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Aripiprazole other name


Aripiprazole, Oral Tablet

  1. Aripiprazole oral tablet is available as a brand-name drug and a generic drug. Brand names: Abilify, Abilify MyCite.
  2. Aripiprazole comes in four forms that you take by mouth: an oral tablet, an orally disintegrating tablet, an oral solution, and an oral tablet that contains a sensor (to let your doctor know if you’ve taken the drug). It also comes as an injectable solution given only by a healthcare provider.
  3. Aripiprazole oral tablet is an antipsychotic drug. It’s used to treat schizophrenia, bipolar I disorder, and major depressive disorder. It’s also used to treat Tourette syndrome and irritability caused by autistic disorder.

Aripiprazole is a prescription drug. It comes in four forms that you take by mouth: a tablet, an orally disintegrating tablet, a solution, and a tablet that contains a sensor (to let your doctor know if you’ve taken the drug). It also comes as an injectable solution given only by a healthcare provider.

Aripiprazole oral tablet is available as the brand-name drugs Abilify (oral tablet) and Abilify MyCite (oral tablet with sensor). The regular oral tablet and orally disintegrating tablet are also available as generic drugs. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Aripiprazole oral tablet may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it’s used

Aripiprazole oral tablet is used to treat:

  • schizophrenia
  • bipolar I disorder (manic or mixed episodes, or maintenance treatment)
  • major depression in people already taking an antidepressant
  • irritability caused by autistic disorder
  • Tourette syndrome

How it works

Aripiprazole belongs to a class of drugs called antipsychotics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

It’s not known exactly how aripiprazole works. However, it’s thought that it helps to regulate the amount of certain chemicals in your brain. These chemicals are dopamine and serotonin. Managing the levels of these chemicals may help to control your condition.

Aripiprazole oral tablet may cause drowsiness. You shouldn’t drive, use heavy machinery, or do any other dangerous activities until you know how this drug affects you.

Aripiprazole oral tablet can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking aripiprazole. This list does not include all possible side effects.

For more information on the possible side effects of aripiprazole, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.

More common side effects

The more common side effects of aripiprazole can include:

  • nausea
  • vomiting
  • drowsiness
  • constipation
  • headache
  • dizziness
  • feeling agitated or distressed
  • anxiety
  • trouble sleeping
  • restlessness
  • tiredness
  • stuffy nose
  • weight gain
  • increased appetite
  • uncontrolled movements, such as tremor
  • muscle stiffness

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Neuroleptic malignant syndrome (NMS). Symptoms can include:
    • fever
    • stiff muscles
    • confusion
    • sweating
    • changes in heart rate
    • changes in blood pressure
  • High blood sugar
  • Weight gain
  • Trouble swallowing
  • Tardive dyskinesia. Symptoms can include:
    • not being able to control your face, tongue, or other body parts
  • Orthostatic hypotension. This is low blood pressure that occurs when you get up quickly after sitting or lying down. Symptoms can include:
    • feeling lightheaded
    • dizziness
    • fainting
  • Low white blood cell count
  • Seizures
  • Stroke. Symptoms can include:
    • numbness or weakness on one side of the body
    • confusion
    • slurred speech
  • Gambling and other compulsive behaviors
  • Falls

Aripiprazole oral tablet can interact with several other medications. Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.

Below is a list of medications that can interact with aripiprazole. This list does not contain all drugs that may interact with this medication.

Before taking aripiprazole, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Interactions that increase your risk of side effects

Taking aripiprazole with certain medications raises your risk of side effects from aripiprazole. This is because the amount of aripiprazole in your body may be increased. Examples of these drugs include:

  • Antifungal drugs, such as ketoconazole or itraconazole. Increased side effects can include nausea, constipation, dizziness, restlessness, or tiredness. They can also include tardive dyskinesia (movements you can’t control), or neuroleptic malignant syndrome (a rare but life-threatening condition). Your doctor may decrease your aripiprazole dosage.
  • Antidepressants, such as fluoxetine or paroxetine. Increased side effects can include nausea, constipation, dizziness, restlessness, or tiredness. They can also include tardive dyskinesia (movements you can’t control), or neuroleptic malignant syndrome (a rare but life-threatening condition). Your doctor may decrease your aripiprazole dose.
  • Quinidine. Increased side effects can include nausea, constipation, dizziness, restlessness, or tiredness. They can also include tardive dyskinesia (movements you can’t control), or neuroleptic malignant syndrome (a rare but life-threatening condition). Your doctor may decrease your aripiprazole dosage.

Interactions that can make your drugs less effective

When aripiprazole is used with certain drugs, it may not work as well to treat your condition. This is because the amount of aripiprazole in your body may be decreased. Examples of these drugs include:

  • Anti-seizure drugs, such as phenytoin or carbamazepine. Your doctor may switch you from aripiprazole to a different antipsychotic if needed, or increase your aripiprazole dosage.

The aripiprazole dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using aripiprazole to treat
  • your age
  • the form of aripiprazole you take
  • other medical conditions you may have

Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Dosage for schizophrenia

Adult dosage (ages 18 to 64 years)

  • Typical starting dosage: 10 to 15 mg once per day.
  • Typical maintenance dosage: 10 to 15 mg once per day.
  • Maximum dosage: 30 mg once per day.

Child dosage (ages 13 to 17 years)

Oral tablet or orally disintegrating tablet:

  • Typical starting dosage: 2 mg once daily for two days, then 5 mg once daily for two days. Then take 10 mg once daily.
  • Dosage increases: If needed, your doctor may increase your dosage by 5 mg/day at a time.
  • Typical maintenance dosage: 10 mg once per day.
  • Maximum dosage: 30 mg once per day.

Child dosage (ages 0 to 12 years)

  • It hasn’t been established that this drug is safe and effective to treat this condition in children in this age group.

Senior dosage (ages 65 years and older)

The kidneys and liver of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This increases your risk of side effects.

Your doctor may start you on a lower dosage or a different medication schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for bipolar I disorder (manic or mixed episodes, or maintenance treatment)

Generic: Aripiprazole

  • Form: oral tablet
  • Strengths: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg
  • Form: orally disintegrating tablet
  • Strengths: 10 mg, 15 mg, 20 mg, 30 mg

Brand: Abilify

  • Form: oral tablet
  • Strengths: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg

Brand: Abilify MyCite

  • Form: oral tablet with sensor
  • Strengths: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg

Adult dosage (ages 18 to 64 years)

All three tablets, when used alone:

  • Typical starting dosage: 15 mg once per day.
  • Typical maintenance dosage: 15 mg once per day.
  • Maximum dosage: 30 mg once per day.

All three tablets, when used with lithium or valproate:

  • Typical starting dosage: 10 to 15 mg once per day.
  • Typical maintenance dosage: 15 mg once per day.
  • Maximum dosage: 30 mg once daily.

Child dosage (ages 10 to 17 years)

Oral tablet or orally disintegrating tablet:

  • Typical starting dosage: 2 mg once daily for two days, then 5 mg once per day for two days. Then take 10 mg once per day.
  • Dosage increases: If needed, your doctor may increase your dosage by 5 mg/day at a time.
  • Typical maintenance dosage: 10 mg once per day.
  • Maximum dosage: 30 mg once per day.

Child dosage (ages 0 to 9 years)

  • It hasn’t been established that this drug is safe and effective to treat this condition in children of this age group.

Senior dosage (ages 65 years and older)

The kidneys and liver of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This increases your risk of side effects.

Your doctor may start you on a lower dosage or a different medication schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for major depression in people already taking an antidepressant

Generic: Aripiprazole

  • Form: oral tablet
  • Strengths: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg
  • Form: orally disintegrating tablet
  • Strengths: 10 mg, 15 mg, 20 mg, 30 mg

Brand: Abilify

  • Form: oral tablet
  • Strengths: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg

Brand: Abilify MyCite

  • Form: oral tablet with sensor
  • Strengths: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg

Adult dosage (ages 18 to 64 years)

Oral tablet and orally disintegrating tablet:

  • Typical starting dosage: 2 to 5 mg once per day.
  • Typical dosage: 2 to 15 mg once per day.
  • Dosage increases: If needed, your doctor may slowly increase your dosage, up to 5 mg at a time. Your dosage should not be increased more than once per week.

Oral tablet with sensor:

  • Typical starting dosage: 2 to 5 mg once per day.
  • Typical dosage: 2 to 15 mg once per day.
  • Maximum dosage: 15 mg once per day.

Child dosage (ages 0 to 17 years)

This drug is not prescribed to treat this condition in children.

Senior dosage (ages 65 years and older)

The kidneys and liver of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This increases your risk of side effects.

Your doctor may start you on a lower dosage or a different medication schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for irritability caused by autistic disorder

Generic: Aripiprazole

  • Form: oral tablet
  • Strengths: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg
  • Form: orally disintegrating tablet
  • Strengths: 10 mg, 15 mg, 20 mg, 30 mg

Brand: Abilify

  • Form: oral tablet
  • Strengths: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg

Adult dosage (ages 18 years and older)

This drug is not prescribed to treat this condition in adults.

Child dosage (ages 6 to 17 years)

  • Typical starting dosage: 2 mg per day.
  • Ongoing dosage range: 5 to 15 mg once per day.
  • Dosage increases: If needed, your child’s doctor may increase their dosage as needed.

Child dosage (ages 0 to 5 years)

  • It hasn’t been established that this drug is safe and effective to treat this condition in children of this age group.

Dosage for Tourette syndrome

Generic: Aripiprazole

  • Form: oral tablet
  • Strengths: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg
  • Form: orally disintegrating tablet
  • Strengths: 10 mg, 15 mg, 20 mg, 30 mg

Brand: Abilify

  • Form: oral tablet
  • Strengths: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg

Adult dosage (ages 19 years and older)

This drug is not prescribed to treat this condition in adults.

Child dosage (ages 6 to 18 years)

  • Typical starting dosage (for children weighing 2 mg once per day.
  • Target dosage: 5 to 10 mg once per day.
  • Typical starting dosage (for children weighing ≥110 lbs. [50 kg]): 2 mg once per day.
  • Target dosage: 10 to 20 mg once per day.

FDA warnings

  • This drug has boxed warnings. These are the most serious warnings from the Food and Drug Administration (FDA). Boxed warnings alert doctors and patients about drug effects that may be dangerous.
  • Increased risk of death in seniors with dementia warning: Use of this drug raises the risk of death in seniors (ages 65 years and older) with dementia-related psychosis.
  • Suicide risk in children warning: The use of antidepressants in children, adolescents, and young adults can increase thoughts of suicide and suicidal behavior. Talk with your doctor about whether this drug is safe for your child. The potential benefit must be greater than the risk of using this drug.
  • Abilify MyCite pediatric warning: This form of aripiprazole has not been established as safe or effective for use in children.

Neuroleptic malignant syndrome warning

In rare cases, this drug can cause a serious reaction called neuroleptic malignant syndrome (NMS). Symptoms can include low blood pressure, increased heart rate, muscle stiffness, confusion, or high body temperature. If you have some or all of these symptoms, call 911 right away.

Metabolic changes warning

This drug can cause changes in the way your body functions. These changes can lead to high blood sugar or diabetes, high cholesterol or triglyceride levels, or weight gain. Tell your doctor if you notice an increase in your weight or blood sugar level. Your diet or medication dosage may need to be changed.

Dysphagia warning

This drug can cause dysphagia (trouble swallowing). If you’re at risk of aspiration pneumonia, talk with your doctor about whether this drug is safe for you.

Falls warning

This drug can cause sleepiness or dizziness, which may lead to falling, which can cause broken bones or other health problems.

Allergy warning

This drug can cause a severe allergic reaction. Symptoms can include:

  • hives (itchy welts)
  • itching
  • swelling of your face, eyes, or tongue
  • trouble breathing
  • wheezing
  • chest tightness
  • fast and weak heart rate
  • nausea or vomiting

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Alcohol interaction warning

Don’t drink alcohol while taking this drug. Aripiprazole causes drowsiness, and alcohol can worsen this side effect. It also raises your risk of liver damage.

Warnings for people with certain health conditions

For people with heart conditions: It hasn’t been established that this drug is safe and effective for use in people with certain heart conditions. These conditions include unstable heart disease or a recent history of stroke or heart attack. Tell your doctor if you have a heart condition before starting this drug.

For people with epilepsy: If you have a history of seizures, talk with your doctor about whether this drug is safe for you. Also talk to your doctor if you have conditions that raise your risk of seizures, such as Alzheimer’s dementia.

For people with a low white blood cell count: This drug can cause a low white blood cell count. Your doctor will monitor you for symptoms of this problem. They will also do regular blood tests. If you develop a low white blood cell count while taking this drug, your doctor will stop this treatment. Tell your doctor if you have a history of low white blood cell count before starting treatment with this drug.

Warnings for other groups

For pregnant women: This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should be used only if the potential benefit justifies the potential risk.

If you become pregnant while taking this drug, call your doctor right away.

If you use the oral tablet with sensor while pregnant, consider joining the National Pregnancy Registry for Atypical Antipsychotics. Your doctor can tell you more.

For women who are breastfeeding: This drug passes into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: Your kidneys and liver may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

For children: For children, this drug is only used to treat:

  • schizophrenia in children older than 13 years of age
  • manic or mixed episodes caused by bipolar I disorder in children ages 10 years or older
  • irritability caused by autistic disorder in children ages 6 years or older
  • Tourette syndrome in children ages 6 years or older

It hasn’t been established that this drug is safe and effective for use in children with certain conditions that this drug can treat in adults. These conditions include major depressive disorder.

Aripiprazole oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: You should not suddenly stop taking this drug or change your dosage without talking to your doctor. Stopping this drug suddenly can cause unwanted side effects. These can include symptoms such as facial tics or uncontrolled speech. They can also include uncontrolled shaking like the shaking caused by Parkinson’s disease.

If you don’t take this drug at all, your symptoms may not improve.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

  • vomiting
  • tremor
  • sleepiness

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: Your symptoms should get better. Your doctor will examine you to see if your symptoms are improving.

Keep these considerations in mind if your doctor prescribes aripiprazole for you.

General

  • Take this drug with or without food.
  • Take this drug at the time(s) recommended by your doctor.
  • You can cut or crush the oral tablet or orally disintegrating tablet. But don’t cut, crush, or chew the oral tablet with sensor.
  • Avoid getting overheated or dehydrated (low fluid levels) while taking this drug. Aripiprazole can make it harder for your body to maintain a normal temperature. This can make your temperature rise too high.

Storage

For all tablets and the MyCite patch:

  • Don’t store these items in moist or damp areas, such as bathrooms.

For the oral tablet and orally disintegrating tablet:

  • Store these tablets at room temperature between 59°F and 86°F (15°C and 30°C).

For the oral tablet with sensor:

  • Store the tablet at a temperature between 68°F and 77°F (20°C and 25°C). You can store it for short periods at temperatures between 59°F and 86°F (15°C and 30°C).

For the MyCite patch:

  • Store the patch at room temperature between 59°F and 86°F (15°C and 30°C).

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Self-management

When using the oral tablet with sensor:

  • Your doctor will explain how to use this tablet.
  • You’ll need to download an application on your smartphone that will track your medication usage.
  • The tablet comes with a patch that you’ll need to wear on your skin. The phone application will tell you when and where to apply the patch.
  • Don’t apply the patch to skin that is scraped, cracked, or irritated. You can keep the patch on when bathing, swimming, or exercising.
  • You’ll need to change the patch each week, or sooner as needed.

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t harm your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

During your treatment with this drug, your doctor will monitor you for side effects. They will also monitor your symptoms, and do regular blood tests to check your:

  • blood sugar
  • cholesterol levels
  • kidney function
  • liver function
  • blood cell count
  • thyroid function

Availability

Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

Hidden costs

You may need blood tests during your treatment with this drug. The cost of these tests will depend on your insurance coverage.

Prior authorization

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Aripiprazole (Abilify) | NAMI: National Alliance on Mental Illness

​Brand names:

    • Abilify®
      • Tablets: 2 mg, 5mg, 10 mg, 15 mg, 20 mg, 30 mg
      • Oral disintegrating: 10 mg, 15 mg
      • Solution: 1 mg/mL
    • Abilify MyCite®
      • Tablet with a digestible sensor: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg
    • Abilify Maintena®
      • Extended-release injectable suspension: 300 mg, 400 mg
    • Abilify Aristada® (aripiprazole lauroxil)
      • Extended-release injectable suspension: 441 mg, 662 mg, 882 mg, 1064 mg
    • Aristada Initio® (aripiprazole lauroxil)
      • Extended-release injectable suspension: 675 mg

    Generic name: aripiprazole (ay ri PIP ray zole), aripiprazole lauroxil (law rox il)

    • Aripiprazole
      • Oral tablet: 2 mg, 5mg, 10 mg, 15 mg, 20 mg, 30 mg
      • Orally disintegrating tablet: 10 mg, 15 mg
      • Oral solution: 1 mg/mL

    All FDA black box warnings are at the end of this fact sheet. Please review before taking this medication.

    What Is Aripiprazole And What Does It Treat?

    Aripiprazole is a medication that works in the brain to treat schizophrenia. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Aripiprazole rebalances dopamine and serotonin to improve thinking, mood, and behavior.

    Symptoms of schizophrenia include:

    • Hallucinations — imagined voices or images that seem real
    • Delusions — beliefs that are not true (e.g., other people are reading your thoughts)
    • Disorganized thinking or trouble organizing your thoughts and making sense
    • Little desire to be around other people
    • Trouble speaking clearly
    • Lack of motivation

    Aripiprazole may help some or all of these symptoms.

    Aripiprazole is also FDA approved for the following indications:

    • Acute treatment of manic or mixed episodes of bipolar disorder (when used alone or with lithium or valproate)
    • Maintenance (long-term) treatment of bipolar disorder
    • Adjunctive treatment of major depressive disorder. This means aripiprazole is used in addition to an antidepressant to help treat depression.
    • Irritability associated with autistic disorders
    • Tourette's syndrome

    This medication sheet will focus primarily on schizophrenia. Find more information about bipolar disorder, depression and autism spectrum disorders here.

    Aripiprazole may also be helpful when prescribed “off-label” for borderline personality disorder or drug-induced hyperprolactinemia (elevated prolactin levels caused by other antipsychotics). “Off-label” means that it hasn’t been approved by the Food and Drug Administration for this condition. Your mental health provider should justify his or her thinking in recommending an “off-label” treatment. They should be clear about the limits of the research around that medication and if there are any other options.

    What Is The Most Important Information I Should Know About Aripiprazole?

    Schizophrenia requires long-term treatment. Do not stop taking aripiprazole, even when you feel better. With input from you, your health care provider will assess how long you will need to take the medicine.

    Missing doses of aripiprazole may increase your risk for a relapse in your symptoms. Do not stop taking aripiprazole or change your dose without talking to with your health care provider first. For aripiprazole to work properly, it should be taken every day as ordered by your health care provider.

    Are There Specific Concerns About Aripiprazole And Pregnancy?

    If you are planning on becoming pregnant, notify your health care provider to best manage your medications. People living with schizophrenia who wish to become pregnant face important decisions. This is a complex decision since untreated schizophrenia has risks to the fetus, as well as the mother. It is important to discuss the risks and benefits of treatment with your doctor and caregivers.

    Antipsychotic use during the third trimester of pregnancy has a risk for abnormal muscle movements (extrapyramidal symptoms [EPS]) and/or withdrawal symptoms in newborns following delivery. Symptoms in the newborn may include agitation, feeding disorder, hypertonia, hypotonia, respiratory distress, somnolence, and tremor; these effects may be self-limiting or require hospitalization.

    In general, infants exposed to SGAs via breast milk should be monitored weekly for the first month of exposure for symptoms, such as appetite changes, insomnia, irritability, or lethargy.

    Caution is advised with breastfeeding since aripiprazole does pass into breast milk.

    What Should I Discuss With My Healthcare Provider Before Taking Aripiprazole?

    • Symptoms of your condition that bother you the most
    • If you have thoughts of suicide or harming yourself
    • Medications you have taken in the past for your condition, whether they were effective or caused any adverse effects
    • If you ever had muscle stiffness, shaking, tardive dyskinesia, neuroleptic malignant syndrome, or weight gain caused by a medication
    • If you experience side effects from your medications, discuss them with your provider. Some side effects may pass with time, but others may require changes in the medication
    • Any psychiatric or medical problems you have, such as heart rhythm problems, long QT syndrome, heart attacks, diabetes, high cholesterol, or seizures
    • If you have a family history of diabetes or heart disease
    • All other medications you are currently taking (including over the counter products, herbal and nutritional supplements) and any medication allergies you have
    • Other non-medication treatment you are receiving, such as talk therapy or substance abuse treatment. Your provider can explain how these different treatments work with the medication
    • If you are pregnant, plan to become pregnant, or are breast-feeding
    • If you smoke, drink alcohol, or use illegal drugs

    How Should I Take Aripiprazole?

    Aripiprazole tablets and suspension are usually taken 1 time per day with or without food. Typically, patients begin at a low dose of medicine and the dose is increased slowly over several weeks.

    The oral dose of aripiprazole usually ranges from 2 mg to 30 mg taken once daily. The dose of aripiprazole maintena extended-release injection ranges from 300 mg to 400 mg given once monthly; the dose of aripiprazole lauroxil extended-release injection ranges from 441 mg to 1064 mg – depending on the dose, it is given once per month, every 6 weeks, or every 2 months. Aripiprazole Maintena requires a two-week oral medication overlap; aripiprazole lauroxil requires a three-week oral overlap. Aripiprazole lauroxil Initio is typically given after an oral dose of aripiprazole along with an aripiprazole lauroxil injection – this allows for a one-day initiation and does not require further oral overlap. Only your health care provider can determine the correct formulation and dose for you.

    Use a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication. You may also ask a family member or a friend to remind you or check in with you to be sure you are taking your medication.

    What Happens If I Miss A Dose Of Aripiprazole?

    If you miss a dose of aripiprazole, take it as soon as you remember, unless it is closer to the time of your next dose. Do not double your next dose or take more than what is prescribed. If you miss an injection, call your doctor or pharmacist right away. Discuss this with your health care provider.

    What Should I Avoid While Taking Aripiprazole?

    Avoid drinking alcohol or using illegal drugs while you are taking aripiprazole. They may decrease the benefits (e.g., worsen your confusion) and increase adverse effects (e.g., sedation) of the medication.

    What Happens If I Overdose With Aripiprazole?

    If an overdose occurs call your doctor or 911. You may need urgent medical care. You may also contact the poison control center at 1-800-222-1222.

    A specific treatment to reverse the effects of aripiprazole does not exist.

    What Are Possible Side Effects Of Aripiprazole?

    Common side effects

    Headache, extrapyramidal symptoms, drowsiness, restlessness, fatigue, sedation, agitation, insomnia, anxiety, weight gain, cholesterol abnormalities, increased glucose, nausea, vomiting, constipation, application site rash (MyCite), tremor

    Rare/serious side effects

    Rash, dry mouth, muscle aches, seizure, agitation

    Aripiprazole may increase the blood levels of a hormone called prolactin. Side effects of increased prolactin levels include females losing their period, production of breast milk and males losing their sex drive or possibly experiencing erectile problems. Long term (months or years) of elevated prolactin can lead to osteoporosis or increased risk of bone fractures.

    Some people may develop muscle-related side effects while taking aripiprazole. The technical terms for these are “extrapyramidal symptoms” (EPS) and “tardive dyskinesia” (TD). Symptoms of EPS include restlessness, tremor, and stiffness. TD symptoms include slow or jerky movements that one cannot control, often starting in the mouth with tongue rolling or chewing movements.

    Temperature regulation: Impaired core body temperature regulation may occur; caution with strenuous exercise, heat exposure, and dehydration.

    Second generation antipsychotics (SGAs) increase the risk of weight gain, high blood sugar, and high cholesterol. This is also known as metabolic syndrome. Your healthcare provider may ask you for a blood sample to check your cholesterol, blood sugar, and hemoglobin A1c (a measure of blood sugar over time) while you take this medication.

    Information on healthy eating and adding exercise to decrease your chances of developing metabolic syndrome may be found at the following sites:

    • http://www.helpguide.org/articles/healthy-eating/healthy-eating.htm
    • http://www.helpguide.org/home-pages/exercise-fitness.htm

    SGAs have been linked with higher risk of death, strokes, and transient ischemic attacks (TIAs) in elderly people with behavior problems due to dementia.

    All antipsychotics have been associated with the risk of sudden cardiac death due to an arrhythmia (irregular heart beat). To minimize this risk, antipsychotic medications should be used in the smallest effective dose when the benefits outweigh the risks. Your doctor may order an EKG to monitor for irregular heartbeat.

    Neuroleptic malignant syndrome is a rare, life threatening adverse effect of antipsychotics which occurs in <1% of patients. Symptoms include confusion, fever, extreme muscle stiffness, and sweating. If any of these symptoms occur, contact your healthcare provider immediately.

    All antipsychotics can cause sedation, dizziness, or orthostatic hypotension (a drop in blood pressure when standing up from sitting or lying down). These side effects may lead to falls which could cause bone fractures or other injuries. This risk is higher for people with conditions or other medications that could worsen these effects. If falls or any of these symptoms occur, contact your healthcare provider.

    The U.S. Food and Drug Administration (FDA) is warning that compulsive or uncontrollable urges to gamble, binge eat, shop, and have sex have been reported with the use of aripiprazole. These uncontrollable urges were reported to have stopped when the medicine was discontinued or the dose was reduced. These impulse-control problems are rare, but they may result in harm to the patient and others if not recognized.

    Are There Any Risks For Taking Aripiprazole For Long Periods Of Time?

    Tardive dyskinesia (TD) is a side effect that develops with prolonged use of antipsychotics. Medications such as aripiprazole have been shown to have a lower risk of TD compared to older antipsychotics, such as Haldol (haloperidol). If you develop symptoms of TD, such as grimacing, sucking, and smacking of lips, or other movements that you cannot control, contact your health care provider immediately. All patients taking either first or second generation antipsychotics should have an Abnormal Involuntary Movement Scale (AIMS) completed regularly by their healthcare provider to monitor for TD.

    Second generation antipsychotics (SGAs) increase the risk of diabetes, weight gain, high cholesterol, and high triglycerides. (See “Serious Side Effects” section for monitoring recommendations).

    What Other Medications May Interact With Aripiprazole?

    The following medications may increase the levels and effects of aripiprazole:

    • The antibiotic clarithromycin (Biaxin®)
    • Antidepressants, such as fluoxetine (Prozac®), paroxetine (Paxil®), and nefazodone
    • Antifungals, such as fluconazole (Diflucan®), ketoconazole (Nizoral®), and itraconazole (Sporanox®)
    • The antiarrhymia agent quinidine
    • HIV medications, such as the protease inhibitors indinavir (Crixivan®), ritonavir (Norvir®), saquinavir (Fortovase®, Invirase®), and lopinavir/ritonavir (Kaletra®)

    The following medications may decrease the levels and effects of aripiprazole:

    • carbamazepine (Tegretol®)
    • rifampin (Rifadin®)

    How Long Does It Take For Aripiprazole To Work?

    It is very important to tell your doctor how you feel things are going during the first few weeks after you start taking aripiprazole. It will probably take several weeks to see big enough changes in your symptoms to decide if aripiprazole is the right medication for you.

    Antipsychotic treatment is generally needed lifelong for persons with schizophrenia. Your doctor can best discuss the duration of treatment you need based on your symptoms and illness.

    • Hallucinations, disorganized thinking, and delusions may improve in the first 1-2 weeks
    • Sometimes these symptoms do not completely go away
    • Motivation and desire to be around other people can take at least 1-2 weeks to improve
    • Symptoms continue to get better the longer you take aripiprazole
    • It may take 2-3 months before you get the full benefit of aripiprazole

    Summary of FDA Black Box Warnings

    Increased mortality in elderly patients with dementia-related psychosis

    • Both first generation (typical) and second generation (atypical) antipsychotics are associated with an increased risk of mortality in elderly patients when used for dementia related psychosis.
    • Although there were multiple causes of death in studies, most deaths appeared to be due to cardiovascular causes (e.g. sudden cardiac death) or infection (e.g. pneumonia).
    • Antipsychotics are not indicated for the treatment of dementia-related psychosis.

    Suicidal Thoughts or Actions in Children, Teens, and Young Adults

    Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide.

    • Patients treated with antidepressants may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking medications. This risk may persist until significant remission occurs.
    • Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient’s prescriber or health care professional.
    • All patients being treated with this medication for depression should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.

     

    Provided by

    (July 2022)

    ©2022 The College of Psychiatric and Neurologic Pharmacists (CPNP) and the National Alliance on Mental Illness (NAMI). CPNP and NAMI make this document available under the Creative Commons Attribution-No Derivatives 4.0 International License. Last Updated: January 2016.

    This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists. This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein.

    Aripiprazole instructions, price in pharmacies of Ukraine

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    Creation date: 04/27/2021 Date updated: 31. 10.2022

    Aripiprazole - antipsychotic zasib.

    Indications

    • Treatment of schizophrenia in adults.
    • Treatment of the middle and severe stages of manic episodes of bipolar disorder type I, as well as for the prevention of new maniacal episodes in adults, who had previously suffered manic episodes and were treated with Aripiprazole.

    Contraindications

    Increased sensitivity to aripiprazole or any other component that enters the drug warehouse.

    Adverse reactions

    In the case of aripiprazole, there were frequent side reactions (more than 3% in the total number of patients who took aripiprazole), akathisia and nudotasia.

    Peculiarities of congestion

    When treated with antipsychotics, the clinical situation of the patient can be taken from a decade to a decade. During this period, there should be a guard over the camp of the patient.

    Haste in the periode Vagiytosti aboathevnya gruntu

    at the Zvyazka іnformasyu about the no -stupid of the gap of the aripiprasol in the perіodnosti yoga yogo tilki.

    Aripiprazole is seen in breast milk. In times of need to take the drug, breastfeeding should be given.

    Children

    Not recommended for use in children.

    Overdosing

    Patients have described navmysional or acute episodes of acute overdose of aripiprazole at doses up to 1260 mg without a fatal outcome. Potentially important from a medical point of view, the symptoms that were suspected were bully lethargy, arterial pressure, drowsiness, tachycardia, nausea, vomiting, and diarrhea. Treatment of overdose should include supportive therapy, ensuring the passage of the dyspepsia, oxygen therapy, piece ventilation of the lungs, as well as symptom control. Slid vrakhovuvaty mozhlivist peredozuvannya numerical likarskim zabob. Therefore, it is necessary to begin control of the heart-vascular system so that you can turn on the constant monitoring of the ECG to detect possible arrhythmias. In case of confirmed or immovable overdose of aripiprazole, it is necessary to have more medical caution and control over the patient's state until his recovery. Activated Vugill (50 g), which stopped 1:00 after taking aripiprazole, reduced the Cmax of aripiprazole by approximately 41% and the AUC by approximately 51%, suggesting that activated Vugill might be effective in overdose. Although there is information about infusion of hemodialysis for the treatment of overdose of aripiprazole daily, it is unlikely that hemodialysis could be similar in the treatment of overdose, and aripiprazole oscillators in a significant world are associated with plasma proteins.

    Wash up saving

    Save up to 25°C in original packaging. Take away in a place inaccessible to children.

    ARIPIPRAZOL TEDEC (UA/17925/01/01)

    Release form: 5 mg tablets, 7 tablets per blister, 4 blister per cardboard box

    Stock: 1 tablet to administer aripiprazole 5 mg

    Manufacturer: Spain

    ARIPIPRAZOL TEDEC (UA/17925/01/02)

    Release form: tablets of 10 mg, 7 tablets in a blister, 4 blisters in a cardboard box

    Stock: 1 tablet to administer aripiprazole 10 mg

    Manufacturer: Spain

    The article came by parcel - Kommersant Krasnoyarsk

    Photo: Sergey Mikheev, Kommersant

    Photo: Sergey Mikheev, Kommersant

    In Kuzbass, law enforcers opened a criminal case on drug smuggling because of the purchase of the antidepressant bupropion, used to treat mental disorders. The drug from India was ordered by 28-year-old resident of Novokuznetsk Renard A., who suffers from a mental illness. He is currently serving as a witness in the case. It should be noted that at the end of 2021, the investigation stopped the criminal prosecution of Daria Belyaeva, a resident of Yekaterinburg. The girl ordered from Poland the popular Elontril drug containing bupropion, which in Russia was recognized as a “derivative” of the illegal drug ephedron.

    Kemerovo customs opened a criminal case on drug smuggling due to the purchase of the antidepressant bupropion in a foreign online store. The events described in the materials of the investigation took place on January 10. As Arseniy Levinson, a legal consultant on drug-related cases, told Kommersant-Siberia, in one of the post offices of Novokuznetsk, law enforcement officers detained the mother of Renar A. (later she was released), who came to receive a package from India with the drug bupropion. The parcel contained about 500 150 mg tablets, which would have been enough for her son, who suffers from a mental illness, for several months.

    According to Arseny Levinson, Renard A. has been under the supervision of psychiatrists for several years. Due to illness, he was released from military service and had to leave his job. Of the many drugs, only bupropion helped the patient: he became ill from SSRIs and aripiprazole, and sulpiride did not give the desired effect. “The psychiatrists with whom he consulted suggested the dosage, but they could not officially recommend this drug, since it was excluded from the state register of medicines,” said Mr. Levinson, noting that until 2016 this drug was freely sold in Russia under the trade name Wellbutrin.

    According to Arseniy Levinson, without the necessary drug, Renard A. began to feel much worse, so he decided to order the drug in an Indian online store.

    On Wednesday, January 19, Renard A. and his mother were summoned for questioning at the customs. “A criminal case has been initiated under Part 3 of Art. 229.1 of the Criminal Code of the Russian Federation (smuggling of narcotic drugs on an especially large scale), but my client was interrogated as a witness. In this status, no one will introduce us to any intermediate documents. In this we see a trick on the part of the investigation. As the operational officer explained to me, there is a certificate from the forensic center of the Internal Affairs Directorate stating that this drug is a narcotic,” lawyer Olga Koinova told Kommersant-Siberia. The lawyer noted that the criminal case was initiated on the fact, and not against a specific person. It was not possible to get a comment from the investigating authorities.

    Lawyer Arseniy Levinson notes that the circumstances of the case confirm that Renard A. purchased exactly the drugs, and not narcotic drugs and their derivatives. “I believe that in the press he watched the case of Darya Belyaeva, who for several years of investigation was not prosecuted, the court returned her case to the prosecutor's office, and then she was completely rehabilitated. Consequently, in relation to bupropion, law enforcement agencies made a mistake,” said Mr. Levinson. In his opinion, the lack of intent to smuggle is confirmed by other circumstances. For example, the fact that Renard A. made an order to his address, called the post office and was interested in the shipment.

    As Kommersant wrote, in December last year, the investigation stopped the criminal prosecution of 26-year-old resident of Yekaterinburg Darya Belyaeva. In 2019, the girl ordered from Poland the popular Elontril drug containing bupropion, which in Russia was recognized as a “derivative” of the illegal drug ephedron. She acquired the medicine on the recommendation of a doctor for the treatment of schizotypal personality disorder, but the investigation accused her of buying and smuggling drugs. The Russian Society of Psychiatrists, during the trial of Darya Belyaeva, prepared an official conclusion that bupropion is not a drug. Doctors said that the drug does not cause euphoria, and its use does not lead to dependence. The lawyer of Darya Belyaeva then said that in the process of correcting the criminal procedural violations of the case materials pointed out by the court, the investigation concluded that there was no evidence of the girl's guilt.

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