Trintellix causing anxiety

What they are and how to manage them

Medically reviewed by Melissa Badowski, PharmD, MPH, FCCP — By Alex Brewer, PharmD, MBA — Updated on May 22, 2022

Trintellix (vortioxetine) is a brand-name prescription medication. It’s approved by the Food and Drug Administration (FDA) to treat major depressive disorder (MDD) in adults. MDD is sometimes called clinical depression.

Trintellix is typically taken long term, as long as you and your doctor determine that the drug is effective for you.

Here are some fast facts on Trintellix:

  • Active ingredient: vortioxetine
  • Drug class: atypical antidepressant
  • Drug form: oral tablet

As with other drugs, Trintellix can cause side effects. Read on to learn about potential common, mild, and serious side effects, so you can compare the pros and cons of using this medication. For a general overview of Trintellix, see this article.

Trintellix can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days or weeks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

These are just a few of the more common side effects reported by people who took Trintellix in clinical trials:

  • constipation
  • diarrhea
  • dry mouth
  • nausea*
  • vomiting

* For more information on this side effect, see “Side effect specifics” below.

Mild side effects can occur with Trintellix use. This list doesn’t include all possible mild side effects of the drug. For more information, refer to Trintellix’s medication guide.

Mild side effects that have been reported with Trintellix include:

  • constipation
  • diarrhea
  • dry mouth
  • vomiting
  • dizziness
  • nausea*
  • itching*

* For more information on this side effect, see “Side effect specifics” below.

These side effects may be temporary, lasting a few days or weeks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you develop a side effect while taking Trintellix and want to tell the FDA about it, visit MedWatch.

Trintellix may cause serious side effects, although this is rare. The list below may not include all possible serious side effects of the drug. For more information, including how long Trintellix side effects last, you can refer to Trintellix’s medication guide.

If you develop serious side effects while taking Trintellix, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Note: A missed dose of Trintellix isn’t likely to cause serious side effects. However, you should not stop taking the drug without first talking with your doctor. Suddenly stopping Trintellix can cause serious side effects, including nausea, confusion, and tiredness. For more information about the dosages for Trintellix, you can see this in-depth article.

Serious side effects and their symptoms

Serious side effects of Trintellix, as well as their symptoms, may include:

  • Serotonin syndrome (having too much of the chemical serotonin in your body). Symptoms can include:
    • anxiety
    • confusion
    • diarrhea
    • fast heart rate
    • irritability
    • increased blood pressure
    • muscle spasms (involuntary muscle tightening) or tremors (shaking that you can’t control)
  • Serious bleeding. Symptoms can include:
    • coughing up blood
    • severe or uncontrollable bleeding
    • stools that look black or red
    • urine that’s red, pink, or brown
    • vomiting blood, which may look similar to coffee grounds
  • Hyponatremia (low blood sodium levels). Symptoms can include:
    • confusion
    • headache
    • trouble concentrating
    • weakness
  • Sexual side effects.†
  • Risk of suicidal thoughts and behaviors in children and young adults.*
  • Withdrawal symptoms.†
  • Allergic reaction.†

* Trintellix has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effect specifics” section below.
† For more information on this side effect, see the “Side effect specifics” section below.

Trintellix may cause several side effects. Here are some frequently asked questions about the drug’s side effects and their answers.

Does Trintellix cause weight gain?

It isn’t likely. In clinical trials of Trintellix, weight gain wasn’t reported as a side effect. Weight gain has been reported by people taking Trintellix since the drug was approved. However, it’s not clear whether Trintellix caused this weight gain.

If you’re concerned about weight gain while taking Trintellix, talk with your doctor. They can suggest ways to maintain a weight that’s healthy for you.

Is drowsiness a side effect of Trintellix?

Probably not. Drowsiness wasn’t a side effect of Trintellix in clinical trials. The drug also wasn’t reported to cause tiredness or fatigue (lack of energy). There have been reports of sleepiness in some people taking Trintellix since the drug was approved. It’s not known if Trintellix was the cause of this sleepiness.

Additionally, tiredness could possibly be a symptom of withdrawal* if you were to suddenly stop taking Trintellix. It’s important to follow your doctor’s instructions for decreasing your dosage gradually. Doing so can help you avoid withdrawal symptoms.

If you’re concerned about drowsiness while taking Trintellix, talk with your doctor. And always follow your doctor’s dosage recommendations.

* Withdrawal symptoms are side effects that can happen when you stop taking a drug your body has become dependent on. (With dependence, your body needs the drug in order to feel like usual.)

Should I expect a headache when using Trintellix?

No, headaches aren’t likely. In clinical trials, people who took Trintellix didn’t report this side effect. Since Trintellix was approved, people have reported headaches while taking it. But it’s not clear whether Trintellix caused this side effect.

Headache could possibly be a symptom of withdrawal* if you were to suddenly stop taking Trintellix. It’s important to follow your doctor’s instructions for decreasing your dosage gradually if you stop taking the drug. Doing so can help you avoid withdrawal symptoms.

If you’re concerned about headaches while taking Trintellix, talk with your doctor. They can recommend ways to treat this side effect, which may include using over-the-counter pain relievers.

* Withdrawal symptoms are side effects that can happen when you stop taking a drug your body has become dependent on. (With dependence, your body needs the drug in order to feel like usual.)

Can using Trintellix cause sweating?

It’s unlikely. Sweating wasn’t reported by people who took Trintellix in clinical trials. But since Trintellix was approved, people have reported sweating while taking it.

And, sweating can be a side effect of several other drugs used to treat major depressive disorder, which Trintellix also treats.

Sweating could be a withdrawal* symptom if you were to suddenly stop taking Trintellix. It’s important to follow your doctor’s instructions for decreasing your dosage gradually if you stop taking this drug. Doing this can help you avoid withdrawal.

Talk with your doctor if you’re concerned about sweating while taking Trintellix.

* Withdrawal occurs when you suddenly stop taking a drug that your body is dependent on. See the “Side effect specifics” section for more information about Trintellix withdrawal symptoms.

Does Trintellix cause any vision-related side effects?

It’s possible, if you already have certain other eye conditions. But in people without existing eye conditions, Trintellix hasn’t been shown to cause vision-related side effects in clinical trials.

Specifically, in people with narrow angles in their eye, antidepressants such as Trintellix can trigger a condition called angle-closure glaucoma. This condition may also be called closed-angle glaucoma. Symptoms can include:

  • changes in vision
  • eye pain
  • redness or swelling in or around the eye

Angle-closure glaucoma is a medical emergency. If you develop the above symptoms, get medical attention right away. Go to your nearest emergency room or hospital, or talk with an eye doctor as soon as possible.

Before you begin taking Trintellix, your doctor may recommend an eye exam to check if you’re at risk for angle-closure glaucoma. If you’re at risk for this condition, your doctor may prescribe treatment to prevent it from developing while you’re taking Trintellix.

If you notice other vision or eye-related side effects while taking Trintellix, call your doctor. They can help determine what could be causing these effects.

Note: Other drugs used to treat major depressive disorder may cause blurry vision, such as Zoloft (sertraline).

Learn more about some of the side effects that Trintellix may cause.


Trintellix may cause generalized itching, which could affect any part of your skin. This was rare during clinical trials.

What you can do

If you experience itching while taking Trintellix, let your doctor know. They may recommend a treatment for this side effect. Or they may have you stop taking Trintellix and try a different medication for your condition.

Sexual side effects

Like other drugs used to treat major depressive disorder, Trintellix can cause sexual side effects. These may include:

  • decreased sex drive
  • erectile dysfunction
  • inability to orgasm or trouble with reaching orgasm

However, sexual side effects were commonly reported in clinical trials of Trintellix.

What you can do

If you experience sexual side effects while taking Trintellix, tell your doctor. They may recommend a treatment to help with this side effect. Or they may recommend that you stop taking Trintellix and try a different medication for your condition.


Mild or moderate nausea was the most common side effect of Trintellix in clinical trials.

Nausea is most common during the first week of taking Trintellix, especially during the first day or two of treatment. On average, nausea from Trintellix tends to last about 2 weeks. Very rarely, people have reported nausea that persisted after 6 to 8 weeks of taking Trintellix.

Also, nausea was found to be more common in females than males in clinical trials. * It isn’t known why these differences occurred.

* Sex and gender exist on spectrums. Use of the terms “female” and “male” in this article refer to sex assigned at birth.

What you can do

If you experience nausea while taking Trintellix, your doctor may recommend a treatment for this side effect. Or they may decide to have you stop taking Trintellix and try a different medication.

Risk of suicidal thoughts and behaviors

Trintellix has a boxed warning about risk of suicidal thoughts and behaviors in children and young adults. This is a serious warning from the Food and Drug Administration (FDA). Boxed warnings alert patients and doctors about potentially dangerous drug effects.

Antidepressants, including Trintellix, can increase the risk of suicidal thoughts and behaviors in children and young adults. It’s important to note that Trintellix is not approved for use in children. It’s only approved for use in adults ages 18 years and older.

This risk is higher when people first start taking Trintellix, and whenever their Trintellix dosage is adjusted.

What you can do

While taking Trintellix, people should try to be aware of any changes in their thoughts and behaviors. Caregivers and people they spend time with should also watch for any changes. This is especially important when they first start taking the medication, and whenever the dosage is adjusted.

Tell your doctor about any changes in your thinking or behaviors while taking Trintellix. And if you have thoughts about suicide, get help right away.

Withdrawal symptoms

It’s possible to have withdrawal symptoms if you abruptly stop taking Trintellix. Withdrawal occurs if you suddenly stop taking a drug that your body has become dependent on. Withdrawal symptoms caused by suddenly stopping Trintellix can include:

  • anger outbursts
  • dizziness
  • headache
  • mood swings
  • muscle tension
  • runny nose
What you can do

Talk with your doctor before you stop taking Trintellix. If you and your doctor agree that it’s best for you to stop treatment with Trintellix, they’ll instruct you how to decrease your dosage over time. This lowers your risk for withdrawal symptoms.

People taking 15 milligrams (mg) or 20 mg of Trintellix per day may be at higher risk for withdrawal than people taking lower dosages. For this reason, your doctor may lower your dosage to 10 mg per day for one week before having you completely stop Trintellix.

Allergic reaction

As with most drugs, Trintellix can cause an allergic reaction in some people. Symptoms can be mild or serious and can include:

  • rash or hives
  • itching
  • flushing (temporary warmth, redness, or deepening of skin color)
  • swelling under your skin, typically in your lips, eyelids, feet, or hands
  • swelling of your mouth, tongue, or throat, which can make it hard to breathe
What you can do

For mild symptoms of an allergic reaction, call your doctor right away. They may recommend ways to ease your symptoms and determine whether you should keep taking Trintellix. But if your symptoms are serious and you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Suicide prevention

If you know someone at immediate risk of self-harm, suicide, or hurting another person:

  • Ask the tough question: “Are you considering suicide?”
  • Listen to the person without judgment.
  • Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
  • Stay with the person until professional help arrives.
  • Try to remove any weapons, medications, or other potentially harmful objects.

If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988.

Click here for more links and local resources.

Below are precautions to consider before taking Trintellix.

Boxed warning: Risk of suicidal thoughts

Trintellix has a boxed warning about risk of suicidal thoughts or behaviors in children and young adults. This is a serious warning from the Food and Drug Administration (FDA). For details, see the “Side effect specifics” section above.

Other precautions

Be sure to talk with your doctor about your health history before you take Trintellix. This drug may not be the right treatment for you if you have certain medical conditions or other factors that affect your health. The conditions and factors to consider include:

Bipolar disorder. Treatment with Trintellix may cause mania or hypomania in people with bipolar disorder. You should tell your doctor if you or members of your family currently have bipolar disorder or mania, or have experienced this in the past. If this applies to you, your doctor may monitor you more closely than usual during Trintellix treatment. They may also recommend a different medication to treat your condition.

Bleeding disorder. Trintellix can increase your risk for bleeding. People with an existing bleeding disorder, such as factor VII deficiency, may have an even higher risk of bleeding with Trintellix. Be sure to discuss any bleeding disorders you may have with your doctor before you start taking Trintellix.

Using Trintellix with certain other drugs can increase this risk even more. If you’re taking warfarin, your doctor will monitor your blood clotting ability. (Warfarin increases the risk of bleeding.) Your doctor will check your blood clotting when you start taking Trintellix, after any dosage changes, and if you stop taking Trintellix.

Certain eye problems. Rarely, antidepressants such as Trintellix can cause a condition called angle-closure glaucoma (also called closed-angle glaucoma) in people with narrow angles in their eye. Angle-closure glaucoma is a medical emergency.

Before you begin taking Trintellix, your doctor may recommend an eye exam to check if you’re at risk for angle-closure glaucoma. If you have narrow angles in your eye, your doctor may prescribe treatment to prevent angle-closure glaucoma while you’re taking Trintellix.

Allergic reaction. You should not take Trintellix if you’ve ever had an allergic reaction to Trintellix or any of its ingredients. Talk with your doctor about other treatments that might be better choices for you.

Use of monoamine oxidase inhibitors (MAOIs). You should not take Trintellix if you’re taking an MAOI to treat a mental health condition. Also, you should not take Trintellix if you are taking the MAOI Zyvox (linezolid), which is an antibiotic. And you should not take Trintellix if you’re receiving the MAOI methylene blue as an intravenous (IV) injection. Be sure to tell your doctor about all the medications you’re taking before starting Trintellix. This includes any MAOIs.

Alcohol use with Trintellix

There aren’t known interactions between Trintellix and alcohol.

However, drinking alcohol may make certain side effects of Trintellix worse, including:

  • confusion
  • dizziness
  • nausea and vomiting

For this reason, talk with your doctor about how much alcohol is safe for you to drink while taking Trintellix.

Pregnancy and breastfeeding while taking Trintellix

It’s not known if Trintellix is safe to take during pregnancy. Your doctor can discuss the risks and benefits of Trintellix use during pregnancy with you. If you use Trintellix while pregnant, there is a pregnancy registry that collects information about antidepressant use during pregnancy. Your doctor can provide more information about this registry.

It’s also not known whether it’s safe to breastfeed while taking Trintellix. This is because it isn’t known whether the drug may pass into breast milk. Talk with your doctor about safe ways to feed your child while taking Trintellix.

Although you may experience side effects while taking Trintellix, they’re not common, and are usually mild. Most mild side effects of the drug go away with time and don’t require medical attention.

You should talk with your doctor if you experience symptoms of serious side effects, including:

  • suicidal thoughts and behaviors*
  • allergic reaction
  • serotonin syndrome (having too much of the chemical serotonin in your body)
  • serious bleeding
  • hyponatremia (low blood sodium levels)
  • withdrawal symptoms (which can occur if you suddenly stop taking Trintellix)

These side effects could be serious and require medical attention. You should also talk with your doctor if you become pregnant while taking Trintellix.

If you’d like to learn more about Trintellix, talk with your doctor or pharmacist. They can help answer any questions you have about side effects from taking the drug.

Note: For more information on major depressive disorder, see our mental health hub and our list of depression articles.

* Trintellix has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effect specifics” section above.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Is Trintellix (vortioxetine) good for anxiety disorders?

Trintellix is FDA approved to treat depression but is sometimes prescribed off-label to treat anxiety

Trintellix is a prescription antidepressant that’s FDA approved to treat major depressive disorder (MDD). It works by balancing levels of the neurotransmitter serotonin, which plays an important role in mood, emotions, and appetite. Because serotonin is believed to help regulate anxiety, Trintellix is also sometimes used off-label to treat anxiety. Let’s take a more in-depth look at taking Trintellix for anxiety. 

Does Trintellix work for anxiety?

Trintellix is one of the brand-names of the generic medication vortioxetine, which belongs to a group of medications called selective serotonin reuptake inhibitors (SSRIs). Trintellix used to be called Brintellix, but it was renamed in 2016 because it was frequently getting confused with an antiplatelet medication called Brilinta. Renaming the medication to Trintellix has helped minimize confusion in doctors and patients.  

Trintellix is an SSRI that can help improve a person’s mood, emotions, and sleep patterns. The Food and Drug Administration (FDA) has only approved Trintellix to treat major depressive disorder, but it can be prescribed off-label to treat anxiety.

Off-label prescribing happens when a doctor prescribes a patient a medication that’s FDA approved to treat a condition that’s different from what the patient has. This is a common occurrence that’s completely legal to do, and it’s estimated that about 1 in 5 prescriptions are actually off-label prescriptions. 

So a doctor can write someone with anxiety a prescription for Trintellix, but why might they do this when there are so many other anti-anxiety medications on the market? Trintellix blocks serotonin reuptake like other SSRIs, but unlike other antidepressants, it also has agonist and antagonistic effects on the 5-HT1A and 5-HT3 serotonin receptors in the brain. Researchers aren’t exactly sure how this works, but they believe it contributes to the antidepressant effects of Trintellix.         

Studies have shown that Trintellix improves symptoms of generalized anxiety disorder more than a placebo and that it is effective and tolerable in patients with severe anxiety. A meta-analysis study published in the Current Drug Targets journal found that Trintellix is effective for people with anxiety disorder with only mild to moderate side effects. Overall, it has proven to be effective at reducing anxiety and depression symptoms for people with major depressive disorder or high levels of anxiety.      

Starting Trintellix for anxiety

Starting any new medication can be stressful, and if you already have anxiety, then knowing what to expect when you start taking Trintellix can help make the process easier. One of the most important things to be aware of when you first start taking Trintellix is that it isn’t a fast-acting medication. It may take some time before you start to see your anxiety symptoms get better. It can take two to four weeks (or longer) to feel the full effects of Trintellix.


Trintellix is available as an immediate-release tablet in three dosage strengths: 5 mg, 10 mg, and 20 mg. The usual starting dose of Trintellix is 10 mg taken once per day with or without food. This dosage may be increased to 20 mg per day or decreased to 5 mg per day depending on how the drug is working or any side effects experienced. 

The exact amount of Trintellix that you’ll need to take and how long you’ll need to take it will vary based on your individual symptoms and medical history. Taking higher doses or more than one dose of Trintellix in an attempt to make it work faster isn’t safe and may cause side effects. This is why it’s important to talk with your healthcare provider about the appropriate dosage for managing your anxiety. If you’ve taken too much Trintellix you should call your doctor or the Poison Control Center at 1-800-222-1222. They will be able to advise you on whether or not you should visit an emergency room or urgent care center.     


Trintellix shouldn’t be taken at the same time as certain medications because of potential drug-drug interactions. It shouldn’t be taken within two weeks of taking: 

  • Monoamine Oxidase Inhibitors (MAOIs)
  • Methylene blue
  • Linezolid 

Trintellix shouldn’t be taken within two weeks of taking a monoamine oxidase inhibitor (MAOI), and an MAOI shouldn’t be taken within 21 days of stopping Trintellix because of a heightened risk of experiencing serotonin syndrome. Serotonin syndrome is a potentially life-threatening condition that happens when too much serotonin builds up in the body. Symptoms of serotonin syndrome include shivering, tremors, high blood pressure, rapid heart rate, confusion, muscle rigidity, and seizures.  

You should tell your doctor if you’re taking any of the following medications as well, because they may affect how Trintellix works or increase the risk of side effects: 

  • Other depressants
  • Antipsychotic medications 
  • Over-the-counter pain medications like NSAIDs or aspirin 
  • Blood thinners like Coumadin (warfarin)
  • Triptan medicines or tryptophan supplements
  • Diuretics
  • St. John’s Wort
  • Carbamazepine 
  • Fentanyl 
  • Lithium 
  • Phenytoin 
  • Quinidine
  • Bupropion 
  • Buspirone  
  • Rifampin 
  • Tramadol 

Side effects

When you first start taking Trintellix, you may experience some possible side effects. Some people may experience feeling restless or energized soon after taking a dose, which could lead to trouble sleeping. Here are some other common side effects that people experience when they start taking Trintellix:

  • Nausea
  • Vomiting
  • Constipation
  • Diarrhea
  • Dry mouth
  • Muscle stiffness 
  • Gas 
  • Weight gain 
  • Abnormal dreams 
  • Eye pain
  • Vision changes
  • Dizziness
  • Sexual dysfunction   

It’s important that you avoid missing a dose of Trintellix to ensure treatment remains consistent and decreases the risk of relapse in depressive symptoms. If you do miss a dose it’s best to take your next dose as soon as you remember, unless it’s almost time to take your next dose. Doubling up on doses can cause side effects and, in rare cases, may cause serotonin syndrome. Many healthcare providers will recommend taking Trintellix at approximately the same time every day.   

Although it’s rare, Trintellix can cause more serious side effects that may require medical attention. The FDA label for Trintellix contains a boxed warning for potential suicidal thoughts and behaviors, especially in children, adolescents, and young adults. If you’re taking Trintellix and start to have any suicidal thoughts or behaviors, you should seek medical help right away.

Trintellix can also cause serious side effects like:  

  • Unusual bleeding
  • Unusual bruising
  • Mania or hypomania in people with bipolar disorder
  • Angle closure glaucoma
  • Low sodium levels in the blood (hyponatremia)

If you experience any of these side effects while taking Trintellix you should talk with your healthcare provider as soon as you can. If you are allergic to vortioxetine or any of the other ingredients in Trintellix should avoid taking the medication because it may cause allergic reactions. 


People with bipolar disorder should take Trintellix only if approved by their doctor because it may cause manic episodes. People with glaucoma and bleeding disorders should only take Trintellix under the supervision of a doctor since it may increase the risk of bleeding episodes and worsen closed-angle glaucoma.  

Certain medications are unsafe for elderly patients, but Trintellix has been shown to be tolerable and safe for adults older than 65 years old. Clinical studies have shown no difference in safety or efficacy between older adults and younger adults, and there has been no noticeable difference in response to the medication between older and younger adults either. Trintellix is not approved for any patients under the age of 18. 

Trintellix may affect the fetus in pregnant women. Taking Trintellix in the third trimester of pregnancy may lead to an increased risk of a condition called persistent pulmonary hypertension in newborns. There’s no data on Trintellix and how it affects breast milk or breastfed infants, which is why it’s important to weigh the benefits and risks of using the medication while breastfeeding with a healthcare provider.      

What is the most effective antidepressant for anxiety?

There isn’t one medication that is most effective at treating anxiety. What works for one person may not work for another, but the good news is that there are many different types of antidepressants that can treat mental health conditions like anxiety. In addition to SSRIs, here are some other categories of antidepressants:  

  • Serotonin and norepinephrine reuptake inhibitors (SNRIs): increase the availability of serotonin and norepinephrine in the brain.
  • Tricyclic antidepressants: increase levels of serotonin and norepinephrine in the brain and block acetylcholine. 
  • Monoamine oxidase inhibitors (MAOIs): prevent the enzyme monoamine oxidase from removing dopamine, serotonin, and norepinephrine from the brain.   

Here are some of the most effective antidepressants for anxiety.   

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My diagnosis is an anxiety disorder, the doctor prescribed this drug. After two months I felt better, but the doctor insisted that I complete the entire course. But not without a drop of tar, half an hour after taking the pill, I began to feel sick. I began to take them immediately before bedtime, I no longer felt nausea.

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I broke up with a young man, graters began at work, because of this I stopped sleeping and eating normally. In general, I had to look for support, which turned out to be this drug. I took it for more than 4 months, the condition stabilized, after another month life began to acquire colors. nine0003

Brintellix tablets 20 mg 28 pcs.

I entered into a depression by negligence. A year ago, I had the same state of apathy: nobody and nothing interests me. In general, there is no interest in life. I was on another medication at the time, but there were side effects. From these pills in just two weeks I wanted to do something.

Brintellix tablets 5 mg 28 pcs.

I had to take a course of brintellix because, against the backdrop of life's problems, I developed persistent depression and even had suicidal thoughts. The doctor prescribed "weak" tablets of all forms of release, but that was enough for me. nine0003

Brintellix tablets 10 mg 28 pcs.

After severe stress, sleep worsened. For two days she could not sleep, then fall into half-asleep. There was no proper sleep. This began to affect the general condition of the body. My husband almost took me by force to the doctor, who prescribed me Brintellix tablets at a dosage of 10 mg. Sleep improved markedly by the third week of admission. The maximum effect came after 12-14 weeks.

Brintellix tablets 10 mg 28 pcs.

Somehow I noticed that I began to delve too deeply into any problems and look for some additional catch in them. I thought about them at home, at work, everywhere. If I found a solution, I immediately noticed another problem .. and so constantly - some kind of vicious circle. In addition, he began to sleep poorly, his appetite worsened. The doctor gave me these pills. They improved my condition, but without the help of a psychiatrist, they could not do

Brintellix tablets 5 mg 28 pcs.

Irritability, nervousness, sudden mood swings made me turn to a neurologist, because my mood directly affected my family and friends. The doctor prescribed these pills for me, there was no immediate effect, but after a month I was a little let down. The maximum effect came after 3 months of admission.

Brintellix tablets 20 mg 28 pcs.

Depression is a serious and long-term illness. For three days, you can’t get rid of it, like with acute respiratory infections. The doctor prescribed these pills for me, took them for more than two months and was very worried that addiction would not arise. But to my joy, the depression left me, and the refusal of the drug was completely painless. nine0003

Brintellix tablets 10 mg 28 pcs.

A good drug for depressive states in an advanced stage. After a couple of weeks of admission, interest in life returned, it became more fun at heart. The only downside is that you can buy it only with a prescription and nothing else, and getting to the doctors at the present time is difficult.

Brintellix tablets 10 mg 28 pcs.

This drug helped me to smile again and see the world in a new way. I took 1 tablet before meals for 12 weeks, my friends did not even immediately recognize me in the smiling girl when they saw me on the street. nine0003

Brintellix tablets 10 mg 28 pcs.

When the panic attacks started, it really interfered with my work. At first they were caused by stressful situations, but then they began to appear more and more often, they began to cover the whole body. The doctor advised these pills in parallel with psychotherapy. After 2 months it became easier, the full course - 3 months. The only negative is that it causes drowsiness.

Brintellix tablets 5 mg 28 pcs.

When problems both at work and in my personal life piled up at the same time, I almost broke down: I went into a deep depression. There are no more goals in life, the look is extinct - in a word, a zombie. When a friend came to visit me and saw that I had even stopped cleaning, she pulled me to the doctor. He prescribed Brintellix for me. I noticed the first glimpses in two or three weeks. Fully recovered in 3 months. nine0003

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What you should know about antidepressants

Ekaterina Kushnir

treats anxiety disorder

I have generalized anxiety disorder.

For a long time I coped without pills and other help, but one day I got tired of constant anxiety and began to interfere with my normal life. As a result, I turned to a private psychiatrist. nine0003

The doctor prescribed an antidepressant from the SSRI group - these are selective serotonin reuptake inhibitors. Such drugs are the first thing prescribed in the treatment of depression and a number of other conditions, including my disease.

The doctor immediately warned me about some peculiarities associated with taking the drug. Some of them I then felt on myself. I think everyone who plans to be treated with antidepressants should know about them.

At the same time, it should be taken into account that most of the negative effects of therapy are temporary and not dangerous, and if they do not go away, one medicine can be replaced with another. Antidepressants help many people with mental disorders and other illnesses get rid of their symptoms and return to a full life, so you definitely should not be afraid of them. The main thing is to take such drugs when they are really needed: as prescribed by a competent doctor and under his control. nine0003

Go see a doctor

Our articles are written with love for evidence-based medicine. We refer to authoritative sources and go to doctors with a good reputation for comments. But remember: the responsibility for your health lies with you and your doctor. We don't write prescriptions, we make recommendations. Relying on our point of view or not is up to you.

Fact No. 1

Antidepressants may make symptoms worse at first

Antidepressants can increase anxiety in anxiety disorders, as well as cause irritability and agitation - the so-called causeless motor agitation, the inability to sit still. It's not dangerous, but rather unpleasant. This condition is sometimes referred to as initial anxiety, that is, the anxiety of starting therapy. Up to 65% of people face it. nine0003

Antidepressant-induced anxiety syndrome - a systematic review in the British Journal of Psychiatry

There is also evidence that some classes of antidepressants, including SSRIs, may increase suicidal ideation in depression in young people aged 18 to 24 years. These data are not very reliable, and in older people, the risk of suicide no longer increases and even decreases.

Without treatment, depression is more likely to lead to suicidal thoughts, and in case of anxiety, you just need to prepare for such an effect, then it will be easier to survive the attacks. nine0003

The doctor told me that in the first two or three weeks there may be an increase in anxiety, but I did not take it too seriously.

Everything was fine for the first week. After about seven days, I became nervous and irritable. And then I woke up at night and after a while I felt an incomprehensible fear. My heartbeat increased, my head was spinning, my throat was constricted. Because of this, I felt a real panic - I spent the rest of the night fighting terrible thoughts, in the morning I got up completely broken. nine0003


8 myths about antidepressants

I have never had such panic attacks before medication - my anxiety was background, general. I got scared and wrote to the doctor, who reassured me and said that it was not dangerous and would pass soon.

After that, I already expected these panic attacks, immediately tried to relax, calm down, remember that this was just a temporary effect of the drugs. And they ended faster, and then they completely disappeared.

My letter to a psychiatrist. I was scared: I expected an increase in background anxiety, but not panic attacks. I even thought about giving up the medicine

Fact No. 2

The effect of antidepressant treatment will not be immediate

Increase the dose of antidepressants gradually to reduce side effects. They usually start with the minimum, and then bring it up to the working one. For example, for SSRIs with the active ingredient "sertraline", the working dose is from 100 mg per day. I started taking such a drug with 25 mg, and then gradually, in several steps, under the supervision of a doctor, raised the dose to 100 mg.

SSRI dosage - NHS

What doses of antidepressants will be optimal - an article in The Lancet

The process of reaching a working dose can take from two weeks to a month or more. It depends on the drug and its tolerance. I turned out to be sensitive to the medicine, it was hard for me to survive every increase in dosage: anxiety increased again, there were other side effects that then stopped. However, this is not the case for everyone, sometimes the process goes faster.

The full therapeutic effect, that is, the disappearance or a strong improvement in the symptoms of the disease, occurs some time after reaching the working dosage. As a rule, this is a week or two, although some positive changes may be earlier. For some people, this process stretches for a longer period: 6-12 weeks. Minimum initial doses of drugs usually do not work. nine0003

It is better to prepare for the fact that the symptoms of the disease will not disappear in the first weeks of treatment. And remember - this does not always mean that the drug needs to be changed, sometimes you just need to wait or further increase the dosage under the supervision of a doctor.

Fact No. 3

Antidepressants are usually taken in combination with other drugs

Another way to mitigate the side effects of antidepressants is to prescribe an additional drug along with them: for example, from the group of tranquilizers. Such drugs may have their own side effects, they should not be taken for a long time. Unlike antidepressants, some of them can be addictive. They are usually appointed for a month, but this period may be shorter or longer. nine0003

Antidepressants together with benzodiazepines work better for depression - BMJ magazine

My doctor prescribed a rather mild drug for me. However, he did not suit me. At first, it caused increased drowsiness: during the period of increased anxiety, it went away for a while, but then returned - even with half a pill I turned off and could sleep all day. And if I drank at night, I woke up with difficulty in the morning. The psychiatrist prescribed another medicine, but I could not buy it: the drug was not available in any pharmacy nearby. nine0003

As a result, I simply endured all the side effects of therapy - they were unpleasant, but tolerable. When discussing with the doctor, she called this option acceptable if the side effects of the second medicine only worsen the situation.

My prescriptions for drugs. I never used one, because there was no such medicine in pharmacies

Fact No. 4

Side effects are not always, but they are

Modern antidepressants, including SSRIs, are mild and have almost no side effects. Older drugs - tricyclic antidepressants and monoamine oxidase inhibitors - cause more side effects. Doctors usually use them when milder first-line drugs don't work or when they can't be prescribed. nine0003

Side effects of antidepressants - the National Health Service of the UK

Side effects of various antidepressants - Uptodate

Side effects of antidepressants and their impact on the treatment of a large depressive disorder - the journal NATURE


. effects of antidepressants - advice from the Mayo Clinic staff

Choosing an SSRI drug does not guarantee the absence of side effects - many people tolerate treatment easily, but sometimes a change in drug may be necessary. nine0003

The first couple of weeks of taking there is a risk that the state of health will be so-so - it's worth thinking about. It may be worth scheduling the start of therapy on vacation.

I work remotely, and it was easier for me: the first pill was taken on Saturday, I slept through the weekend. Then she continued to work, but refused any additional loads: housework, part-time jobs, training and everything else.

It was hard work: I wanted to sleep, then I began to worry and get distracted. I also had diarrhea, nausea, headaches, tremors, i.e. hand trembling, hot flashes, sweating, palpitations. At night, panic attacks began, in the morning I had difficulty getting up because I was in pain and dizzy. nine0003

There are mixed data on how common the side effects of antidepressants are. If we summarize them, then the numbers look something like this:

  • nausea - about 25% feel it;
  • diarrhea - it happens in 15% of people, and 5%, on the contrary, will have constipation;
  • about 20% of people experience sweating and feeling hot;
  • sexual dysfunction, decreased libido may occur in 80% of cases;
  • insomnia - in 11% of cases;
  • headache and dizziness - in about 10-11% of cases; nine0122
  • weight gain - not all drugs give this effect. Some, on the contrary, can reduce weight. On my medicine, I lost 2 kilograms in the first month, despite the fact that I quit training due to poor health. True, then they returned back.

It can be seen that most side effects occur in less than half of the cases. In addition, in most cases they pass in the first weeks and are not dangerous.

Side effects not listed above are very rare. I was "lucky", and I faced one such - a decrease in visual acuity. Once in the morning I noticed that I see worse without glasses. A little later, I realized that something was wrong with the glasses. nine0003

I wrote to the doctor, she replied that this happens, as a rule, is not dangerous and passes, but it is better to visit an ophthalmologist. I went to the ophthalmologist, everything was fine with my eyes, there was nothing terrible, but my vision really worsened - it was not a subjective feeling. On the right eye, it was -0.5 diopters, it became -0.75, and on the left eye it was -1. 5, and it became -3.5.

I was offered to try changing the drug, but I decided to wait. Vision was then restored. I have not yet gone to the doctor to have it measured, but according to subjective feelings, it is at the same level as before: I am comfortable again in my glasses. nine0003

Side effects should not be tolerated - if something greatly worries, scares or interferes with life, it is better to tell the doctor right away. The psychiatrist will be able to determine whether the side effect of the drug is dangerous and whether it is worth continuing to take it. There are several antidepressants of the SSRI group, in addition, there are groups of drugs with a slightly different mechanism of action. As a rule, doctors manage to find a medicine that gives a good effect without side effects.

If there is no danger, the doctor can adjust the dose or increase it more gradually - this often helps to cope with unpleasant effects. nine0003 I wrote to the doctor again when my visual acuity decreased

Fact No. 5

Antidepressants need to be taken long term

Antidepressants are not drugs that you can stop drinking as soon as you get better. They are taken for a long time: usually from several months, less often several years.

Anxiety Therapy - UpToDate

For example, for generalized anxiety disorder, the duration of treatment is at least a year. Moreover, the date is not counted from the very beginning, but from the moment when a lasting effect appeared from the pills. In fact, they will have to be drunk for about 1.5 years - it depends on how long it takes to reach the working dosage of the medicine. nine0003

The cost of a package of the most famous antidepressant "Zoloft" is about 700 R, enough for about a month. That is, a course of therapy will cost about 10,000 R - maybe more or less, depending on which drug is selected.

Psychotherapy review - UpToDate

Another drug of the same group already costs more than 2000 R per pack. Source:

The cost of an appointment with a good psychiatrist in Moscow is 3000-5000 R. At first, you will need to visit him about once every 1-1.5 months, then less often. nine0003

You can apply to the psycho-neurological dispensary at the place of residence under compulsory medical insurance - it's free. At the same time, they will not put you on psychiatric registration: it was canceled in 1993. People with disorders that do not threaten their lives or those around them are on consultative and diagnostic care. If you stop going to the doctor, he will not find out what happened: a person seeks help at will.

Psychotherapy, usually cognitive-behavioral, is also commonly prescribed to enhance and sustain the effects of antidepressants. In many cases, it improves the effectiveness of drugs, including depression and generalized anxiety disorder. An appointment with a psychotherapist in Moscow costs an average of 5000 R. For treatment, you will need about 10 sessions or more. nine0003


How psychotherapy works

Fact No. 6

Antidepressants should not be stopped abruptly

Antidepressants are not addictive. However, if you abruptly stop drinking them, there will be a withdrawal syndrome. This is felt as electric current discharges while moving or turning the head, headaches, dizziness, insomnia. Many people experience symptoms similar to the flu or an intestinal virus: low fever, diarrhea, general malaise, chills. Often there is anxiety, there are intrusive images. nine0003

Withdrawal symptoms after taking serotonin reuptake inhibitors - Journal of Clinical Psychiatry

How hard it is to stop taking antidepressants - American Psychological Association

Stopping antidepressants in adults - UpToDate

treatment, they should be canceled only under the supervision of a doctor.

Antidepressant withdrawal occurs as gradually as the start of treatment. The dosage is slowly reduced, usually at this time again a cover-up drug is prescribed to alleviate side effects. As a rule, this is the same medicine that was at the beginning of the intake. nine0003

Withdrawal is usually harmless and resolves within the first weeks of stopping the drug. Sometimes even within a few days - it still depends on which medicine was prescribed. If severely disturbing symptoms appear during the withdrawal period, you should consult a doctor.

Fact No. 7

If you need to change the drug, everything will start over

It is far from always possible to immediately find the right antidepressant - sometimes the side effects do not go away and you need to take a new one. nine0003

Changing antidepressants in adults - UpToDate

Serotonin syndrome - MSD

Most often, it is started again with a small dosage, this delays the process of obtaining the effect of treatment. The new drug may also have side effects - the same or different. We will have to wait again until they pass.

You won't be able to change the drug on your own, since all antidepressants are sold only by prescription - and that's good. Switching from one drug to another can be dangerous if you do not know the characteristics of different groups of drugs. nine0003

For example, taking SSRIs is possible only some time after the withdrawal of antidepressants from the group of monoamine oxidase inhibitors - due to the risk of developing serotonin syndrome. This is a potentially fatal condition, accompanied by a change in mental state, high fever, increased muscle tone and other symptoms.

If the drug is changed correctly, there will be no dangerous negative effects, so consultation with a doctor is required.


How to choose a psychotherapist

Fact No. 8

Among antidepressants there are original drugs and generics

Preparations may be original or generic. Originals are medicines first released by some pharmaceutical company that have passed all clinical trials and checks. Generics are drugs with the same active ingredient from another pharmaceutical company, that is, copied from the original drug.

Theoretically, the action of generics should not differ from the action of original drugs. However, this is possible, since generics may contain other additional substances or the manufacturer may use other raw materials. nine0003

Due to my anxiety, I did not read anything in detail about specific drugs before I bought my first antidepressant in a pharmacy so as not to be scared and not think about taking it. I also didn’t think to ask the doctor about this question.


Psychoneurological complications after covid: memory problems and depression

As a result, I first bought a generic because it was in stock. Then it turned out that, after all, according to the experience of my psychiatrist, the original drug often gives fewer side effects and is better tolerated. As a result, I changed the generic to the original drug - and, indeed, the side effects softened. nine0003

In my subjective opinion, which is supported by some data, in the case of antidepressants and other psychotropic drugs, you should always choose the original medicine. Moreover, the cost of originals and generics is not always very different.

Originals and generics of some SSRIs

Active ingredient Original Original price Generics Cost of generics
Sertraline Zoloft About 700 R, 100 mg tablets Serenata, Sirlift 500-600 R, 100 mg tablets
Escitalopram Cipralex 3000 R, tablets 10 mg "Selektra", "Elycea" 500-1300 R 10 mg tablets
Fluoxetine Prozac About 350 R, 20 mg tablets Profluzak, Fluoxetine 100-200 R, tablets 20 mg




Original cost of the original

about 700 r, tablets 100 mg


"Serenata", "Cerelift"

The cost of generies

9000 500-600 r. , tablets 100 mg




Original cost

3000 r, tablets 10 mg


“Chektra”, “Elice”

The cost of generics

500-1300 r, tablets 10 mg




Cost cost cost

9000 original

About 350 R, tablets 20 mg


Profluzak, Fluoxetine

Cost of generics

100—200 R, tablets 20 mg

one remained unclaimed

Fact No. 9

Do not take alcohol along with antidepressants

Drinking alcohol while taking antidepressants may exacerbate unpleasant side effects. Also, alcohol is a depressant, that is, it has the opposite effect, and its intake can adversely affect the results of treatment.

Why you shouldn't mix antidepressants and alcohol - Mayo Clinic

Alcohol is strictly forbidden to drink with some groups of antidepressants, for example, tricyclic antidepressants and monoamine oxidase inhibitors: combination with the latter, for example, can lead to an uncontrolled increase in pressure. MAO inhibitors in general require a special diet - it is unlikely that a doctor will prescribe such drugs as the first antidepressants, but if necessary, he will issue a list of what is allowed and prohibited. nine0003

With other antidepressants, moderate use may not be dangerous and may even pass without consequences, but doctors still recommend abstaining so as not to increase side effects and improve treatment outcome.

The main thing is not to temporarily stop taking the drug in order to drink. This can lead to the development of a withdrawal syndrome.


How I Treated Generalized Anxiety Disorder under CHI

Fact No. 10

Antidepressants are incompatible with certain drugs and have contraindications nine0145

It is important to tell your doctor what medications you are taking and what chronic illnesses you have. For example, SSRIs may not be suitable for epilepsy and bleeding disorders, and tricyclic antidepressants are usually not prescribed for those who have recently had a heart attack, suffer from glaucoma, or porphyria.

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