How does maoi work

Monoamine Oxidase Inhibitors (MAOI) - StatPearls

Continuing Education Activity

Monoamine oxidase inhibitors (MAOIs) are a separate class from other antidepressants, treating different forms of depression and other nervous system disorders such as panic disorder, social phobia, and depression with atypical features. Even though MAOIs were the first antidepressants introduced, they are not the first choice in treating mental health disorders due to several dietary restrictions, side effects, and safety concerns. MAOIs are only a treatment option when all other medications are unsuccessful. This activity will highlight the mechanism of action, adverse event profile, pharmacology, monitoring, and relevant interactions of MAOIs, pertinent for members of the interprofessional team in treating patients with conditions where this drug class has a therapeutic purpose.

Objectives:

Summarize the mechanisms of actions of the MAOI class of drugs.
Identify the approved and off-label indications for MAOI therapy.
Review the adverse event profile of MAOIs.
Outline the importance of collaboration and communication among interprofessional team members to improve outcomes and treatment efficacy for patients who might benefit from MAOI therapy.

Access free multiple choice questions on this topic.

Indications

Monoamine oxidase inhibitors (MAOIs) were first introduced in the 1950s.[1][2] They are a separate class from other antidepressants, treating different forms of depression as well as other nervous system disorders such as panic disorder, social phobia, and depression with atypical features.[3] Examples of atypical features are oversleeping and overeating. Even though MAOIs were the first antidepressants introduced, they are not the first choice in treating mental health disorders due to several dietary restrictions, side effects, and safety concerns. MAOIs are only a treatment option when all other medications are unsuccessful.

Furthermore, examples of neurological disorders that can benefit from MAOIs are patients with Parkinson disease and those diagnosed with multiple system atrophy.[4][5] Multiple system atrophy is a neurodegenerative disease that includes symptoms affecting movement as well as blood pressure.

Mechanism of Action

Monoamine oxidase inhibitors are responsible for blocking the monoamine oxidase enzyme. The monoamine oxidase enzyme breaks down different types of neurotransmitters from the brain: norepinephrine, serotonin, dopamine, and tyramine. MAOIs inhibit the breakdown of these neurotransmitters thus, increasing their levels and allowing them to continue to influence the cells that have been affected by depression.[6]

There are two types of monoamine oxidase, A and B. The MAO A is mostly distributed in the placenta, gut, and liver, but MAO B is present in the brain, liver, and platelets. Serotonin and noradrenaline are substrates of MAO A, but phenylethylamine, methylhistamine, and tryptamine are substrates of MAO B. Dopamine and tyramine are metabolized by both MAO A and B. Selegiline and rasagiline are irreversible and selective inhibitors of MAO type B, but safinamide is a reversible and selective MAO B inhibitor.[7]

MAOIs are reversible or irreversible. Moclobemide is an example of a reversible MAOI I (RIMA), tranylcypromine, phenelzine, isocarboxazid, and selegiline irreversibly inhibit MAO. Selegiline in low doses is a selective, irreversible MAO B inhibitor, but it is no longer selective at higher doses.[8]

Administration

MAOI administration is almost always orally but sometimes comes in the form of a skin patch.[1] The skin patches were FDA approved and can be more beneficial to patients than oral dose forms. An example of this is selegiline, which can be given in a skin patch and causes fewer side effects than oral administration.[1] Patients with lower doses of MAOIs may not have to be as strict with their diet as those with higher doses.

The different types of MAOIs approved by the FDA include isocarboxazid, phenelzine, selegiline, and tranylcypromine. [9] When patients are prescribed antidepressants like MAOIs, they must be aware of the time it takes to start experiencing the therapeutic effects of the drug. Usually, the medication starts to become effective within two to three weeks. However, patients should take the antidepressant for at least six months for the maximal therapeutic benefit. Patients who take an antidepressant for less than six months are shown to have a high symptomatic relapse rate.

Adverse Effects

The most frequently encountered side effects are dry mouth, nausea, diarrhea, constipation, drowsiness, insomnia, dizziness, and/or lightheadedness. Furthermore, if applied via patch, a skin reaction may occur at the patch site.[9] Recommendations are that any patient scheduled for an elective surgery that requires general anesthesia should not take MAOIs for at least ten days before the surgery to avoid any drug interaction.[10][11]

Contraindications

MAOIs can potentially cause drug-to-drug interactions, drug-food interaction, and overdoses, of which the patient should be aware. [9] For example, patients should not be mixing MAOIs with other antidepressants like selective serotonin reuptake inhibitors (SSRIs).[12] These two drugs combined can cause serotonin syndrome, which is potentially fatal. The first cases of serotonin syndrome were reported during the 1960s when patients were on MAOIs and tryptophan. Patients showed signs and symptoms of fever, confusion, increased perspiration, muscle rigidity, seizures, liver or kidney problems, fluctuation of heart rhythms, and blood pressure. Furthermore, when changing MAOIs to another antidepressant, patients should give themselves 14 days to pass before initiating the new treatment, to prevent any drug interaction.

MAOIs prevent the breakdown of tyramine found in the body and certain foods, drinks, and other medications. Patients that take MAOIs and consume tyramine-containing foods or drinks will exhibit high serum tyramine level.[13][14] A high level of tyramine can cause a sudden increase in blood pressure, called the tyramine pressor response. [14] Even though it is rare, a high tyramine level can trigger a cerebral hemorrhage, which can even result in death.

Eating foods with high tyramine can trigger a reaction that can have serious consequences.[14] Patients should know that tyramine can increase with the aging of food; they should be encouraged to have fresh foods instead of leftovers or food prepared hours earlier. Examples of high levels of tyramine in food are types of fish and types of meat, including sausage, turkey, liver, and salami.[15][16] Also, certain fruits can contain tyramine, like overripe fruits, avocados, bananas, raisins, or figs. Further examples are cheeses, alcohol, and fava beans; all of these should be avoided even after two weeks of stopping MAOIs.[16] Anyone taking MAOIs is at risk for an adverse hypertensive reaction, with accompanying morbidity.

Tramadol, meperidine, dextromethorphan, and methadone are contraindicated in patients on MAOIs as they are at high risk for causing serotonin syndrome. [8]

In general, SSRIs, SNRIs, TCAs, bupropion, mirtazapine, St. John's Wort and, sympathomimetic amines, including stimulants, are contraindicated with MAOIs.[8]

Monitoring

Even though MAOIs are no longer a first-line treatment option, they are still in use, and it is essential to note the precautions when initiating treatment.[12] Patients should be encouraged by health providers to carry identification cards or wear a wristband.[9] Patients always need to notify every doctor they encounter, whether dental or medical, to avoid any health consequences, especially due to the medications' influence on the vasculature.

Toxicity

Patients taking MAOIs can overdose and may show similar side effects, as stated above, except with more severe presentation.[17] Anyone on MAOIs may experience symptoms slowly within the first 24 to 48 hours. However, symptoms can be nonspecific, which range from mild to severe to even life-threatening. Depending on the MAOI prescribed, some can cause patients to go into a coma, and others (e. g., overdosing on tranylcypromine) can result in death.[9] The severity depends on the amount consumed and the type of MAOIs the patient took. For example, phenelzine and tranylcypromine being nonselective and nonreversible, increase the risk of a patient experiencing a hypertensive crisis when ingested with tyramine. However, selegiline is a selective MAO-B inhibitor with less hypertensive risk.[4] Any patient experiencing any of the following: agitation, flushing, tachycardia, hypotension or hypertension, palpations, twitching, increased deep tendon reflexes, seizures, or high fevers should immediately report to a health provider.[9]

Enhancing Healthcare Team Outcomes

Safety and optimal treatment are vital to patient health. Patients with a history of seizures or epilepsy should avoid MAOIs; these medications can increase the occurrence of seizures. Also, people with a history of alcoholism, angina, severe headaches, blood vessel disease, diabetes, kidney or liver disease, history of a recent heart attack or stroke, overactive thyroid, and pheochromocytoma should not receive MAOI therapy; since this may cause a hypertensive crisis. [2] This caution is also necessary for patients with a family history of depression, any neurological disorders, or even if any family members have attempted suicide. Due to the high risks, patients must provide a complete family history. Educating the patient on the importance of possible risks and side effects of the drug is critical for their well-being. It provides them an opportunity for a better outcome.

Ads with other illnesses, depression, and other psychiatric treatment plans pose multiple dilemmas for physicians.[17] These patients may need to try various medication regimens before achieving effective treatment. Someone experiencing depression or panic attacks may have significant life changes, and usually, the family physician is aware of these changes. While a psychiatric physician is almost always involved with patients dealing with different types of mental health issues, it is important to consult with an interprofessional group specialist that includes a family physician, internal medicine, specialty-trained mental health nurse, neurologist, and pharmacist. [18] Also, all other health providers involved in the patient's care are vital members of the interprofessional team, for example, other nurses and social workers. Each member provides an essential element to the patient's treatment plan. Evidence has shown that promoting interprofessional communication by consulting specialists can improve the outcome of a patient's health and their adherence to the plan.[19] [Level 5]

Review Questions

Access free multiple choice questions on this topic.
Comment on this article.

References

1.: Culpepper L. Reducing the Burden of Difficult-to-Treat Major Depressive Disorder: Revisiting Monoamine Oxidase Inhibitor Therapy. Prim Care Companion CNS Disord. 2013;15(5) [PMC free article: PMC3907330] [PubMed: 24511450]
2.: Rapaport MH. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: the state of the art. J Clin Psychiatry. 2007;68 Suppl 8:42-6. [PubMed: 17640157]
3.: Thase ME. MAOIs and depression treatment guidelines. J Clin Psychiatry. 2012 Jul;73(7):e24. [PubMed: 22901357]
4.: Volz HP, Gleiter CH. Monoamine oxidase inhibitors. A perspective on their use in the elderly. Drugs Aging. 1998 Nov;13(5):341-55. [PubMed: 9829163]
5.: McFarland NR. Diagnostic Approach to Atypical Parkinsonian Syndromes. Continuum (Minneap Minn). 2016 Aug;22(4 Movement Disorders):1117-42. [PMC free article: PMC5567217] [PubMed: 27495201]
6.: Baker GB, Coutts RT, McKenna KF, Sherry-McKenna RL. Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review. J Psychiatry Neurosci. 1992 Nov;17(5):206-14. [PMC free article: PMC1188458] [PubMed: 1362653]
7.: Müller T, Riederer P, Grünblatt E. Determination of Monoamine Oxidase A and B Activity in Long-Term Treated Patients With Parkinson Disease. Clin Neuropharmacol. 2017 Sep/Oct;40(5):208-211. [PubMed: 28682929]
8.: Thomas SJ, Shin M, McInnis MG, Bostwick JR. Combination therapy with monoamine oxidase inhibitors and other antidepressants or stimulants: strategies for the management of treatment-resistant depression. Pharmacotherapy. 2015 Apr;35(4):433-49. [PubMed: 25884531]
9.: Fiedorowicz JG, Swartz KL. The role of monoamine oxidase inhibitors in current psychiatric practice. J Psychiatr Pract. 2004 Jul;10(4):239-48. [PMC free article: PMC2075358] [PubMed: 15552546]
10.: Saraghi M, Golden LR, Hersh EV. Anesthetic Considerations for Patients on Antidepressant Therapy-Part I. Anesth Prog. 2017 Winter;64(4):253-261. [PMC free article: PMC5715313] [PubMed: 29200376]
11.: Saraghi M, Golden L, Hersh EV. Anesthetic Considerations for Patients on Antidepressant Therapy - Part II. Anesth Prog. 2018 Spring;65(1):60-65. [PMC free article: PMC5841487] [PubMed: 29509514]
12.: Flockhart DA. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: an update. J Clin Psychiatry. 2012;73 Suppl 1:17-24. [PubMed: 22951238]
13.: Brown C, Taniguchi G, Yip K. The monoamine oxidase inhibitor-tyramine interaction. J Clin Pharmacol. 1989 Jun;29(6):529-32. [PubMed: 2666453]
14.: Sathyanarayana Rao TS, Yeragani VK. Hypertensive crisis and cheese. Indian J Psychiatry. 2009 Jan;51(1):65-6. [PMC free article: PMC2738414] [PubMed: 19742203]
15.: Walker SE, Shulman KI, Tailor SA, Gardner D. Tyramine content of previously restricted foods in monoamine oxidase inhibitor diets. J Clin Psychopharmacol. 1996 Oct;16(5):383-8. [PubMed: 8889911]
16.: Sullivan EA, Shulman KI. Diet and monoamine oxidase inhibitors: a re-examination. Can J Psychiatry. 1984 Dec;29(8):707-11. [PubMed: 6394124]
17.: Thorp M, Toombs D, Harmon B. Monoamine oxidase inhibitor overdose. West J Med. 1997 Apr;166(4):275-7. [PMC free article: PMC1304212] [PubMed: 9168689]
18.: Culpepper L. The use of monoamine oxidase inhibitors in primary care. J Clin Psychiatry. 2012;73 Suppl 1:37-41. [PubMed: 22951241]
19.: Agius M, Murphy CL, Zaman R. Does shared care help in the treatment of depression? Psychiatr Danub. 2010 Nov;22 Suppl 1:S18-22. [PubMed: 21057395]

Monoamine Oxidase Inhibitors (MAOI) - StatPearls

Continuing Education Activity

Objectives:

Summarize the mechanisms of actions of the MAOI class of drugs.
Identify the approved and off-label indications for MAOI therapy.
Review the adverse event profile of MAOIs.
Outline the importance of collaboration and communication among interprofessional team members to improve outcomes and treatment efficacy for patients who might benefit from MAOI therapy.

Access free multiple choice questions on this topic.

Indications

Monoamine oxidase inhibitors (MAOIs) were first introduced in the 1950s.[1][2] They are a separate class from other antidepressants, treating different forms of depression as well as other nervous system disorders such as panic disorder, social phobia, and depression with atypical features. [3] Examples of atypical features are oversleeping and overeating. Even though MAOIs were the first antidepressants introduced, they are not the first choice in treating mental health disorders due to several dietary restrictions, side effects, and safety concerns. MAOIs are only a treatment option when all other medications are unsuccessful.

Mechanism of Action

Administration

The different types of MAOIs approved by the FDA include isocarboxazid, phenelzine, selegiline, and tranylcypromine.[9] When patients are prescribed antidepressants like MAOIs, they must be aware of the time it takes to start experiencing the therapeutic effects of the drug. Usually, the medication starts to become effective within two to three weeks. However, patients should take the antidepressant for at least six months for the maximal therapeutic benefit. Patients who take an antidepressant for less than six months are shown to have a high symptomatic relapse rate.

Adverse Effects

The most frequently encountered side effects are dry mouth, nausea, diarrhea, constipation, drowsiness, insomnia, dizziness, and/or lightheadedness. Furthermore, if applied via patch, a skin reaction may occur at the patch site. [9] Recommendations are that any patient scheduled for an elective surgery that requires general anesthesia should not take MAOIs for at least ten days before the surgery to avoid any drug interaction.[10][11]

Contraindications

MAOIs can potentially cause drug-to-drug interactions, drug-food interaction, and overdoses, of which the patient should be aware.[9] For example, patients should not be mixing MAOIs with other antidepressants like selective serotonin reuptake inhibitors (SSRIs).[12] These two drugs combined can cause serotonin syndrome, which is potentially fatal. The first cases of serotonin syndrome were reported during the 1960s when patients were on MAOIs and tryptophan. Patients showed signs and symptoms of fever, confusion, increased perspiration, muscle rigidity, seizures, liver or kidney problems, fluctuation of heart rhythms, and blood pressure. Furthermore, when changing MAOIs to another antidepressant, patients should give themselves 14 days to pass before initiating the new treatment, to prevent any drug interaction.

MAOIs prevent the breakdown of tyramine found in the body and certain foods, drinks, and other medications. Patients that take MAOIs and consume tyramine-containing foods or drinks will exhibit high serum tyramine level.[13][14] A high level of tyramine can cause a sudden increase in blood pressure, called the tyramine pressor response.[14] Even though it is rare, a high tyramine level can trigger a cerebral hemorrhage, which can even result in death.

Eating foods with high tyramine can trigger a reaction that can have serious consequences.[14] Patients should know that tyramine can increase with the aging of food; they should be encouraged to have fresh foods instead of leftovers or food prepared hours earlier. Examples of high levels of tyramine in food are types of fish and types of meat, including sausage, turkey, liver, and salami.[15][16] Also, certain fruits can contain tyramine, like overripe fruits, avocados, bananas, raisins, or figs. Further examples are cheeses, alcohol, and fava beans; all of these should be avoided even after two weeks of stopping MAOIs. [16] Anyone taking MAOIs is at risk for an adverse hypertensive reaction, with accompanying morbidity.

Tramadol, meperidine, dextromethorphan, and methadone are contraindicated in patients on MAOIs as they are at high risk for causing serotonin syndrome.[8]

In general, SSRIs, SNRIs, TCAs, bupropion, mirtazapine, St. John's Wort and, sympathomimetic amines, including stimulants, are contraindicated with MAOIs.[8]

Monitoring

Toxicity

Patients taking MAOIs can overdose and may show similar side effects, as stated above, except with more severe presentation. [17] Anyone on MAOIs may experience symptoms slowly within the first 24 to 48 hours. However, symptoms can be nonspecific, which range from mild to severe to even life-threatening. Depending on the MAOI prescribed, some can cause patients to go into a coma, and others (e.g., overdosing on tranylcypromine) can result in death.[9] The severity depends on the amount consumed and the type of MAOIs the patient took. For example, phenelzine and tranylcypromine being nonselective and nonreversible, increase the risk of a patient experiencing a hypertensive crisis when ingested with tyramine. However, selegiline is a selective MAO-B inhibitor with less hypertensive risk.[4] Any patient experiencing any of the following: agitation, flushing, tachycardia, hypotension or hypertension, palpations, twitching, increased deep tendon reflexes, seizures, or high fevers should immediately report to a health provider.[9]

Enhancing Healthcare Team Outcomes

Safety and optimal treatment are vital to patient health. Patients with a history of seizures or epilepsy should avoid MAOIs; these medications can increase the occurrence of seizures. Also, people with a history of alcoholism, angina, severe headaches, blood vessel disease, diabetes, kidney or liver disease, history of a recent heart attack or stroke, overactive thyroid, and pheochromocytoma should not receive MAOI therapy; since this may cause a hypertensive crisis.[2] This caution is also necessary for patients with a family history of depression, any neurological disorders, or even if any family members have attempted suicide. Due to the high risks, patients must provide a complete family history. Educating the patient on the importance of possible risks and side effects of the drug is critical for their well-being. It provides them an opportunity for a better outcome.

Ads with other illnesses, depression, and other psychiatric treatment plans pose multiple dilemmas for physicians.[17] These patients may need to try various medication regimens before achieving effective treatment. Someone experiencing depression or panic attacks may have significant life changes, and usually, the family physician is aware of these changes. While a psychiatric physician is almost always involved with patients dealing with different types of mental health issues, it is important to consult with an interprofessional group specialist that includes a family physician, internal medicine, specialty-trained mental health nurse, neurologist, and pharmacist.[18] Also, all other health providers involved in the patient's care are vital members of the interprofessional team, for example, other nurses and social workers. Each member provides an essential element to the patient's treatment plan. Evidence has shown that promoting interprofessional communication by consulting specialists can improve the outcome of a patient's health and their adherence to the plan.[19] [Level 5]

Review Questions

Access free multiple choice questions on this topic.
Comment on this article.

References

1.: Culpepper L. Reducing the Burden of Difficult-to-Treat Major Depressive Disorder: Revisiting Monoamine Oxidase Inhibitor Therapy. Prim Care Companion CNS Disord. 2013;15(5) [PMC free article: PMC3907330] [PubMed: 24511450]
2.: Rapaport MH. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: the state of the art. J Clin Psychiatry. 2007;68 Suppl 8:42-6. [PubMed: 17640157]
3.: Thase ME. MAOIs and depression treatment guidelines. J Clin Psychiatry. 2012 Jul;73(7):e24. [PubMed: 22901357]
4.: Volz HP, Gleiter CH. Monoamine oxidase inhibitors. A perspective on their use in the elderly. Drugs Aging. 1998 Nov;13(5):341-55. [PubMed: 9829163]
5.: McFarland NR. Diagnostic Approach to Atypical Parkinsonian Syndromes. Continuum (Minneap Minn). 2016 Aug;22(4 Movement Disorders):1117-42. [PMC free article: PMC5567217] [PubMed: 27495201]
6.: Baker GB, Coutts RT, McKenna KF, Sherry-McKenna RL. Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review. J Psychiatry Neurosci. 1992 Nov;17(5):206-14. [PMC free article: PMC1188458] [PubMed: 1362653]
7.: Müller T, Riederer P, Grünblatt E. Determination of Monoamine Oxidase A and B Activity in Long-Term Treated Patients With Parkinson Disease. Clin Neuropharmacol. 2017 Sep/Oct;40(5):208-211. [PubMed: 28682929]
8.: Thomas SJ, Shin M, McInnis MG, Bostwick JR. Combination therapy with monoamine oxidase inhibitors and other antidepressants or stimulants: strategies for the management of treatment-resistant depression. Pharmacotherapy. 2015 Apr;35(4):433-49. [PubMed: 25884531]
9.: Fiedorowicz JG, Swartz KL. The role of monoamine oxidase inhibitors in current psychiatric practice. J Psychiatr Pract. 2004 Jul;10(4):239-48. [PMC free article: PMC2075358] [PubMed: 15552546]
10.: Saraghi M, Golden LR, Hersh EV. Anesthetic Considerations for Patients on Antidepressant Therapy-Part I. Anesth Prog. 2017 Winter;64(4):253-261. [PMC free article: PMC5715313] [PubMed: 29200376]
11.: Saraghi M, Golden L, Hersh EV. Anesthetic Considerations for Patients on Antidepressant Therapy - Part II. Anesth Prog. 2018 Spring;65(1):60-65. [PMC free article: PMC5841487] [PubMed: 29509514]
12.: Flockhart DA. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: an update. J Clin Psychiatry. 2012;73 Suppl 1:17-24. [PubMed: 22951238]
13.: Brown C, Taniguchi G, Yip K. The monoamine oxidase inhibitor-tyramine interaction. J Clin Pharmacol. 1989 Jun;29(6):529-32. [PubMed: 2666453]
14.: Sathyanarayana Rao TS, Yeragani VK. Hypertensive crisis and cheese. Indian J Psychiatry. 2009 Jan;51(1):65-6. [PMC free article: PMC2738414] [PubMed: 19742203]
15.: Walker SE, Shulman KI, Tailor SA, Gardner D. Tyramine content of previously restricted foods in monoamine oxidase inhibitor diets. J Clin Psychopharmacol. 1996 Oct;16(5):383-8. [PubMed: 8889911]
16.: Sullivan EA, Shulman KI. Diet and monoamine oxidase inhibitors: a re-examination. Can J Psychiatry. 1984 Dec;29(8):707-11. [PubMed: 6394124]
17.: Thorp M, Toombs D, Harmon B. Monoamine oxidase inhibitor overdose. West J Med. 1997 Apr;166(4):275-7. [PMC free article: PMC1304212] [PubMed: 9168689]
18.: Culpepper L. The use of monoamine oxidase inhibitors in primary care. J Clin Psychiatry. 2012;73 Suppl 1:37-41. [PubMed: 22951241]
19.: Agius M, Murphy CL, Zaman R. Does shared care help in the treatment of depression? Psychiatr Danub. 2010 Nov;22 Suppl 1:S18-22. [PubMed: 21057395]

how to use the application to pay taxes

Ekaterina Miroshkina

economist

Author profile

To become self-employed, it is enough to have a smartphone. You don’t have to go to the tax office, write an application and pay something.

The mobile application "My Tax" is available for the self-employed. It is necessary for those who want and can use the new special regime "Tax on professional income".

If you don't know what it is yet, read our articles:

What is the self-employed tax.
How the professional income tax deduction works.
How to use special mode in different situations.
45 questions with short answers.
Difficult questions on NAP.
10 myths you can't believe.
Duties of the self-employed.
Self-employed rights.

The Professional Income Tax Act came into force on January 1, 2019. In order to pay tax at preferential rates and work without a cash desk, you need to register - for this you need the My Tax application and a self-employed person's personal account.

Source:: Federal Tax Service

Here is the most detailed instruction on how to use all this.

What is the application "My tax" and how it works

"My tax" is an official application from the Federal Tax Service. Through it, the self-employed remotely interacts with the tax office.

The mobile application replaces the cash register and all reporting. Through it, self-employed people can register, accept payments from clients, generate checks and invoices, pay taxes, and request certificates from the tax office. There you can also apply to the pension fund and voluntarily pay insurance premiums to accrue pension points.

Analytics tools are available in the My Tax application to evaluate your activities. For example, you can track how income has changed over the past months.

The app is available on Epstore and Google Play. Don't run into scammers: there are already fake apps on the Internet. Here are the correct links from the Federal Tax Service:

"My tax" in Epstore.
"My tax" in Google Play.

How to register as self-employed

Only those who apply through the application or web office and receive confirmation from the tax office will be able to apply the new special regime "Tax on professional income". You don’t need to fill out any paperwork and submit it to the tax office - everything is only via the Internet. There is no state duty for registration.

Through the My Tax application there are two ways to register - with a passport and with the help of a taxpayer's personal account. To register through your personal account, you will need a TIN and a password that is given in the tax office - you enter it to check property taxes. To register according to the document, you need to take a photo of your passport, take a selfie and send an application to the tax office for registration.

How to get a password from personal account

Registration through personal account will be faster, but you can also use your passport

The system will offer to confirm the phone number using the code from SMS. Without a code, the number will not be confirmed and registration will not pass. If you are already registered as self-employed, then after entering your phone number you will automatically be taken to your personal account.

Confirm phone number

Then select a region. It does not take into account the place of residence, but the place of business. You can live in Orel, and provide services to a customer from Moscow. Professional income tax is valid throughout Russia. You decide which region to choose, but there should be only one.

Specify the place of business

You don’t have to enter data, the application will scan documents itself and fill out application

Specify the place of business You don't have to enter data, the application will scan documents and fill out the application itself

Point the camera at the spread with the photo so that everything is readable

Check the data in the application for registration. If orange labels appear, they can be corrected manually. Sometimes you have to scan documents again

Point the camera at the photo spread so that everything is readable Check the data in the application for registration. If orange labels appear, they can be corrected manually. Sometimes you have to scan documents again Take a selfie without a hat and glasses and blink at the camera. Now your photo will be checked against your passport. If the photo is not recognized, you need to repeat everything. Sometimes you need to take a photo three times - be patient If the registration is successful, you will receive an SMS message and an notification will appear in the application If the registration is successful, you will receive an SMS message and an notification will appear in the application

Then confirm the registration. If you agree, you will now become self-employed. At the very least, get access to the app's features: you can send checks and keep track of tax accruals.

You are one step away from legal work without a cash register and declarations. You can not confirm anything, then there will be no registration If the registration is successful, an SMS message will come and a notification will appear in the application If the registration is successful, an SMS message will come and a notification will appear in the application

You also need to enter a PIN for access. Next, set up fingerprint or face ID login, depending on your phone. But this does not affect the operation of the application.

You can also register in the application with an account on public services.

Sometimes, after registration, a message appears that you have test access. This means that the tax checks the data. She has six days to do so. But checks can be generated and sent to customers right now. Keep an eye on the status: if something goes wrong, registration may be denied.

/guide/kak-stat-samozanyatym/

How to become self-employed

Through the web office for self-employed. The nalog.ru website has a taxpayer's personal account, which everyone already knows about. But - attention! - this is not the personal account through which the self-employed register. They have their own service and a separate personal account.

Here is the correct link for access and registration: https://lknpd. nalog.ru/

Through the web office, you can register only by TIN and password. You can't with a passport. But this option is suitable for those who do not have a smartphone or who do not want to download the application. The personal account for the special regime "Tax on professional income" is available from a desktop computer, even if you have a push-button telephone. The My Tax app won't come in handy here.

When registering through the site, you also need to confirm your phone number and select a region.

You can register through the application, and send checks through the site - and vice versa. When you become self-employed, you can use any service. Income information is also available everywhere.

Registration with a password for public services is also available in the web account. If you have a verified account, you can use it to enter your personal account. But here you need to be very careful: at the first authorization in this way, automatic registration as a self-employed person will occur.

In the web account of the self-employed, everything is the same as in the application

Options for entering the personal account

By login and password. The TIN of the self-employed person serves as the login. Enter the password that is used in the personal account of an individual on the website of the Federal Tax Service. There is no separate password for the self-employed.

By phone number. Enter the phone number that you provided when registering self-employment. It will receive a message with a confirmation code.

Through public services. For access, you will need a login and password from a public services account.

How to reset your password if you forgot it. The web account does not have the usual "Recover password" button, because you enter using your phone number or password from the account of an individual or public services. Therefore, one of them will have to be restored.

How to use the My Tax application

Register, accept payments, receive notifications, generate certificates, pay taxes - all this can be done remotely through the My Tax mobile application. Next, we will tell you more about its capabilities.

How to issue an invoice

According to the invoice, the customer or buyer transfers money to a self-employed person and takes the transfer into account in his accounting. First of all, legal entities request invoices, since they have more requirements for accounting.

To issue an invoice, select the "New Sale" section on the main page of the application. Then enter the name of the service or product, as well as the cost in rubles.

If you are invoicing to an individual, please provide your full name and email address. If an individual entrepreneur or legal entity, enter its TIN and the name of the organization

The invoice can be saved in PDF format or printed directly on paper

How to generate and send a check

You need to generate a check for each receipt from customers. How you got the money doesn't matter. To a bank account, in cash or on a card - it's up to you. You create the check yourself.

This must be done through the application or on the website.

Click the "New Sale" button Specify the amount, who paid for what. If the money is from a company or individual entrepreneur, you must specify the TIN. Indicate the amount, who paid for what and for what. If the money is from a company or individual entrepreneur, you must specify TIN

Choose a descriptive name for the service or product you are selling. Not “For an apartment”, but “For renting an apartment from January 1 to January 31”. This is important for both you and the client.

You can send a check in any way. For example, print it on paper and hand it in person or send it in a messenger.

Send a check by SMS or email to the customer. Or let me read the QR code from your phone. At the same time, the tax office will also receive this check

How to cancel a check

If there is an error in the check or the client had to return the money, the check can be canceled or corrected. The adjustment is carried out by reissuing a check: first you cancel the old one, and then generate a new one for the same date. Simply making changes to an already generated receipt will not work.

The terms within which checks can be canceled are not specified in the law.

In the My Tax application, you can cancel any check - starting from the day you registered self-employment. You can also create checks retroactively: the system will allow.

The program cancels the check, recalculates the amount of income and tax from it. The result will immediately be displayed in your personal account. The check will still be visible with a note that it has been canceled

How to find out how much tax has been accrued

You do not need to calculate taxes yourself. Everything happens automatically. The rate depends on who you indicated on the check. If the money came from an individual, the tax will be charged at a rate of 4%. From a company or individual entrepreneur - at a rate of 6%. Taking into account the deduction of the bets, they come out less, but all this is also considered without your participation.

You can immediately see the accrued tax in the application or in your personal account. That is, you do not have to wait for the next month - you can immediately monitor how much money you have to pay to the budget from each sale.

All checks and accrued taxes are visible in the application

Provisional charges from each sale are displayed immediately, and not only at the end of the month

All receipts and taxes are visible in the app Provisional charges for each sale are displayed immediately, not just at the end of the month

Provisional tax is what you accrued during the month. You do not need to pay this amount right away. The payment deadline is the 25th of the following month.

So what? 09/23/19

How to confirm income for the self-employed when applying for a loan

Debt is something that it was time to pay. Penalties are charged on this amount.

How to pay taxes through "My tax"

The application will automatically calculate the final payment amount no later than the 12th day of the next month. You will receive a notification about the need to pay off the debt.

Tax can be paid in two ways:

Directly in the application using a bank card.
Generate a payment order and pay tax at any bank.

How to confirm the status of self-employed

For this, a separate certificate is generated - also in the My Tax application or on the website from a computer. On the part of the tax inspectorate, it is signed with an electronic signature and has the same legal force as a paper one.

In the web office, it is already possible to generate a certificate. This is confirmation that you are self-employed. The same can be done from the phone.

To generate help, go to the "Other" section and click on the "Help" button

Certificate of registration as self-employed

All checks and accrued taxes are visible in the application Certificate of registration as self-employed

How to link a card in the application

You can link your bank card to the My Tax application. In this case, you will not have to constantly enter details - and every month the tax amount will be deducted automatically. The card can be unlinked at any time.

To link a bank card, go to the "Other" section and click on the "Payments" button

How to withdraw money from the application

It is impossible to withdraw money from the application: money is not stored there to withdraw it from there. There is no wallet there and is not provided. The application is designed for the interaction of the self-employed with the tax office and clients: take into account income, calculate and pay tax, generate receipts.

You can only link a card to pay tax, but the money from this card will not go to "My tax".

How to close self-employment in the application

Deregistration is possible for two reasons:

If you refuse to apply this tax regime. Then an application is required.
If you are on the list of those who are not eligible to use it. In this case, the tax authority removes the taxpayer from the register on its own initiative, without an application, and notifies him of this through the My Tax application. Taxes will have to be paid in other regimes. An individual entrepreneur, for example, has only 20 days to choose another special mode. You don’t automatically switch to simplified taxation - you can suddenly find yourself on the general taxation system and get on VAT.

You can terminate registration on your own initiative directly in the My Tax application or in your web account. To do this, in the "Profile" section, click the "Remove from the VAT register" button.

After deregistration, accrued taxes for the entire period of work will still have to be paid. If you have no income, then there will be no tax. You don't have to pay fees for this period either. Therefore, deregistration only due to a break in work is not necessary.

But you can register, then withdraw, then register again - at least every month. The registration procedure will be the same as the first time.

The system will prompt you to select the reason for deregistration: voluntary refusal or loss of the right to use the NAP

What to do if the application does not work

If something is wrong with the application due to technical work, a receipt can be generated the next day after how to fix everything. Technical work will be reported on the website of the Federal Tax Service.

If the application is running, but there is no Internet access, you can still generate a check - it will be sent later.

How to register an individual entrepreneur through the My Tax application

You cannot register an individual entrepreneur through this application. IP status must be obtained in the usual manner - upon application. And also close it.

You can work on the new special regime "Tax on professional income" both as an individual entrepreneur and as an individual. Nobody pays dues.

/ip-vse/

How to close IP

I don't have a smartphone or computer.

How to work in this mode?

Alas, no way. You won't be able to use this tax regime without a smartphone, computer and the Internet.

There is another My Tax app in Epstore and Google Play. Does it fit too?

No, no other applications, other than those listed in the links in our article, are suitable for working under the new tax regime. Even if you are somehow registered there, you will not become self-employed and will not receive benefits. It is possible that some money will even be written off from you, but they will not fall into the budget. The situation is the same with applications that have similar names and logos.

So what? 07.04.20

Self-employed people can pay pension contributions through the My Tax app

The Federal Tax Service has launched a special website on professional income tax. If in doubt, look for all the links there.

How My District, Business and Home modes work

Choose the area or direction where you want to fulfill orders, and Yandex Pro can pick up orders there.

My District

Many drivers are more comfortable fulfilling orders in an area they know well. The "My Area" mode will help with this. It allows you to select an area for orders: both point A and point B will be inside it.

"My Area" is useful if you want to work for a short time in an area from which you don't want to travel far - for example, close to home. Or you can turn on the mode at the end of the day so that you definitely do not receive a long order before you are about to leave the line.

Be careful:

How to turn on

Scroll the pictures left and right with your fingers or arrows.

Features of My District

All orders - only in the area on the map you select.
Inside the zone there will be both the start and end points of the route - you will see it before you accept the order.
The service commission is higher than for regular orders.
"My District" with a commission is available in the "Effective" income mode. In it, during the current shift, the commission for "My District" is not reset to zero.
With a valid promotional code for orders without a service commission in Effective, the commission for My District is reset to zero.
"My Area" is not available in the "Flexible" income mode.
Bonuses do not work in My District, including travel goals.

How many hours a day you can use "My District"

The number of hours varies in different cities. Yandex Pro will tell you how much time is left for today. Testing showed that drivers who used the mode for a long time had less income per day than they could have been.

Why card bonuses and income guarantee do not work in My Neighborhood

In the many short trips mode: bonuses for drivers who use My Neighborhood will be much higher than those who simply fulfill orders.

"Home" and "Business"

Sometimes you need to receive orders in a certain direction. For such cases, there are "Home" and "Business" modes. They can indicate the address in which direction you will go. Then the system will start looking for orders that will end in the direction you need.

In the "Home" and "Business" modes, Yandex Pro may not find an order that best suits your route. For example, point B in such an order will be on your way, and point A, on the contrary, will not be on your way, and in order to pick up the user, you will have to deviate greatly from the route

Therefore, if you are in a hurry or you need to be on business or at home at exactly appointed time, it is better to leave the line. To do this, click on the yellow circle at the top left of the main screen. The circle will turn gray and the "Busy" status will turn on - then orders will not be received. You can return to them at any time when you finish your business.

Business mode is suitable for cases when you need to go to a specific area of the city. In some cities, it can be turned on as many times as you like, in others - 2 times a day for drivers with a Platinum level in the privilege program and 1 time for everyone else.
Home mode can be used up to twice a day. In it, Yandex Pro will start looking for orders in the direction of your home address.

In Yandex Pro, you will always find out how many times before the end of the day you can use the "Home" and "Business" modes. This will be visible if you pull up the curtain on the screen with the map.

How to work with addresses

Addresses that you often visit can be easily saved in each mode so that you do not have to enter them every time. But not all addresses may be available - for example, you won't be able to select an airport.

Learn more