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  • SAMHSA’s National Helpline is a free, confidential, 24/7, 365-day-a-year treatment referral and information service (in English and Spanish) for individuals and families facing mental and/or substance use disorders.

    Also visit the online treatment locator.

SAMHSA’s National Helpline, 1-800-662-HELP (4357) (also known as the Treatment Referral Routing Service), or TTY: 1-800-487-4889 is a confidential, free, 24-hour-a-day, 365-day-a-year, information service, in English and Spanish, for individuals and family members facing mental and/or substance use disorders. This service provides referrals to local treatment facilities, support groups, and community-based organizations.

Also visit the online treatment locator, or send your zip code via text message: 435748 (HELP4U) to find help near you. Read more about the HELP4U text messaging service.

The service is open 24/7, 365 days a year.

English and Spanish are available if you select the option to speak with a national representative. Currently, the 435748 (HELP4U) text messaging service is only available in English.

In 2020, the Helpline received 833,598 calls. This is a 27 percent increase from 2019, when the Helpline received a total of 656,953 calls for the year.

The referral service is free of charge. If you have no insurance or are underinsured, we will refer you to your state office, which is responsible for state-funded treatment programs. In addition, we can often refer you to facilities that charge on a sliding fee scale or accept Medicare or Medicaid. If you have health insurance, you are encouraged to contact your insurer for a list of participating health care providers and facilities.

The service is confidential. We will not ask you for any personal information. We may ask for your zip code or other pertinent geographic information in order to track calls being routed to other offices or to accurately identify the local resources appropriate to your needs.

No, we do not provide counseling. Trained information specialists answer calls, transfer callers to state services or other appropriate intake centers in their states, and connect them with local assistance and support.

  • Suggested Resources

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    It's Not Your Fault (NACoA) (PDF | 12 KB)
    Assures teens with parents who abuse alcohol or drugs that, "It's not your fault!" and that they are not alone. Encourages teens to seek emotional support from other adults, school counselors, and youth support groups such as Alateen, and provides a resource list.

    After an Attempt: A Guide for Taking Care of Your Family Member After Treatment in the Emergency Department
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    For additional resources, please visit the SAMHSA Store.

Last Updated: 08/30/2022

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11 herbs and supplements to fight depression

Depression is a disease that annually affects 8 million people in Russia, 2 million in Ukraine, 1 million in Belarus, and 2 million in Kazakhstan. In total, there are about 264 million people diagnosed with depression in the world. However, it should be noted that the actual number of cases is much higher. We all understand perfectly well that in order to diagnose a mental illness, a person must voluntarily turn to a specialist. But in many countries, including ours, such diseases are not taken seriously, and sometimes even become an occasion for ridicule. nine0003

There are five classifications of depressive disorders whose symptoms include low mood, irritability, feelings of emptiness and cognitive changes that affect quality of life. Among them:

  • major depressive disorder (MDD)
  • disruptive mood dysregulation disorder
  • persistent depressive disorder
  • premenstrual dysphoric disorder
  • depressive disorder due to another illness

Depressive disorders are treated with medication and psychotherapy, but it is also good to change your eating habits and include active supplements in your diet.

Studies and practice show that certain vitamins, minerals, herbs, and other nutrients can have a positive effect on the dynamics of depression.

Read about which active supplements will help you fight depression in our article.

Omega-3 fatty acids

Omega-3s are essential fats. The word "essential" means that they must be present in our diet under all circumstances. Some studies have confirmed that omega-3 supplements can help treat depression. nine0003

Tests conducted in 2020 on 638 women showed that omega-3 fatty acids significantly improved symptoms of depression in pregnant women and women with PTSD.

It is worth noting that when choosing omega-3 supplements, you need to pay attention to the content of EPA and DHA. The more of them contained in one capsule, the better.

An analysis of 26 studies involving 2,160 people found that omega-3 supplements help treat symptoms of depression. In particular, scientists noted the effectiveness of drugs containing from 60% EPA per gram. nine0003

In any case, the more healthy fats in your diet, the better for your health.

Acetylcysteine ​​(NAC)

NAC is a precursor of the amino acids L-cysteine ​​and glutathione. The latter is considered one of the most important antioxidants in the human body and is vital for normalizing inflammatory processes and protecting cells from oxidative stress.

Taking acetylcysteine ​​is beneficial not only for general health promotion, but also because it speeds up the production of glutathione. nine0003

Studies show that people with depression have elevated levels of inflammatory cytokines such as C-reactive protein, interleukin-6 and tumor necrosis factor-alpha. Acetylcysteine ​​helps reduce inflammation and relieve symptoms of depression.

Furthermore, NAC helps with neurotransmitter dysregulation in people with psychiatric disorders. This condition is associated with mood disorders and schizophrenia, so taking NAC can greatly help in the prevention and treatment of such diseases. nine0003

By the way, acetylcysteine ​​also won in the duel with placebo. In one of the tests, participants were divided into two groups, one of which took empty pills, and the other - a supplement with NAC. The results of the latter showed that the substance reduces the symptoms of the disease and improves the quality of life. Plus, NAC drugs are safe and well tolerated.

It is believed that doses of 2-2.4 grams are sufficient to help patients with depression and other psychiatric diseases.

Saffron

nine0002

Saffron is a vibrant spice rich in antioxidants, including the carotenoids crocin and crocetin. Recently, the scientific community has been discussing the prospects for using saffron as a natural cure for depression.

Studies have shown that it increases the level of serotonin, which is responsible for a good mood. Unfortunately, it is not yet fully understood how this works, but saffron inhibits the reuptake of serotonin, which helps keep it at a high level for a long time. nine0003

Analysis of five tests found that saffron supplementation significantly reduced symptoms of major depressive disorder in adults compared with placebo.

Moreover, they are almost as effective as some antidepressants.

Vitamin D

Vitamin D is vital for our body. But, unfortunately, the percentage of people who get it in sufficient quantities is quite miserable.

Interestingly, people with depression very often have low levels of vitamin D. Therefore, this relationship can be called two-way: the lower the level of the vitamin, the higher the chances of getting depressed, and the more severe depression is, the lower the level of the vitamin. nine0003

Vitamin D helps fight depression in several ways: reduces inflammation, normalizes mood, and protects against neurocognitive dysfunction.

A 2019 analysis of four randomized trials of vitamin D found that vitamin D supplementation significantly improved the condition of people with major depressive disorder.

In addition, in 2020, a study was conducted in which people with depressive disorders and low levels of vitamin D were given a single injection of vitamin D at a dose of 300,000 IU (while the usual treatment was not canceled). As a result, the symptoms of the disease were significantly reduced, and the quality of life improved. nine0003

Rhodiola

Rhodiola is one of those plants that are credited with a huge number of useful properties. But it is especially useful in the form of tablets and capsules. Rhodiola supplementation has been shown to reduce symptoms of depression and improve stress response, which helps your body better adapt to stressful situations.

The plant has an antidepressant effect due to the ability to improve communication between nerve cells and reduce hyperactivity of the hypothalamic-pituitary-adrenal axis. nine0003

The hypothalamic-pituitary-adrenal axis is a complex system that regulates the body's response to stress. Her hyperactivity can lead to severe depression.

Rhodiola supplementation has been shown to help with depressive disorders.

A study of 57 people showed that taking 340 mg of Rhodiola extract for 12 weeks was able to reduce symptoms of depression. While this herb is less effective than conventional medicines, it has far fewer side effects. nine0003

B vitamins

B vitamins play an important role in neurological function and mood regulation. Folic acid, vitamins B12 and B6 are needed by the body to produce neurotransmitters such as serotonin, gamma-aminobutyric acid (GABA) and dopamine.

Deficiency of vitamin B12 and folate can increase the risk of depression, and taking drugs with these components reduces the symptoms of the disease.

Thus, folic acid reduces the symptoms of drug-resistant depression in both children and adults who have a genetic mutation that affects the metabolism of this acid. nine0003

Vitamin B12 supplementation with antidepressants has been shown to reduce symptoms in people with major depressive disorder. In addition, vitamin B12 can be taken to prevent mental illness and enhance the effect of antidepressants.

But vitamin B6 shows very good results when paired with other nutrients, including tryptophan and nicotinamide.

Zinc

This mineral is vital for our brain, including for the regulation of neurotransmitter pathways. In addition, it has antioxidant and anti-inflammatory properties. Zinc deficiency is strongly associated with an increased risk of depression as well as the severity of its symptoms. Depressed people have 0.12 mcg/mL lower zinc levels than healthy people. Taking zinc along with antidepressants helps to significantly reduce the symptoms of the disease and improve the quality of life. nine0003

Other supplements that may help fight depression

In addition to the supplements that we have listed above, it would not be superfluous to mention other, less popular, but no less useful nutrients and herbs that can help you fight this ailment.

S-adenosylmethionine (SAMe)

SAMe is a sulfur compound that many doctors are betting heavily on in the treatment of depressive disorders. It is produced in our body and plays an important role in the functioning of the brain. nine0003

An analysis of eight studies using the substance showed that its use alone or with antidepressants reduced the symptoms of major depressive disorder. S-adenosylmethionine is usually prescribed at a dosage of 200 to 3,200 mg. The course of admission is from 2 to 12 weeks.

St. John's wort

St. John's wort is a very popular plant that, in addition to its well-known properties, shows promising results in the treatment of depression.

An analysis of 35 tests in 2016 found that St. John's wort drugs reduced symptoms in people with moderate depression. However, supplements have not been shown to be effective in treating a disorder with severe symptoms. nine0003

Like many other herbs, St. John's wort can interact with medications in different ways. Using it with some antidepressants can lead to serious side effects, so if you're already taking any medications, it's best to check with your doctor.

Magnesium

Magnesium deficiency is very common in people with depression, and studies show that magnesium supplementation can reduce symptoms.

Thus, one test showed that 248 mg of magnesium daily for 6 weeks can significantly reduce the symptoms of depression. nine0003

Creatine

Creatine is an organic acid that, among other functions, plays an important role in maintaining energy levels in the brain. It is believed that changes in brain energy levels may be associated with the development of depressive disorders.

Some studies have shown that supplementation with 2-10 g of creatine daily reduces symptoms of major depressive disorder.

Where to go for help?

If you or someone close to you suffer from depressive disorders and are suicidal or self-harmful, you can get psychological help on these numbers:

Ukraine - suicide prevention line - tel. 7333. Around the clock 24/7

Russia - psychological help hotline - tel. 8 495 025 15 35.

If you live in another country, you can easily find psychological help numbers on the Internet. Just enter the query "psychological assistance + your country name" into the search engine.

Don't wait if you feel you can't handle your problem yourself. Call and they will help you. You are not alone.

nine0106 Instead of output

Depression is a mental disorder that affects millions of people around the world. While depression is usually treated with medication and therapy, changing your eating habits and taking natural supplements can make a big difference in your recovery.

The supplements we are talking about today have been clinically tested and can actually help reduce the symptoms of depression.

However, if you already have a depressive disorder, any of these should be discussed with your doctor. Take care of yourself and remember that you are unique and there are people in this world who care about you. nine0003

Non-prescription antidepressants for anxiety and depression, list of titles

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NOT A MEDICINEInsomniaVitamin AVitamin DVitamin EVitamin KVitamin RVitamin SVitamins of group BFor adultsFor immunityIronCalciumMagnesiumOmega-3Under stressStressImmunity strengtheningZinc

Article author

Svetlana Bukharova,

Dietitian, fitness instructor

12 years of experience. Diploma of Medical Education: DVS 1724848

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Contents of the article

  • Seasonal depression or beriberi - how to distinguish?
  • Why are we sad in winter?
  • Non-prescription antidepressants, drug names
  • What is the best antidepressant for anxiety and depression
  • What is the safest antidepressant
  • Antidepressants and alcohol
  • Ask an expert about the topic of the article

Outside the window is grey, dreary and empty. Summer colors faded, replaced by winter cold. Together with the withering of nature, the mood fades, and sadness rolls over every now and then. There is a close relationship between the onset of cold weather and depression of the psycho-emotional state.

Manifestations of dissatisfaction with oneself and the world around can be mild, not always noticeable, but can literally “cover”, deprive one of the desire to do something. Then hopelessness is felt, tearfulness appears. If you have these symptoms, you need specialist help. But with a breakdown, irritability, general lethargy, you can cope on your own. There are effective remedies that will help cheer you up during the seasonal spleen. In this article, we will tell you how to return the former energy, get rid of the winter blues and see all the colors of life again. nine0003

Seasonal depression or beriberi - how to tell the difference?

Depression is experienced by 264 million people in the world - these are the WHO data. If depression drags on, becomes moderate or severe, it can lead to serious health problems.

Seasonal depression, in contrast to a simple drop in mood due to stress or beriberi, has its own characteristics:

  • Lasts longer than two weeks, there is a decrease in mood.
  • Apathy occurs, there is a decrease in activity. nine0008
  • Appetite disorder appears. A person gains weight up to 6-7 kg in 2-3 months, or, conversely, loses weight dramatically.
  • Dramatically increases the duration of sleep.

Why are we sad in winter?

In the last two decades, the number of patients with seasonal depression has increased. According to doctors, from 4 to 10% of people suffer from such depressions. There are several reasons for winter melancholy. Let's talk about the main ones.

  • Lack of sun. In summer, there is enough sunshine and you feel comfortable. With the onset of cold weather, the dose of the sun decreases, biochemical processes slow down. The body begins to "protest", there is fatigue in the muscles, nervousness. The fact that the sun is the “supplier” of vitamin D has been known to everyone since childhood. And it is the lack of this vitamin that provokes an unstable psycho-emotional state in people of different ages. For example, Italian scientists from the National Institute of Aging have found a relationship between vitamin D deficiency and the onset of depressive symptoms in patients aged 65 and older. The lower the level of the "sunshine" vitamin, the higher was the risk of developing a depressive mood. And researchers from the UK have identified such a relationship in adolescents and concluded that the relationship between the concentration of vitamin D and depression occurs in childhood. nine0008
  • Psychological factors. The autumn-winter period is a kind of completion of the annual cycle. People begin to analyze their time, sum up. And plans not always conceived at the beginning of the year are implemented by the end of the year. Therefore, there is a feeling of dissatisfaction. By the end of the year, physical and moral strength is also running out, and the lack of rest, experienced emotional upheavals cause a feeling of melancholy. Sudden mood swings are possible.
  • Stress. An emergency at work, conflicts in the family lead to the fact that a person begins to negatively perceive everything that happens. According to statistics, the peak of nervous tension and fatigue occurs precisely at the end of autumn - the beginning of winter. nine0008
  • Reduced immunity. According to experts, this feature of autumn depression is associated with a decrease in the quality of the immune system. The lack of vitamins and nutrients, as well as the exacerbation of chronic diseases against the background of a decrease in immunity, negatively affects the state of the human psyche.

Over-the-counter antidepressants, drug names

Naturally formulated supplements can help with seasonal disorders and mild depression. We have collected the top 5 most popular according to the retail audit of the pharmaceutical market in Russia. Let's talk about the pros and cons of each dietary supplement. nine0003

  • Detrimax from Unipharm. The composition of "Detrimax" includes vitamin D3 (cholecalciferol). This vital fat-soluble vitamin is needed for the activity of almost all organs and systems of the body, including the nervous one. Regulates the psycho-emotional sphere, improves memory, performance, mood, increases the overall tone of the body. "Detrimax" has no contraindications during pregnancy, but it should be taken with caution. Clinical studies conducted by medical scientists of the St. Petersburg North-Western State Medical University named after I.I. Mechnikov, confirmed the effectiveness of the drug. Patients improved cognitive function, decreased levels of anxiety and depression. nine0008
  • "Neurouridin" from "Unipharm". Replenishes the deficiency of biologically active substances. Strengthens the nervous system, improves the general condition of the body, memory, attention. Reduces stress reactions. As part of the drug: uridine monophosphate, choline, vitamins B6, B1 and B12. Uridine monophosphate is important for the rapid recovery of damaged nerves. B vitamins ensure the normal functioning of the nervous system. Folic Acid is important for the brain and maintaining mental and emotional health. nine0236 Choline improves the transmission of neuromuscular signals, increases the speed of transmission of impulses along nerve fibers. The disadvantages of the drug include the fact that it can not be used during pregnancy and lactation.
  • Stressovit from Unipharm. Has a sedative effect. Helps reduce psycho-emotional stress, relieve stress, improves overall well-being, increases efficiency. The main component of the drug is magnesium . Magnesium has been proven to be the fourth most abundant mineral in the body. Magnesium deficiency leads to increased irritability, fatigue, sleep disturbance. A sufficient amount of magnesium in the body increases resistance to stress, reduces the excitation of the nervous system, and normalizes sleep. The composition of "Stressovita" also includes motherwort, hops and linden flowers. nine0236 Motherwort relieves manifestations of psycho-emotional overstrain. It has a calming, anti-stress and relaxing effect. Hops Calms and reduces stress. A similar effect in linden flowers. It is not recommended to use "Stressovit" with individual intolerance to its components, as well as pregnant and lactating mothers.
  • "Kinetop" from "Artlife". Improves mood, increases efficiency, relieves stress, anxiety, eliminates irritability. An important component of Kinetop is 5-hydroxy-L-tryptophan (5-HTP), an amino acid that serves as an intermediate for the conversion of tryptophan into serotonin. It is often referred to as the "happiness hormone". Serotonin improves mood. Lack of hormone leads to depression, insomnia. There is an unhealthy craving for sweets. Kinetop contains the optimal dosage of 5-HTP, as well as magnesium, zinc, vitamins B5 and B6. Another plus of Kinetop is that it does not cause addiction and withdrawal syndrome. At the same time, the drug should not be used during pregnancy, lactation, and up to 18 years.
  • Calm formula from Evalar. Dietary supplement based on motherwort . The composition of the drug also includes magnesium and vitamin B6. It has a sedative, anti-anxiety effect. Helps to resist stress, better endure psycho-emotional stress. "Calm formula" is used for increased nervous excitability, irritability, anxiety, insomnia. The drug should not be used for peptic ulcer of the stomach and duodenum in the acute phase, children under 18 years of age, severe renal failure. Not recommended for pregnant and lactating women. nine0168 BAA can cause allergic reactions, abdominal pain, nausea, heartburn, flatulence, diarrhea, constipation.

Important! Non-prescription herbal antidepressants are not a panacea. It is an accompanying and restorative element. He will not be able to cure a severe disease.

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Add color and positive to your life!

Many people say that dietary supplements are a placebo. In most cases, we assign them to ourselves and think that they work. And so it happens, because the power of thought is already a medicine. Think positively and a good mood will not keep you waiting. Positive emotions in life will bring the purchase of various little things that will improve your mood. The colors of life will return the study of something new, self-development, communication with relatives and friends, playing sports. Physical activity has a positive effect on the psycho-emotional balance due to the stimulation of the nervous system. Pay attention to yoga. Scientifically proven fact: Indian hatha yoga helps to forget about depression. Scientists from the Smolensk State Medical Academy studied the effects of yoga therapy on people with various forms of depressive disorders and asthenia. Patients attended classes three times a week for a month and a half. After a yoga course, 12 out of 19patients noted a significant improvement in well-being, up to the complete disappearance of signs of fatigue, increased activity, working capacity, improved mood, significantly improved overall self-esteem.

Look around - the world is full of joy at any time of the year. The main thing is to notice it in time. If your depression is not clinical in nature, you can get rid of the disease yourself and look at life with different eyes.

Sources:

  • PubMed: Serum 25-hydroxyvitamin D and depressive symptoms in older women and men. National Institute on Aging, Clinical Research Unit, USA. nine0008
  • PubMed: "Association of serum 25-hydroxyvitamins D3 and D2 with depressive symptoms in childhood - a prospective cohort study." Center for Causal Analysis in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, UK.
  • Russian pharmaceutical market.
  • Medical scientific and practical journal "Attending Doctor": "Evaluation of the effectiveness of the use of vitamin D3 (cholecalciferol) in the correction of cognitive disorders in patients with cerebrovascular disease." G. I. Shvartsman, E. M. Pervova, I. V. Chistova, E. A. Yurkina. FGBOU VO SZGMU them. I. I. Mechnikov of the Ministry of Health of Russia, St. Petersburg. nine0008
  • Magnesium in Prevention and Therapy, Academy of Micronutrient Medicine, Germany.
  • Sciencedirect.com: "Effect of magnesium supplementation on depressive status in depressed magnesium-deficient patients: a randomized, double-blind, placebo-controlled trial. " Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Cyberleninka.ru: "Application of the Hatha Yoga system as a stage in the complex therapy of depressive disorders." Scientific article by K. A. Yakunin I. A. Zubova. nine0008
  • World Health Organization.
  • Register of medicines of Russia.

Which antidepressant is best for anxiety and depression

Do you want to understand drug analogues in order to skillfully select drugs for your budget? Our manual from expert pharmacists "Analogues of popular drugs" will help you with this! Getting a training manual is easy: subscribe to our social networks and write “analogues” in the messages.

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Antidepressant drugs are prescribed strictly by a doctor, after consultation. Thus, it is not possible to say which antidepressant is better, as the doctor decides. For each individual case.

Let's talk about some prescribed antidepressants:

  • Phenibut is a prescription drug. Helps reduce or disappear feelings of anxiety, tension, anxiety and fear, normalizes sleep, has some anticonvulsant effect. nine0008
  • Phenazepam is a prescription drug. The effect is manifested in a decrease in emotional stress, weakening anxiety, fear, anxiety.
  • Anafranil is a prescription drug. It has a strong antidepressant effect and common side effects. In addition to the antidepressant effect, it reduces obsession and anxiety.
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What is the safest antidepressant

The safest antidepressant, like the best, has yet to be invented. Any drugs have side effects. We can talk about drugs that have less, compared to others, negative reactions to the patient.

These include antidepressants from the group of SSRIs - selective serotonin reuptake inhibitors. Their advantages:

  • high efficiency
  • short course of treatment
  • no withdrawal syndrome
  • easy dosing
  • good tolerance

Because of their properties, they are often prescribed:

  • Zoloft
  • Paxil
  • Prozac
  • Trittiko
  • Fevarin
  • Cipralex
  • Cipramil

Antidepressants of a new class: Brintellix and Valdoxan also have minimal side effects.

Antidepressants and alcohol

Drinking alcohol for depression is common. What happens if antidepressants are added to this relaxation method? The group of antidepressants includes drugs with different mechanisms of action. The effect of co-administration of alcohol and antidepressants is not well understood.

Learn more