Xanax headache side effect
Symptoms, Tips for Relief, Prevention, and More
Xanax Hangover: Symptoms, Tips for Relief, Prevention, and MoreMedically reviewed by Alan Carter, Pharm.D. — By Kimberly Holland — Updated on July 23, 2021
What is a Xanax hangover?
Xanax, or alprazolam, belongs to a class of drugs called benzodiazepines. Benzos are among the most commonly abused types of drugs. That’s because most of these drugs, including Xanax, have a high risk for dependency.
When benzos like Xanax wear off, the user may experience mild symptoms of withdrawal. With Xanax, this is known as a “Xanax hangover.”
Although people who misuse or abuse the medication are more likely to experience a hangover, it can affect anyone who takes the medication.
If your doctor prescribed Xanax to help you manage an anxiety or panic disorder, you may experience hangover symptoms while your body adjusts to the medication. It may also happen if your doctor adjusts your dose.
Read on to learn more about the symptoms, including how long they last, how to find relief, and how to prevent them from coming back.
The symptoms of a Xanax hangover are similar to the symptoms of an alcohol hangover. A Xanax hangover can cause both physical and mental or emotional symptoms.
The most common physical symptoms include:
- difficulty falling asleep (insomnia)
- fatigue
- increased pulse
- increased blood pressure
- increased body temperature
- excessive sweating
- rapid breathing
- blurred vision
- headache
- decreased appetite
- diarrhea
- nausea
- stomach cramps
- muscle tension and tremors
- difficulty breathing
Mental or emotional symptoms include:
- memory impairment
- difficulty concentrating
- difficulty thinking clearly
- lack of motivation
- heightened senses
- agitation
- depression
- increased anxiety
- thoughts of suicide
If you regularly experience symptoms like these, talk to your doctor. They may be able to adjust your dosage or prescribe a different medication.
Time is the only foolproof solution for a Xanax hangover. Your symptoms should subside once the drug has completely metabolized and cleared from your system.
In the meantime, you may be able to find relief if you:
- Exercise. Give yourself a natural boost of energy and endorphins by going for a walk. Don’t push yourself too hard; just get some natural movement in. As a bonus, exercise is a natural stress reducer and can help ease anxiety.
- Eat. Xanax is absorbed and metabolized through your gastrointestinal (GI) system, so pushing fiber, protein, and fat through your GI system can help your body process the drug faster.
- Sleep. If you can afford to spend extra time in bed, sleep is one of the best ways to cope with the symptoms of a Xanax hangover. You can sleep through the worst of the symptoms and wake up later, after less of the drug is circulating in your body.
Immediate release formulations of Xanax have an approximate half-life of 11 hours but can vary from 6 to 27 hours for some individuals. It takes several more cycles for the drug to be eliminated from your body entirely. Your symptoms will likely fade before the medication has completely left your system.
The bulk of your symptoms should subside within 24 hours of your last dose. You may still experience minor symptoms, such as decreased appetite, for one to two days after your last dose.
If you take Xanax for any reason, there’s always a chance that you’ll experience a hangover when the medication wears off.
You’re more likely to experience a Xanax hangover if:
- it’s your first time taking the medication
- you use the medication infrequently
- you’ve used the medication for a while but have recently changed your dose
- you’ve used the medication for a while but have recently missed one or more doses
If you continue to take the medicine, your body may become more accustomed to the drug, and the side effects may not be as severe.
However, long-term use or high-dose use can lead to a drug dependency. You should only take Xanax as prescribed by your doctor.
If you take steps to help your body adjust to the medication, you may be able to reduce your risk of side effects. You should:
- Get adequate sleep. When you’re well rested, you’re less likely to be emotional and can think more clearly. Both of these tasks are difficult without sleep, but when you add in the effects of a Xanax hangover, they can be nearly impossible. Go to bed early the night you take Xanax, and plan to sleep later so you can sleep through some of the hangover symptoms.
- Take Xanax as prescribed. You shouldn’t take more or less than your prescribed dose without consulting your doctor. Never mix Xanax with other medicines, recreational drugs, or alcohol. The risk for negative interactions is high with this medication.
- Limit caffeine. Your first instinct may be to pour a tall cup of coffee or soda, but these caffeinated drinks can cause jitteriness and anxiety.
This will work against the intended effects of the Xanax, so limit your intake of caffeine until your body has adjusted to the medication.
If you have frequent Xanax hangovers, talk with your doctor. They may be able to adjust your dosage to help minimize side effects.
They may recommend taking smaller doses throughout the day instead of taking a larger dose all at one. They may also lower your overall dose.
You should never stop taking Xanax without your doctor’s supervision. If you need to come off the medication, your doctor will help you gradually reduce your dose. You’re more likely to experience withdrawal symptoms if you abruptly stop taking the medication.
Last medically reviewed on April 16, 2018
How we reviewed this article:
Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
- Alprazolam (by mouth). (n.d.).
ncbi.nlm.nih.gov/pubmedhealth/PMHT0008896/ - Alprazolam (xanax). (2016).
nami.org/Learn-More/Treatment/Mental-Health-Medications/Alprazolam-%28Xanax%29 - Despite risks, benzodiazepine use highest in older people. (2014).
nih.gov/news-events/news-releases/despite-risks-benzodiazepine-use-highest-older-people - FDA requiring Boxed Warning updated to improve safe use of benzodiazepine drug class. (2020).
fda.gov/drugs/drug-safety-and-availability/fda-requiring-boxed-warning-updated-improve-safe-use-benzodiazepine-drug-class - Prescription drug abuse. (2011).
drugabuse.gov/sites/default/files/rxreportfinalprint.pdf - Xanax. (2016).
accessdata.fda.gov/drugsatfda_docs/label/2016/018276s052lbl.pdf - XANAX XR - alprazolam tablet, extended release. (2017).
dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aa58fff3-c297-49be-838b-599c32ad9835
Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.
Current Version
Jul 23, 2021
Written By
Kimberly Holland
Edited By
Yvette Brazier
Copy Edited By
Copy Editors
Apr 16, 2018
Written By
Kimberly Holland
Medically Reviewed By
Alan Carter, PharmD
Share this article
Medically reviewed by Alan Carter, Pharm.D. — By Kimberly Holland — Updated on July 23, 2021
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Symptoms, Tips for Relief, Prevention, and More
Xanax Hangover: Symptoms, Tips for Relief, Prevention, and MoreMedically reviewed by Alan Carter, Pharm.D. — By Kimberly Holland — Updated on July 23, 2021
What is a Xanax hangover?
Xanax, or alprazolam, belongs to a class of drugs called benzodiazepines. Benzos are among the most commonly abused types of drugs. That’s because most of these drugs, including Xanax, have a high risk for dependency.
When benzos like Xanax wear off, the user may experience mild symptoms of withdrawal. With Xanax, this is known as a “Xanax hangover.”
Although people who misuse or abuse the medication are more likely to experience a hangover, it can affect anyone who takes the medication.
If your doctor prescribed Xanax to help you manage an anxiety or panic disorder, you may experience hangover symptoms while your body adjusts to the medication. It may also happen if your doctor adjusts your dose.
Read on to learn more about the symptoms, including how long they last, how to find relief, and how to prevent them from coming back.
The symptoms of a Xanax hangover are similar to the symptoms of an alcohol hangover. A Xanax hangover can cause both physical and mental or emotional symptoms.
The most common physical symptoms include:
- difficulty falling asleep (insomnia)
- fatigue
- increased pulse
- increased blood pressure
- increased body temperature
- excessive sweating
- rapid breathing
- blurred vision
- headache
- decreased appetite
- diarrhea
- nausea
- stomach cramps
- muscle tension and tremors
- difficulty breathing
Mental or emotional symptoms include:
- memory impairment
- difficulty concentrating
- difficulty thinking clearly
- lack of motivation
- heightened senses
- agitation
- depression
- increased anxiety
- thoughts of suicide
If you regularly experience symptoms like these, talk to your doctor. They may be able to adjust your dosage or prescribe a different medication.
Time is the only foolproof solution for a Xanax hangover. Your symptoms should subside once the drug has completely metabolized and cleared from your system.
In the meantime, you may be able to find relief if you:
- Exercise. Give yourself a natural boost of energy and endorphins by going for a walk. Don’t push yourself too hard; just get some natural movement in. As a bonus, exercise is a natural stress reducer and can help ease anxiety.
- Eat. Xanax is absorbed and metabolized through your gastrointestinal (GI) system, so pushing fiber, protein, and fat through your GI system can help your body process the drug faster.
- Sleep. If you can afford to spend extra time in bed, sleep is one of the best ways to cope with the symptoms of a Xanax hangover. You can sleep through the worst of the symptoms and wake up later, after less of the drug is circulating in your body.
Immediate release formulations of Xanax have an approximate half-life of 11 hours but can vary from 6 to 27 hours for some individuals. It takes several more cycles for the drug to be eliminated from your body entirely. Your symptoms will likely fade before the medication has completely left your system.
The bulk of your symptoms should subside within 24 hours of your last dose. You may still experience minor symptoms, such as decreased appetite, for one to two days after your last dose.
If you take Xanax for any reason, there’s always a chance that you’ll experience a hangover when the medication wears off.
You’re more likely to experience a Xanax hangover if:
- it’s your first time taking the medication
- you use the medication infrequently
- you’ve used the medication for a while but have recently changed your dose
- you’ve used the medication for a while but have recently missed one or more doses
If you continue to take the medicine, your body may become more accustomed to the drug, and the side effects may not be as severe.
However, long-term use or high-dose use can lead to a drug dependency. You should only take Xanax as prescribed by your doctor.
If you take steps to help your body adjust to the medication, you may be able to reduce your risk of side effects. You should:
- Get adequate sleep. When you’re well rested, you’re less likely to be emotional and can think more clearly. Both of these tasks are difficult without sleep, but when you add in the effects of a Xanax hangover, they can be nearly impossible. Go to bed early the night you take Xanax, and plan to sleep later so you can sleep through some of the hangover symptoms.
- Take Xanax as prescribed. You shouldn’t take more or less than your prescribed dose without consulting your doctor. Never mix Xanax with other medicines, recreational drugs, or alcohol. The risk for negative interactions is high with this medication.
- Limit caffeine. Your first instinct may be to pour a tall cup of coffee or soda, but these caffeinated drinks can cause jitteriness and anxiety.
This will work against the intended effects of the Xanax, so limit your intake of caffeine until your body has adjusted to the medication.
If you have frequent Xanax hangovers, talk with your doctor. They may be able to adjust your dosage to help minimize side effects.
They may recommend taking smaller doses throughout the day instead of taking a larger dose all at one. They may also lower your overall dose.
You should never stop taking Xanax without your doctor’s supervision. If you need to come off the medication, your doctor will help you gradually reduce your dose. You’re more likely to experience withdrawal symptoms if you abruptly stop taking the medication.
Last medically reviewed on April 16, 2018
How we reviewed this article:
Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
- Alprazolam (by mouth). (n.d.).
ncbi.nlm.nih.gov/pubmedhealth/PMHT0008896/ - Alprazolam (xanax). (2016).
nami.org/Learn-More/Treatment/Mental-Health-Medications/Alprazolam-%28Xanax%29 - Despite risks, benzodiazepine use highest in older people. (2014).
nih.gov/news-events/news-releases/despite-risks-benzodiazepine-use-highest-older-people - FDA requiring Boxed Warning updated to improve safe use of benzodiazepine drug class. (2020).
fda.gov/drugs/drug-safety-and-availability/fda-requiring-boxed-warning-updated-improve-safe-use-benzodiazepine-drug-class - Prescription drug abuse. (2011).
drugabuse.gov/sites/default/files/rxreportfinalprint.pdf - Xanax. (2016).
accessdata.fda.gov/drugsatfda_docs/label/2016/018276s052lbl.pdf - XANAX XR - alprazolam tablet, extended release. (2017).
dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aa58fff3-c297-49be-838b-599c32ad9835
Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.
Current Version
Jul 23, 2021
Written By
Kimberly Holland
Edited By
Yvette Brazier
Copy Edited By
Copy Editors
Apr 16, 2018
Written By
Kimberly Holland
Medically Reviewed By
Alan Carter, PharmD
Share this article
Medically reviewed by Alan Carter, Pharm.D. — By Kimberly Holland — Updated on July 23, 2021
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Xanax is a lethal sedative for teenagers
Drug addiction is a disease that can overtake any person. Unfortunately, addictions don't take long to develop. Yes, and highly addictive drugs may seem at first glance, safe drugs. Xanax is such a drug. The drug, designed to help in the fight against insomnia, is easy to buy in pharmacies. Xanax is a medicine that has hidden possibilities. Often it is he who is chosen by drug addicts in pursuit of an inexpensive and affordable buzz.
Even if Xanax is prescribed by a doctor and bought with a prescription, you should not forget that the treatment can cause serious consequences. The strongest sedative quickly causes addiction and should be taken under the strict supervision of a doctor and only in the doses indicated by a specialist. Exceeding the dosage or increasing the number of doses can become addictive.
Xanax is a form of benzodiazepine that helps with anxiety and insomnia. The drug slows down the nervous system, helps relieve anxiety, a sense of threat. The person calms down, his life rhythm is getting better. But only if you follow all the rules and recommendations for taking the medicine.
In addition to dealing with anxiety, Xanax helps to cope with alcohol addiction. When refusing alcohol, a person experiences feelings of anxiety, panic attacks and other problems, the solution of which is the drug prescribed by the doctor. For medical purposes, Xanax is also used in the treatment of seizures. This is really one of the most effective and effective psychoactive substances, for which drug addicts choose it.
Xanax as a drug can radically change a person's life. Even the slightest overdose causes addiction, and with the systematic use of the drug without the supervision of a specialist, the consequences can be fatal.
Xanax: how the drug works
Treatment with Xanax rarely leads to addiction if done correctly. But the development of drug addiction due to medical care happens infrequently. Much more often, drug addicts deliberately begin to take pills of the drug.
The human brain is a receptacle for a huge number of gamma receptors (neurons). They are responsible for anxiety, restlessness, a sense of danger and other symptoms, which are eliminated with the help of Xanax. With severe anxiety, the activity of neurons increases excessively, and the drug helps to “extinguish” it. Xanax acts very quickly - anxiety and panic disappear almost immediately after taking the pill. But addiction develops quickly. Under the supervision of a doctor, the drug is quickly canceled, replacing it with other methods of treatment. With drug addiction, withdrawal does not occur.
Reviews for Xanax vary. For some patients, this medicine helps to cope with the disease. In other people, it causes serious health problems and addiction, which can be felt even between doses prescribed by a doctor.
Xanax is a drug, and if taken the way drug addicts take it, anyone can become addicted. As a result, there is a feeling of euphoria, lightness, mental activity becomes dull, the body relaxes, mood improves. A long period of Xanax use leads to dementia, mental disorders, poor coordination. With each new dose of the drug, the condition will worsen, the doses of the drug will increase, the risks to life will increase. If you have been prescribed Xanax for treatment, keep the tablets out of the reach of children and strangers. Carefully monitor your condition and be sure to visit your doctor regularly.
How to understand that a person needs help
Xanax is the effect of calmness and carelessness. But it also has a lot of side effects. Symptoms of dependence on Xanax are easy enough to recognize:
- rapid onset of fatigue, severe fatigue;
- a person is confused in his thoughts, judgments;
- the addict's speech is confused, slurred;
- severe headaches appear;
- increases sensitivity to noise;
- tremor of hands and whole body develops;
- mood changes abruptly;
- insomnia develops;
- emotions disappear;
- increased sweating;
- may experience numbness of the extremities, vomiting, nausea;
- weight changes dramatically.
Dependence on Xanax also has external manifestations. The skin may turn red and develop a rash. The face swells, becomes puffy, swelling may occur in other parts of the body, including the throat, tongue. Speech in this case becomes difficult, the voice changes.
Taking Xanax also affects the state of the gastrointestinal tract. Drug addicts experience stomach pain, diarrhea or constipation. Cardiac activity is disturbed, as a result of which an aggravated feeling of cold appears, a person shakes, freezes even in the heat. Over time, the feeling of euphoria is replaced by increased anxiety, suicidal thoughts, fears appear. This condition cannot last long - a person either goes to a specialized clinic for treatment, or dies.
The active substance of Xanax is alprazolam. The consequences of taking it can only be eliminated by specialists, so dealing with the problem on your own is not an option.
Xanax is a powerful drug, but what effect should be expected from its correct use? When treated with Xanax, the patient may experience a feeling of lethargy, slight fatigue, but such manifestations do not entail serious consequences. Report any changes in your condition to your doctor immediately! After the abolition of Xanax, anxiety, panic attacks can develop, a person can harm himself and others. Therefore, the drug is not canceled just like that - a replacement is selected for it, the intake of which is also strictly controlled by a specialist. Cancellation of the drug takes place in stages.
💊 Ingredients of Xanax ® ✅ Use of Xanax ® Keep for yourself Search for analogues ⚠️ The state registration of this drug has been canceled Description of the active ingredients of the preparation Xanax ® (Xanax ® ) The scientific information provided is general and cannot be used to make decisions. Update date: 2020.11.07 Marketing authorization holder:PHARMACIA, NV/SA (Belgium) ATX code: N05BA12 (Alprazolam) Active substance: alprazolam (alprazolam) Rec.INN WHO registered Dosage form
Release form, packaging and composition Xanax®
10 pcs. - cellular contour packings (3) - packs of cardboard. Clinical and pharmacological group: Anxiolytic (tranquilizer) Pharmacotherapeutic group: Anxiolytic agent (tranquilizer) Pharmacological action Anxiolytic agent (tranquilizer), triazolo-benzodiazepine derivative. It has an anxiolytic, sedative, hypnotic, anticonvulsant, central muscle relaxant effect. The mechanism of action is to enhance the inhibitory effect of endogenous GABA in the CNS by increasing the sensitivity of GABA receptors to the mediator as a result of stimulation of benzodiazepine receptors located in the allosteric center of postsynaptic GABA receptors of the ascending activating reticular formation of the brainstem and intercalary neurons of the lateral horns of the spinal cord; reduces the excitability of the subcortical structures of the brain (limbic system, thalamus, hypothalamus), inhibits polysynaptic spinal reflexes. Pronounced anxiolytic activity (reduction of emotional stress, weakening of anxiety, fear, restlessness) is combined with a moderately pronounced hypnotic effect; shortens the period of falling asleep, increases the duration of sleep, reduces the number of night awakenings. The mechanism of hypnotic action is to inhibit the cells of the reticular formation of the brain stem. Reduces the impact of emotional, vegetative and motor stimuli that disrupt the mechanism of falling asleep. PharmacokineticsAfter oral administration, alprazolam is rapidly and completely absorbed from the gastrointestinal tract. C max in plasma is achieved within 1-2 hours. Plasma protein binding is 80%. Metabolized in the liver. T 1/2 averages 12-15 hours. Alprazolam and its metabolites are excreted mainly by the kidneys. Indications of the active substances of the drug Xanax® Anxiety, neurosis, accompanied by a sense of anxiety, danger, restlessness, tension, worsening sleep, irritability, and somatic disorders; mixed anxiety-depressive states; neurotic reactive-depressive states, accompanied by a decrease in mood, loss of interest in the environment, anxiety, loss of sleep, loss of appetite, somatic disorders; anxiety states and neurotic depressions that have developed against the background of somatic diseases; panic disorder with and without phobia symptoms. Open list of ICD-10 codes
Dosing regimenThe route of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed. Individual. It is recommended to use the minimum effective dose. The dose is adjusted during treatment, depending on the effect achieved and tolerability. If it is necessary to increase the dose, it should be increased gradually, first in the evening, and then in the daytime. The initial dose is 250-500 mcg 3 times / day, if necessary, a gradual increase to 4.5 mg / day is possible. For elderly or debilitated patients, the initial dose is 250 mcg 2-3 times / day, maintenance doses - 500-750 mcg / day, if necessary, taking into account tolerability, the dose can be increased. Cancel or reduce the dose of alprazolam should be carried out gradually, reducing the daily dose by no more than 500 micrograms every 3 days; sometimes even slower cancellation may be needed. Side effectsFrom the side of the central nervous system: at the beginning of treatment (especially in elderly patients) drowsiness, fatigue, dizziness, decreased ability to concentrate, ataxia, disorientation, unsteady gait, slowing mental and motor reactions; rarely - headache, euphoria, depression, tremor, memory loss, impaired coordination of movements, depressed mood, confusion, dystonic extrapyramidal reactions (uncontrolled movements, including the eyes), weakness, myasthenia gravis, dysarthria; in some cases, paradoxical reactions (aggressive outbursts, confusion, psychomotor agitation, fear, suicidal tendencies, muscle spasm, hallucinations, agitation, irritability, anxiety, insomnia). From the digestive system: possible dry mouth or salivation, heartburn, nausea, vomiting, loss of appetite, constipation or diarrhea, impaired liver function, increased activity of liver transaminases and alkaline phosphatase, jaundice. On the part of the hematopoietic system: possible leukopenia, neutropenia, agranulocytosis (chills, hyperthermia, sore throat, excessive fatigue or weakness), anemia, thrombocytopenia. From the urinary system: Urinary incontinence, urinary retention, impaired renal function, decreased or increased libido, dysmenorrhea are possible. On the part of the endocrine system: possible changes in body weight, libido disorders, menstrual cycle disorders. From the side of the cardiovascular system: possible decrease in blood pressure, tachycardia. Allergic reactions: possible skin rash, itching. Contraindications for use Coma, shock, myasthenia gravis, angle-closure glaucoma (acute attack or predisposition), acute alcohol poisoning (with weakening of vital functions), opioid analgesics, hypnotics and psychotropic drugs, chronic obstructive airways disease with initial manifestations of respiratory insufficiency, acute respiratory failure, severe depression (suicidal tendencies may occur), pregnancy (especially the first trimester), lactation, children and adolescents under 18 years of age, hypersensitivity to benzodiazepines. Use during pregnancy and lactationAlprazolam has a toxic effect on the fetus and increases the risk of congenital malformations when used in the first trimester of pregnancy. Chronic use during pregnancy can lead to physical dependence with the development of withdrawal syndrome in the newborn. Reception in therapeutic doses in later stages of pregnancy can cause depression of the central nervous system of the newborn. Use immediately before or during labor may cause respiratory depression, decreased muscle tone, hypotension, hypothermia, and poor suckling (poor neonatal sucking syndrome) in the neonate. Benzodiazepines may be excreted in breast milk, which may make the newborn drowsy and make feeding difficult. experimental studies show that alprazolam and its metabolites are excreted in breast milk. Use in hepatic impairmentAlprazolam should be used with caution in patients with hepatic impairment. Use in Impaired Renal Function Alprazolam should be used with caution in patients with impaired renal function. Use in childrenContraindication: children and adolescents under 18 years of age. Use in elderly patientsFor elderly or debilitated patients, the initial dose is 250 mcg 2-3 times / day, maintenance doses - 500-750 mcg / day, if necessary, taking into account tolerability, the dose can be increased. Special instructionsIn endogenous depression, alprazolam can be used in combination with antidepressants. When using alprazolam in patients with depression, there have been cases of the development of hypomanic and manic states. Alprazolam should be used with caution in patients with hepatic and/or renal impairment. In patients who have not previously taken drugs that affect the central nervous system, alprazolam is effective at lower doses compared with patients who received antidepressants, anxiolytics or suffering from chronic alcoholism. With long-term use in high doses, the development of addiction and the formation of drug dependence is possible, especially in patients prone to drug abuse. With rapid dose reduction or abrupt withdrawal of alprazolam, a withdrawal syndrome occurs, the symptoms of which can range from mild dysphoria and insomnia to a severe syndrome with abdominal and skeletal muscle cramps, vomiting, increased sweating, tremors and convulsions. The withdrawal syndrome is more common in individuals who have received alprazolam for a long time (more than 8-12 weeks). Other tranquilizers should not be co-administered with alprazolam. The safety of alprazolam in children and adolescents under 18 years of age has not been established. Children, especially at a younger age, are very sensitive to the inhibitory effect of benzodiazepines on the central nervous system. Avoid drinking alcohol during treatment. Influence on the ability to drive vehicles and mechanisms During the period of treatment, one should refrain from engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions (driving vehicles or working with mechanisms). Drug interactionsWith the simultaneous use of psychotropic, anticonvulsants, drugs and ethanol, an increase in the inhibitory effect of alprazolam on the central nervous system is observed. With simultaneous use of blockers of histamine H 2 receptors reduce the clearance of alprazolam and increase the inhibitory effect of alprazolam on the central nervous system; macrolide antibiotics - reduce the clearance of alprazolam. With simultaneous use of hormonal contraceptives for oral administration increase T 1/2 alprazolam. With the simultaneous use of alprazolam with dextropropoxyphene, more pronounced CNS depression is observed than in combination with other benzodiazepines, tk. it is possible to increase the concentration of alprazolam in the blood plasma. Simultaneous intake of digoxin increases the risk of developing intoxication with cardiac glycosides. Alprazolam increases the plasma concentration of imipramine. |