Sertraline adverse effects
Side effects of sertraline - NHS
Like all medicines, sertraline can cause side effects in some people, but many people have no side effects or only minor ones.
Some of the common side effects of sertraline will gradually improve as your body gets used to it.
Some people who take sertraline for panic attacks find their anxiety gets worse during the first few weeks of treatment. This usually wears off after a few weeks, but speak to your doctor if it bothers you. A lower dose may help reduce your symptoms.
Common side effects
These common side effects of sertraline happen in more than 1 in 100 people. There are things you can do to help cope with them:
Feeling sick (nausea)Try taking sertraline with or after food. It may also help if you avoid rich or spicy food.
Make sure you rest and drink plenty of fluids. It's best not to drink too much alcohol. Ask your pharmacist to recommend a painkiller. Headaches should usually go away after the first week of taking sertraline. Talk to your doctor if they last longer than a week or are severe.
Being unable to sleepTake sertraline first thing in the morning.
Feeling sleepyTake sertraline in the evening and cut down the amount of alcohol you drink. Do not drive, ride a bike or use tools or machinery if you're feeling sleepy. If this does not help, talk to your doctor.
DiarrhoeaDrink plenty of water or other fluids to avoid dehydration. Signs of dehydration include peeing less than usual and having dark, strong-smelling pee. Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor.
If you take contraceptive pills and you have severe diarrhoea for more than 24 hours, your contraception may not protect you from pregnancy. Check the pill packet for advice.
Dry mouthChew sugar-free gum or suck sugar-free sweets.
Feeling dizzyIf sertraline makes you feel dizzy, stop what you're doing and sit or lie down until you feel better.
Feeling tired or weakIf sertraline makes you feel tired or weak, stop what you're doing and sit or lie down until you feel better. Do not drive, ride a bike or use tools or machinery if you're feeling tired.
It's best not to drink alcohol as it will make you feel worse. If these symptoms do not go away after 1 or 2 weeks, ask your pharmacist or doctor for advice.
Keep taking the medicine, but speak to a doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away.
Serious side effects
It happens rarely (in less than 1 in 100 people), but some people may have serious side effects when taking sertraline.
Book an appointment with your doctor if you get:
- changes in your periods, such as heavy bleeding, spotting or bleeding between periods
- weight gain or weight loss without trying
Call a doctor or contact 111 now if:
- you have feelings of overwhelming happiness (euphoria), excessive enthusiasm or excitement, or a feeling of restlessness that means you cannot sit or stand still
- the whites of your eyes turn yellow, or your skin turns yellow (this may be less noticeable on brown or black skin) – these can be signs of liver problems
- you cough up blood or have blood in your pee
- you have black or red poo or blood in your vomit – these can be signs of bleeding from the gut
- you are bleeding from the gums, or get bruises that appear without a reason or that get bigger
Go to 111.
nhs.uk or call 111.
Immediate action required: Call 999 or go to A&E now if you:
- get chest pain or pressure, or shortness of breath
- get headaches, have trouble focusing, have memory problems, cannot think clearly, have weakness, have a seizure or fit, or lose your balance – these can be signs of low sodium levels
- have thoughts about harming yourself or ending your life
- get severe dizziness or pass out
- get painful erections that last longer than 2 hours – this may happen even when you're not having sex
- get any heavy bleeding or bleeding that you cannot stop, such as cuts or nosebleeds that do not stop within 10 minutes
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to sertraline.
Immediate action required: Call 999 or go to A&E now if:
- you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
- you're wheezing
- you get tightness in the chest or throat
- you have trouble breathing or talking
- your mouth, face, lips, tongue or throat start swelling
You could be having a serious allergic reaction and may need immediate treatment in hospital.
Long-term side effectsA few people may get sexual side effects, such as problems getting an erection or a lower sex drive. In some cases these can continue even after stopping the medicine. Speak to your doctor if you are worried.
Taking sertraline for more than a year has also been linked to a small increased risk of getting diabetes. You'll be regularly checked for this.
Other side effectsThese are not all the side effects of sertraline. For a full list, see the leaflet inside your medicine packet.
Information:
You can report any suspected side effect using the Yellow Card safety scheme.
Visit Yellow Card for further information.
Page last reviewed: 2 February 2022
Next review due: 2 February 2025
Sertraline Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Warnings:
Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders.
These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. It is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition.
Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
Warnings:
Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders.
These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. It is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition.
Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
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Uses
Sertraline is used to treat depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. It may decrease fear, anxiety, unwanted thoughts, and the number of panic attacks. It may also reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, and checking) that interfere with daily living. Sertraline is known as a selective serotonin reuptake inhibitor (SSRI). It works by helping to restore the balance of a certain natural substance (serotonin) in the brain.
How to use Sertraline HCL
Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using sertraline and each time you get a refill.
If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually once daily either in the morning or evening. The tablet or liquid form of this medication may be taken with or without food.
The 25 milligrams, 50 milligrams, and 100 milligrams capsule is usually taken with food. The 150 milligrams and 200 milligrams capsule may be taken with or without food. Swallow the capsules whole. Do not crush or chew the capsules. If you have any questions about how to take the capsule form of this medication, ask your doctor or pharmacist.
The liquid form of this medication must be mixed with another liquid before use. Just before taking, carefully measure the dose using the medicine dropper provided. Do not use a household spoon because you may not get the correct dose. Mix the dose with a half cup (4 ounces/120 milliliters) of water, ginger ale, lemon-lime soda, lemonade, or orange juice. Do not use other liquids to mix this drug.
The mixture may appear cloudy, which is normal and harmless. Drink all of the mixture right away. Do not prepare a supply in advance.
If you are taking this medication for premenstrual problems, your doctor may direct you to take this drug every day of the month or for only the 2 weeks before your period until the start of your period.
The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
Keep taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience symptoms such as mood swings, headache, tiredness, sleep changes, and brief feelings similar to electric shock.
To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Report any new or worsening symptoms right away.
Tell your doctor if your condition lasts or gets worse.
Side Effects
See also Warning section.
Nausea, dizziness, drowsiness, dry mouth, loss of appetite, increased sweating, diarrhea, upset stomach, or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: easy bleeding/bruising, decreased interest in sex, changes in sexual ability, muscle cramps/weakness, shaking (tremor), unusual weight loss.
Get medical help right away if you have any very serious side effects, including: fast/irregular heartbeat, fainting, black stools, vomit that looks like coffee grounds, eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night, blurred vision).
This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.
Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Precautions
Before taking sertraline, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as latex found in the medicine dropper, tartrazine found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of bipolar/manic-depressive disorder, bleeding problems, liver disease, seizure disorder, thyroid disease, personal or family history of glaucoma (angle-closure type).
Sertraline may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.
The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using sertraline, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using sertraline safely.
This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
The liquid form of this medication contains alcohol. Caution is advised if you have diabetes, alcohol dependence, or liver disease. Some medications (such as metronidazole, disulfiram) can cause a serious reaction when combined with alcohol. Ask your doctor or pharmacist about using this product safely.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be more sensitive to the side effects of this drug, especially bleeding, loss of coordination, or QT prolongation (see above). Loss of coordination can increase the risk of falling. Older adults may also be more likely to develop a type of salt imbalance (hyponatremia), especially if they are taking "water pills" (diuretics).
Children may be more sensitive to the side effects of the drug, especially loss of appetite and weight loss. Monitor weight and height in children who are taking this drug.
During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Also, babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop withdrawal symptoms such as feeding/breathing difficulties, seizures, muscle stiffness, or constant crying. If you notice any of these symptoms in your newborn, tell the doctor promptly.
Since untreated mental/mood problems (such as depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, discuss with your doctor right away the benefits and risks of using this medication during pregnancy.
This drug passes into breast milk. Consult your doctor before breast-feeding.
Interactions
See also Precautions section.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug are: pimozide, other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen/naproxen, "blood thinners" such as dabigatran/warfarin).
Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication.
Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication.
The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including other SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), tryptophan, among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.
Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and opioid pain or cough relievers (such as codeine, hydrocodone).
Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness.
Ask your pharmacist about using those products safely.
Aspirin can increase the risk of bleeding when used with this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually 81-162 milligrams a day), you should continue taking it unless your doctor instructs you otherwise.
This medication may interfere with certain medical/lab tests (including brain scan for Parkinson's disease), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.
Does Sertraline HCL interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Symptoms of overdose may include: severe dizziness, fainting.
Do not share this medication with others.
Keep all regular medical and psychiatric appointments.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Images
sertraline 100 mg tablet
Color: light yellowShape: ovalImprint: I G 214
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 50 mg tablet
Color: light blueShape: ovalImprint: I G 213
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 100 mg tablet
Color: yellowShape: roundImprint: S3
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 50 mg tablet
Color: light blueShape: roundImprint: S2
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 50 mg tablet
Color: blueShape: oblongImprint: A 1 7
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 25 mg tablet
Color: greenShape: oblongImprint: A 1 6
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 25 mg tablet
Color: light greenShape: ovalImprint: I G 212
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 100 mg tablet
Color: light yellowShape: oblongImprint: T 100
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 50 mg tablet
Color: blueShape: oblongImprint: T 50
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 25 mg tablet
Color: greenShape: oblongImprint: T 25
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 100 mg tablet
Color: yellowShape: oblongImprint: A 1 8
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 20 mg/mL oral concentrate
Color: colorlessShape: Imprint:
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 100 mg tablet
Color: light yellowShape: oblongImprint: G 4910 100 mg
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 50 mg tablet
Color: light blueShape: oblongImprint: G 4900 50 MG
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 20 mg/mL oral concentrate
Color: colorlessShape: Imprint:
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 50 mg tablet
Color: light blueShape: oblongImprint: ZOLOFT 50 MG
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 50 mg tablet
Color: blueShape: oblongImprint: L U D02
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 25 mg tablet
Color: greenShape: oblongImprint: L U D01
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 100 mg tablet
Color: light yellowShape: oblongImprint: ZOLOFT 100 MG
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 25 mg tablet
Color: light greenShape: oblongImprint: ZOLOFT 25 MG
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 100 mg tablet
Color: yellowShape: oblongImprint: L U D03
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 25 mg tablet
Color: light greenShape: roundImprint: S1
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 25 mg tablet
Color: whiteShape: roundImprint: S 21
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
sertraline 20 mg/mL oral concentrate
Color: colorlessShape: Imprint:
This medicine is a light yellow, oval, scored, film-coated, tablet imprinted with "I G" and "214".
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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals.
The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
| Rec.INN WHO registered Included in preparations: list Pharmacological action Antidepressant, naphthylamine derivative. Selective blocker of neuronal reuptake of serotonin in the brain. PharmacokineticsWhen administered orally sertraline in doses of 50-200 mg 1 time / day for 14 days C max in blood plasma is reached after 4.5-8.4 hours. The average T 1/2 in young and elderly men and women is 22 -36 hours According to the half-life period, approximately two-fold cumulation of the active substance is observed until an equilibrium state is reached after 1 week of treatment. Plasma protein binding is about 98%, V d - 20 l / kg. Intensively metabolized during the first passage through the liver. The main metabolite found in plasma, N-desmethylsertraline, has weak pharmacological activity. T 1/2 N-desmethylsertraline varies within 62-104 hours. Indications of the active substance SERTRALINETreatment of depressive states of various origins in patients with mono- and bipolar affective disorders. Prevention of recurrence of episodes of depression. Open list of ICD-10 codes
Dosage regimen Inside - 50 mg 1 time / day, if necessary, the dose can be increased to 200 mg / day over several weeks. Side effectsFrom the side of the central nervous system: dizziness, drowsiness, headache, insomnia, fatigue, weakness, tremor; rarely - manic or hypomanic state, anxiety, restlessness, visual disturbances. From the side of the cardiovascular system: rarely - redness of the skin with a feeling of heat or warmth, palpitations. From the digestive system: decreased appetite, diarrhea, dry mouth, nausea, stomach or intestinal cramps, flatulence; rarely - constipation, vomiting. From the side of metabolism: increased sweating. On the part of the reproductive system: rarely - decreased potency. Allergic reactions: rarely - fever, skin rash, urticaria or itching. Contraindications for useSimultaneous use with MAO inhibitors, hypersensitivity to sertraline. Use in pregnancy and lactation Adequate and well-controlled safety studies of sertraline during pregnancy have not been conducted, so the use is possible only in cases where the expected benefit to the mother outweighs the possible risk to the fetus. It is not known whether sertraline is excreted in breast milk, so use during lactation is not recommended. Separate studies have shown that in infants whose mothers received sertraline during the feeding period, its plasma levels are negligible or not detectable, while concentrations in breast milk exceed concentrations in the mother's blood. Women of childbearing age should use reliable methods of contraception during treatment with sertraline. In experimental studies no teratogenic and mutagenic effects of sertraline were detected. However, at doses approximately 2.5-10 times the maximum daily clinical dose, sertraline caused a delay in fetal bone ossification, possibly as a result of maternal exposure. With the introduction of sertraline at doses approximately 5 times the maximum clinical dose, a decrease in neonatal survival was observed. Use in hepatic dysfunctionUse with caution in hepatic dysfunction. Use in impaired renal function Use with caution in impaired renal function. Pediatric usePediatric safety has not been established. Special instructionsUse with caution in cases of drug abuse or dependence in history, liver dysfunction, kidney dysfunction, epileptic seizures, weight loss. Should not be used in patients undergoing electroshock therapy. The use of sertraline is possible no earlier than 14 days after the abolition of MAO inhibitors. Avoid drinking alcohol during treatment. Pediatric safety has not been established. Influence on the ability to drive vehicles and mechanisms During the treatment period, activities requiring increased attention and high speed of psychomotor reactions should be avoided. Drug interactionsSimultaneous use of coumarin derivatives with anticoagulants significantly increases prothrombin time. Co-administration of sertraline may displace other drugs from plasma protein binding, resulting in an increase in plasma concentration of the corresponding active substance and an increased risk of side effects.    Copyright © · The Wright Initiative · Articles · Site Map 
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Neuronal uptake of norepinephrine and dopamine is practically not affected. It does not have specific affinity for adreno- and m-cholinergic receptors, GABA receptors, dopamine, histamine, serotonin or benzodiazepine receptors. Does not inhibit MAO. Causes anorexia, effective in obsessive states. 
It is excreted mainly through the intestines and in the urine in equal amounts as metabolites, less than 0.2% is excreted in the urine unchanged. 
The effect appears 7 days after the start of treatment, reaching a maximum after 2-3 weeks. 
