Maximum dose fluoxetine
How and when to take fluoxetine
Dosage
The usual dose of fluoxetine for adults is 20mg a day. However, you may start at a lower dose and gradually be increased to a maximum dose of 60mg a day.
Some people might need to take a lower dose of fluoxetine. This includes people with liver problems, and older people.
The usual dose of fluoxetine for children is 10mg a day but this may be increased to 20mg a day.
How to take it
You’ll usually take fluoxetine once a day, with or without food.
You can take fluoxetine at any time, but it’s best to stick to the same time every day.
If you have trouble sleeping, try taking it in the morning.
How long to take it for
Once you're feeling better it's likely that you will continue to take fluoxetine for several more months.
Most doctors recommend that you take antidepressants for 6 months to a year after you no longer feel depressed. Stopping before that time can make depression come back.
If you forget to take it
If you occasionally forget to take a dose, just take your next dose the next day at the usual time. Never take 2 doses at the same time to make up for a forgotten one.
If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.
Stopping fluoxetine
If you stop taking fluoxetine suddenly, you may get withdrawal symptoms such as:
- feeling dizzy
- feeling sick
- numbness or tingling in the hands or feet
- trouble sleeping
- feeling agitated or anxious
- headaches
- shaking
Talk to your doctor if you want to stop.
They will reduce your dose gradually to help you with any side effects.
If you take too much
The amount of fluoxetine that can lead to an overdose varies from person to person.
Taking too much can cause symptoms such as:
- being sick (vomiting)
- shaking
- feeling sleepy
- feeling agitated
- feeling dizzy
- racing heart
- fits or seizures
Urgent advice: Contact 111 for advice now if:
- you take more than your prescribed dose of fluoxetine
Go to 111.nhs.uk or call 111.
If you need to go to A&E, do not drive yourself.
Get someone else to drive you or call for an ambulance.
Take the fluoxetine packet, or the leaflet inside it, plus any remaining medicine with you.
Page last reviewed: 10 February 2022
Next review due: 10 February 2025
Side effects, dosage, uses, and more
- Fluoxetine oral capsule is available as a brand-name drug and as a generic drug. Brand name: Prozac.
- Fluoxetine comes in four forms: capsule, delayed-release capsule, tablet, and solution. All forms are taken by mouth.
- Fluoxetine oral capsule is used to treat different types of depression, obsessive-compulsive disorder, some eating disorders, and panic attacks.
Other warnings
- Serotonin syndrome warning: This drug can cause a life-threatening condition called serotonin syndrome. This syndrome happens when medications cause too much serotonin to build up in your body.
Symptoms can include agitation, hallucinations (seeing or hearing something that isn’t there), problems with coordination, and a racing heart rate. They can also include overactive reflexes, fever, nausea, vomiting, or diarrhea. Call your doctor right away if you have any signs of this condition. - Mania warning: This drug may cause mania or hypomania. Symptoms include greatly increased energy, extreme irritability, talking more or faster than usual, racing thoughts, or severe trouble sleeping. If you have a history of mania or bipolar disorder, talk to your doctor before using this drug.
- Low salt levels warning: This drug may cause you to have dangerously low salt levels in your blood. Symptoms include headache, weakness, confusion, trouble concentrating, memory problems, and feeling unsteady. Call your doctor right away if you have any symptoms of this condition.
Fluoxetine is a prescription drug. It comes as a capsule, delayed-release capsule, tablet, and solution.
All forms are taken by mouth. (A delayed-release capsule is released into your body more slowly.)
Fluoxetine oral capsule is available as the brand-name drug Prozac. It’s also available as a generic drug. Generic drugs usually cost less than brand-name versions. In some cases, they may not be available in every strength or form as brand-name drugs.
Fluoxetine oral capsule may be used as part of a combination therapy. This means you may need to take it with other medications. For the treatment of depressive episodes related to bipolar I disorder and treatment-resistant depression, this drug must be used with olanzapine.
Why it’s used
Fluoxetine oral capsule is used to treat the following conditions:
- Depression. This includes major depression.
- Obsessive-compulsive disorder. This condition causes bothersome thoughts that won’t go away (obsessions) and the need to do certain actions over and over (compulsions).
- Bulimia nervosa. This condition is an eating disorder marked by binge eating followed by extreme behaviors to avoid gaining weight (purging, fasting, or excessive exercise).
- Panic attacks. These are sudden episodes of extreme fear and worry even though no threat exists.
How it works
Fluoxetine oral capsule belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Fluoxetine works by increasing the amount of serotonin (a natural substance) in your brain. Serotonin helps maintain mental health balance. An increase in serotonin helps to treat symptoms of depression, obsessive-compulsive disorder, bulimia nervosa, and panic attacks.
Fluoxetine oral capsule doesn’t cause drowsiness, but it can cause other side effects.
More common side effects
The more common side effects of fluoxetine can include:
- strange dreams
- decreased sex drive and trouble having an orgasm
- decreased appetite
- anxiety and nervousness
- weakness
- diarrhea
- dry mouth
- indigestion
- flu
- erectile dysfunction (trouble getting or keeping an erection)
- trouble sleeping
- nausea
- sore throat
- rash
- watery nasal discharge
- sleepiness
- sweating and hot flashes
- tremors (uncontrollable rhythmic movement in one part of your body)
- yawning
- If these effects are mild, they may go away within a few days or a couple of weeks.
If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Serotonin syndrome. Symptoms can include:
- agitation (feeling aggravated or restless)
- hallucinations (seeing or hearing something that isn’t there)
- problems with coordination
- racing heart rate
- overactive reflexes
- fever
- nausea
- vomiting
- diarrhea
- Abnormal bleeding. Symptoms can include:
- bruising or bleeding more easily than normal
- Mania. Symptoms can include:
- greatly increased energy
- severe trouble sleeping
- racing thoughts
- reckless behavior
- unusually grand ideas
- excessive happiness or irritability
- talking more or faster than normal
- Seizures
- Low salt levels in your blood.
Symptoms can include: - headache
- weakness
- confusion
- trouble concentrating
- memory problems
- feeling unsteady
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Fluoxetine oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with fluoxetine are listed below.
Drugs you should not use with fluoxetine
Do not take these drugs with fluoxetine. Doing so can cause dangerous effects in your body. Examples of these drugs include:
- Monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, phenelzine, and tranylcypromine. You shouldn’t take fluoxetine if you take an MAOI or if you’ve stopped taking an MAOI within the last two weeks. Don’t take an MAOI within five weeks of stopping fluoxetine. Taking these drugs too close together could cause serious and life-threatening side effects. Symptoms include high fever, constant muscle spasms that you can’t control, and stiff muscles. They also include fast changes in your heart rate and blood pressure, confusion, and unconsciousness.
- Thioridazine. You shouldn’t take these drugs together. Don’t take thioridazine within five weeks of stopping fluoxetine.
Taking these drugs together can cause serious heart rhythm problems. These problems can cause you to die suddenly. - Pimozide. You shouldn’t take these drugs together. Fluoxetine can cause the levels of pimozide to increase in your body. This raises your risk for heart rhythm problems.
Interactions that increase your risk of side effects
Increased side effects: Taking fluoxetine with certain medications raises your risk of side effects. This is because fluoxetine and these other medications can cause the same side effects. These drugs include serotonergic drugs, such as:
- selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and sertraline
- serotonin-norepinephrine reuptake inhibitors (SNRIs) such as duloxetine and venlafaxine
- tricyclic antidepressants (TCAs) such as amitriptyline and clomipramine
- the opioids fentanyl and tramadol
- the anxiolytic buspirone
- triptans
- lithium
- tryptophan
- St.
John’s wort - amphetamines
Taking these drugs with fluoxetine may increase your risk of serotonin syndrome, which can be fatal. If you take any of these drugs, your doctor will start you on a lowered dosage of fluoxetine and monitor you for signs of serotonin syndrome. Symptoms can include agitation, sweating, muscle twitches, and confusion.
Increased side effects from other drugs: Taking fluoxetine with certain medications raises your risk of side effects from these drugs. Examples of these drugs include:
- Benzodiazepines, such as triazolam and midazolam. Taking these drugs together may cause more sedation and drowsiness.
- Warfarin. Taking these drugs together may cause an increase in bleeding. Your doctor will monitor you closely.
- Nonsteroidal anti-inflammatory drugs (NSAIDs). Taking these drugs together may cause an increase in bleeding. Your doctor will monitor you closely.
- Aspirin. Taking these drugs together may cause an increase in bleeding. Your doctor will monitor you closely.
- Drugs broken down by the enzyme CYPD2D6, such as aripiprazole, dextromethorphan, and risperidone. Taking these drugs with fluoxetine may increase your risk of serotonin syndrome, heart rhythm problems, and involuntary muscle movements.
- Lithium. Your doctor should monitor your lithium blood levels if you need to take these drugs together.
- Phenytoin. Taking these drugs together may cause confusion, dizziness, and fever. You may also have changes in your behavior. These changes include anger, irritability, or sadness. Your doctor should monitor the level of phenytoin in your body.
- Carbamazepine. Taking these drugs together can cause blurred vision, vertigo, or tremors. Your doctor should monitor the level of carbamazepine in your body.
Disclaimer: Our goal is to provide you with the most relevant and current information.
However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
This drug comes with several warnings.
Allergy warning
This medication can cause a severe allergic reaction. Symptoms can include:
- hives
- rash alone or with a fever and joint pain
- trouble breathing
- swelling of your throat or tongue
If you develop these symptoms, call 911 or go to the nearest emergency room.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Warnings for people with certain health conditions
For people with blood clotting disorders: This drug may cause you to bleed more easily.
If you take another drug to thin your blood, it could cause dangerous bleeding.
For people with diabetes: This drug may cause low blood sugar levels. Once you stop taking this drug, it may cause your blood sugar levels to increase.
For people with bipolar I disorder: You shouldn’t take this drug alone to treat depression associated with bipolar I disorder. This drug may increase your risk of a mixed or manic episode.
For people with liver disease: If you have liver problems or a history of liver disease, your body may not be able to process this drug as well. This may increase the levels of this drug in your body and cause more side effects. Your doctor may lower your dose or have you take this drug less often.
For people with closed-angle glaucoma (a sudden buildup of pressure inside your eye): Fluoxetine may cause a glaucoma attack. If you have closed-angle glaucoma, talk with your doctor before taking this drug.
For people with epilepsy or other conditions that cause seizures: This drug can increase your risk of seizures. If you’ve had seizures in the past, talk with your doctor before taking this drug. Tell them if you have increased seizures after starting the treatment.
For people with heart rhythm problems: This drug can cause your heart to beat abnormally. Sometimes, this has led to an unsafe abnormal heartbeat called torsades de pointes. You have a higher risk if you’ve ever had heart problems. Call your doctor right away if you have a fast or irregular heartbeat. Anyone who loses consciousness requires urgent medical care.
Warnings for other groups
For pregnant women: Talk to your doctor if you’re pregnant or plan to become pregnant. Research in animals has shown adverse effects to the fetus when the mother takes the drug. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.
This drug should only be used if the potential benefit justifies the potential risk.
For women who are breastfeeding: This drug may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.
For seniors: Seniors may have a higher risk of side effects from this drug. Because of this risk, your doctor may lower your dosage or have you take the medication less often.
Bulimia nervosa and panic disorder: This drug hasn’t been studied in children for these conditions. It shouldn’t be used in people younger than 18 years.
Major depressive disorder: This drug shouldn’t be used in children younger than 8 years for this condition.
Obsessive-compulsive disorder: This drug shouldn’t be used in children younger than 7 years for this condition.
All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
Dosage for bulimia nervosa
Generic: Fluoxetine
- Form: oral capsule
- Strengths: 10 mg, 20 mg, 40 mg
Brand: Prozac
- Form: oral capsule
- Strengths: 10 mg, 20 mg, 40 mg
Adult dosage (ages 18 to 64 years)
Typical dosage: 60 mg per day taken in the morning.
Child dosage (ages 0 to 17 years)
This drug hasn’t been studied in children for this condition. It shouldn’t be used in people younger than 18 years.
Senior dosage (ages 65 years and older)
Seniors may have a higher risk of side effects from this drug.
Because of this risk, your doctor may lower your dosage or reduce how often you take the drug.
Dosage for major depressive disorder
Generic: Fluoxetine
- Form: oral capsule
- Strengths: 10 mg, 20 mg, 40 mg
- Form: oral delayed-release capsule
- Strength: 90 mg
Brand: Prozac
- Form: oral capsule
- Strengths: 10 mg, 20 mg, 40 mg
Adult dosage (ages 18 to 64 years)
- Typical dosage: 20–80 mg per day.
- Maximum dosage: 80 mg per day.
- Initial dosage: 20 mg per day taken in the morning.
- Alternative dosage: You may be a candidate for taking this drug once per week. In this case, your doctor will stop your daily dose of the immediate-release capsules and switch you over to the delayed-release capsules.
You’ll take 90 mg once per week. You’ll start taking it seven days after your last daily dose of fluoxetine.
Child dosage (ages 8 to 17 years)
- Typical dosage: 10–20 mg per day.
- Initial dosage: After your child takes 10 mg per day for one week, your doctor may increase their dosage to 20 mg per day.
Child dosage (ages 0–7 years)
This drug shouldn’t be used in children younger than 8 years for this condition.
Senior dosage (ages 65 years and older)
Seniors may have a higher risk of side effects from this drug. Because of this risk, your doctor may lower your dose or reduce how often you take the drug.
Dosage for obsessive-compulsive disorder
Generic: Fluoxetine
- Form: oral capsule
- Strengths: 10 mg, 20 mg, 40 mg
Brand: Prozac
- Form: oral capsule
- Strengths: 10 mg, 20 mg, 40 mg
Adult dosage (ages 18 to 64 years)
- Typical dosage: 20–60 mg per day.
- Maximum dosage: 80 mg per day.
- Initial dosage: 20 mg per day taken in the morning.
Child dosage (ages 13 to 17 years, and higher weight children)
- Typical dosage: 20–60 mg per day.
- Initial dosage: 10 mg per day. After two weeks, your doctor will likely increase your child’s dosage to 20 mg per day.
Child dosage (ages 7 to 12, and lower weight children)
- Typical dosage: 20–30 mg per day.
- Initial dosage: 10 mg per day.
Child dosage (ages 0 to 6 years)
This drug shouldn’t be used in children younger than 7 years for this condition.
Senior dosage (ages 65 years and older)
Seniors may have a higher risk of side effects from this drug. Because of this risk, your doctor may lower your dosage or reduce how often you take the drug.
Dosage for panic disorder
Generic: Fluoxetine
- Form: oral capsule
- Strengths: 10 mg, 20 mg, 40 mg
Brand: Prozac
- Form: oral capsule
- Strengths: 10 mg, 20 mg, 40 mg
Adult dosage (ages 18 to 64 years)
- Typical dosage: 20–60 mg per day.
- Initial dosage: 10 mg per day. After one week, your doctor will likely increase your dosage to 20 mg per day.
Child dosage (ages 0 to 17 years)
This drug hasn’t been studied in children for this condition. It shouldn’t be used in people younger than 18 years.
Senior dosage (ages 65 years and older)
Seniors may have a higher risk of side effects from this drug. Because of this risk, your doctor may lower your dosage or reduce how often you take the drug.
Disclaimer: Our goal is to provide you with the most relevant and current information.
However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Fluoxetine oral capsule is used for short- and long-term treatment of bulimia nervosa, major depression, and obsessive-compulsive disorder. It’s also used for short-term treatment of panic attacks.
This drug comes with serious risks if you don’t take it as prescribed.
If you stop taking the drug suddenly or don’t take it at all: If you don’t take this drug, the symptoms of your condition may not improve.
Don’t stop taking this drug without talking to your doctor first. Stopping this drug too quickly may cause serious symptoms. These can include:
- anxiety
- irritability
- mood swings
- restlessness
- changes in your sleep habits
- headache
- sweating
- nausea
- dizziness
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely.
For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:
- tiredness
- vomiting
- fast heart rate
- nausea
- dizziness
- agitation
- tremors
If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.
What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.
How to tell if the drug is working: The symptoms of your condition should improve.
However, you might not feel better right when you start taking this drug. It can take 1–4 weeks to start working.
Keep these considerations in mind if your doctor prescribes fluoxetine for you.
General
- You can take this drug with or without food.
- Take this drug at the time(s) recommended by your doctor.
- Don’t open the oral capsules or oral delayed-release capsules.
Storage
- Store this drug at room temperature. Keep it between 59°F and 86°F (15°C and 30°C).
- Keep this drug away from light.
- Don’t store this medication in moist or damp areas, such as bathrooms.
Refills
A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.
Travel
When traveling with your medication:
- Always carry your medication with you. When flying, never put it into a checked bag.
Keep it in your carry-on bag. - Don’t worry about airport X-ray machines. They can’t harm your medication.
- You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
- Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.
Clinical monitoring
You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These health issues include:
- Mental health and behavioral problems. You and your doctor should watch for any unusual changes in your behavior and mood. This drug can cause new mental health and behavior problems. It may also worsen problems you already have.
There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
| 💊 The composition of the drug Fluoxetine ✅ Use of Fluoxetine Save Search for analogues Interaction Description of the active ingredients of the preparation fluoxetine (Fluoxetine) The scientific information provided is general and cannot be used to make decisions. decisions about the use of a particular drug. Update date: 2020.06.09 Marketing authorization holder:OZON, OOO (Russia) ATX code: N06AB03 (Fluoxetine) Active substance: fluoxetine (fluoxetine) Rec. Dosage form
Release form, packaging and composition Fluoxetine
7 pcs. - blisters (1) - packs of cardboard. Clinical and pharmacological group: Antidepressant Pharmacotherapeutic group: Antidepressant Pharmacological action Antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of neuronal reuptake of serotonin in the CNS. PharmacokineticsAbsorbed from the gastrointestinal tract. Weakly metabolized during the "first pass" through the liver. Eating does not affect the degree of absorption, although it may slow down its rate. C max in plasma is achieved after 6-8 hours. C ss in plasma is achieved only after continuous administration for several weeks. Protein binding 94.5%. Easily penetrates through the BBB. It is metabolized in the liver by demethylation to form the main active metabolite of norfluoxetine. T 1/2 fluoxetine is 2-3 days, norfluoxetine is 7-9 days. Indications of the active substances of the drug fluoxetineDepression of various origins, obsessive-compulsive disorders, bulimic neurosis. Open list of ICD-10 codes
Dosage regimen The route of administration and dosing regimen of a particular drug depends on its form of release and other factors. Initial dose - 20 mg 1 time / day in the morning; if necessary, the dose can be increased after 3-4 weeks. The frequency of admission is 2-3 times / day. The maximum daily oral dose of for adults is 80 mg. Side effectsFrom the side of the central nervous system: possible anxiety, tremor, nervousness, drowsiness, headache, sleep disturbances. From the digestive system: possible diarrhea, nausea. From the side of metabolism: increased sweating, hypoglycemia, hyponatremia (especially in elderly patients and with hypovolemia) are possible. From the reproductive system: decreased libido. Allergic reactions: possible skin rash, itching. Other: pain in the joints and muscles, shortness of breath, fever. Contraindications for useGlaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, concomitant administration of MAO inhibitors, convulsive syndrome of various origins, epilepsy, pregnancy, lactation, hypersensitivity to fluoxetine. Use in pregnancy and lactationContraindicated in pregnancy and lactation. Use in hepatic impairmentUse with extreme caution in patients with hepatic impairment. Use in impaired renal functionContraindicated in severe renal impairment. Use with extreme caution in patients with moderate and mild renal impairment. Use in childrenThe safety of fluoxetine in children has not been established. Use in elderly patientsElderly patients require dosage adjustment. Special instructions Use with extreme caution in patients with impaired liver and kidney function, with a history of epileptic seizures, cardiovascular diseases. In patients with diabetes mellitus, changes in blood glucose levels are possible, which requires correction of the dosing regimen of hypoglycemic drugs. When used in debilitated patients while taking fluoxetine, the likelihood of developing epileptic seizures increases. With the simultaneous use of fluoxetine and electroconvulsive therapy, prolonged epileptic seizures may develop. Fluoxetine can be used no earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of fluoxetine before the start of therapy with MAO inhibitors should be at least 5 weeks. Elderly patients require dosage adjustment. The safety of fluoxetine in children has not been established. Do not drink alcohol during treatment. Influence on the ability to drive vehicles and mechanisms During the period of treatment, one should refrain from potentially hazardous activities that require increased attention and rapid psychomotor reactions. Drug interactionsWhen used simultaneously with drugs that have a depressant effect on the central nervous system, with ethanol, a significant increase in the inhibitory effect on the central nervous system, as well as an increase in the likelihood of convulsions, is possible. With simultaneous use with MAO inhibitors, furazolidone, procarbazine, tryptophan, serotonin syndrome may develop (confusion, hypomania, restlessness, agitation, convulsions, dysarthria, hypertensive crisis, chills, tremor, nausea, vomiting, diarrhea). With simultaneous use, fluoxetine inhibits the metabolism of tricyclic and tetracyclic antidepressants, trazodone, carbamazepine, diazepam, metoprolol, terfenadine, phenytoin, which leads to an increase in their concentration in blood serum, an increase in their therapeutic and side effects. With simultaneous use, inhibition of the biotransformation of drugs metabolized with the participation of the CYP2D6 isoenzyme is possible. When used simultaneously with hypoglycemic agents, their action may be enhanced. There have been reports of increased effects of warfarin when co-administered with fluoxetine. When used simultaneously with haloperidol, fluphenazine, maprotiline, metoclopramide, perphenazine, periciazine, pimozide, risperidone, sulpiride, trifluoperazine, cases of extrapyramidal symptoms and dystonia have been described; with dextromethorphan - a case of the development of hallucinations is described; with digoxin - a case of increasing the concentration of digoxin in the blood plasma. When used simultaneously with lithium salts, an increase or decrease in the concentration of lithium in the blood plasma is possible. With simultaneous use, an increase in the concentration of imipramine or desipramine in the blood plasma by 2-10 times is possible (may persist for 3 weeks after fluoxetine is discontinued). When used simultaneously with propofol, a case has been described in which spontaneous movements were observed; with phenylpropanolamine - a case is described in which dizziness, weight loss, hyperactivity were observed. Co-administration may enhance the effects of flecainide, mexiletine, propafenone, thioridazine, zuclopenthixol. Keep |
(21151) 
INN WHO registered 
- polymer containers (10) - packs of cardboard. 
Fluoxetine is a weak antagonist of cholino-, adreno- and histamine receptors. Unlike most antidepressants, fluoxetine does not appear to cause a decrease in the functional activity of postsynaptic β-adrenergic receptors. Helps improve mood, reduces feelings of fear and tension, eliminates dysphoria. Does not cause sedation. When taken in average therapeutic doses, it practically does not affect the functions of the cardiovascular and other systems. 
Excreted by the kidneys 80% and through the intestines - about 15%. 
The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed. 
Active ingredient FLUOXETINUM | Compendium - drug reference book
- Pharmacological properties
- Indications FLUOXETINE
- Application of FLUOXETINE
- Contraindications
- Side effects
- Special instructions
- Interactions
- Overdose
- Diagnosis
- Recommended alternatives
- Trading names
Medicines containing the active substance fluoxetine
Capture
Capsules 20 mg strip, No. 60
Sun
In pharmacies
Fluxen ®
, 30 , 30 Kievmedpreparat
Prices in pharmacies
Fluoxetine
hard capsules 20 mg blister, № 30, 60
Kusum Helthker Pvt.
Ltd.
Prices in pharmacies
Prices in pharmacies
Fluoxetine
coated tablets 20 mg, № 10, 20 Slightly affects the uptake of norepinephrine and dopamine. Weakly acts on cholinergic and H 1 - receptors. Helps to improve mood, eliminates the feeling of fear and tension, dysphoria. Does not have a sedative effect. It has no cardiotoxic effect. A stable clinical effect develops after 3-4 weeks of continuous use.
Well absorbed in the digestive tract. Bioavailability when taken orally is more than 60%. C max fluoxetine in blood plasma is observed 6-8 hours after administration. About 94.5% of fluoxetine binds to serum plasma proteins, including albumin and α 1 - glycoprotein. Undergoes biotransformation in the liver with the formation of norfluoxetine and a number of unidentified metabolites. In terms of activity and selectivity of action, norfluoxetine is equivalent to fluoxetine. Inactive metabolites formed in the liver are excreted by the kidneys.
The relatively slow elimination of fluoxetine (T ½ - from 2 to 3 days) ensures the maintenance of therapeutic plasma concentrations for several weeks, so discontinuation of therapy does not cause the development of a withdrawal syndrome.
various types of depression (especially depression accompanied by fear), including those resistant to treatment with other antidepressants, obsessive-phobic disorders, bulimic neurosis (to reduce appetite and reduce body weight).
is for adults only. The usual dose for depression is 20 mg once daily. If necessary, after 3-4 weeks, the dose is increased by 20 mg / day. The maximum daily dose is 80 mg.
Elderly and senile persons are prescribed in a dose not exceeding 60 mg / day.
With a single dose (20 mg), the drug is taken in the morning, with a double dose - in the morning and evening.
In case of bulimic neurosis, a daily dose of 60 mg is prescribed in 3 divided doses; with obsessive-phobic disorders - 20-60 mg / day, depending on the severity of the disease.
The course of treatment should be sufficiently long (2-3 months).
hypersensitivity to fluoxetine, simultaneous treatment with MAO inhibitors, pregnancy and lactation, childhood, decompensated epilepsy, severe renal dysfunction (glomerular filtration rate less than 10 ml / min).
asthenia, sweating, nausea, diarrhea, anorexia, dyspepsia, vomiting, dry mouth, headache, dizziness, irritability, insomnia, tremor, fatigue, convulsions, mania and hypomania, pharyngitis, dysphonia, bronchitis, allergic and immunopathological reactions (pruritus, rash, vasculitis, serum sickness, thrombocytopenia, thrombocytopenic purpura, rarely - anaphylactic shock), sexual disorders (increased libido, weakened orgasm or anorgasmia), rarely - hyponatremia, especially when combined therapy with diuretics.
care must be taken when prescribing to patients with cardiovascular diseases and persons performing potentially dangerous work (driving vehicles, mechanisms). In diabetic patients, fluoxetine can change blood glucose levels, which requires dose adjustment of antidiabetic drugs.
