Can guaifenesin cause heart palpitations

Side Effects, Dosage, Precautions, Uses

1. Is Guaifenesin safe?

Yes, Guaifenesin is generally a safe oral expectorant. It is considered the first line of treatment for cough, as the side effects are very rare. No severe allergic reaction has been seen with the use of Guaifenesin if taken under the recommended dosage.

2. Is Guaifenesin safe for heart patients?

Guaifenesin is generally safe for heart patients. This drug is not known to elevate blood pressure. If an overdose of Guaifenesin is taken, it may cause severe effects on the heart and increase heart rate. For heart patients or any previous history of cardiac illness, take the drug under medical supervision.

3. Does Guaifenesin make you cough more?

Guaifenesin will not cause severe and frequent coughing but can cause your cough to be productive (cough with phlegm or mucus). The drug helps to thin the secretion from your lungs and loosen the mucus. This effect can result in a productive cough that aims to clear excessive secretions from the airways.

4. Does Guaifenesin keep you awake?

No, Guaifenesin usually does not keep you awake. But in some individuals, it is reported that it is harder for them to sleep after intake of Guaifenesin, which is not a common side effect of this drug. If you experience this, you are advised to take the recommended dose in the morning and early afternoon. Never take the dose too close to bedtime.

5. Is Guaifenesin safe for pregnancy?

Guaifenesin can be used during pregnancy if your doctor recommends it. But it should be avoided during the first trimester. Experts highly recommend that Guaifenesin formulation be alcohol-free and not be used too frequently by pregnant women.

6. When to take Guaifenesin for fertility?

The scientific study on Guaifenesin for fertility needs more validation. It is not clear that thinning of cervical mucus alone can make you fertile. So based on the theory, if you want to try Guaifenesin for fertility, you may start taking it just before you are due to ovulate. Get in touch with our medical experts at Yashoda Hospitals to learn more about Guaifenesin and fertility.

7. Who should not take Guaifenesin?

  • Children under the age of 4
  • People with persistent chronic cough due to tobacco smoking, asthma or emphysema
  • People with chronic bronchitis or significant respiratory depression
  • Guaifenesin can alter the urine laboratory test; discontinue its intake at least 48 hours before the collection of urine
  • If you are pregnant or breastfeeding, you should talk to your doctor about whether or not to take Guaifenesin

8. Is it okay to take Guaifenesin every day?

Cough medicines are usually taken for a short time until your symptoms clear up. In patients with chronic respiratory symptoms or chronic bronchitis, Guaifenesin is advisable for long term use in a recommended dosage. This medicine has contributed to a rapid improvement in the symptoms. However, always seek advice from a physician for long-term use. Regular visits to your doctor are necessary to screen for side effects.

9. Does Guaifenesin dry up mucus?

No, Guaifenesin does not dry up mucus; it only loosens or thins the mucus already present in the respiratory tract. It increases the volume of bronchial secretions and decreases the mucus viscosity. So this makes it easier to expel mucus or phlegm by coughing.

10. Is Guaifenesin bad for kidneys?

Guaifenesin is generally a safe cough medication to take in patients with kidney disease. However, it is essential to remember that you must take only the recommended dosage per day. If you are suffering from existing renal impairments, it is always advisable to seek a doctor's suggestion.

Common and Rare Side Effects for Guaifenesin DAC

COMMON side effects

If experienced, these tend to have a Severe expression i

Sorry, we have no data available. Please contact your doctor or pharmacist.

If experienced, these tend to have a Less Severe expression i

  • constipation
  • drowsiness
  • inducing of a relaxed easy state
  • excessive sweating
  • nausea
  • vomiting
  • stomach cramps
  • difficulty sleeping
  • headache
  • INFREQUENT side effects

    If experienced, these tend to have a Severe expression i

  • orthostatic hypotension, a form of low blood pressure
  • low blood pressure
  • a complete or partial collapse of the lung airways called atelectasis
  • decreased lung function
  • trouble breathing
  • abnormal nervous system function affecting alertness
  • If experienced, these tend to have a Less Severe expression i

  • a change in vision
  • dry mouth
  • fainting
  • dizziness
  • decreased appetite
  • headache
  • heart throbbing or pounding
  • decreased urine production
  • nervousness
  • generalized weakness
  • feelings of dissatisfaction, sadness, and unease
  • agitation
  • drowsiness
  • muscle tremors
  • loss of skin color
  • nausea
  • difficult or painful urination
  • fast heartbeat
  • RARE side effects

    If experienced, these tend to have a Severe expression i

  • decreased function of the adrenal gland
  • deficiency of a substance that promotes masculinization
  • dependence on opioid-type drugs
  • addiction to a drug
  • complete stoppage of the heart
  • slow heartbeat
  • lung failure causing loss of breath
  • blocked bowels with decreased peristaltic movement
  • seizures
  • sleep apnea
  • a condition where the body is unable to maintain adequate blood flow called shock
  • a significant type of allergic reaction called anaphylaxis
  • accidental falls
  • pancreatitis
  • high blood pressure
  • insufficient blood supply to the colon
  • hallucinations
  • trouble breathing
  • vomiting
  • a type of skin disorder called acute generalized exanthematous pustulosis
  • If experienced, these tend to have a Less Severe expression i

  • an extreme sense of wellbeing called euphoria
  • depression
  • widening of blood vessels
  • irritation of the stomach or intestines
  • spasm of a bile duct tract
  • the inability to have an erection
  • sensation of spinning or whirling
  • difficulty sleeping
  • low energy
  • temporary redness of face and neck
  • diarrhea
  • anxious feelings
  • nausea
  • vomiting
  • over excitement
  • indigestion
  • excessive sweating
  • heart throbbing or pounding
  • Full Drug Information

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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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    instructions for use, home delivery


    Round, flat-cylindrical tablets, white or almost white, with a bevel and one-sided notch.

    Active substances

    Bromhexine + Gweifenzin + Salbutamol

    Form of release


    BROMGEKB drug contains:

    Acting substances are Bromhekenzin, Habeaphenin and Salbutamol. nine0005

    Each tablet contains 8 mg bromhexine (as hydrochloride), 100 mg guaifenesin, 2.41 mg salbutamol (as sulfate), corresponding to 2 mg salbutamol.

    The other ingredients (auxiliaries) are calcium hydrogen phosphate, corn starch, colloidal silicon dioxide, magnesium stearate, talc.

    Pharmacological effect

    Combined expectorant

    BromgeComb is a combined preparation containing fixed doses of bromhexine, guaifenesin and salbutamol. nine0005

    The action of the drug BromgeComb is due to the effects of its components: salbutamol expands the bronchi and facilitates breathing, bromhexine and guaifenesin contribute to liquefaction of sputum and facilitate its expectoration.


    BromgeComb is used in adults and children over 6 years of age for the symptomatic treatment of productive (wet) cough associated with various diseases of the respiratory system, including:

  • acute bronchitis (inflammation of the bronchi), including tracheobronchitis, nine0049
  • acute bronchitis due to respiratory viruses,
  • chronic bronchitis not otherwise specified,
  • chronic obstructive pulmonary disease,
  • asthmatic bronchitis,
  • pneumonia (pneumonia).

    If there is no improvement or if you feel worse after 4-5 days, you should consult a doctor.

  • Contraindications

    Do not take BromgeComb:

  • if you are allergic (hypersensitive) to bromhexine and/or guaifenesin and/or salbutamol or any of the other ingredients of this medicine (listed in section 6 of this leaflet),
  • if you are pregnant or breastfeeding,
  • if you have tachyarrhythmia (fast heart rate) or myocarditis (inflammation of the heart muscle),
  • if you have a heart disease (including a narrowing of the aorta, called aortic stenosis),
  • if you have decompensated diabetes mellitus,
  • if you have thyrotoxicosis (hyperthyroidism),
  • if you have glaucoma (increased intraocular pressure),
  • if you have liver and/or kidney failure,
  • if you have gastric and/or duodenal ulcers in the acute stage,
  • if you have stomach bleeding.

    Children and adolescents

    BromgeComb is not intended for use in children under 6 years of age.

  • Precautions

    Talk to your doctor or pharmacist before taking BromgeComb, especially if you have: . You need to tell your doctor if you develop chest pain or shortness of breath while taking BromgeComb, as these may be signs of myocardial ischemia (insufficient supply of oxygen to the heart muscle) associated with salbutamol,

  • difficulty urinating with prostate adenoma,
  • diabetes mellitus,
  • peptic ulcer of the stomach or duodenum.
  • Use in pregnancy and lactation

    If you are pregnant or breastfeeding, think you may become pregnant or plan to become pregnant, consult your doctor before using this medicine.

    BromgeComb is contraindicated during pregnancy and during breastfeeding. nine0005

    Dosage and Administration

    Always take your medicine exactly as directed in this package leaflet or as advised by your doctor or pharmacist. If in doubt, ask your doctor or pharmacist for advice.

    Recommended adult dose

    1 tablet 3 times a day.

    Recommended doses for children and adolescents

    Children over 12 years old - 1 tablet 3 times a day.

    Children aged 6 to 12 years - 1/2 or 1 tablet 3 times a day. nine0005

    Route and/or route of administration

    For oral administration.

    Duration of therapy

    Do not take the drug for more than 4-5 days.

    If you forget to take a tablet of BromgeComb

    If you forget to take a dose of the drug, take it as soon as you remember. However, if it is almost time for the next dose, skip the forgotten dose. Take your next dose at the usual time. Do not take a double dose to make up for a missed dose. nine0005

    If you have any questions about the use of this medicine, ask your doctor or pharmacist.

    Side effects

    Like all medicines, BromgeComb can cause side effects, although not everyone gets them.

    Serious adverse reactions

    Stop taking the drug immediately and contact your doctor if you notice any of the following serious adverse reactions:

    Very rare - may affect up to 1 in 10,000 people:

  • hypersensitivity reactions such as angioedema (rapid swelling of the skin, subcutaneous tissue, mucous or submucosal membranes), urticaria (white or red, swollen, itchy skin rash), bronchospasm (difficulty breathing), hypotension and collapse (a sudden drop in blood pressure),
  • 0049
  • muscle cramps.

    Unknown (frequency of occurrence cannot be estimated from the available data):

  • severe skin reactions (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis and acute generalized exanthematous pustulosis),
  • exacerbation of gastric and duodenal ulcers , the signs of which may be pain in the upper abdomen on an empty stomach or immediately after eating, heartburn, nausea, vomiting. nine0002 Other adverse reactions

    Tell your doctor if you notice any of the following adverse reactions:

    Very common - may affect more than 1 in 10 people:

  • involuntary rapid movements of parts of the body or the whole body (tremor).

    Common - may affect up to 1 in 10 people:

  • trembling of the hands (small-scale tremor), which may interfere with work requiring precise hand movements,
  • palpitations (tachycardia),
  • headache,
  • tension, anxiety.

    Rare - may affect up to 1 in 1,000 people:

  • irregular heartbeat (arrhythmias, including atrial fibrillation, supraventricular tachycardia and extrasystoles),
  • peripheral vasodilation,
  • hyperactivity in children.

    Very rare - may affect up to 1 in 10,000 people:

  • feeling of muscle tension,
  • increased motor activity and excessive excitability (hyperactivity). nine0002 Not known (frequency cannot be determined from available data):

  • insufficient supply of oxygen to the heart muscle (myocardial ischemia),
  • nausea, vomiting, diarrhea and upper abdominal pain,
  • rash, itching,
  • staining of urine in pink.

    Call your doctor right away if you have any side effects not listed in this package insert.

    Reporting adverse reactions

    If you experience any adverse reactions, talk to your doctor or pharmacist. This recommendation applies to any possible adverse reactions, including those not listed in this package insert. You can also report adverse reactions directly (see below). By reporting adverse reactions, you help to get more information about the safety of the drug.

  • Overdose

    If you took more BromgeComb than you should have

    If you (or your child) accidentally take more BromgeComb tablets than you should, contact your doctor immediately.

    Overdose symptoms include:

  • drowsiness,
  • nausea and vomiting (mainly in children),
  • abdominal discomfort,
  • hyperactivity,
  • tachycardia (rapid heartbeat or rapid body movements),
  • voluntary movements whole body),
  • low blood potassium: muscle twitching or weakness, irregular heartbeat,
  • increased level of lactate (lactic acid) in the body: rapid heartbeat, nausea, abdominal pain,
  • increased level of glucose (sugar) in the blood,
  • increased number of ketone bodies in the body (ketoacidosis) in diabetics.
  • Interactions with other drugs

    Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. nine0005

    In particular:

    diuretics, guanethidine, reserpine or methyldopa (to treat high blood pressure),

    tricyclic antidepressants or monoamine oxidase inhibitors (to treat depression),


    if you require dental or surgical intervention),

    drugs for the treatment of diabetes,

    digoxin (for the treatment of heart disease),

    beta-blockers such as propranolol,

    methylxanthines such as theophylline (for the treatment of diseases of the respiratory system).

    When taken simultaneously, Bromhexine, which is part of the drug BromgeComb, promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue.

    BromgeComb should not be taken concomitantly with drugs that suppress coughs, as this makes it difficult to expectorate thin sputum, as well as with combination cold medicines. nine0005

    Some drugs (diuretics, digoxin, methylxanthines, glucocorticosteroids) may increase the risk of hypokalemia, a condition in which there is a low level of potassium in the blood (see sections 3 and 4). This condition can lead to cardiac arrhythmias. If you are taking any of these medicines, please consult your doctor before taking BromgeComb.

    Special instructions

    Very rare cases of severe skin reactions associated with the use of bromhexine have been reported. If you develop a skin rash (including sores on mucous membranes such as the mouth, throat, nose, eyes, or genital area), stop taking BromgeComb and contact your doctor immediately. nine0005

    Guaifenesin can color urine pink and also distort laboratory tests (5-hydroxyindoleacetic and vanillylmandelic acids can be detected in urine).

    Long-term use of high doses of BromgeComb may cause the formation of kidney stones.

    Read this leaflet completely before taking this medicine because it contains important information for you.

    Keep the leaflet. You may need to read it again. nine0005

    If you have any further questions, ask your doctor or pharmacist.

    The drug has been prescribed specifically for you. Do not pass it on to other people. It can harm them even if their symptoms are the same as yours. If you experience any adverse reactions, contact your doctor or pharmacist. This recommendation applies to any possible adverse reactions, including those not listed in section 4 of the package insert. nine0005

    Influence on the ability to drive vehicles. cf. and fur.:

    Considering the possibility of developing adverse reactions during treatment with the drug (for example, dizziness, drowsiness and others), it is recommended to refrain from activities that require increased concentration of attention and speed of reactions, including driving vehicles and working with mechanisms.

    Storage conditions

    Keep the drug out of the reach of the child so that the child could not see it. nine0005

    Store at temperatures below 25 °C in the original packaging (blister pack in a pack).



    Bromhexine + Guaifenesin + Salbutamol

    Dosage form


    Composition per 1 ml:

    Active ingredients:

    • Salbutamol sulfate - 0.24 mg nine0049
    • corresponds to salbutamol - 0.2 mg
    • Bromhexine hydrochloride - 0.4 mg
    • Guaifenesin - 10 mg


    • Sucrose (sugar) - 500 mg
    • Sorbitol (70% solution) - 263 mg
    • Glycerol (glycerin) - 125 mg nine0049
    • Propylene glycol - 62 mg
    • Sodium benzoate - 2 mg
    • Citric acid monohydrate - 2. 4 mg
    • Sorbic acid - 1 mg
    • Dye sunset yellow (FCF) - 0.028 mg
    • Levomenthol (menthol) - 0.1 mg
    • Blackcurrant flavor - 3 mg nine0049
    • Flavoring pineapple - 1 mg
    • Purified water - up to 1 ml


    Transparent viscous orange liquid with a characteristic odor. Slight opalescence is allowed.

    Pharmacotherapeutic group: combined expectorant.

    ATX code nine0372 : R05C

    Pharmacological properties

    The combined drug has a bronchodilator, expectorant and mucolytic effect. Salbutamol is a bronchodilator that stimulates beta 2 - adrenoreceptors of the bronchi, blood vessels and myometrium. Prevents or eliminates bronchospasm, reduces resistance in the airways, increases the vital capacity of the lungs. Causes expansion of the coronary arteries, does not lower blood pressure. Bromhexine is a mucolytic agent. It has an expectorant effect, improves sputum discharge. Guaifenesin is a mucolytic agent that reduces the surface tension of the structures of the bronchopulmonary apparatus; stimulates the secretory cells of the bronchial mucosa that produce neutral polysaccharides, depolymerizes acid mucopolysaccharides, reduces the viscosity of sputum, facilitates the removal of sputum and promotes the transition of an unproductive cough into a productive one. nine0005


    Salbugamol: when taken orally, absorption is high. Food intake reduces the rate of absorption, but does not affect bioavailability. Communication with plasma proteins - 10%. Penetrates through the placenta.

    It undergoes first pass metabolism in the liver and in the intestinal wall, by means of phenol sulfotransferase it is inactivated to 4-o-sulfate ester. The half-life (T1 / 2) is 3.8-6 hours. It is excreted by the kidneys (69-90%), mainly as an inactive phenol sulfate metabolite (60%) for 72 hours and with bile (4%). The bioavailability of orally administered salbutamol is about 50%. nine0005

    Bromhexine: when taken orally, it is almost completely (99%) absorbed in the gastrointestinal tract (GIT) within 30 minutes. Bioavailability is low (the effect of the primary "passage" through the liver). Penetrates through the placental and blood-brain barriers. In the liver, it undergoes demethylation and oxidation, and is metabolized to the pharmacologically active ambroxol. T1 / 2 - 15 hours (due to slow reverse diffusion from tissues). Excreted by the kidneys. In chronic renal failure, excretion of metabolites is impaired. With repeated use, it can accumulate. nine0005

    Guaifenesin: absorption from the gastrointestinal tract is fast (25-30 minutes after ingestion). T1 / 2 - 1 hour Penetrates into tissues containing acid mucopolysaccharides.

    Approximately 60% of the administered drug is metabolized in the liver. It is excreted by the lungs (with sputum) and by the kidneys both unchanged and in the form of inactive metabolites.

    Indications for use

    As part of the combined therapy of acute and chronic bronchopulmonary diseases, accompanied by the formation of a difficult-to-separate viscous secretion: nine0005

    • bronchial asthma;
    • tracheobronchitis;
    • obstructive bronchitis;
    • pneumonia;
    • emphysema;
    • whooping cough;
    • pneumoconiosis;
    • pulmonary tuberculosis, etc.

    Contraindications nine0004

    • hypersensitivity to the components of the drug;
    • pregnancy, breastfeeding period;
    • tachyarrhythmia, myocarditis;
    • heart defects;
    • decompensated diabetes mellitus;
    • thyrotoxicosis;
    • glaucoma;
    • liver or kidney failure; nine0049
    • peptic ulcer of the stomach and duodenum in the acute stage;
    • children's age up to 2 years;
    • sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.

    Carefully prescribed to patients with diabetes mellitus, arterial hypertension, peptic ulcer of the stomach and duodenum in remission, hyperthyroidism, severe diseases of the cardiovascular system; with diseases of the bronchi, accompanied by excessive accumulation of secretions; children's age from 2 to 6 years; should not be used in combination with beta-blockers. nine0005

    Use during pregnancy and during breastfeeding

    The drug is contraindicated during pregnancy and during breastfeeding.

    Dosage and administration

    inside. Adults and children over 12 years of age are prescribed 10 ml (2 teaspoons) 3 times / day. Children aged 2 to 6 years - 5 ml (1 teaspoon) 3 times / day, from 6 to 12 years - 5-10 ml (1-2 teaspoons) 3 times / day. Shake before use. nine0005

    Side effect

    The assessment of the frequency of occurrence of adverse reactions was made on the basis of the following criteria: very frequent ( > 1/10), frequent (from > 1/100 to < 1/10), infrequent (from > 1/1000 to < 1/100), rare (from > 1/10,000 to < 1/1,000), very rare (< 1/10,000), frequency unknown (no frequency estimate available). nine0005

    Immune system disorders.

    Rarely: allergic reactions (rash, urticaria), bronchospasm (as a sign of a hypersensitivity reaction).

    Frequency unknown: anaphylactic reactions, including anaphylactic shock, angioedema, pruritus, severe skin reactions, including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis and acute generalized exanthematous pustulosis. nine0005

    Nervous System Disorders

    Rarely: when used in high doses, headache, dizziness, increased nervous excitability, sleep disturbance, drowsiness, tremor, convulsions are sometimes observed.

    Cardiovascular disorders

    Rare: palpitations, low blood pressure, collapse. nine0005

    Frequency unknown: myocardial ischemia.

    Gastrointestinal disorders

    Rare: nausea, vomiting, diarrhea, exacerbation of peptic ulcer of the stomach and duodenum.

    Renal and urinary tract disorders

    Rare: Pink coloration of urine is possible.


    It is possible to increase the manifestations of the described side effects. Treatment is symptomatic.

    Interaction with other drugs

    Other beta-2-agonists and theophylline increase the effect of salbutamol and increase the likelihood of side effects.

    The drug is not prescribed simultaneously with drugs containing codeine, and other antitussives, as this makes it difficult to expel liquefied sputum. nine0005

    Bromhexine, which is part of the drug, promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue.

    It is not recommended to use the drug simultaneously with non-selective beta-adrenergic blockers, such as propranolol.

    Salbutamol, which is part of the drug, is not recommended for patients who receive monoamine oxidase inhibitors (MAOIs) and / or tricyclic antidepressants. nine0005

    Diuretics and glucocorticosteroid preparations enhance the hypokalemic effect of salbutamol.

    It is not recommended to take an alkaline drink simultaneously with the drug.

    special instructions

    With post-registration use of salbutamol, there have been a small number of reports of rare cases of myocardial ischemia associated with the use of this drug. There have been reports of severe skin reactions such as erythema multiforme, Stevens-Johnson syndrome (SSD), toxic epidermal necrolysis (TEN) and acute generalized exanthematous pustulosis (AGEP) associated with the use of ambroxol (the active metabolite of bromhexine). If symptoms of a progressive skin reaction occur (sometimes associated with lesions of the mucous membranes of the mouth, throat, nose, eyes, genitals), stop using the drug immediately and consult a doctor. It is not recommended to take alkaline solutions simultaneously with the drug. Guaifenesin turns urine pink. nine0005

    Influence on the ability to drive vehicles, mechanisms

    Not studied. Given the profile of side effects (dizziness, drowsiness, and others), it is recommended during treatment to refrain from driving vehicles and mechanisms, from engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

    Release form nine0004


    50 ml, 60 ml, 70 ml, 80 ml, 90 ml, 100 ml, 120 ml, 150 ml or 200 ml of the drug in dark glass vials sealed with polyethylene stoppers and screw-on plastic caps or sealed with polyethylene or polymeric polyethylene closures, or corked with aluminum caps.

    50 ml, 60 ml, 70 ml, 80 ml, 90 ml, 100 ml, 120 ml, 150 ml or 200 ml of the drug in polyethylene polymer vials, sealed with polyethylene stoppers and screw-on plastic caps or sealed with polyethylene or polymeric closures.

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