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60 mg of ritalin


Ritalin, Concerta (methylphenidate) dosing, indications, interactions, adverse effects, and more

  • albuterol

    albuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • aluminum hydroxide

    aluminum hydroxide decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • amitriptyline

    amitriptyline, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

  • amlodipine

    methylphenidate will decrease the level or effect of amlodipine by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • amoxapine

    amoxapine, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

  • apomorphine

    apomorphine, methylphenidate. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Potential for additive CNS stimulation.

  • arformoterol

    arformoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • aripiprazole

    aripiprazole increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • armodafinil

    armodafinil increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

  • asenapine

    asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • aspirin/citric acid/sodium bicarbonate

    aspirin/citric acid/sodium bicarbonate decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • atomoxetine

    methylphenidate will increase the level or effect of atomoxetine by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

  • azilsartan

    methylphenidate will decrease the level or effect of azilsartan by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • benazepril

    methylphenidate will decrease the level or effect of benazepril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • benzhydrocodone/acetaminophen

    benzhydrocodone/acetaminophen, methylphenidate. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.

  • bromocriptine

    bromocriptine, methylphenidate. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Potential for additive CNS stimulation.

  • caffeine

    caffeine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

  • calcium carbonate

    calcium carbonate decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • candesartan

    methylphenidate will decrease the level or effect of candesartan by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • captopril

    methylphenidate will decrease the level or effect of captopril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • carbamazepine

    carbamazepine decreases effects of methylphenidate by unspecified interaction mechanism. Use Caution/Monitor. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased.

  • cariprazine

    cariprazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • chlorpromazine

    chlorpromazine, methylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.

  • cimetidine

    cimetidine decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • clevidipine

    methylphenidate will decrease the level or effect of clevidipine by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • clomipramine

    clomipramine, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

  • clozapine

    clozapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • cocaine topical

    cocaine topical increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

  • desipramine

    desipramine, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

  • dexfenfluramine

    dexfenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • dexlansoprazole

    dexlansoprazole decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • dexmethylphenidate

    dexmethylphenidate increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

  • dextroamphetamine

    dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

  • didanosine

    didanosine will decrease the level or effect of methylphenidate by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor. Interaction specifically associated with Ritalin LA.

  • diltiazem

    methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • dobutamine

    dobutamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • dopamine

    dopamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • dopexamine

    dopexamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • doxepin

    doxepin, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

  • dronabinol

    methylphenidate will increase the level or effect of dronabinol by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

  • enalapril

    methylphenidate will decrease the level or effect of enalapril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • ephedrine

    ephedrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • epinephrine

    epinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • epinephrine inhaled

    methylphenidate, epinephrine inhaled. Either increases effects of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • epinephrine racemic

    epinephrine racemic and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • eprosartan

    methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • esketamine intranasal

    esketamine intranasal, methylphenidate. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. .

  • esomeprazole

    esomeprazole decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • famotidine

    famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Applies only to extended release formulation

    famotidine decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • felodipine

    methylphenidate will decrease the level or effect of felodipine by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • fenfluramine

    fenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • fluphenazine

    fluphenazine, methylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.

    fluphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • formoterol

    formoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • fosinopril

    methylphenidate will decrease the level or effect of fosinopril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • fosphenytoin

    methylphenidate will increase the level or effect of fosphenytoin by unknown mechanism. Use Caution/Monitor. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased.

  • green tea

    green tea, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Green tea may include caffeine. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Caffeine should be avoided or used cautiously.

  • haloperidol

    haloperidol increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • hydralazine

    hydralazine, methylphenidate. Mechanism: pharmacodynamic antagonism. Use Caution/Monitor. Sympathomimetics can antagonize the activity of some antihypertensive agents.

  • hydrocodone

    hydrocodone, methylphenidate. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.

  • ibuprofen/famotidine

    ibuprofen/famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Applies only to extended release formulation

  • iloperidone

    iloperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • imipramine

    imipramine, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

  • iohexol

    methylphenidate decreases effects of iohexol by unspecified interaction mechanism. Modify Therapy/Monitor Closely. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure.

  • iopamidol

    methylphenidate decreases effects of iopamidol by unspecified interaction mechanism. Modify Therapy/Monitor Closely. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure.

  • irbesartan

    methylphenidate will decrease the level or effect of irbesartan by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • isoproterenol

    isoproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • isradipine

    methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • lansoprazole

    lansoprazole decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • levalbuterol

    levalbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • levodopa

    levodopa, methylphenidate. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Potential for additive CNS stimulation.

  • lisdexamfetamine

    lisdexamfetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

  • lisinopril

    methylphenidate will decrease the level or effect of lisinopril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • losartan

    methylphenidate will decrease the level or effect of losartan by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • loxapine

    loxapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • loxapine inhaled

    loxapine inhaled increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • lurasidone

    lurasidone, methylphenidate. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for additive CNS effects.

    lurasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • magnesium oxide

    magnesium oxide decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • metaproterenol

    metaproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • methamphetamine

    methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

  • methyldopa

    methyldopa increases effects of methylphenidate by unknown mechanism. Use Caution/Monitor.

  • modafinil

    modafinil increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

  • moexipril

    methylphenidate will decrease the level or effect of moexipril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • molindone

    molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • nadolol

    methylphenidate will decrease the level or effect of nadolol by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • nicardipine

    methylphenidate will decrease the level or effect of nicardipine by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • nifedipine

    methylphenidate will decrease the level or effect of nifedipine by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • nimodipine

    methylphenidate will decrease the level or effect of nimodipine by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • nisoldipine

    methylphenidate will decrease the level or effect of nisoldipine by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • nizatidine

    nizatidine will increase the level or effect of methylphenidate by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor. Applies only to extended release formulation

    nizatidine decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • norepinephrine

    norepinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • nortriptyline

    nortriptyline, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

  • olanzapine

    olanzapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • olmesartan

    methylphenidate will decrease the level or effect of olmesartan by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • omeprazole

    omeprazole decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • oxytocin

    oxytocin increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor.

  • paliperidone

    paliperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • pantoprazole

    pantoprazole decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • penbutolol

    methylphenidate will decrease the level or effect of penbutolol by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • perindopril

    methylphenidate will decrease the level or effect of perindopril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • perphenazine

    perphenazine, methylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.

    perphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • phenobarbital

    methylphenidate will increase the level or effect of phenobarbital by unknown mechanism. Use Caution/Monitor. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased.

  • phenoxybenzamine

    methylphenidate will decrease the level or effect of phenoxybenzamine by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • phentolamine

    methylphenidate will decrease the level or effect of phentolamine by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • phenytoin

    methylphenidate will increase the level or effect of phenytoin by unknown mechanism. Use Caution/Monitor. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased.

  • pimavanserin

    pimavanserin increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • pimozide

    pimozide increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • pirbuterol

    pirbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • pramipexole

    pramipexole, methylphenidate. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Potential for additive CNS stimulation.

  • prazosin

    methylphenidate will decrease the level or effect of prazosin by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • procarbazine

    procarbazine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

  • prochlorperazine

    prochlorperazine, methylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.

  • promazine

    promazine, methylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.

  • promethazine

    promethazine, methylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.

  • propranolol

    methylphenidate will decrease the level or effect of propranolol by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • protriptyline

    protriptyline, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

  • quetiapine

    quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • quinapril

    methylphenidate will decrease the level or effect of quinapril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • rabeprazole

    rabeprazole decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided.

  • ramipril

    methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • risperidone

    risperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • ropinirole

    ropinirole, methylphenidate. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Potential for additive CNS stimulation.

  • rotigotine

    rotigotine, methylphenidate. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Potential for additive CNS stimulation.

  • sacubitril/valsartan

    methylphenidate will decrease the level or effect of sacubitril/valsartan by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • salmeterol

    salmeterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • serdexmethylphenidate/dexmethylphenidate

    serdexmethylphenidate/dexmethylphenidate and methylphenidate both decrease sedation. Use Caution/Monitor.

    serdexmethylphenidate/dexmethylphenidate and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

    serdexmethylphenidate/dexmethylphenidate increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.

  • sodium zirconium cyclosilicate

    sodium zirconium cyclosilicate will increase the level or effect of methylphenidate by increasing gastric pH. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Check specific recommendations for drugs that exhibit pH-dependent solubility that may affect their systemic exposure and efficacy. In general, administer drugs at least 2 hr before or after sodium zirconium cyclosilicate. Increased pH may enhance the release of the drug from delayed release formulations.

  • solriamfetol

    methylphenidate and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • sotalol

    methylphenidate will decrease the level or effect of sotalol by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • sufentanil SL

    sufentanil SL, methylphenidate. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.

  • telmisartan

    methylphenidate will decrease the level or effect of telmisartan by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • terazosin

    methylphenidate will decrease the level or effect of terazosin by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • terbutaline

    terbutaline and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

  • thioridazine

    thioridazine, methylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.

  • thiothixene

    thiothixene increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • timolol

    methylphenidate will decrease the level or effect of timolol by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • trandolapril

    methylphenidate will decrease the level or effect of trandolapril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • trazodone

    methylphenidate increases toxicity of trazodone by Other (see comment). Modify Therapy/Monitor Closely. Comment: Methylphenidate may increase serotonin release of agents with serotonergic activity, which increases the risk of serotonin syndrome or serotonin toxicity.

  • trifluoperazine

    trifluoperazine, methylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.

    trifluoperazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

  • trimipramine

    trimipramine, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

  • valsartan

    methylphenidate will decrease the level or effect of valsartan by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • verapamil

    methylphenidate will decrease the level or effect of verapamil by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • warfarin

    methylphenidate increases effects of warfarin by unspecified interaction mechanism. Use Caution/Monitor.

  • ziprasidone

    ziprasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.

    • Side Effects, Dosage, Uses, and More

    Highlights for methylphenidate

    1. Methylphenidate oral tablet is available as a generic drug and as brand-name drugs. Brand names: Ritalin, Ritalin-SR, Concerta, Metadate ER, QuilliChew ER, Cotempla XR-ODT.
    2. Methylphenidate tablet comes in these forms: oral immediate-release tablet, extended-release oral tablet, chewable oral tablet, extended-release chewable oral tablet, and extended-release orally disintegrating tablet. Methylphenidate also comes as an extended-release oral capsule, transdermal patch, oral suspension, and oral solution.
    3. Methylphenidate oral tablet is used to treat narcolepsy and attention deficit hyperactivity disorder (ADHD).

    FDA Warning: Abuse and dependence


    • This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.
    • Taking methylphenidate for a long period of time may lead to dependence and addiction. Use it with caution if you have a history of alcohol or drug misuse. Your doctor will stop this medication slowly to prevent symptoms of withdrawal.

    Other warnings

    • Heart problems warning: Methylphenidate may cause stroke, heart attack, or sudden death in people with heart issues. People with serious heart problems shouldn’t take this drug. This medication may increase your blood pressure and heart rate. If you have high blood pressure, heart failure, a history of heart attack, or an abnormal heart rate, ask your doctor if this drug is safe for you.
    • Psychiatric disorders warning: If you have mental health conditions, this drug may make your symptoms worse. It can also cause psychotic or manic symptoms in children and teenagers without a history of these problems. They may have symptoms such as hallucinations (seeing, hearing, or believing things that aren’t real) or paranoia (feeling suspicious).
    • Digestive problems warning: This warning is only for the brand Concerta. Concerta may cause a blockage of the esophagus, stomach, or intestines in people who already have a narrowing in any of these organs. Concerta tablets should only be used if you can swallow the tablet whole. Cutting or breaking apart the tablet might increase the amount of medication in your body. This increases your risk of side effects.

    Methylphenidate oral tablet is a prescription drug. It comes in these forms: oral tablet, extended-release tablet, extended-release capsule, chewable tablet, extended-release chewable tablet, and extended-release orally disintegrating tablet. Methylphenidate also comes as a transdermal patch, oral suspension, and oral solution.

    Methylphenidate is a controlled substance. This means that its use will be closely monitored by your doctor.

    Methylphenidate oral tablet is available as the brand-name drugs Ritalin, Ritalin SR, Concerta, Metadate ER, QuilliChew ER, and Cotempla XR-ODT. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

    Methylphenidate oral tablet may be used as part of a combination therapy. That means you may need to take it with other drugs.

    Why it’s used

    Methylphenidate oral tablet is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. It may help to increase attention and decrease impulsiveness and hyperactivity if you have ADHD.

    How it works

    Methylphenidate belongs to a class of drugs called central nervous system (CNS) stimulants. It works by increasing the amount of the chemicals norepinephrine and dopamine in your brain. These chemicals send signals to other parts of your body, which will help to improve your symptoms.

    Methylphenidate oral tablet doesn’t cause drowsiness, but it can cause other side effects.

    More common side effects

    The more common side effects that can occur with methylphenidate include:

    • headache
    • decreased appetite
    • upset stomach
    • nervousness
    • trouble sleeping
    • nausea

    If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

    Serious side effects

    Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

    • Heart problems. Symptoms can include:
      • pain in your chest, left arm, jaw, or between your shoulders
      • increased blood pressure
      • increased heart rate
      • shortness of breath
    • Stroke. Symptoms can include:
      • weakness in one part or side of your body
      • slurred speech
    • Abnormal liver function that may be mild or lead to severe liver damage
    • Mental health problems. Symptoms can include:
      • symptoms of mania, such as racing thoughts, feelings of power, and excessive energy
      • aggression or hostility
      • hallucinations (seeing or hearing things that aren’t real)
      • paranoia (feeling suspicious)
      • feeling overexcited
    • Seizures
    • Slowed growth (height and weight) in children
    • Changes in eyesight or blurred vision
    • Circulation problems. Symptoms in your fingers or toes can include:
      • numbness
      • feeling cool (sensitive to temperature)
      • pain
      • changes in skin color from pale to blue to red
      • new, unexplained wounds
    • Priapism (painful and prolonged erections)

    Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Methylphenidate oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with methylphenidate are listed below.

    Acid reflux drugs

    Taking these drugs with methylphenidate may increase the level of methylphenidate in your body and lead to more side effects. These medications may also affect the way long-acting forms of methylphenidate work. Examples of these drugs include:

    • antacids
    • h3 blockers
    • proton pump inhibitors

    Serotonergic drugs

    Taking these drugs with methylphenidate may increase your risk of serotonin syndrome, which can be fatal. If you take any of these drugs, your doctor will start you on a lowered dosage of methylphenidate and monitor you for signs of serotonin syndrome. Symptoms can include agitation, sweating, muscle twitches, and confusion.

    Examples of these drugs include:

    • selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and sertraline
    • serotonin-norepinephrine reuptake inhibitors (SNRIs) such as duloxetine and venlafaxine
    • tricyclic antidepressants (TCAs) such as amitriptyline and clomipramine
    • monoamine oxidase inhibitors (MAOIs) such as selegiline and phenelzine
    • the opioids fentanyl and tramadol
    • the anxiolytic buspirone
    • triptans
    • lithium
    • tryptophan
    • St. John’s wort

    Methylphenidate cannot be used during treatment with MAOIs. You can’t take it within 14 days of stopping treatment with an MAOI. Using these medications together can lead to a dangerous increase in your blood pressure.

    Blood pressure drugs

    Taking these drugs with methylphenidate may reduce the intended effects of these medications. This means that they will be less effective. Examples of these drugs include:

    • angiotensin II receptor blockers such as losartan, valsartan, and irbesartan
    • angiotensin-converting enzyme (ACE) inhibitors such as enalapril and lisinopril
    • diuretics (water pills) such as hydrochlorothiazide and furosemide

    Antipsychotics

    Using these drugs with methylphenidate may increase your risk of side effects from both the antipsychotics and from methylphenidate. Examples of these antipsychotics include:

    • chlorpromazine
    • haloperidol

    Seizure medications

    Using these drugs with methylphenidate may increase the amount of the seizure drug in your body. This can lead to more side effects from the seizure drug. Examples of these drugs include:

    • phenytoin
    • phenobarbital

    Warfarin

    Using warfarin, a blood thinner, with methylphenidate may increase the effect of warfarin in your body. This can raise your risk of bleeding.

    Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

    This drug comes with several warnings.

    Allergy warning

    Methylphenidate can cause a severe allergic reaction. Symptoms can include:

    • trouble breathing
    • swelling of your throat or tongue
    • rash
    • hives (itchy welts)

    If you develop these symptoms, call 911 or go to the nearest emergency room.

    Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

    Alcohol interaction warning

    Alcohol may increase the effects of methylphenidate. You should not use alcohol while taking this drug.

    Alcohol may cause Metadate CD and Ritalin LA to be released in your body more quickly. This can cause more side effects and lower the effect of the medication.

    Warnings for people with certain health conditions

    For people with heart problems: Methylphenidate may increase the risk of sudden death, stroke, and heart attack. If you have a heart condition, a history of heart attack, high blood pressure, or an abnormal heart rate, ask your doctor if this drug is safe for you.

    For people with psychiatric disorders: Methylphenidate may make the symptoms of your condition worse. It can also cause new psychotic symptoms, especially in children and adolescents. You may need to stop taking this drug if this happens.

    For people with circulation problems: This drug can worsen circulation problems in your fingers and toes.

    For people with seizures: If you or your child has a history of seizures, don’t take methylphenidate. It may increase your risk of having a seizure.

    For people with glaucoma: Methylphenidate may worsen your vision.

    For people with growth issues: Methylphenidate has been shown to slow growth in children. Your child’s doctor will monitor your child’s height and weight while they take this drug. If your child is not gaining height or weight, methylphenidate may need to be stopped.

    For people with digestive tract problems: Don’t use the brand-name drug Concerta if you have a blockage in your esophagus, stomach, or small or large intestine. Concerta can make this problem worse.

    Warnings for other groups

    For pregnant women: Methylphenidate is a category C pregnancy drug. That means two things:

    1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
    2. There haven’t been enough studies done in humans to be certain how the drug might affect a fetus.

    Tell your doctor if you’re pregnant or plan to become pregnant. Methylphenidate should be used during pregnancy only if the potential benefit justifies the potential risk.

    If you become pregnant while taking this drug, call your doctor right away.

    For women who are breastfeeding: It’s not known if methylphenidate passes through breast milk. You and your doctor may need to decide if you’ll take methylphenidate or breastfeed.

    For seniors: This drug hasn’t been established as safe and effective for use in people over 65 years of age.

    For children: This drug hasn’t been established as safe and effective for use in children under 6 years old.

    Children should have their growth monitored by their doctor while they’re taking methylphenidate.

    All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

    • your age
    • the condition being treated
    • how severe your condition is
    • other medical conditions you have
    • how you react to the first dose

    Dosage for attention deficit hyperactivity disorder (ADHD)

    Generic: Methylphenidate

    • Form: oral immediate-release tablet
    • · Strengths: 5 mg, 10 mg, 20 mg
    • Form: chewable tablet
    • Strengths: 2.5 mg, 5 mg, 10 mg
    • Form: oral extended-release tablet
    • Strengths: 10 mg, 18 mg, 20 mg, 27 mg, 36 mg, 54 mg, 72 mg

    Brand: Ritalin

    • Form: oral immediate-release tablet
    • Strengths: 5 mg, 10 mg, 20 mg

    Brand: Ritalin SR

    • Form: extended-release oral tablet
    • Strength: 20 mg

    Brand: Concerta

    • Form: extended-release oral tablet
    • Strengths: 18 mg, 27 mg, 36 mg, 54 mg

    Brand: Cotempla XR-ODT

    • Form: extended-release orally disintegrating tablet
    • Strengths: 8. 6 mg, 17.3 mg. 25.9 mg

    Brand: Metadate ER

    • Form: oral extended-release tablet
    • Strengths: 20 mg

    Brand: QuilliChew ER

    • Form: extended-release chewable tablet
    • Strengths: 20 mg, 30 mg, 40 mg

    CONCERTA:

    Adult dosage (ages 18 years and older)

    • Typical dosage: 18 mg or 36 mg taken once per day.
    • Dosage increases: Your doctor may increase your dosage by 18 mg each week.
    • Maximum dosage: 72 mg per day.

    Child dosage (ages 13–17 years)

    • Typical dosage: 18 mg per day.
    • Dosage increases: Your doctor may increase your child’s dosage by 18 mg each week.
    • Maximum dosage: 72 mg per day.

    Child dosage (ages 6–12 years)

    • Typical dosage: 18 mg per day.
    • Dosage increases: Your doctor may increase your dosage by 18 mg each week.
    • Maximum dosage: 54 mg per day.

    Child dosage (ages 0–5 years)

    Dosages for people younger than 6 years haven’t been established.

    RITALIN, GENERIC IMMEDIATE-RELEASE TABLETS AND CHEWABLE TABLETS:

    Adult dosage (ages 18–64 years)

    • Typical dosage: 20–30 mg per day taken in 2–3 divided doses.

    Child dosage (ages 6–17 years)

    • Typical dosage: 5 mg taken twice per day before breakfast and lunch.
    • Dosage increases: Your doctor may increase your dosage by 5–10 mg each week.

    Child dosage (ages 0–5 years)

    Dosages for people younger than 6 years haven’t been established.

    RITALIN SR, METADATE ER, GENERIC EXTENDED-RELEASE TABLETS:

    Adult dosage (ages 18 years and older)

    • Typical dosage: These extended-release tablets work for about 8 hours. These tablets may be used in place of immediate-release tablets when the 8-hour dose of the extended-release tablet corresponds to the titrated 8-hour dose of the immediate-release tablet. Your doctor can tell you more.

    Child dosage (ages 6–17 years)

    • Typical dosage: These extended-release tablets work for about 8 hours. These tablets may be used in place of immediate-release tablets when the 8-hour dose of the extended-release tablet corresponds to the titrated 8-hour dose of the immediate-release tablet. Your child’s doctor can tell you more.

    Child dosage (ages 0–5 years)

    Dosages for people younger than 6 years haven’t been established.

    COTEMPLA XR-ODT

    Adult dosage (ages 18 years and older)

    This drug is not prescribed for this age range.

    Child dosage (ages 6–17 years)

    • Typical dosage: 17. 3 mg taken once per day in the morning.
    • Dosage increases: Your doctor may increase your child’s dosage by 8.6 mg to 17.3 mg each week until a suitable dosage is determined. If prescribed for long-term use, your doctor may adjust your child’s dosage from time to time.
    • Maximum dosage: 51.8 mg per day.

    Child dosage (ages 0–5 years)

    This drug has not been established as safe or effective in children younger than 6 years.

    QUILLICHEW ER

    Adult dosage (ages 18 years and older)

    • Typical dosage: 20 mg once daily in the morning.
    • Dosage increases: Your doctor may increase or decrease your dosage by 10, 15, or 20 mg each week until they determine a suitable dosage.
    • Maximum dosage: 60 mg daily.

    Child dosage (ages 6–17 years)

    • Typical dosage: 20 mg once daily in the morning.
    • Dosage increases: Your doctor may increase or decrease your dosage by 10, 15, or 20 mg each week until they determine a suitable dosage.
    • Maximum dosage: 60 mg daily.

    Child dosage (ages 0–5 years)

    This drug has not been established as safe or effective in children younger than 6 years.

    Dosage for narcolepsy

    Generic: Methylphenidate

    • Form: oral immediate-release tablet
    • Strengths: 5 mg, 10 mg, 20 mg
    • Form: oral extended-release tablet
    • Strengths: 10 mg, 20 mg
    • Form: chewable tablet
    • Strengths: 2.5 mg, 5 mg, 10 mg

    Brand: Ritalin

    • Form: oral immediate-release tablet
    • Strengths: 5 mg, 10 mg, 20 mg

    Brand: Ritalin SR

    • Form: extended-release oral tablet
    • · Strength: 20 mg

    Brand: Metadate ER

    • Form: oral extended-release tablet
    • Strengths: 20 mg

    RITALIN, GENERIC IMMEDIATE-RELEASE TABLETS AND CHEWABLE TABLETS:

    Adult dosage (ages 18–64 years)

    • Typical dosage: 20–30 mg per day taken in 2–3 divided doses.

    Child dosage (ages 6–17 years)

    • Typical dosage: 5 mg taken twice per day before breakfast and lunch.
    • Dosage increases: Your doctor may increase your dosage by 5–10 mg each week.

    Child dosage (ages 0–5 years)

    Dosages for people younger than 6 years haven’t been established.

    RITALIN SR, METADATE ER, GENERIC EXTENDED-RELEASE TABLETS:

    Adult dosage (ages 18–64 years)

    • Typical dosage: These extended-release tablets work for about 8 hours. These tablets may be used in place of immediate-release tablets when the 8-hour dose of the extended-release tablet corresponds to the titrated 8-hour dose of the immediate-release tablet. Your doctor can tell you more.

    Child dosage (ages 6–17 years)

    • Typical dosage: These extended-release tablets work for about 8 hours. These tablets may be used in place of immediate-release tablets when the 8-hour dose of the extended-release tablet corresponds to the titrated 8-hour dose of the immediate-release tablet. Your child’s doctor can tell you more.

    Child dosage (ages 0–5 years)

    Dosages for people younger than 6 years haven’t been established.

    Dosage warning

    Don’t take methylphenidate late at night. Doing so can cause trouble sleeping.

    Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

    Methylphenidate oral tablet is used for short-term or long-term treatment. This drug is usually stopped after puberty. Your doctor may try to stop your treatment with methylphenidate on occasion to see if you still need to take it. If your symptoms return, you may need to keep taking it.

    Methylphenidate comes with serious risks if you don’t take it as prescribed.

    If you stop taking it: Your symptoms won’t be controlled. If you’ve been taking high doses of this drug for a long time and stop it suddenly, you may have extreme tiredness, fatigue, or severe depression.

    If you don’t take it on schedule: If you take methylphenidate later in the day, you may have trouble falling asleep.

    If you take too much: If you take too much methylphenidate, you may experience:

    • restlessness
    • muscle pain and weakness
    • faster breathing
    • confusion
    • high or low blood pressure
    • nausea
    • vomiting
    • diarrhea
    • seizures
    • coma

    If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

    What to do if you miss a dose: If you miss a dose, take it as soon as possible. If it’s almost time for your next dose, wait until then and take a single dose.

    Don’t double the dose to try to catch up. This could result in dangerous side effects.

    How to tell if the drug is working: For ADHD: You should be able to focus and pay attention better and be less impulsive and hyperactive.

    For narcolepsy: You should feel less sleepy and more alert.

    Keep these considerations in mind if your doctor prescribes methylphenidate for you.

    General

    • Certain forms shouldn’t be taken with food. If you take the immediate-release tablets or chewable tablets, take methylphenidate 30–45 minutes before meals.
    • You can take the extended-release orally disintegrating tablets with or without food. However, you should take them the same way each time.
    • Take the extended-release tablets when you wake up in the morning. This form releases the drug into your body throughout the day. Don’t take it in the late afternoon or at night because it can cause trouble sleeping.

    Self-administration

    For the immediate-release and chewable tablets:

    • You can cut these tablets.

    For the extended-release (non-orally disintegrating) tablets:

    • Do not cut, chew, crush, or divide these tablets.
    • Swallow them whole with water or other liquids.

    For the extended-release orally disintegrating tablets:

    • Use each tablet right after removing it from the blister pack.
    • With dry hands, peel back the foil on the blister pack. Don’t push the tablet through the foil.
    • Place the tablet on your tongue right away. Allow it to dissolve without chewing it. No liquid is needed.

    Storage

    • Each form should be stored at the appropriate temperature:
    • o All generic tablets:Store at a temperature between 68°F and 77°F (20°C and 25°C).
    • Concerta, Ritalin: Store these tablets at room temperature of 77°F (25°C). You can store them for a short time at temperatures between 59°F and 86°F (15°C and 30°C).
    • Metadate ER: Store at a temperature between 68°F and 77°F (20°C and 25°C). You can store it for a short time at temperatures between 59°F and 86°F (15°C and 30°C).
    • Cotempla XR-ODT: Store at a temperature between 59°F and 86°F (15°C and 30°C). After removing the blister packs from the carton, store them in the reusable travel case.
    • Don’t freeze methylphenidate. Keep it away from high temperatures.
    • Keep this drug away from light.
    • Don’t store this medication in moist or damp areas, such as bathrooms.

    Refills

    A prescription for this medication is not refillable. You or your pharmacy will have to contact your doctor for a new prescription if you need this medication refilled.

    Travel

    When traveling with your medication:

    • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
    • Don’t worry about airport X-ray machines. They can’t harm your medication.
    • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
    • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

    Clinical monitoring

    Your doctor will check you for the following while you take this drug:

    • blood pressure and heart rate
    • signs of aggressive behavior or changes in mental health conditions
    • growth and weight in children

    Availability

    Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

    Prior authorization

    Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

    There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

    Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

    Methylphenidate (Ritalin). Reference - RIA Novosti, 29.01.2009

    https://ria.ru/200/160419471.html

    Methylphenidate (Ritalin). Help

    Methylphenidate (Ritalin). Reference - RIA Novosti, 29.01.2009

    Methylphenidate (Ritalin). Reference

    Methylphenidate (Meridil, Centedrin, Ritalin) is an aphrodisiac, non-amphetamine psychostimulant. It can be used for depression of the nervous system caused by antipsychotic drugs, narcolepsy. It is also prescribed to treat attention deficit disorder and depression.

    2009-01-29T11:05

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    All American teenagers who participated in the executions of their peers took Ritalin, but for various reasons they did not receive it on the day of the tragedy, scientists say. The withdrawal syndrome is so strong, experts say, that a teenager who is forgotten to give a dose of medication falls into a deep depression, becomes uncontrollable and aggressive, which has led to many tragedies.

    Methylphenidate (Meridil, Centedrin, Ritalin) is an aphrodisiac, non-amphetamine psychostimulant.
    In medicine, the drug has limited use as a psychostimulant in asthenic conditions, increased fatigue. It can be used for depression of the nervous system caused by antipsychotic drugs, narcolepsy. It is also prescribed for the treatment of lack of attention, activity disorders, depression.

    Methylphenidate was synthesized in 1944. At 19In 1961, physicians from around the United States drew attention to the fact that the new generation of central nervous system stimulant drugs methylphenidate and dextroamphetamine help children with attention deficit hyperactivity disorder (ADHD), but compared to the previously used benzedrine, they cause much less side effects. After that, Ciba Geigy proposed the use of Ritalin (methylphenidate) for the treatment of this disease. The remedy was initially rejected by the US Food and Drug Administration (FDA), but in 1963 was approved for this indication.

    Pharmaceutical tablets are most commonly taken orally or crushed and sniffed as a powder.

    Methylphenidate is similar in action to amphetamine, but has a less strong stimulating effect and less effect on the peripheral adrenergic systems; does not cause a pronounced increase in blood pressure. Suppresses appetite, causes wakefulness, euphoria, increases concentration and attentiveness.

    Possible side effects: insomnia, nausea, sometimes agitation and anxiety, exacerbation of psychopathological symptoms. Addictive.

    Complications arising from the use of methylphenidate are due to the insoluble excipients used in the tablets. When injected, these materials block small blood vessels, causing serious damage to the lungs and retina. Methylphenidate also produces an increase in heart rate and blood pressure due to high doses, and can lead to serious psychological dependence.

    According to the Australian Medicines Administration (TGA), Ritalin and dexamphetamine have resulted in 400 serious adverse reactions in children aged three to ten years. In particular, there was a case of sudden death of a seven-year-old child and a stroke in a five-year-old child after the use of Ritalin. Dexamphetamine use has been associated with palpitations and shortness of breath in some cases. In addition, adverse reactions such as hair loss, muscle spasms, severe abdominal pain, tremors, insomnia, severe weight loss, depression and paranoia have been reported.

    In recent years, the use of Ritalin for the purpose of psychological self-improvement has become widespread. Currently, students have begun to widely consume it, according to which the drug helps to concentrate during pre-examination preparation. What may be the long-term effect of such initiative is still unknown.

    According to the US Drug Enforcement Administration, street abuse of methylphenidate has become a major problem in the country. The United States consumes 85% of the total production of methylphenidate (Ritalin).
    In 2002, the Parliamentary Assembly of the Council of Europe noted the high levels of legal consumption of methylphenidate in Belgium, Germany, Iceland, Luxembourg, the Netherlands, Switzerland and the United Kingdom.

    Methylphenidate is on schedule 1 (psychotropic substances) of the list of narcotic drugs, psychotropic substances and their precursors subject to control in the Russian Federation, and produces pharmacological effects similar to those of cocaine and amphetamine.

    The material was prepared on the basis of information from open sources

    Do we need a magic pill to improve memory and attention?

    • Zaria Gorvette
    • BBC Capital

    Image credit: Getty Images

    But are they really effective? And what will happen if everyone starts using them?

    Honore de Balzac was an avid coffee drinker who believed that coffee was the best way to stimulate the brain. Every evening he went in search of night coffee shops, and then wrote until morning.

    It is said that he drank 50 cups of his favorite drink daily. And ... he literally swallowed ground coffee with spoons - it "worked" well on an empty stomach.

    The writer said that after a sip of coffee powder "the ideas in my head began to march briskly, like battalions of a great army that go to the battlefield to rush into battle."

    Obviously it really helped. Balzac was an incredibly prolific writer, writing almost a hundred novels, short stories and plays. True, he died of heart failure at the age of only 51 years.

    Image copyright, Getty Images

    Caption before photo,

    Honore de Balzac was one of the first proponents of nootropics - to stimulate creativity, he consumed huge amounts of caffeine daily

    For centuries, caffeine was the only help in overcoming the mountain of boring and painstaking work .

    And only the last generation of workers began to experiment with substances that, in their opinion, increase intellectual abilities and contribute to fantastic performance.

    In fact, some of these "smart drugs" ("mind pills") are already quite popular. A recent survey of tens of thousands of Americans found that 30% of them had taken such drugs within the past year.

    Perhaps soon we will start doing all this.

    But what will be the consequences? Will a new generation of giants of thought appear, whose brilliant inventions will mark the space age of mankind? Will we achieve insane economic growth? Or maybe the working week will become noticeably shorter, because people will work more efficiently?

    "Changes the mind"

    To answer these questions, we first need to figure out what scientists are offering us.

    The first drug of this group, piracetam, was synthesized in the early 1960s by the Romanian chemist and psychologist Corneliu George. He was looking for a substance that would cause drowsiness, and after a few months he came up with the drug Compound 6215.

    It was safe, but there was no sedative effect either. It seemed to be the other way around. Patients who took it for a month had a significant improvement in memory.

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    George immediately realized the significance of his invention and coined the term "nootropic" - a combination of the Greek words νους ("mind") and τροπή ("turn, interfere, change").

    Today piracetam is a favorite "magic pill" of students and young professionals who seek to improve their performance. Although several decades after the invention of the drug, there is no sufficient evidence of its effectiveness.

    In the UK, Piracetam is available by prescription only, although the US Food and Drug Administration has not approved Piracetam and has not allowed Piracetam to be sold as a dietary supplement.

    Texas entrepreneur and podcast author Mansal Denton takes phenylpiracetam, a close analogue of piracetam developed in the Soviet Union to help astronauts cope with the stresses of space life.

    Image copyright, Getty Images

    Image caption,

    Creatine has always been a mainstay of bodybuilding dietary supplements, but now it is also used to improve mental alertness

    "When I use this drug, my speech skills improve, and therefore I usually record a lot of podcasts on such days," he says.

    In fact, this effect is quite typical for nootropics. Despite the abundance of their passionate admirers, the intellectual effect is almost imperceptible or non-existent.

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    2 take, for example, monogitrates. This white powder dietary supplement is usually mixed with sugary drinks or milkshakes, or taken as a tablet.

    The substance enters the brain, and recent research shows that creatine does improve working memory and intelligence.

    Although creatine was discovered relatively recently by ambitious young professionals, it has been known to bodybuilders for decades. The substance is the main element of many dietary supplements, and in the US, sports supplements are a multi-billion dollar industry.

    In a survey last year by Ipsos Public Affairs, 22% of adults said they had used a dietary supplement in the last year.

    If creatine had a serious effect on human performance, we would certainly notice it.

    Of course, there are drugs with a stronger effect.

    "Some of them are quite effective," says Andrew Huberman, a neuroscientist at Stanford University.

    There is one category of nootropics that scientists and biohackers (amateurs who try to change the physiology of their body at the molecular level) are very interested in.

    These are psychostimulants.

    The most common of these are amphetamines and methylphenidate, which are sold by prescription under the brand names Adderall and Ritalin.

    In the United States, both drugs are approved for the treatment of people with Attention Deficit Hyperactivity Disorder.

    But now they are often abused by people whose work requires a high concentration of attention.

    Image copyright, Getty Images

    Image caption,

    The psychostimulant Ritalin is designed to treat attention deficit hyperactivity disorder, but is often used simply to improve attention.

    Amphetamines have long established themselves as nootropics.

    This feature was well known to the legendary Hungarian mathematician Pal Erdős, who with the help of amphetamines withstood 19-hour mathematical sessions.

    Writer Graham Greene used them to write two books at the same time. Today, their use is quite common among journalists, creative professionals and financiers.

    Those who have taken them swear that they really change consciousness, although not in the way you expected.

    Back in 2015, a scientific review showed that the effect of amphetamines on intelligence is quite "modest". But most people use them to improve their mental abilities, but rather to increase energy and motivation to work.

    (Both drugs have serious side effects, more on that later).

    One of the effects of psychostimulants like Adderall and Ritalin is to make it easier to perform psychologically exhausting tasks.

    One study showed that under the influence of "Ritalin" mathematical problems seemed to be studied more interesting.

    Assuming that all people start using mental stimulants, we will have at least two main consequences.

    First, people will stop avoiding unpleasant tasks.

    Tired office workers who have spent years perfecting the art of idleness in the workplace will frantically sort through documents, update spreadsheets, and enthusiastically attend boring meetings.

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      But whether this is so good is a debatable question.

      "Many Silicon Valley and Wall Street professionals are already using mental stimulants. It's starting to feel like a professional mental sport where the stakes and competition are increasing daily," said Jeffrey Wu, CEO and co-founder of HVMN, which makes a line of nootropic supplements. .

      But there are also significant shortcomings in this. Amphetamines are structurally similar to methamphetamine, a powerful addictive drug that has ruined countless lives. It can also have fatal consequences.

      There are many reports that Adderall and Ritalin are addictive. And they also have a number of side effects, such as nervousness, anxiety, insomnia, stomach pain, and even hair loss.

      Finally, psychostimulants are unlikely to increase overall productivity.

      An important question, how will a person feel the next day? You can work at your peak for 12 hours, but then for a day or two you will feel a strong decline in activity.

      However, we still have a few proven options that can be bought without a prescription in every coffee shop.

      This is, first of all, coffee. Unfortunately, no one has yet calculated the impact of caffeine on economic growth, but many other studies have found many of its benefits.

      Image copyright, Getty Images

      Image caption,

      Coffee still seems to be the best stimulant of intellectual activity

      Interestingly, caffeine turned out to be more effective than a commercial caffeine-based supplement produced by Woo, which now costs 17.9$5 for 60 tablets.

      Well, and secondly, nicotine. Scientists are increasingly realizing that it has a powerful nootropic effect that improves a person's memory and helps focus.

      Although the risks and side effects are well known to everyone.

      "Some well-known neuroscientists chew Nicorette to improve their mental alertness. But they've all smoked in the past, so it's probably a replacement for a bad habit," says Guberman.

      Learn more