What antidepressant makes you lose weight

Antidepressants that Cause Weight Loss: What You Need To Know

Antidepressants are commonly prescribed, FDA-approved medications used to treat depression, anxiety, and other related mental health disorders.

Though antidepressants can be effective at treating these conditions, they can also cause a range of side effects, including weight loss.

In this article, I’ll describe what antidepressants are, their effect on weight, and which antidepressants are known to cause weight gain or weight loss.

Finally, I’ll explain whether antidepressants have ever been prescribed specifically for weight loss and whether you can safely prevent weight loss due to antidepressants. 

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What are Antidepressants?

Over 264 million people worldwide live with depression and an estimated 40 million people in the U. S. experience an anxiety disorder in any given year.

Thankfully, both anxiety and depression can be treated with antidepressants, cognitive behavioral therapy, or a combination of treatment modalities.

Antidepressants are a popular prescription treatment for several mental health conditions, including:

  • Major depressive disorder (MDD)
  • Obsessive-compulsive disorder (OCD)
  • Panic disorder
  • Premenstrual dysphoric disorder (PMDD)
  • Posttraumatic stress disorder (PTSD)
  • Social anxiety disorder (SAD)

Most antidepressants work by affecting chemicals in the brain called neurotransmitters, including serotonin, norepinephrine, and dopamine.

There are five main classes of antidepressants which affect these neurotransmitters in different ways:

  • Selective serotonin reuptake inhibitors (SSRIs): SSRIs are often the first-line treatment prescribed by doctors for depression and anxiety. SSRI medications generally cause fewer side effects and are less likely to cause problems at higher therapeutic doses than other types of antidepressants. As suggested by their name, SSRIs work by increasing the activity of the chemical serotonin in the brain. Examples of SSRI medications include sertraline (Zoloft), fluoxetine (Prozac), paroxetine (Paxil), fluvoxamine (Luvox), citalopram (Celexa), escitalopram (Lexapro) and vilazodone (Viibryd).
  • Serotonin and norepinephrine reuptake inhibitors (SNRIs): SNRIs work by blocking the reabsorption of the neurotransmitters serotonin and norepinephrine in the brain. Examples of SNRI medications are duloxetine (Cymbalta), venlafaxine (Effexor XR), desvenlafaxine (Pristiq), and levomilnacipran (Fetzima). 
  • Tricyclic antidepressants: Tricyclic antidepressants can cause more side effects than SSRIs or SNRIs. For this reason, doctors will generally prescribe tricyclic antidepressants only if previous prescriptions of SSRIs or SNRIs failed to improve symptoms, or for specific symptoms for which they are known to be more effective. Examples of tricyclic antidepressants include imipramine (Tofranil), nortriptyline (Pamelor), amitriptyline, doxepin, and desipramine (Norpramin).
  • Monoamine oxidase inhibitors (MAOIs): Like tricyclic antidepressants, MAOIs are generally prescribed only if other medications have failed to work. MAOI use can have serious side effects and must be supported by a strict diet, as interactions with some foods—including certain cheeses, pickles and wines—can be dangerous or even fatal. MAOIs cannot be combined with SSRIs. Examples of MAOIs include tranylcypromine (Parnate), phenelzine (Nardil), and isocarboxazid (Marplan). 
  • Atypical antidepressants: Antidepressants that don’t fit into the other four classes of medication are grouped into this category. Some common examples of atypical antidepressants include trazodone, mirtazapine (Remeron), vortioxetine (Trintellix), and bupropion (Wellbutrin SR, Wellbutrin XL).

If you’re prescribed an antidepressant medication, be sure to take it only as directed by your doctor.

Don’t take a different dose than what was prescribed and don’t take it for a longer or shorter period of time than recommended by your doctor.

Once you’ve been prescribed an antidepressant, keep in mind that it may take two to eight weeks for the medication to start taking effect.

Some mild side effects can occur within the first two weeks of starting the medication, but many will resolve after that. 

Can Antidepressants Cause Weight Loss?

Most antidepressant medications are more commonly associated with weight gain, but there are three that have been connected to weight loss:

  • Bupropion (Wellbutrin)
  • Fluoxetine (Prozac)
  • Duloxetine (Cymbalta)

Studies on the effect of fluoxetine (Prozac) on weight are varied, with only some people experiencing weight loss. And while it may cause weight loss in the short-term, but after six months or longer can lead to an increase in weight.

Similarly, the research on the impact of duloxetine (Cymbalta) on weight loss is unclear. Duloxetine can decrease appetite, which can lead to weight loss in some people. However, research has yet to show a compelling and consistent connection between duloxetine (Cymbalta) and weight loss.

Of these three medications, bupropion (Wellbutrin) is the most consistently associated with weight loss.

Several studies, including a 2019 meta-analysis of 27 studies, found that bupropion (Wellbutrin) was the only commonly used antidepressant associated with weight loss.

In the analysis, all of the antidepressants caused an average increase in body weight of 5%, except for bupropion (Wellbutrin).

Bupropion (Wellbutrin), an atypical antidepressant, works by altering the brain chemicals norepinephrine and dopamine.

In addition to being the only antidepressant consistently associated with weight loss, it’s also associated with fewer rates of sexual side effects and sexual dysfunction than SSRIs and SNRIs. 

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Which Antidepressants Cause Weight Gain?

Though most antidepressants can cause weight gain as side effect, some antidepressants seem more likely to cause weight gain than others, including:

  • Amitriptyline (Elavil)
  • Imipramine (Tofranil)
  • Nortriptyline (Aventyl)
  • Paroxetine (Paxil, Pareva)
  • Mirtazapine (Remeron)
  • The effect of SSRIs on weight is mixed.

Despite the fact that many SSRIs cause weight loss during short-term treatment, other studies show that these drugs may cause long-term weight gain. The effects of these drugs will need continued study before we know more.

Why Do Antidepressants Affect Weight?

There are different theories as to why antidepressants affect weight.

Some believe that the medication’s impact on neurotransmitters in the brain have an indirect impact on metabolism.

Others believe that weight gain or weight loss is an indirect side effect of the medications’ efficacy or inefficacy of treating the condition. 

For example, some people use food and overeating to cope with anxiety and depression.

In this case, when they start antidepressant medication, they no longer feel the need to eat emotionally, which can lead to weight loss.

The opposite reaction is possible, too. For people who lose their appetite as a result of their depression, effective treatment for their symptoms may help their appetite return, causing a modest weight gain.  

Have Antidepressants Ever Been Prescribed for Weight Loss?

Neither weight loss nor weight gain is a guarantee when taking antidepressants.

Like many medications, side effects can vary depending on the patient. Additionally, antidepressant medications have not been approved for weight loss by the Food and Drug Administration (FDA).

Finally, antidepressants can cause rare but serious side effects, including:

  • Nausea
  • Vomiting
  • Dizziness
  • Agitation
  • Confusion
  • Fever
  • Fainting
  • Hallucinations
  • Changes in blood pressure
  • Rapid heartbeat
  • Tremors 
  • Seizures

With these potential serious side effects in mind, antidepressants are not prescribed for weight loss.

If you’re looking for antidepressants that cause weight loss, perhaps you should consider K Health’s online weight management program instead, with medications designed specifically to support weight loss.

How to Prevent Weight Loss Due to Antidepressants

When taken as directed, antidepressants can be effective in treating both depression and anxiety.

If you lose an excessive amount of weight after starting an antidepressant, talk to your doctor about the medication’s benefits and side effects.

If the benefits don’t outweigh the weight loss side effects, you can also ask if adjusting the dose—or switching medications—might be helpful. Discuss the pros and cons with your doctor before making such a decision.

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K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.

K Health has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references.

  • Anxiety Facts and Statistics. (2020).

  • Antidepressant utilisation and incidence of weight gain during 10 years’ follow-up: population based cohort study. (2018).

  • Is increased antidepressant exposure a contributory factor to the obesity pandemic? (2016).

  • Bupropion: A systematic review and meta-analysis of effectiveness as an antidepressant. (2016).

  • Depression. (2020).

  • Effects of antidepressant and antipsychotic use on weight gain: A systematic review. (2019).

  • What is Anxiety and Depression? (n.d.).

Antidepressants that cause weight loss: Risks, benefits, and more

Most antidepressant medications cause weight gain as a side effect. However, bupropion is an antidepressant that may lead to weight loss in some people.

Antidepressants are a common form of treatment for depression. However, some people with the condition may encounter issues managing their weight.

These issues are sometimes due to the symptoms of depression that may affect appetite. They may also result from antidepressant use, which could lead to weight gain as a possible side effect.

In this article, we discuss antidepressants that cause weight loss. We also look at the benefits and risks of antidepressants for weight loss and consider alternative options.

If a person is considering taking medication for weight loss, it is important to consult with a healthcare professional, as not everyone will benefit from these drugs.

Share on PinterestAntidepressants may cause some people to have problems with managing their weight.

Buproprion is a common antidepressant medication, and its brand names include Aplenzin and Wellbutrin. It comes as an immediate and extended-release pill.

Buproprion works by altering chemical levels in the brain. It disrupts the enzymes that regulate the hormones norepinephrine and dopamine.

Buproprion is an atypical form of antidepressant, which means its class differs from other types of antidepressants, such as serotonin reuptake inhibitors.

While it can help with depression, some people may also take bupropion to stop smoking, as the drug can reduce nicotine cravings.

A 2016 study found that people who took bupropion lost around 7 pounds more than those who took other antidepressants over 2 years. However, the researchers only discovered this effect in nonsmokers.

A 2019 review of 27 studies in children and adults who took antidepressants found that only those taking bupropion lost weight, while people who took other antidepressants gained weight.

Studies show bupropion is an effective treatment for depression. Therefore, it may be a suitable option for people with depression and concerns about possible weight gain.

For example, taking bupropion may be useful for those with depression and obesity. If people take another type of antidepressant, it could cause further health problems in these situations.

People without depression should not take antidepressants for weight loss, as there is no evidence bupropion causes weight loss in individuals without this condition.

Additionally, a person who takes bupropion increases their risk of the following side effects:

  • dry mouth
  • dizziness
  • headaches
  • tiredness
  • nausea and vomiting
  • stomach pain
  • appetite changes
  • digestive problems
  • sore throat
  • sweating
  • mood swings

In rare cases, bupropion can trigger serious side effects, including:

  • seizures
  • confusion
  • fever
  • rashes or hives
  • swelling around the body
  • hallucinations and delusions
  • paranoia
  • changes in heart rate
  • difficulty breathing
  • chest pain

These signs could indicate a medical emergency or other serious health concerns. People who experience any of these side effects should stop taking bupropion immediately and contact a doctor.

The Food and Drug Administration (FDA) also warns these drugs may increase the risk of suicide. Bupropion may cause unpredictable changes in mood and suicidal thoughts.

Suicide prevention

If you know someone at immediate risk of self-harm, suicide, or hurting another person:

  • Ask the tough question: “Are you considering suicide?”
  • Listen to the person without judgment.
  • Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
  • Stay with the person until professional help arrives.
  • Try to remove any weapons, medications, or other potentially harmful objects.

If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988.

Click here for more links and local resources.

The best alternative for weight loss is a combination of a nutritious diet and exercise.

A person can follow a diet rich in vegetables and fruit and eat whole grains instead of refined grains or foods with added sugars. Some people may also need to reduce their calorie intake and portion sizes.

Regular exercise is another important step. People should aim to do at least 150–300 minutes of moderate-intensity activity per week.

Here are some answers to common questions regarding antidepressants and weight gain.

Can you lose weight on depression medication?

Antidepressants can cause a variety of side effects, including weight gain and weight loss. Some forms of antidepressants have links to weight loss in some people.

Which antidepressant does not cause weight gain?

Some antidepressants will not cause weight gain — some can even cause weight loss.

A 2022 study found that fluoxetine could cause weight loss of up to 2. 7 kilograms compared with a placebo. However, this may come with side effects such as nausea, dizziness, and fatigue.

Researchers have also associated bupropion with weight loss in some people. Additionally, health experts have found imipramine may cause weight loss in both acute and long-term treatments.

Why does Zoloft make you lose weight?

Zoloft may have links to weight loss, particularly among children.

This medication can cause a variety of side effects, and it is possible some of these may contribute to weight loss. Nausea and decreased appetite are both known adverse effects of Zoloft. If a person is taking Zoloft and experiences adverse effects, such as appetite issues or nausea, they may wish to consult a doctor.

Although most antidepressants can cause weight gain, bupropion is a medication for depression that can lead to weight loss. If people with depression have concerns about weight gain, this might be a suitable option.

People without depression should not take bupropion to lose weight. There is no evidence that this drug causes weight loss in those without depression, while there is a risk of serious side effects.

The best way for individuals to lose weight is to eat a nutritious diet and exercise regularly.

Find out what are the best antidepressants for weight loss?

The problem of excess weight is often associated with disorders of the nervous system. This group of ailments includes compulsive overeating and bulimia. Taking antidepressants for weight loss, some patients hope to get rid of the pathological condition. But is it really so? Can drugs, whose action is aimed at the treatment of neurosis and depression, help to cope with the constant desire to eat?

Reasons for overeating

The female half of the population is more susceptible to eating disorders. The first signs of deviation may appear even in the tender adolescence. Various problems characteristic of this age are often "jammed" in attempts to compensate for the feelings and emotions shown. At some point, it begins to seem that overeating helps to overcome life's troubles.

Bulimia nervosa and compulsive overeating (binge eating) are more common than anorexia. And if in the latter case the symptoms of the pathological condition quickly become noticeable to others, then in the case of excessive food intake, normal weight can be maintained for a long time. nine0003

The following factors can influence the development of an eating disorder:

  • depression;
  • depression;
  • psychological trauma;
  • low self-esteem;
  • genetic predisposition;
  • high standards.

Bouts of uncontrolled food consumption often occur against the background of sudden mood swings.

It should be borne in mind that, in addition to disorders of the psycho-emotional state, the disease can also lead to obesity, metabolic disorders, and cardiovascular pathologies. nine0003

Methods of treatment

Complex therapy usually helps to completely get rid of both the causes that led to weight gain and extra pounds. In treatment, it is important to influence the problem from different angles. First of all, special attention is paid to the normalization of the nervous system. Many people start taking antidepressants for weight loss. Without prescriptions in a pharmacy, you can buy only the safest drugs from this group.

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Indeed, some antidepressants, in addition to their main purpose, contribute to weight loss by increasing the production of the hormone serotonin. However, without strict indications - diseases of the nervous system - taking drugs that have a toxic effect is highly discouraged. Only a specialist can prescribe such drugs, since some antidepressants containing a high concentration of psychotropic substances can cause a backlash and “turn off” the feeling of fullness. nine0003

For weight loss, you should choose antidepressants that will have a positive effect on tone and increase vitality. This will be of particular benefit when playing sports. In addition to drug exposure, it will also be necessary to normalize the regime of rest and work, to avoid stressful situations as much as possible.

Specialists warn that any medications that can affect the psycho-emotional state are intended solely to suppress a depressive state, eliminate severe nervous overexcitation. Therefore, only in the presence of similar deviations and weight gain against this background, antidepressants for weight loss can be prescribed. nine0003

Sedative for depression. The list of medicines...

In fact, there are much more patients with depression than the official statistics. Some of them...

The list of drugs that can be freely purchased at the pharmacy is not long. To reduce weight and restore a normal psycho-emotional state, antidepressants belonging to the group of selective serotonin reuptake inhibitors are suitable. The substance is necessary for the brain to transmit signals to neurons. The drugs are able to normalize the level of serotonin and at the same time do not cause serious side effects, unlike the drugs that were used before. nine0003

Popular and effective drugs

In medical practice, one antidepressant is especially often used for weight loss. The name of this drug is Fluoxetine. It is not specifically designed for weight loss, but the effect that it has on the nervous system allows you to cope with the feeling of hunger.

The most common antidepressants used for weight loss also include the following:

  • Bupropion;
  • Zoloft;
  • Venlafaxine;
  • Prozac;
  • Citalopram;
  • Paxil.

Once the diagnosis is made and the causes of the pathological condition are established, the doctor may prescribe an antidepressant for weight loss. What is best for a particular case and which treatment regimen will help to cope with the problem depends on the severity of the patient's condition. It should be borne in mind that antidepressants are completely different drugs that can be taken without prior consultation with a specialist. Each remedy has certain indications and contraindications for use, and can also provoke the development of a number of negative consequences. nine0003

Fluoxetine Slimming

This is one of the most commonly used antidepressants for eating disorders. "Fluoxetine" is prescribed for patients suffering from bulimia and compulsive overeating. With the timely start of treatment with this drug, it is possible to prevent the development of obesity, metabolic disorders in the body.

The pharmacological action of the drug, according to the instructions, is aimed at inhibiting the reuptake of serotonin. This helps to improve mental activity, raise mood, reduce feelings of helplessness and apathy, get rid of anxieties, fears and worries. Fluoxetine, like other antidepressants for weight loss from the group of selective serotonin reuptake inhibitors, should be taken for at least 2 weeks to achieve a pronounced therapeutic effect. nine0003

Indications for prescription

Self-administration of even the safest antidepressant in an attempt to lose weight is considered a rather dangerous experiment. The manufacturer recommends taking "Fluoxetine" for obsessive-compulsive disorders, depression of varying severity, neuroses, insomnia, malfunctions of the nervous system.

The desire to constantly consume a large amount of food under the influence of the drug is significantly reduced. Therefore, an antidepressant is also prescribed for eating disorders. nine0003

Treatment regimen

Many experts believe that weight gain is associated with insufficient production of serotonin. A deficiency of this substance provokes the development of a depressed state, stress, and as a result, a desire to “eat” your bad mood. In the future, such a reflex will work already at a subconscious level, which indicates dependence.

Gradually increasing body weight will again worsen mood and cause a desire to have a tasty snack. It is not always possible to get out of this vicious circle on your own. As a result of treatment with Fluoxetine, the feeling of hunger is suppressed, a surge of vigor is felt, and sleep is normalized. nine0003

Start taking the medicine with 20 mg (1 capsule) in the morning. In the absence of a clinical effect, the dose is increased to 40-60 mg and divided into several doses. According to the instructions, it is forbidden to take more than 4 capsules per day when losing weight. Otherwise, the drug may provoke the development of side effects.


Antidepressants for weight loss should only be taken if there are no contraindications in the patient's history. It is forbidden to use them in the following pathologies:

  • glaucoma;
  • epilepsy;
  • pathologies of the central nervous system;
  • diabetes mellitus;
  • pregnancy, lactation;
  • pathologies of the liver and kidneys;
  • intolerance to the components of the medicine.

Antidepressants for weight loss: reviews

It is possible to achieve a positive effect when getting rid of extra pounds with the help of antidepressants only if the diet is followed. It does not hurt to do and improve the appearance. nine0003

Increased tone and a constant feeling of cheerfulness, a surge of strength will allow you to spend a long time in the gym. According to reviews, antidepressants such as Fluoxetine (analogous to Prozac) and Venlafaxine contribute to a noticeable weight loss as early as 2-3 months after the start of treatment. However, not all patients manage to lose weight.

Do not forget about the side effects of antidepressants. Most often they cause headaches, manic syndrome, hallucinations, tremors, hyperhidrosis, tachycardia, dysphagia, incoordination, nausea. Loss of appetite and consequent weight loss is also a side effect of many antidepressants. nine0003

How to lose weight while taking antidepressants?

How to lose weight with . ..

43 answers Removing




Then change the doctor, this is unacceptable for a serious weight gain on the amatriplin and ameriplin does nothing. If you take it, you will definitely earn type 2 diabetes for yourself. Then you will take metformin all your life and go on a diet. November 16, 2020, 16:23 Are they not accepted by the course? nine0003



We have the only psychiatrist on campus. I must go to Nizhny Novgorod. My mom is diabetic and it's scary. November 16, 2020
In such dosages, it has a very weak effect.
If it helps you in such ultra-low dosages, then you have mild depression. nine0036 Normal doctors prescribe amitriptyline only for severe depression. The dosages there are appropriate.
In your case, you need to change this drug, any antidepressant in therapeutic dosages will be stronger than 50 mg of amitriptyline.
But I would change the same doctor, because 50 mg of amitriptyline and without first trying drugs of the SSRI class could only be prescribed by a not very competent doctor

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In general, when taking amitriptyline, a patient prone to weight gain should adhere to a strict diet.
You need to count calories and not exceed your daily requirement. And it is better to have a small deficit (200-400 kilo calories). It is necessary to completely exclude foods with a high glycemic index and limit foods with an average one.
Preference should be given to lean meat, fish - you need more protein less carbohydrates. From carbohydrates - buckwheat, cabbage, brown rice (normal should be severely limited). nine0036 No sweets, bread, potatoes, sweet fruits, sugar, sweet drinks, honey, etc.



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Good afternoon. I have been taking antidepressants for three years now. On the contrary, I lost 20 kg. Antidepressants do not have the side effect of weight gain. I asked my psychotherapist.




#30,0002 Gost

I drink more than 10 years and more than 10 years and more than 10 years I can say for sure that they are recovering from them and all of my friends have encountered this. It's just that everyone has their own set of weights. Personally, I have 7 kg for all these years. Gradually. nine0003




Interesting, and weight gain from the tricyclics is due in yourself? or some other reason, don't you think?



The therapist told me that the weight gain is not from the drugs themselves, but from food, and when taking certain antidepressants, appetite increases. It seems to me that in addition to appetite, the metabolism also slows down and it is more difficult to lose weight, so it is important to monitor nutrition. And regular physical loads never interfere, they also help to cope with depression, if it is not too strong. nine0003



Good afternoon. I have been taking antidepressants for three years now. On the contrary, I lost 20 kg. Antidepressants do not have the side effect of weight gain. I asked my psychotherapist.



Good afternoon. I have been taking antidepressants for three years now. On the contrary, I lost 20 kg. Antidepressants do not have the side effect of weight gain. I asked my psychotherapist. nine0003



Hello. This is an excerpt from the annotation - "On the part of the digestive system: nausea, heartburn, vomiting, gastralgia, increased or decreased appetite (increase or decrease in body weight), stomatitis, change in taste, diarrhea, darkening of the tongue; rarely - impaired liver function, cholestatic jaundice, hepatitis. " You just got lucky apparently)

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Good afternoon. I have been taking antidepressants for three years now. On the contrary, I lost 20 kg. Antidepressants do not have the side effect of weight gain. I asked my psychotherapist.



Good afternoon. I have been taking antidepressants for three years now. On the contrary, I lost 20 kg. Antidepressants do not have the side effect of weight gain. I asked my psychotherapist.



Good afternoon. I have been taking antidepressants for three years now. On the contrary, I lost 20 kg. Antidepressants do not have the side effect of weight gain. I asked my psychotherapist.



What is your dosage of amitriptyline? How much per day do you take?



Good afternoon. I have been taking antidepressants for three years now. On the contrary, I lost 20 kg. Antidepressants do not have the side effect of weight gain. I asked my psychotherapist. nine0003







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