Prozac is amazing reddit

Why I believe Fluoxetine / Prozac is the best SSRI overall : depressionregimens

After discovering Moclobemide was causing a bizarre increase in daytime sleepiness/ fatigue, and also after realising that it isn't available in a country I plan to move to, I've recently decided to wean off it, and then had a very painful time finding a suitable replacement antidepressant. Having finally landed on Fluoxetine, it has reminded me why Fluoxetine may be the better option over other SSRIs when it comes to treating severe depression, based on studies I've read:

P-Glycoprotein. This is definitely the most important factor when choosing SSRIs. P-Glycoprotein is basically an enzyme that limits the ability of several drugs/antidepressants from entering the brain. The most notorious for being affected is Citalopram/Escitalopram, though a range of other antidepressants are also affected. For myself, even when on high dose Escitalopram, my depression deteriorated so bad that suicide suddenly became 'an option' again. When I got my genes tested: surprise surprise, I found that I have a hyperactive variant of P-Glycoprotein. As it turns out, Fluoxetine is one of the few antidepressants that is not affected by it, so even if you have a highly active version of P-Glycoprotein, Fluoxetine will bypass it anyway. Other drugs that have found to be unaffected include Mirtazapine, Moclobemide, Bupropion and Duloxetine (though there may be others). Interesting note: there have been studies that show that if you combine Escitalopram with a potent P-Glycoprotein inhibitor like Verapamil, its concentration in the brain increases significantly - but this is merely academic at this stage.
Behind Fluvoxamine, Fluoxetine is the 2nd most potent Sigma-1 agonist of all antidepressants. Activation of Sigma-1 receptor itself has shown to cause antidepressant & anxiolytic effects. Note: Sertraline also has a high affinity for Sigma-1 receptors, but is considered to be an antagonist rather than an agonist -> A study found that the positive effects of neurite outgrowth induced by Fluoxetine and Fluvoxamine were antagonised by Sertraline, thus supporting the belief that Sertraline is an antagonist of Sigma-1 receptors.
Fluoxetine is the only antidepressant so far that has been shown to directly elevate certain neurosteroids like Allopregnanolone, which itself has shown independent antidepressant & anxiolytic effects. Interestingly, Fluoxetine and its metabolite was able to raise this neurosteroid even at doses way below those used therapeutically.
Of all the SSRIs, Fluoxetine was the only one that was found to elevate Dopamine and Norepinephrine in the Prefrontal Cortex. This could be attributed to Fluoxetine's modest antagonist effect on the 5-HT2C receptor.
Fluoxetine has a really long half life (3-7 days approx), so if you skip a dose, you won't notice an immediate crash / rebound symptoms.

Only downside is that it inhibits a lot of enzymes that metabolise other drugs, so it has the potential to interact with a lot of other meds (by elevating their concentrations), so caution must be exercised if you plan to use any other drugs alongside Fluoxetine.

Can't find ANY positive stories about Prozac. What's going on? : depression

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Children's Dental Clinic #46

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Tatarsky Evgeny Vasilyevich wrote on 11/18/2022 06:05:43 PM:
Good afternoon. My daughters are observed in this "miracle" polyclinic. Nothing for the youngest. But the eldest suffered enough ... almost all circles passed. Starting from a dentist, continuing with surgeons and ending with orthodontists. Everyone had surgeons. So, Mandel and Egorov, in my opinion, are absolutely not intended to work with children. Children are hurt and scared, and it is unpleasant for parents to listen to their reproaches that the child does not even want to sit down in a chair. I thought I just had such a child, too afraid, but no. For us, the work of another surgeon Fedotov G.V. was a discovery and a reward. He is not just a doctor, he is truly a master of his craft! Knows how to find an approach to the child and do everything quickly and painlessly. At the previous ones, we left in hysterics and with a swollen lip, due to the fact that it was pushed back a lot. Fedotov knows how to win over a frightened child (8 years old, for a second). I am so very grateful to him Link to blackspruit. blacksprut blacksprut.co official site Because each trip to the surgeons was a test of stress resistance. We will only see him! We advise everyone! Take care of yourself and your children! And nerves! nine0004

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Olga. wrote on 25.04.2022 23:41:04:
For the last 10 years I have been regularly treating and removing the teeth of my girls in chipboard √ 46. It is difficult to sign up, but in the morning, when the registration is opened, it is possible. Polite girls at the front desk. For acute pain, they will always accept without an appointment. Our favorite dentist Antigova Patimat Antigovna. A wonderful Doctor, children go to her without fear, or rather they did, now she is temporarily not working, but we are really looking forward to her. When teeth are to be removed, there are always tears. Although the doctors are young now, they are always men and do their job very well. Today, for the first time, we got to be removed to Arestova Valeria Nikolaevna, and for the first time, in many years, we did not shed a single tear. The child has ceased to be afraid of both injection and removal. Thank you very much, Valeria Nikolaevna!!! Now, remove only to you! nine0004

Shmytkova Julia Valerievna wrote on 12.07.2021 14:23:10:
I express my deep gratitude to the doctors! July 12, 2021 Came in with my son in severe pain. Without any questions, they sent us to the doctor on duty, took a picture, received a dental surgeon, and after that the doctor removed the diseased teeth (milk teeth, caused suppuration of the gums). Thank you for your kind and caring attitude. Many thanks for the professionalism of Morozova I.K., Mandel M.I. and of course the front desk staff. nine0004

Larina Maria Sergeevna wrote on 04/05/2021 18:29:54:
Good afternoon. My daughters are observed in this "miracle" polyclinic. Nothing for the youngest. But the eldest suffered enough . .. almost all circles passed. Starting from a dentist, continuing with surgeons and ending with orthodontists. Everyone had surgeons. So, Mandel and Egorov, in my opinion, are absolutely not intended to work with children. Children are hurt and scared, and it is unpleasant for parents to listen to their reproaches that the child does not even want to sit down in a chair. I thought I just had such a child, too afraid, but no. For us, the work of another surgeon Fedotov G.V. was a discovery and a reward. He is not just a doctor, he is truly a master of his craft! Knows how to find an approach to the child and do everything quickly and painlessly. At the previous ones, we left in hysterics and with a swollen lip, due to the fact that it was pushed back a lot. Fedotov knows how to win over a frightened child (8 years old, for a second). I am so very grateful to him. Because every trip to the surgeons was a test of stress resistance. We will only see him! We advise everyone! Take care of yourself and your children! And nerves! nine0004

Shcherbakova Maria Georgievna wrote on 21. 09.2019 15:22:12:
I would like to express my deep, priiii huge gratitude to the dentist Makoev Azamat Khasanovich for the miraculous removal of a PROBLEM tooth from my daughter. We met the doctor at an appointment at DSP No. 46 and did not regret that she signed up her daughter for removal just to him. The removal procedure was PAINLESS!!!, I was constantly interested during the injection and during removal, what sensations she had, whether it hurt her, whether her head was spinning, etc. Everything was done very neatly and efficiently! Kind, knowledgeable, caring and professional. My daughter said that now we will delete ONLY from Azamat Khasanovich. It's a pleasure to deal with such doctors. There should be more such doctors in children's clinics. nine0003 I wish you health, strength and patience, Azamat Khasanovich!!!

Yulia Vladimirovna Kiseleva wrote on 05/28/2018 11:34:32 PM:
I want to express my deep gratitude to Rychikhina Marina Vladimirovna, Ramazanov Gamzat Sergeevich, Poddubny Vyacheslav Mikhailovich, Thank you for your attention. accuracy, care for my son.
I am satisfied with these wonderful doctors, my son calmly walks with him and knows that they will not hurt, that they will talk and calm. Thank you so much! food second review! but I don't see the first one. nine0004

Olga wrote on 11.04.2018 10:25:13:
Many thanks to Dr. Besedina Maria Sergeevna for the treatment and preservation of milk teeth! The reception was held in a comfortable and friendly atmosphere, which is very important for young patients.

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Walks in New York. 36. Stars in a glass. – Elegant New York

For a previous walk see: New York Walks 35. Unique neighborhoods; nine0003 Walking around New York with a Manhattan fashionista.

Author of the cycle Tatyana Borodina

at first glance, New York seems to be open, open to you, with an obvious parallel-perpendicular structure and universal well-known skyscrapers and gasters. But with a longer acquaintance, you notice that it is not so simple. This city, like an ocean, is driven by dozens of different currents, penetrated by many different layers, each of which is inhabited by residents who feel quite comfortable in “their depths” and practically do not intersect with those who live in neighboring ones. We are not talking about social strata, they are, of course, present, but much more important are the many other tastes and habits formed by the community, hobbies and leisure, work, music, art, ethnicity. It is they who form and define the diverse world of unique New York life. nine0047

In New York, like nowhere else in the world, there are a large number of nesting levels - the more you get to know the city, the more hidden and inaccessible it turns out to be. This is what provokes new steps towards rapprochement, excites the imagination, stimulates the appetite for revealing his secrets.

The banal phrase that you can discover New York indefinitely becomes extremely personal and unhackneyed when you go through your own way of getting to know him. Moreover, this applies not only to the historical, social or ethnic secrets of the city or its private life, which is inaccessible to a visitor - surprises can be hidden from an immodest glance simply physically, for example, on the roofs. These are the "simple secrets" that will be discussed today. nine0004
*

Summer is at its zenith, but we have not had time to get tired of it yet and we are thinking with pleasure about the opportunities that New York gives this time. Let's put aside trips to museums and shops for rainy days, and now let's better study what is happening on the roofs of the city. I hope you don't have an instant association with the title of Tennessee Williams' famous play, Cat on a Hot Tin Roof.

No, the roofs that I invite you to visit are not hot at all, but very comfortable and pleasant in every respect. Climbing the Empire State Building is a good thing, but only if you are a tourist and you are obligated to do so by a sense of duty and a desire to post your selfies with a view of conquered Manhattan on social networks. But if you are a local resident, can you imagine that you will decide on such a feat voluntarily? The fact of the matter is, many citizens have never been to the famous observation deck, but this does not mean that they did not admire the city from a bird's eye view, high or low, what, in fact, is the difference. nine0004
Yes, imagine, there are options, you can climb on the roof of a house 60, 30, 20 or 15 floors high and see the city from completely different “points of view”. A lot of New Yorkers do this benchmarking fairly regularly—a good time, I tell you.

Frankly, we have not been able to visit all the places that will be discussed, but the summer is not over, and maybe we will run into you on one of the roofs when we continue our journey of exploring the city. nine0004
New York, rooftop view.

But before starting the walk, we want to note: this time we do not urge you to take the route as a guide to action. Break it down into several stages, and then our recommendations will be enough for you for quite a long time. But, on the other hand, it all depends on your temperament, health and wallet.

So, up - twenty-one rooftops of New York are waiting for us.

Of course, the Rooftop Bar is a common sight in the city of the Big Apple. Moreover, in the last 2-3 years, their number has increased dramatically and a new wave has significantly pressed the veterans of this very profitable business. It so happened that the officially existing Rooftop Bars in New York belong to the hotels, in fact, on the roofs of which they are located. I only know one that has nothing to do with the hotel, but we will talk about it later .

Of course, there are private New York rooftops where parties are held, sunbathed, bathed, held exhibitions and photo shoots, and, at times, grow vegetables for sale, but today they are outside the scope of our interest.

For Walk 36, we selected fifteen rooftop bars in Manhattan and six in other parts of the city. Probably, this list will not completely coincide with the 2014 rating, because it contains everything that was to the taste of Elegant New York.

But, most likely, our recommendations will be quite close to what Zagat recommends - The 10 Best Rooftop Bars In NYC

Here you can read about 5 new ones opened in 2014.

THE KIMBERLY

1. UPSTAIRS AT THE KIMBERLY. 30th floor, starry sky above and Manhattan at your feet. What could be better? The same thing, plus a small detail - a glass of excellent wine or a signature cocktail, preferably in the atmosphere of a classic New York bar "like in a novel" with a bird's-eye view of the Chrysler Building. It's all there in the Upstairs bar at the Kimberley Hotel. Its design is based on the harmony of many smooth lines embodied in the panels, partitions, walls and ceilings of the bar halls. Elegant furniture, subdued soft lighting create a sophisticated and cozy atmosphere, and bright garlands add a festive and joyful accent. nine0004
Opened in 2010, the bar continues to attract many people who want to see the magnificent skyline of New York. Upstairs is famous for the variety of cocktails offered by world famous bartender Alexander Ott. There is also an excellent wine list and a huge selection of beers. By the way, if it's raining outside, it's not a problem, the bar has a retractable roof, so you can enjoy drinks and a view of the city in any weather. But be aware that the average price of a cocktail is $18 and a light meal is $24. nine0004

Open: 5:00 PM-1:00 AM
Address: 145 E 50th ST, New York, Ny 10022
Phone: (212) 702-1600 9000 9000 9000 9000 9000 9000 9000 9000 9000 9000 9000 Website

Empire Hotel Rooftop

2. Empire Hotel Rooftop. The legendary Empire Hotel is famous for many of its virtues, it has excellent rooms, a cozy 2-tier hall with comfortable sofas, a good restaurant and an exceptionally convenient neighborhood with Lincoln Center. But its gem is the rooftop bar, which is so big and comfortable that it's regularly rented out by designers for their runway shows during New York Fashion Week. The bar has several halls and a spacious terrace, divided into comfortable zones in such a way that everyone sitting at a table or in a sun lounger feels quite private, but has the opportunity to enjoy a beautiful view of the city. The name of the hotel shining in the sky, constructed from metal pipes and neon letters, romantically illuminates the bar and shimmers with all the colors of the rainbow in glasses with original signature cocktails. At the top level of the bar is a pool, however, available only to hotel guests. The bar was opened by restaurateur Jeffrey Chodorow. nine0004

Open: · 5:00 am-2:00 am Address: 44 W 63RD ST, NEW York, Ny 10023 Phone: (212) 956-313 9000 Hudson Sky Terrace.

3. Hudson Sky Terrace. This place is considered one of New York's biggest secrets. Located on the 15th floor of the hotel, literally 2 steps from Central Park, next to the Jazz at Lincoln center, it looks more like the courtyard of an elegant country house than a roof in the wilds of the "stone jungle". Here you can relax and unwind in the shade of trees or soak up the sunset sun, sitting comfortably in a soft sun lounger or hammock. A large selection of martinis, homemade sangria and the signature Pink Prozac cocktail with an unusual combination of alcoholic drinks, lime, grapefruit juice and cranberry will definitely brighten up your evening. nine0004

Open: 3:00 PM-10:30 PM
Address: 356 W 58TH ST #15, New York, Ny 10019 Phone: (212) 554-6217
WEB SITE

4. HAVEN Rooftop bar is located in the theater district, literally on Times Square, in The Haven at the Sanctuary hotel. Leaving the noisy city far below, guests take a private elevator to the rooftop, where they can relax and forget about the hustle and bustle of a working day in a cozy hall, divided into small separated spaces, elegantly decorated with blue pillows and many exotic plants. The bar area is surrounded by panoramic glass, thanks to which guests can admire the sunset. In this bar, willy-nilly, there is a feeling of a meal on top of a huge rock, surrounded by "ridges" of similar stone giants. Pleasure complements the French menu. The Haven Bar has 150 seating options ranging from linen lounge chairs to plush benches or sofas. nine0004

Open: 4:00 PM-2:00 AM
Address: 132 W 47th ST, New York, Ny 10036
Phone: (212) 466-9000 Reservations: opentable.com

Rooftop Terrace Renaissance New York Hotel 57

5. Rooftop Terrace Renaissance New York Hotel 57. Modern urban design with a touch of elegant classics gives this bar charm and charm. The unique atmosphere is created by the surrounding facades of houses - glass, steel, red brick. A fantastic cityscape adorns the illuminated spire of the Chrysler Building. nine0004
Address: 130 E 57th ST, New York, Ny 10022
Phone: (212) 753-8841 9000 9000 9000 9000 9000 9000 FIFTH 230 FIFTH is one of the classic rooftop bars, famous for its largest outdoor rooftop garden in New York. Its no less important distinguishing feature is that it is located literally 2 blocks from the famous Iron Building (Iron) and has a stunning view of the Empire State Building. In addition to the outdoor terrace and garden, there are 3 indoor halls: Penthouse Lounge, FIFTH AVENUE EMPIRE PENTHOUSE and Hard Bar for private indoor events. nine0004
Open: 4:00 PM-4:00 am
Address: 230 5th Ave, New York, Ny 10001
Phone: (212) 725-4300 MANU : 230-fifth.com

GANSEVOORT PARK AVENUE BAR

the work of Devorah Anderson. The bar is located on the roof of a 20-story hotel with stunning views of the Empire State Building. nine0004
Address: 420 Park Ave S, New York, NY 10016
Phone:(212) 317-2900
Web site.

8. Le Bain. This very trendy bar is located on the rooftop of The STANDARD hotel, right above the HIGH LINE park. For the last couple of years, this place has been gathering young musicians, artists and artists. Surrounded by a glass wall, the bar looks very bright with its children's air mattresses and pink chairs. The best cocktail is Fraise 76 (vodka, lemon, syrup, strawberries and champagne) - a hell of a mixture, but, nevertheless, incredibly tasty. Perhaps this is one of the best places to enjoy a beautiful sunset, although the reflection of the moon in the bay at night is also very romantic. The hotel also offers binoculars to its guests so that they can look at the Statue of Liberty in detail. nine0004
The Press Lounge
Open: 4:00 PM-4:00 am
Address: 848 Washington ST, New York, Ny 10014 9000 Phone: (212)

9. The Press Lounge is located on the rooftop of the Ink48 Hotel in Hells Kitchen. The glass railings of the terrace spice up the place, but if you're afraid of heights, try to sit further away from the edge. The Press Lounge, opened in 2010, quickly became one of the best bars in New York. It offers signature cocktails and light snacks, as well as the opportunity to enjoy the best views of New York unhindered. New York Magazine and The New York Times have repeatedly listed The Press Lounge as one of the most attractive bars in the city. nine0004
Open: 5:00 PM-2:00 AM
Address: 653 11th Ave, New York, Ny 10036
Phone: (212) 757-22224 9000 9000 RAREW Rooftop

10. GALLOW GREEN. This cozy and affordable bar is located on the roof of the hotel, its interior is decorated with exotic plants and sometimes a jazz quartet plays by the fireplace.

Open: 5:00 – 11:00 pm
Address: 542 W 27th St, New York, NY 10001
Phone: (212) 564-1662

11. Rare View Rooftop. Located in Murray Hill, this bar offers breathtaking views of the Empire State Building and the Chrysler Building from the 16th-floor veranda and traditional cocktails prepared by experienced bartenders with new, refreshing ingredients.

Address: 152 W 26th St, New York, NY 10001
Phone: (212) 807-7273
Reservations: opentable.com

A60 BAR

12. A60 BAR 9004 The A60 has become a favorite destination among Hollywood celebrities such as Russell Crowe, Nicole Kidman, George Clooney and Sienna Miller. As part of the 60 Thompson Hotel, the bar is considered a closed club - "only for its own."

What does it mean for your own? The A60 is located in the elegant 60 Thompson Hotel and its own are those who live in the hotel or are members of this hotel. Despite the fact that the bar is open only to the "chosen ones", it is one of the most democratic and unpretentious in the city. To enter it, you just need to have a personal electronic card - the key to one of the hotel rooms or be familiar with those who have it. Becoming a member of the circle of the elite is not difficult (how - look at the website), and it's worth it, because the view from this bar is so beautiful that, as they say, you must see it before you die. The same can be said about the cocktails served here, so taking into account all the advantages, the A60 falls into the category of the best bars in the city and, for sure, is considered the most secret and mysterious. nine0004
Address: 60 Thompson St, New York, NY 10079
Phone: 877-431-0400
Web site

W New York Downtown

13. W New York Downtown is a chic, urban-inspired bar at the new W Hotel, built right next to the World Trade Center tower. The terrace offers a beautiful view of the city, despite the fact that the construction of the World Trade Center and the transport terminal continues. This, of course, does not decorate the landscape, but gives a sense of belonging to the dynamics of the ever-changing New York. The modern bar impresses not only with the view, but also with the convenience and quality of service. But take into account that the hotel and bar are in a fairly high price range. nine14. HOTEL. 14. HOTEL. The bar, like the hotel on the roof of which it is located, is imbued with the atmosphere of the 40s. Simple and solid, in the best traditions of New York, it is quite democratic in all respects, including the dress code and prices for drinks, especially after hours. So, for brunch, they can offer cocktails for 92 cents, as well as pancakes and burgers for just ridiculous money. But, nevertheless, a solid audience gathers in the bar and a good jazz quartet often plays. nine0004
The Chantelle Hotel is located at 92 Ludlow Street between Broome and Delancey Streets in the Lower East Side.
Phone: 212-254-9100.
www.hotelchantelle.com

Metropolitan Museum of Art's Roof Garden Cafe

And, as promised, at the end of our recommended Manhattan rooftop bars - Metropolitan Museum of Art's Roof Garden Cafe and Martini Bar or simply - MET`S BAR . The only bar in the city that is not on the roof of the hotel is the Metropolitan bar in the museum of the same name. The various opening martini cocktails are the most popular drink options, including Big Bambú, On the Roof, and TheMetropolitan Martini. Definitely the best place in New York City to enjoy both art and drink at the same time. In addition, this rooftop offers stunning views of Central Park. By the way, now the bar is hosting an interesting exposition of a mirror wall, which is worth seeing. I will not reveal the secret of this exhibition, let it serve as an incentive to visit the Museum and the bar. nine0004
15. The Roof Garden Cafe and Martini Bar are located on the 5th floor of the Metropolitan Museum of Art, at 1000 5th Avenue.

Open in May on Tuesdays, Wednesdays, Thursdays, Sundays from 10:00 to 16:30; Friday and Saturday from 10:00 to 20:00 (Martini Bar opens at 17:30).
Phone: 212-535-7710;
www.metmuseum.org

And now let's go over the neighborhoods of greater New York. Of course, Williamsburg, New York's modern artistic Mecca, leads the way in the best Rooftop Bars, but other areas have something to boast about. nine0004
BERRY PARK

16. BERRY PARK is considered the best rooftop brasserie. The menu includes Belgian and German beers - Leffe Blonde ($6) and Hofbrau ($7), as well as various signature cocktails and cider. Snacks include Bavarian pretzels ($9) and sausage rolls ($12).

Address: 4 Berry Street between North 13th Street and Nassau Avenue in Williamsburg
Phone: 718-782-2829.
www. berryparkbk.com

17. THE IDES is located on the roof of the 6-storey THE WYTHE HOTEL in Williamsburg, offering a gorgeous view of Manhattan.

Address: 80 Wythe Avenue between North 11th and 12th Streets (Williamsburg, Brooklyn).
Phone: 718-460-8000.
www.wythehotel.com

NIGHT OF JOY

18. NIGHT OF JOY. nine0047 Considered to be the best rooftop bar in Williamsburg because it offers the best prices during happy hour. They operate from 5 to 8 pm. You will be offered signature cocktails from $6, draft beer from $4.

Address: 667 Lorimer Street between Jackson Street and the BQE in Williamsburg (Brooklyn).
Phone: 718-388-8693.
www.nightofjoybar.com.

19. Upper Elm. nine0047 In the new Upper Elm bar on the roof of the King & Grove Hotel in Williamsburg, you will be amazed not only by the stunning view of New York, but also by the unusual interior of the institution.

Bartender Johnny Swet's signature cocktails can be enjoyed on the deck, with finely crafted ivory wood benches and cozy and relaxing cushions

Address: 160 N 12th St (btwn Berry St & Bedford Ave, Brooklyn

PENTHOUSE 808

20. PINE BAR AND GRILL is the best rooftop bar in the Bronx. Plush sofas, palm trees, a beautiful marble bar. In a relaxed environment, you can enjoy steaks, seafood and Italian cuisine.

Address: 1634 Eastchester Road in the Bronx.
Phone: 718-319-0900. Website - pinebargrill.com

21. PENTHOUSE 808 is located on the roof of THE RAVEL HOTEL - the best rooftop bar in Queens. During the day you can taste excellent sushi and drink sake, and at night you can dance to the incendiary melodies of DJs. Great view of Manhattan. nine0004
Address: 8-08 Queens Plaza South, Long Island City.
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