Ondansetron for anxiety

Ondansetron reduces mood disturbance among biologically predisposed, alcohol-dependent individuals

Clinical Trial

. 2003 Nov;27(11):1773-9.

doi: 10.1097/01.ALC.0000095635.46911.5D.

Bankole A Johnson  1 , Nassima Ait-Daoud, Jennie Z Ma, Yanmei Wang



  • 1 Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229-3900, USA. [email protected]
  • PMID: 14634493
  • DOI: 10.1097/01.ALC.0000095635.46911.5D

Clinical Trial

Bankole A Johnson et al. Alcohol Clin Exp Res. 2003 Nov.

. 2003 Nov;27(11):1773-9.

doi: 10.1097/01.ALC.0000095635.46911.5D.


Bankole A Johnson  1 , Nassima Ait-Daoud, Jennie Z Ma, Yanmei Wang


  • 1 Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229-3900, USA. [email protected]
  • PMID: 14634493
  • DOI: 10.1097/01.ALC.0000095635.46911.5D


Background: Early-onset alcoholics (EOA) differ from late-onset alcoholics (LOA) by developing problem drinking during youth, experiencing severe behavioral problems, having a familial disease history, and possessing a tendency toward subsyndromal mood disturbance, including symptoms of depression, anxiety, and hostility. Subsyndromal mood disturbance is, therefore, an important component of the early-onset syndrome and may be mediated by serotonin dysfunction. Therefore, the serotonin-3 antagonist ondansetron, which has been shown to be effective at improving drinking outcomes and promoting abstinence among EOA, presumably by ameliorating serotonin dysfunction, also may exert its beneficial effects by alleviating mood disturbance among EOA.

Methods: After one lead-in week of single-blind placebo administration, subjects underwent 11 weeks of double-blind outpatient treatment using a 2 x 4 factorial design that examined age of onset (EOA versus LOA) and medication dose (placebo, or ondansetron 1, 4, or 16 microg/kg twice daily) combined with weekly standardized group cognitive-behavioral therapy. The placebo lead-in week was used to adjust for study entrance effects but not for excluding subjects. Assessments of mood were performed by using the overall score and subscales of the Profile of Mood States both at screening and at weekly intervals during the study.

Results: Subsyndromal mood disturbance was shown to be an important component of early-onset alcoholism. Ondansetron (16 microg/kg twice daily) showed greater therapeutic efficacy at alleviating symptoms of overall mood disturbance, fatigue, vigor, confusion/bewilderment, and depression among EOA compared with LOA. EOA-associated improvements in mood disturbance seemed to be independent of drinking behavior.

Conclusions: Ondansetron has been shown to be an effective treatment for early-onset alcoholism. Ondansetron's ability to improve symptoms of depression, anxiety, and hostility among EOA may make an additional contribution to its therapeutic effect. Mechanistic studies are needed to delineate more clearly the relationship between serotonin dysfunction and pathophysiology among various subtypes of alcohol-dependent individuals.

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Grant support

  • AA 10522-08/AA/NIAAA NIH HHS/United States
  • AA 12964-01/AA/NIAAA NIH HHS/United States
  • K23 AA 00329-01/AA/NIAAA NIH HHS/United States

Does Zofran Help With Anxiety? - Anxiety FAQs

Does Zofran Help With Anxiety? - Anxiety FAQs | XanFree

Aug 21, 2020 Posted by: XanFree Nutrition Possible Anxiety Treatment

Regardless of the reason for your anxiety, there are many ways to find relief. One common way relief is acquired is by medication. Some medications may work better than others, one that may be used sometimes is Zofran, but does Zofran help with anxiety?

The only way to find out what treatment works for you is to partner with your doctor. With their knowledge of medicine and your history, they can create a treatment plan just for you. Deciding on a course of action on your own can have severe consequences.

When it comes to certain mental illnesses, anti-nausea medication, Zofran, has found some success. However, this drug can also make other conditions worse. Adverse interactions and side effects are why you must work together with your doctor to find what is best for you.

Bipolar Disorder

The mental health condition that has the most success with Zofran treatment is bipolar disorder. Previously known as manic depression, this mood disorder can cause problems in daily life. Unpredictable emotional lows and highs are the main symptoms of bipolar disorder.

Bipolar I
  • Episodes of mania lasting at least seven days with bouts of depression that last up to two weeks
  • A mix of mania and depression is possible
  • Severe symptoms may require care at the hospital immediately

Bipolar II
  • Cycles between hypomanic and depressive episodes
  • Lacks the same intense manic episodes of Bipolar I

Symptoms of Bipolar Disorder
  • Mania
  • Decreased need for sleep
  • Feeling irritable or elated
  • Appetite loss
  • Racing thoughts
  • Unusual feelings of power or importance
  • The belief of the ability to do everything at once
  • Fast-talking about multiple topics
  • Wired or jumpy feeling
  • Hypomania
    • A less intense form of mania
    • Sudden ability to keep up with daily life
    • Feeling good enough to get things done
  • Depression
    • Increased appetite and subsequent weight gain
    • Feelings of worthlessness, thoughts of suicide or death
    • Empty feeling or hopelessness
    • Slow talking and forgetfulness
    • Indecisiveness
    • Feeling unable to do mundane things
    • Decreased interest in hobbies or sex
    • Sleeping too much
    • Restless feeling

Zofran may work for bipolar disorder but can increase some feelings of anxiety. Also, this drug has the ability cause serotonin toxicity. It is essential to inform your doctor of all medication you take.

This severe psychological reaction and allergic response, are both rare, but knowing about them is critical. If you experience any symptoms, such as swelling, hallucinations, or breathing problems, you must immediately find medical help. Ensure you take Zofran as directed by medical professional to help prevent overdose or withdrawal symptoms.

What is Zofran?

Most used as an anti-nausea treatment in chemotherapy patients, Zofran is known for its almost immediate relief of nausea and vomiting. By blocking certain chemicals that trigger nausea, it can work to prevent any further discomfort. Even though it is quite successful, there are factors to consider that may impact its efficacy.

Risk Factors
  • Use of apomorphine
  • Liver disease
  • Slow heartbeats or congestive heart failure
  • Zofran, Granisetron, Dolasetron, or Palonosetron allergy
  • Imbalance of electrolytes
  • Digestive tract blockage
  • Family or personal history of long QT syndrome

If any of the above risk factors apply to you, your doctor needs to know. The presence of an allergy or the use of apomorphine prevents you from being able to take this medication safely. Your doctor will know how to help you in this case, whether it be changing your current medication or considering other options.

Side effects are possible, but most are relatively common and not cause for concern. However, some of these side effects may need immediate medical attention. It is always essential to know the possible extreme side effects of any medication that you take.

Zofran Side Effects
  • Tiredness
  • Headache
  • Constipation or diarrhea
  • Drowsiness
  • Serious side effects
  • Temporary vision loss or blurred vision
  • Can last from a few minutes to a few hours
  • Pounding or fast heartbeat
  • Headache accompanied by fainting, dizziness, and chest pain
  • Severe stomach pain, bloating, or constipation
  • High serotonin levels
    • Fever
    • Nausea
    • Agitation
    • Overactive reflexes
    • Loss of coordination
    • Hallucinations
    • Vomiting
    • Fainting
    • Fast heart rate
  • Jaundice

Other less common side effects can occur, but these are the most mentioned or potentially dangerous. Any sign of an allergic reaction or serotonin toxicity requires immediate attention. The best way to avoid it is to inform your doctor of everything that you take.

Heart rhythm medications, antipsychotics, cancer treatment, HIV or AIDS drugs, antibiotics, malaria drugs, and antipsychotics can potentially cause adverse reactions when taken with Zofran. Certain ones of these medications can make your body produce too much serotonin, which can be fatal.

Zofran for Anxiety Disorders

When it comes to anxiety disorders, there is not much research to reach a consensus. A few studies found promising signs of its ability to help alleviate symptoms. However, there is also evidence of the contrary.

Zofran works by antagonizing serotonin receptors in the brain. This interaction can be good or bad, depending on how your body translates it. Zofran is not a conventional treatment for anxiety, and you should always speak with your doctor before taking anything.


Since one of the symptoms of serotonin toxicity is a fast heartbeat, it is a definite potential trigger for anxiety. In the case of Zofran, it is incredibly important to have an unbroken line of communication with your doctor if an unexpected reaction occurs. There is no way to be sure how a drug will work with your body or work at all.

In rare cases, Zofran may help to alleviate anxiety from anxiety disorders. It may also help with anxiety-related nausea, which can break any cycle the feelings caused. However, it is up to your doctor to decide if it will benefit you, primarily due to the potentially severe complications that may arise.

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  2. https://www.drugs.com/mtm/zofran-odt.html
  3. https://www.upi.com/Archives/1997/09/17/Cancer-drug-works-for-anxiety/4157874468800/
  4. https://www.webmd.com/drugs/2/drug-30/zofran-oral/details
  5. https://www. rxlist.com/zofran-drug.htm
  6. https://www.mayoclinic.org/diseases-conditions/bipolar-disorder/symptoms-causes/syc-20355955#:~:text=Overview,or%20pleasure%20in%20most%20activities.
  7. https://clinicaltrials.gov/ct2/show/NCT02082678
  8. https://www.nimh.nih.gov/health/topics/bipolar-disorder/index.shtml
  9. https://www.mayoclinic.org/diseases-conditions/bipolar-disorder/diagnosis-treatment/drc-20355961
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184575/

Does Ginger Help with Anxiety? Dec 22, 2020

Eufillin - Uzkhimfarm JSC


22-03-2020 5852 Injection preparations

The trade name of the drug (MNN): Eufillin

Active substance (MNN): aminofillin

Delicious form: solution for injections



active substances: theophylline - 19. 2 mg, ethylenediamine - 4.8 mg,

excipients colors solution

Pharmacotherapeutic group: Bronchodilator.

ATC code: R03DA05

Pharmacological action


The drug inhibits phosphodiesterase, increases the accumulation of cAMP in tissues, blocks adenosine (purine) receptors; has the ability to inhibit the transport of calcium ions through the channels of cell membranes, reduces the contractile activity of smooth muscles. Relaxes the muscles of the bronchi, relieves bronchospasm. It has a moderate inotropic and diuretic effect. Eufillin lowers vascular resistance, reduces the tone of blood vessels (mainly the vessels of the brain, skin and kidneys), dilates coronary vessels, lowers pressure in the pulmonary artery system, improves diaphragm contraction, increases mucociliary clearance, inhibits the release of mediators (histamine and leukotrienes) from obese cells, stimulates the respiratory center, increases the release of adrenaline by the adrenal glands, inhibits platelet aggregation, improves microcirculation. nine0008


Bioavailability for liquid dosage forms - 90-100%. The time to reach the maximum concentration in blood plasma with intravenous administration of 0.3 g is 15 minutes, the maximum concentration in blood plasma is 7 μg / ml. 60% of eufillin (in healthy adults) and 36% (in newborns) binds to plasma proteins and is distributed in the blood, extracellular fluid and muscle tissue. Eufillin penetrates into breast milk (10% of the accepted dose), through the placental barrier (the concentration in the fetal blood serum is slightly higher than in the mother's serum), does not accumulate in adipose tissue. nine0% of the drug is metabolized in the liver. Metabolites are excreted by the kidneys, 7-13% of the drug is excreted unchanged. The elimination half-life is 5 to 10 hours in non-smoking adults and 2.5 to 5 hours in children older than 10 months. Smoking and alcohol significantly affect the metabolism and excretion of the drug, in particular, in smokers this period is significantly reduced and ranges from 4 to 5 hours. The elimination of the drug is prolonged in patients with respiratory failure, with hepatic and heart failure, with viral infections and hyperthermia. nine0008

Indications for use

Broncho-obstructive syndrome in bronchial asthma, bronchitis, pulmonary emphysema, hypertension in the pulmonary circulation.

Ischemic cerebrovascular accident (as part of combination therapy to reduce intracranial pressure).

Left ventricular failure with bronchospasm and respiratory failure of the Cheyne-Stokes type (as part of complex therapy).

Dosage and administration


5-10 ml of a 2.4% solution (0.12-0.24 g) is slowly injected into a vein in adults (over 4-6 minutes), which is first diluted in 10-20 ml of isotonic sodium chloride solution. When palpitations, dizziness, nausea appear, the rate of administration is slowed down or switched to drip administration, for which 10-20 ml of a 2. 4% solution (0.24-0.48 g) is diluted in 100-150 ml of isotonic sodium chloride solution; administered at a rate of 30-50 drops per minute. Eufillin is administered parenterally up to 3 times a day, no more than 14 days. nine0008

The highest doses of aminophylline for adults in a vein: single - 0.25 g, daily 0.5 g.

The drug is not recommended for children under 14 years of age due to side effects.

However, if necessary, children are administered eufillin intravenously at the rate of a single dose of 2-3 mg/kg, preferably by drip.

Higher doses for children intravenously: single - 3 mg / kg, daily - under the age of 3 months. - 0.03-0.06 g, from 4 to 12 months. - 0.06-0.09 g, from 2 to 3 years - 0.09-0.12 g, from 4 to 7 years - 0.12-0.24 mg, from 8 to 18 years - 0.25 -0.5 g.


Severe arterial hypotension or hypertension, paroxysmal tachycardia, extrasystole, myocardial infarction with cardiac arrhythmias, epilepsy, increased convulsive readiness, hypertrophic obstructive cardiomyopathy, thyrotoxicosis, pulmonary edema, severe renal coronary and/or hepatic insufficiency, hepatic insufficiency , hemorrhagic stroke, retinal hemorrhage, bleeding in a recent history, hypersensitivity to the drug to the drug (including other xanthine derivatives: caffeine, pentoxifylline, theobromine). nine0008

Precautions: pregnancy, neonatal period, age over 55 and uncontrolled hypothyroidism (possibility of cumulation), sepsis, prolonged hyperthermia, gastroesophageal reflux, prostatic hyperplasia, widespread vascular atherosclerosis, patients with severe liver and kidney dysfunction , peptic ulcer of the stomach and 12 duodenal ulcer (history).

Use caution when consuming large amounts of caffeinated foods or drinks during treatment. nine0008

Side effects

From the digestive system: gastroesophageal reflux, heartburn, exacerbation of gastric and duodenal ulcer, gastralgia, diarrhea.

From the side of the central nervous system: - headache, anxiety, anxiety, irritability, dizziness, rarely - convulsions, nausea, vomiting, insomnia, tremor.

From the side of the cardiovascular system: palpitations, tachycardia (including in the fetus when taken by a pregnant woman in the third trimester), cardialgia, an increase in the frequency of angina attacks, cardiac arrhythmia, a decrease in blood pressure up to collapse - with fast in / in the introduction. nine0008

Allergic reactions: exfoliative dermatitis, fever.

Local reactions: induration at the injection site - hyperemia, soreness.

Other: flushing, increased diuresis, chest pain, tachypnea, albuminuria, hematuria, hypoglycemia, increased sweating, skin rash, skin itching.

Drug interactions

In combination with phenobarbital, phenytoin, rifampicin, isoniazid, carbamazepine or sulfinpyrazone, a decrease in the effectiveness of aminophylline is observed, which may require an increase in the doses of the drug used. The clearance of the drug is reduced when it is used in combination with antibiotics of the macrolide group, lincomycin, allopurinol, cimetidine, isoprenaline, enoxacin, beta-blockers, which may require a dose reduction. Ephedrine and caffeine enhance the effect of the drug. With simultaneous use with small doses of ethanol, disulfiram, fluoroquinolones, recombinant interferon alpha, methotrexate, mexiletine, propafenone, thiabendazole, ticlopidine, verapamil, and with influenza vaccination, the intensity of the action of aminophylline may increase, which may require a reduction in its dose. Enhances the action of beta-agonists. nine0008

Oral estrogen-containing contraceptives, antidiarrheals, intestinal sorbents weaken, and H 2 - histamine blockers, blockers of "slow" calcium channels enhance the action (bind to the cytochrome P450 enzymatic system and slow down metabolism) of aminophylline. The use of beta-blockers interferes with the bronchodilating effect of eufillin and can cause bronchospasm. Eufillin potentiates the action of diuretics by increasing glomerular filtration and reducing tubular reabsorption, reduces the effectiveness of lithium preparations. With caution, aminophylline is used simultaneously with anticoagulants, with other derivatives of theophylline or purine. nine0008

Increases the likelihood of developing side effects of CNS stimulants (increases neurotoxicity), glucocorticosteroids, mineralocorticosteroids (hypernatremia), general anesthetics (increased risk of ventricular arrhythmias). Compatible with antispasmodics. The drug is incompatible with a solution of glucose, fructose and levulose. The pH of the solutions to be mixed should be taken into account: pharmaceutically incompatible with acid solutions.

Special instructions

Before parenteral administration, the solution must be warmed to body temperature. The drug is prescribed with caution to patients with severe violations of the liver and kidneys, peptic ulcer of the stomach and duodenum.

Elderly patients are advised to reduce the dose of the drug due to its delayed excretion from the body. Smoking patients are advised to increase the dose due to the accelerated excretion of the drug from the body.

Use during pregnancy and lactation

If it is necessary to prescribe the drug during pregnancy and lactation, the expected benefit to the mother and the potential risk to the fetus or newborn should be compared. If necessary, the use of the drug during lactation, breastfeeding should be discontinued.

Influence on the ability to drive vehicles, mechanisms . nine0008

Keep out of the reach of children and do not use after the expiration date.


Symptoms: loss of appetite, gastralgia, diarrhea, nausea, vomiting (including with blood), gastrointestinal bleeding, tachypnea, flushing of the skin of the face, tachycardia, ventricular arrhythmias, insomnia, motor agitation, anxiety, photophobia, tremor, convulsions. In severe poisoning, epileptoid seizures can develop (especially in children without any precursors), hypoxia, metabolic acidosis, hyperglycemia, hypokalemia, lowering blood pressure, skeletal muscle necrosis, confusion, renal failure with myoglobinuria. nine0008

Treatment: withdrawal of the drug, forced diuresis, hemosorption, plasmasorption, hemodialysis (low efficiency, peritoneal dialysis is ineffective), symptomatic therapy (including metoclopramide and ondansetron for vomiting). If convulsions occur, maintain airway patency and carry out oxygen therapy. For the relief of a seizure - intravenous diazepam, 0. 1-0.3 mg / kg (but not more than 10 mg). For severe nausea and vomiting, metoclopramide or ondansetron (iv).


⚓ All About Seasickness

Differences in resistance to seasickness depend on ship size, sea conditions and sailing experience. Thus, if the provocative movement is active for a long time (for example, on board a ship during a storm), then in most people the degree of manifestations of motion sickness gradually decreases as they adapt to the rocking. The dynamics of this adaptation, as well as other characteristics of motion sickness, has individual differences, however, as a rule, noticeable adaptation occurs on the second or third day of swimming, and by the fourth, all symptoms usually completely disappear. Seasickness is rare among professional sailors. This is due to strict professional selection and training of the vestibular apparatus during training and subsequent work. But sometimes a person cannot adapt to rolling on a ship, even for a long sea service. The famous English naval commander Admiral Nelson spent many years at sea and, nevertheless, every time during a storm he suffered greatly from this disease. Approximately 5% of people do not adapt to rolling at sea at all, and they are subject to motion sickness throughout their lives. Persons with innate stability adapt more quickly to provoking accelerations. nine0224 Among other factors influencing the resistance to seasickness, personality traits (extroverts are more resistant than introverts), motivation, emotionality and activity of the central nervous system, as well as fear and anxiety are of great importance.
So how can the unpleasant symptoms associated with seasickness be alleviated or prevented? First of all, it is necessary to limit head movements to a minimum, which affect the development of motion sickness, this is well known. You can limit the movement of your head arbitrarily, but it is better if it rests on an appropriate support - a headrest, roller, etc. It should be remembered that on board a ship experiencing motion, seasickness will be less pronounced with acceleration acting along the longitudinal axis of the head than along its anteroposterior axis. nine0224 It may be useful during swimming to reduce visual-vestibular mismatch. For example, while on a ship, at the first signs of motion sickness, it is advisable to sit with your eyes closed or fix your gaze, as noted above, on the horizon line or visible land.
A tried and tested remedy for nausea is a lemon, a slice of which should be put into the mouth as soon as possible at the first sign of seasickness. Less effective but still helpful are menthol caramel, chewing gum, spices, or anything acidic. It is good if the cabin smells of mint or pine needles (preferably the use of flavors). nine0224 Breakfast (lunch, dinner) before going to sea should be light, because both a full stomach and an empty stomach are an additional burden on the body. From food on the road, choose low-fat and hot food. Soda water, cake or cake with a lot of cream are not for you. It is useful to wipe the neck and temples with a damp towel. Hand massage will also help: put one hand on your knee, palm up. Gently massage under the wrist with the thumb of the other hand, and then the middle of the palm with the index and thumb. nine0224 If a person experiences seasickness precisely in the expanses of water, then during pitching, proper breathing helps: the deck lowers - inhale, rises - exhale.
In the long term, various types of vestibular training can be the most effective means of preventing seasickness: special physical and gymnastic exercises, volleyball, swimming, acrobatic trampolining, exercises on sports equipment: the Rhine wheel, triplex, etc. For passive - a swivel chair , swing, etc. With combined methods, active and passive exercises are combined. Such training not only contributes to the suppression of unpleasant vestibular reactions, but also improves orientation in space. nine0224 Active vestibular training is carried out daily in the morning before meals (eyes should be open when performing). All head movements are performed at a fast pace (approximately 120 per minute) for one minute, and after 30 seconds of movement, a pause of 5 seconds should follow. The whole set of exercises takes 8 minutes.
Starting from the first exercise, the complex is repeated and, if you feel well, perform for another eight minutes. At the end of the workout, you need to rest for two to three minutes. nine0224 The duration of the first classes is two minutes, and it is advisable to carry out the exercises while sitting. Subsequently, with each lesson, the training time should be increased by one to two minutes and, starting from the third to fifth lesson, movements should be performed in a standing position.
During training, coordination disorders (up to a fall) are possible, for the prevention of which it is necessary to provide insurance to the practitioner. If some people have pronounced vestibulo-vegetative reactions (severe pallor, sweating, nausea, etc.), the session must be stopped. nine0224 In recent years, for the prevention of seasickness, methods of psychoprophylaxis and psychotherapy, autogenic training with training in self-control of some vegetative reactions, using biofeedback, which allows you to control, prevent or weaken the manifestations of motion sickness, have begun to be used.
A large role in the prevention and relief of seasickness is assigned to pharmacological agents, the number of which is currently significant.
It should, however, be remembered that almost all drugs used as a means of preventing and relieving motion sickness have their own indications and contraindications. Therefore, before taking this or that drug with you on a trip, you must carefully read the corresponding instructions for its use. And be sure to test it on yourself even before the start of the sea voyage for individual intolerance. nine0008

Most often, so-called antihistamines are used to combat kinetosis - diphenhydramine, suprastin, pipolfen. Many of these drugs are familiar as allergy drugs, and the fight against motion sickness is “part-time work” for them. True, for some of these drugs, it becomes the main one. Aviomarin, bonin and kinedril are only sold as motion sickness remedies.

Kinedryl stands out a little in this group: in addition to the antihistamine, it also contains caffeine. And this supplement allows you to reduce the "inhibitory" effect of the antihistamine component - to reduce lethargy and drowsiness. But even despite the invigorating caffeine, kinedril could not completely get rid of the soporific effect. nine0008

It should be remembered that antihistamines do not act immediately (after 2 hours or more), but for a relatively long time. Bonin has a particularly long-lasting effect - up to 12 hours. Therefore, this group of medicines should be taken at least one hour before the trip.

Fast-acting drugs containing belladonna alkaloids can be referred to. Among them is such a well-known drug as Aeron, and not so often used Bellataminal and Bellaspon.

Among the official fighters against motion sickness there are also homeopathic preparations - domestic air-sea and German vertigoheel. These drugs act according to the classic homeopathic principle "like cures like": they contain those components that provoke symptoms typical of motion sickness - nausea, vomiting, dizziness. But thanks to meager doses, they have a curative, not provocative effect. nine0008

A biologically active supplement "Companion" has recently appeared. This is also an effective remedy for motion sickness, containing natural plant products - peeled ginger rhizome and chamomile flowers. You need to take it 1-2 tablets 30 minutes before the trip. By the way, ginger has long been used by sailors. Chinese sailors chewed it to reduce seasickness.

None of these drugs available? Validol or Valocordin can help: they can be used as sedatives and antiemetics. Peppermint tea or peppermint extract can help in this situation. nine0008

To help people overcome seasickness or airsickness, pharmacologists have invented many remedies. But most of them have many contraindications and side effects. Natural remedies for motion sickness are absolutely safe, but at the same time they are no less effective than drugs.

The best homeopathic remedy for motion sickness is Nux Vomica. The standard dosage for adults is 10 drops or 3-5 grains to be taken before boarding a vehicle. You can buy Nux Vomica at any homeopathic pharmacy. This component is also part of the complex preparations - the Russian "Avia-Sea" or the German Nux Vomica-Homaccord. nine0008

Ginger root
In ancient times, Asian sailors had a habit of chewing ginger during long sea voyages. In the early 1990s, scientists from the US Herbal Medicine Research Laboratory in Salt Lake City decided to test the effectiveness of this ancient custom and conducted an experiment with 36 volunteers who suffered from motion sickness. It turned out that the effectiveness of ginger root powder is superior to known pharmacological drugs for motion sickness. To get rid of seasickness, take one gram of dried ginger root powder before you travel. If you feel nauseous during the trip, it is worth "upping the dose" - drink some ginger beer or eat a couple of gingerbread cookies. Ginger caramels are also suitable - after taking them, do not brush your teeth or rinse your mouth for a while. nine0008

Another piece of advice borrowed from sailors. Before the trip, you need to carefully, but tightly enough, tighten your wrists with elastic bandages, which are sold in any pharmacy. This simple measure will create a pressure drop that will save you from discomfort while traveling. In addition, the bandages will constantly act on a special point in the wrist area, which will help overcome nausea. If you are still seasick, for several minutes rhythmically press with a fingernail or a match on another point under the earlobe. nine0008

Proper nutrition
Before a trip, you should neither starve nor indulge in gluttony. The best option is a small amount of lean protein food such as cottage cheese or a piece of fish. During the trip, especially if you are flying by plane, it is better to refresh yourself with food that you have brought from home in advance. On board, they usually offer quite fatty and sweet food, which can only worsen the condition. Therefore, the best option would be to take a bottle of drinking yogurt or kefir with you, a small portion of cold boiled chicken or turkey. Especially salty and sour foods help to cope with motion sickness. Therefore, during the trip, you can enjoy, for example, pickled herring, various pickles. Remember only that food should be taken in very small portions. nine0008

Cold compress
Scientists have shown that an ice pack applied to the head and neck during travel can significantly reduce the intensity of unpleasant symptoms, especially nausea. Ice can be replaced with a damp, cold cloth. This method is especially effective in combination with a warm heating pad on the feet.

Inner mood
An important factor is your mood and behavior during the trip. First, before the trip, convince yourself that this time you definitely won’t get seasick. Focus your eyes on some fixed object or horizon line. Try to provide yourself with constant access to a source of fresh air.

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