnancy.
If you become pregnant while taking Rexulti, tell your doctor immediately.
If you are using Rexulti during pregnancy, consider enrolling in the pregnancy registry, which is available for drugs called atypical antipsychotics. (Be aware that Rexulti is an atypical antipsychotic.) You can either call 866-961-2388, or visit the registry website for more information.
It is not known if Rexulti is safe to use while breastfeeding. The drug can pass into breast milk and cause side effects in a breast-fed baby.
Ask your doctor about the risks of using Rexulti if you plan to breastfeed. They can recommend whether you should stop breastfeeding while taking this drug.
What should I know about Rexulti vs. Latuda?
Rexulti and Latuda have some similarities and differences. They belong to the same group of drugs called atypical antipsychotics. These drugs are newer drugs that have fewer serious side effects than older antipsychotics (so-called first-generation antipsychotics).
Rexulti and Latuda have different active ingredients. Rexulti contains the active drug brexpiprazole and Latuda contains the active drug lurasidone hydrochloride.
Both of these drugs are used to treat schizophrenia in adults. But Latuda can also be used in children and adolescents aged 10 to 17 who have schizophrenia.
Rexulti is also used to treat depression. And Latuda is also used to treat bipolar disorder.
See the detailed comparison between Rexulti and Latuda for more information. And ask your doctor which drug they recommend for your condition.
What to do in case of an overdose?
Do not take more Rexulti than prescribed by your doctor. Using more can lead to serious side effects. For a list of possible side effects of Rexulti, see What are the side effects of Rexulti? section above.
What to do if you take too much Rexulti
Call your doctor if you think you have taken too much Rexulti. You can also call 800-222-1222 to contact the American Association of Poison Control Centers or use their online resource.
However, if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.
What to ask your doctor
There are several treatment options for depression and schizophrenia. Rexulti is one option your doctor may discuss with you. For more information on these conditions, see Is Rexulti Used for Depression? and "Is Rexulti used for other conditions?" sections above.
Ask your doctor about the pros and cons of Rexulti treatment and what you can expect when taking it. Here are some questions to help you get started:
And consider reading these articles for more information:
You can also subscribe to the Drink-Drink Depression Newsletter for the latest information on this condition.
Ask a pharmacist
Q:
Should I stop taking Rexulty if I am taking an antibiotic to treat an infection?
Anonymous patient
A:
Maybe. It depends on the antibiotic your doctor prescribes to treat the infection. But most antibiotics can be taken with Rexulti.
Some drugs may increase the effect of Rexulti. These include some antibiotics.
If you have been prescribed an antibiotic that increases the risk of side effects from Rexulti, your doctor may ask you to temporarily stop taking Rexulti until the infection clears up.
Examples of antibiotics that may interact with Rexulti include:
most likely will not interact with Rexulti.
If your doctor or dentist prescribes an antibiotic to treat an infection, make sure they know you are taking Rexulti. They can check for any drug interactions and recommend treatments that are safe for you.
Alex Brewer, PharmD, MBA Answers represent the opinions of our medical experts. All content is for informational purposes only and should not be considered medical advice.
Registration data: Drink-Drink has made every effort to ensure that all information is accurate, complete and up to date. However, this article should not be used as a substitute for the knowledge and experience of a licensed healthcare professional. You should always check with your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or side effects. The absence of warnings or other information for a given medicinal product does not mean that the drug or combination of drugs is safe, effective, or suitable for all patients or for all specific uses.
WHAT YOU SHOULD KNOW ABOUT REXULTI (BREXPIPRAZOLE)!
What is Rexulti?
Rexulti is a medicine known as an atypical antipsychotic used to treat the symptoms of schizophrenia.
Sometimes Rexulti is also prescribed to treat symptoms of depression when antidepressants alone do not relieve symptoms.
When did the Food and Drug Administration (FDA) approve the drug?
Rexulti was first approved by the FDA for the treatment of schizophrenia in 2015.
Is there a universal version of Rexulti?
No, there is currently no generic version available in the US.
Are there any significant differences between Rexulti and other antipsychotics used to treat Rexulti?
Rexulti belongs to a class of drugs known as atypical antipsychotics or second generation psychotics. Atypical antipsychotics usually have fewer side effects than conventional antipsychotics. Talk to your doctor about what is best for you and the cost and benefits of taking medications.
Some people may need to try several different antipsychotics before they find the most effective one with the fewest side effects.
Can children take Rexulti?
The efficacy and safety of the drug has not been tested in patients under 18 years of age. Talk to your child's doctor about the risks of using the medication, which may include increased suicidal thoughts and behavior among those aged 24 years and younger.
Are there potential interaction problems for people taking Rexalti and any other drugs?
What does my dream mean
There are hundreds of medications known to interact with Rexulti mostly, moderately or mildly, so tell your doctor what other medications you are taking before you start taking them. Some of these include antidepressants, antifungals, blood pressure medications, clarithromycin, quinidine, and rifampicin.
Are there any other conditions for which someone is not eligible for Rexulti therapy?
Talk to your doctor about other medical conditions such as dementia, stroke, seizures, neuroleptic malignant syndrome (NMS), diabetes, kidney or liver disease, or tardive dyskinesia before taking Rexulti.
What is the typical dose given to a person taking Rexulti?
A typical starting dose for the treatment of schizophrenia in adults is 1 mg once daily. The maximum recommended dose is 4 mg once daily.
what is Ritalin made of
What should I do if I miss a dose?
Take a dose of Rexulti when you remember, but skip the missed dose if it is almost time for your next dose. You should never take additional doses of medication to make up for missed doses.
What common side effects can Rexulti cause?
General side effects REXULTI may include:
