Lyrica on empty stomach

Lyrica - Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

Pregabalin belongs to the class of medication known as analgesics. It is used to relieve neuropathic pain associated with diabetic peripheral neuropathy (pain from damaged nerves due to diabetes) and postherpetic neuralgia (persisting pain following healing of the rash due to shingles).

Pregabalin is also used to relieve pain associated with fibromyalgia (pain in the muscles, ligaments, and tendons). It is also useful in managing central neuropathic pain (pain from damaged nerves of the brain and spinal cord).

Pain from damaged nerves may feel sharp, burning, tingling, shooting, or numb. It is not known exactly how pregabalin works, but it is thought to work in the brain to decrease the release of chemicals responsible for pain. For some people, improvement in pain may occur as early as the first week of treatment with pregabalin.

This medication may be available under multiple brand names and/or in several different forms.  Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

25 mg
Each white, hard gelatin capsule, printed with black ink "Pfizer" on the cap, "PGN 25" on the body contains pregabalin 25 mg. Nonmedicinal ingredients: lactose monohydrate, maize starch, and talc; capsule shell: colloidal silicon dioxide (manufacturing aid, which may not be present), gelatin, sodium lauryl sulfate, and titanium dioxide; black ink: black iron oxide, potassium hydroxide, propylene glycol, shellac, and water.

50 mg
Each white, hard gelatin capsule, printed with black ink "Pfizer" on the cap, "PGN 50" and an ink band on the body contains pregabalin 50 mg. Nonmedicinal ingredients: lactose monohydrate, maize starch, and talc; capsule shell: colloidal silicon dioxide (manufacturing aid, which may not be present), gelatin, sodium lauryl sulfate, and titanium dioxide; black ink: black iron oxide, potassium hydroxide, propylene glycol, shellac, and water.

75 mg
Each white-orange, hard gelatin capsule, printed with black ink "Pfizer" on the cap, "PGN 75" on the body contains pregabalin 75 mg. Nonmedicinal ingredients: lactose monohydrate, maize starch, and talc; orange capsule shell: gelatin, red iron oxide, and titanium dioxide; white capsule shell: colloidal silicon dioxide and sodium lauryl sulfate; black ink: black iron oxide, potassium hydroxide, propylene glycol, shellac, and water.

100 mg
Each orange, hard gelatin capsule, printed with black ink “Pfizer” on the cap, “PGN 100” on the body contains pregabalin 100 mg. Nonmedicinal ingredients: lactose monohydrate, maize starch, and talc; capsule shell: colloidal silicon dioxide (manufacturing aid, which may not be present), gelatin, titanium dioxide and red iron oxide; black ink: black iron oxide, potassium hydroxide, propylene glycol, shellac, and water.

150 mg
Each white, hard gelatin capsule, printed with black ink "Pfizer" on the cap, "PGN 150" on the body contains pregabalin 150 mg. Nonmedicinal ingredients: lactose monohydrate, maize starch, and talc; capsule shell: colloidal silicon dioxide (manufacturing aid, which may not be present), gelatin, sodium lauryl sulfate, and titanium dioxide; black ink: black iron oxide, potassium hydroxide, propylene glycol, shellac, and water.

200 mg
Each light orange, hard gelatin capsule, printed with black ink “Pfizer” on the cap, “PGN 200” on the body contains pregabalin 200 mg.Nonmedicinal ingredients: lactose monohydrate, maize starch, and talc; capsule shell: colloidal silicon dioxide (manufacturing aid, which may not be present), gelatin, titanium dioxide and red iron oxide; black ink: black iron oxide, potassium hydroxide, propylene glycol, shellac, and water.

225 mg
Each white, light orange, hard gelatin capsule, printed with black ink "Pfizer" on the cap, "PGN 225" on the body contains pregabalin 225 mg. Nonmedicinal ingredients: lactose monohydrate, maize starch, and talc; orange capsule shell: red iron oxide, gelatin, and titanium dioxide; white capsule: sodium lauryl sulfate, colloidal silicon dioxide (manufacturing aid, which may not be present), gelatin, and titanium dioxide; black ink: shellac, black iron oxide, propylene glycol, potassium hydroxide, and water.

300 mg
Each white-orange, hard gelatin capsule, printed with black ink "Pfizer" on the cap, "PGN 300" on the body contains pregabalin 300 mg. Nonmedicinal ingredients: lactose monohydrate, maize starch, and talc; orange capsule shell: gelatin, red iron oxide, and titanium dioxide; white capsule shell: colloidal silicon dioxide (manufacturing aid, which may not be present), gelatin, sodium lauryl sulfate, and titanium dioxide; black ink: black iron oxide, potassium hydroxide, propylene glycol, shellac, and water.

How should I use this medication?

To treat neuropathic pain associated with diabetic neuropathy and post herpetic neuralgia, the recommended adult starting dose of pregabalin is 150 mg per day, given in 2 or 3 divided doses (e.g., 75 mg twice a day or 50 mg 3 times a day).

To treat neuropathic pain associated with the central nervous system, the recommended adult starting dose of pregabalin is 150 mg per day, given in 2 divided doses (e. g., 75 mg twice a day).

To treat pain associated with fibromyalgia, the recommended adult starting dose of pregabalin is 150 mg per day, given in 2 divided doses (e.g., 75 mg twice a day).

After one week of treatment, your doctor may increase the dose of pregabalin to 300 mg per day, given in 2 divided doses (e.g., 150 mg twice a day). The maximum recommended daily dose of pregabalin is 600 mg.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Pregabalin may be taken with food or on an empty stomach.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose of this medication by a few hours, take it as soon as possible and continue your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature in the original packaging and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Pregabalin should not be taken by anyone who is allergic to pregabalin or to any of the ingredients of the medication.

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• constipation
• dizziness
• drowsiness or sleepiness
• dry mouth
• forgetfulness
• lack of energy
• muscle weakness
• trouble concentrating
• weight gain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• balance problems
• blurred vision
• cough
• extreme fatigue or tiredness
• signs of kidney problems (e. g., increased urination at night, decreased urine production, blood in the urine)
• swelling of the extremities (hands and feet)
• thoughts of harming yourself or suicide
• unexplained muscle pain, tenderness, or weakness (especially if accompanied by fever or a general feeling of being unwell)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• seizures
• signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
• symptoms of an allergic reaction (shortness of breath or difficulty breathing; hives; swelling of the eyes, mouth, or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergic reaction: Some people have developed a serious allergic reaction called angioedema to this medication. Symptoms include swelling of the face, mouth (lips, gums, tongue), neck, throat, and upper airway. If these occur, seek immediate medical attention.

Central nervous system (CNS) depressants: Taking CNS depressants such as opiates (e.g., morphine, codeine) and benzodiazepines (e.g., diazepam, lorazepam) or alcohol while taking pregabalin could result in excessive sleepiness or drowsiness and even coma. Talk to your doctor if you are taking these medications.

Drowsiness/reduced alertness: Pregabalin may cause dizziness and drowsiness. Do not engage in activities requiring mental alertness, such as driving or operating machinery, until you know how this medication affects you.

Drinking alcohol while you are taking pregabalin may make these effects stronger. It is strongly recommended that you avoid drinking alcohol while you are taking pregabalin.

Gastrointestinal problems: Pregabalin can cause constipation. When taken with other medications that cause constipation, such as narcotic pain relievers or some antidepressants, the combination may cause blockage of the digestive system. Talk to your doctor or pharmacist for suggestions on how to manage constipation.

Heart problems: Pregabalin may cause fluid to build up in the body. If the fluid accumulates around the lungs or heart, symptoms of heart failure may become worse. If you have heart failure or other heart problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Report any signs of heart problems getting worse, such as difficulty breathing, rapid weight gain or chest pain to your doctor immediately.

Kidney function: Pregabalin is primarily eliminated from the body by the kidneys. Kidney disease or decreased kidney function may cause this medication to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregabalin may reduce kidney function and can cause kidney failure. If you notice any signs of your kidneys not working well, such as decreased amounts of urine being produced, swelling of the legs and ankles, difficulty urinating, or an increased need to urinate at night, contact your doctor as soon as possible.

Male fertility: Animal studies have shown the use of pregabalin to be associated with decreased fertility, sperm abnormalities, and birth defects. It is not known if these effects would happen in people. If you plan to father a child, discuss using this medication with your doctor first.

Muscle pain: If you experience muscle pain, tenderness, or weakness with or without fever, contact your doctor immediately.

Skin problems: Pregabalin may cause skin ulcers or sores. Pay extra attention to your skin while taking this medication, especially if you have diabetes. If you notice any new skin sores or skin problems let your doctor know.

Stopping this medication: Stopping pregabalin suddenly may result in withdrawal symptoms such as insomnia, nausea, headache, diarrhea, and seizures. If it is necessary to stop taking this medication, talk to your doctor about the best way to reduce your dose before stopping your medication.

Suicidal behaviour: People taking this medication may feel that they may want to hurt themselves or others. These symptoms may occur within several weeks after starting this medication. If you experience these side effects or notice them in a family member who is taking this medication, contact your doctor immediately. You should be closely monitored by your doctor for emotional and behaviour changes while taking this medication.

Vision disturbances: Pregabalin may cause disturbances in your vision such as blurred vision, double vision, and vision loss. Report any changes in your vision to your doctor immediately.

Weight gain: Pregabalin may cause weight gain and swelling of the extremities. Report any significant weight gain or any swelling of the legs, arms, or other areas of the body to your doctor.

Pregnancy: Information about the safety and effectiveness of using pregabalin during pregnancy is limited. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking pregabalin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children and adolescents: The safety and effectiveness of using this medication have not been established for children and adolescents less than 18 years of age.

Seniors: The effectiveness of the kidneys in removing pregabalin from the body tends to decrease with age. Seniors may need lower doses of this medication to reduce the possibility for side effects.

What other drugs could interact with this medication?

There may be an interaction between pregabalin and any of the following:

• alcohol
• angiotensin converting enzyme inhibitors (ACEIs; captopril, ramipril)
• antihistamines (e.g., diphenhydramine, doxylamine, hydroxyzine)
• anti-psychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
• azelastine
• barbiturates (e.g., butalbital, phenobarbital)
• benzodiazepines (e.g., lorazepam, alprazolam, diazepam)
• brimonidine
• buprenorphine
• buspirone
• cannabis
• chloral hydrate
• clonidine
• diphenoxylate
• efavirenz
• general anesthetics (medications used to put people to sleep before surgery)
• kava kava
• ketorolac
• mefloquine
• mirtazapine
• nabilone
• narcotic pain relievers (e. g., codeine, fentanyl, morphine, oxycodone)
• muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine)
• orlistat
• pramipexole
• ropinirole
• rotigotine
• scopolamine
• seizure medications (e.g., carbamazepine, gabapentin, levetiracetam, phenytoin)
• selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
• suvorexant
• tapentadol
• thalidomide
• thiazolidinediones (e.g., pioglitazone, rosiglitazone)
• tolcapone
• tramadol
• tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
• zolpidem
• zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2022. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Lyrica

How does lyrics affect the body?

Posted: 07/05/2021

In 2012, lyrics were banned from being sold without a prescription in pharmacies, and for good reason. The fact is that the drug almost immediately causes addiction. Taking it, a person feels euphoria - it seems to him that life is beautiful, he is as relaxed as possible. The antiepileptic drug was a favorite for drug addicts and substance abusers, because they became happy and enjoyed using the drug.

Lyrics are a drug!

Drug addicts often create a so-called cocktail by mixing lyrics with alcoholic beverages. Such a shock drink causes irreparable harm to health.

Surprisingly, the lyrics are able to fight withdrawal attacks in drug addicts.

Lyrica is an excellent pain reliever. It also remarkably helps patients with diabetic neuropathy. The medicine remarkably relieves anxiety syndromes. The patient quickly calms down from the potent pills.

The harmful effect of lyrics on the body

The drug has a lot of side effects:

• patients note a violation of coordination of movements;
• drowsiness all day long;
• often patients begin to suffer from forgetfulness;
• become inattentive, unable to concentrate;
• speech is disturbed, the person pronounces slurred words;
• shortness of breath and tachycardia constantly cause discomfort to patients;
• possible short-term syncope.

In severe cases, seizures may occur. Also, the lyrics harm the taste sensations - the patient ceases to distinguish what he eats.

If the lyric is taken continuously, the patient experiences arousal. At first he likes the feeling of euphoria, but then it abruptly changes into a severe form of depression. There is irritability, anxiety, suspiciousness. Perhaps the appearance of hallucinations.

Since the drug has a stimulating effect, it directly affects the patient's sleep. The patient stops sleeping fully, he is constantly excited, active. Of course, lack of sleep has a very negative impact on health. The nervous system is exhausted more and more.

How lyrics affect a person

It is quite difficult to understand that the patient is using Lyrica. The thing is that the symptom complex of the use of lyrics is quite easy to confuse with symptoms from the use of other drugs. Using the lyrics, the pupils of patients significantly dilate, as well as from taking similar drugs.

Sharp mood swings of the patient are clear signs of the influence of lyrics. From the signs of depression, he can suddenly become the happiest joyful person and vice versa. The patient has excessive sweating, he becomes aggressive and irritable, nervous.

Since, along with aggression, sweating and hysteria, the patient experiences dizziness and incoordination, he constantly lies. It is very difficult for him to sit or stand, almost impossible. At the moment, there is no test that would clearly show whether the patient uses lyrics or not.

Why lyrics are dangerous

Ephedrine and methadone addictions are almost one hundred percent similar in their symptoms to lyric addiction. Constantly using the lyrics, the patient becomes completely dependent on the drug.

The psyche is disturbed. The patient constantly experiences a feeling of anxiety, he develops tachycardia. It is very easy to get hooked on medicine. Many drug addicts start using lyrics just to get rid of drug addiction. They drown out the withdrawal, using lyrics in small doses and quantities. However, drug addicts quickly break down. They use lyrics several times more than necessary. The result is very deplorable - the patient becomes dependent on the lyrics, with all the ensuing negative consequences.

Memory problems, headaches and dizziness are the main symptoms experienced by a person hooked on this drug. Lyricism harms libido, erection problems appear, sexual weakness

It is almost impossible to wean yourself from using lyrics. And if you take the lyrics for a long time, without resorting to the help of doctors, it is likely that the patient will die soon. The body cannot withstand such a load.

Lyric addiction treatment needed?

The specialists of the Unika + clinic will professionally help you get rid of your addiction. Doctors will start with cleansing the body, relieve withdrawal symptoms and cravings for this drug. After a whole complex of detoxification procedures, rehabilitation is carried out with the regular work of a psychologist, narcologist and other specialists. After a full course of therapy at the Unika + clinic, the patient will understand that life can be interesting without the use of drugs!

Contact our specialist: +7(495) 220-87-15 (24/7)

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Description of PREGABALIN indications, dosages, contraindications of the active substance PREGABALIN

Rec.INN WHO registered drug interaction Included in preparations: list Pharmacological action Anticonvulsant with analgesic and anxiolytic action. Pregabalin is a GABA analogue. It is assumed that the analgesic and anticonvulsant effect is due to the binding of pregabalin to an additional subunit (α 2 -delta protein) of voltage-gated calcium channels in the CNS, which leads to an irreversible replacement of [3H]-gabapentin. Pregabalin reduces the clinical manifestations of generalized anxiety disorder. Pharmacokinetics After oral administration on an empty stomach, pregabalin is rapidly absorbed from the gastrointestinal tract. C max in plasma is achieved after 1 hour, both with a single and repeated intake. The oral bioavailability of pregabalin is ≥ 90% and does not depend on the dose. With repeated use, the equilibrium state is reached after 24-48 hours. When used after a meal, C max is reduced by approximately 25-30%, and the time to reach C max increases to approximately 2.5 hours. However, food intake does not have a clinically significant effect on the total absorption of pregabalin. The pharmacokinetics of pregabalin in the range of recommended daily doses is linear, inter-individual variability is low (<20%). The apparent V d of pregabalin after oral administration is approximately 0.56 l/kg. Pregabalin does not bind to plasma proteins. Pregabalin is practically not metabolized. After administration of labeled pregabalin, approximately 98% of the radioactive label was determined in the urine in unchanged form. The proportion of the N-methylated derivative of pregabalin, which is the main metabolite found in urine, was 0.9% of the dose. There were no signs of racemization of the S-enantiomer of pregabalin to the R-enantiomer. Pregabalin is excreted mainly by the kidneys unchanged. The average T 1/2 is 6.3 hours. Plasma clearance of pregabalin and renal clearance are directly proportional to CC. Pregabalin pharmacokinetic parameters at steady state in healthy volunteers, in patients with epilepsy who received antiepileptic therapy, and in patients who received it for chronic pain syndromes, were similar. In case of impaired renal function, it should be borne in mind that the clearance of pregabalin is directly proportional to CC. Pregabalin is effectively removed from plasma by hemodialysis (after a 4-hour hemodialysis session, plasma pregabalin concentrations are reduced by about 50%). The pharmacokinetics of pregabalin has not been specifically studied in patients with hepatic impairment. Pregabalin is practically not metabolized and is excreted mainly unchanged in the urine, so impaired liver function should not significantly alter plasma concentrations of the drug. When prescribing the drug to elderly patients over 65 years of age, it should be taken into account that the clearance of pregabalin tends to decrease with age, which reflects the age-related decrease in CC. Elderly people with impaired renal function may need to reduce the dose of the drug. Indications of the active substance PREGABALIN Treatment of neuropathic pain in adults. Treatment of fibromyalgia in adults. Epilepsy: as adjunctive therapy in adults with partial seizures with or without secondary generalization. Treatment of generalized anxiety disorder in adults. Open list of ICD-10 codes F41.1 Generalized anxiety disorder G40 Epilepsy G53.0 Neuralgia after herpes zoster (B02.2) G63.2 Diabetic polyneuropathy M79.7 Fibromyalgia (including fibromyositis, fibrositis) R52.2 Other persistent pain (chronic) Dosage regimen Take orally regardless of food intake in a daily dose of 150 to 600 mg in 2 or 3 divided doses. If treatment must be discontinued, it is recommended that this be done gradually over a period of at least 1 week. For patients with impaired renal function , the dose is selected individually, taking into account QC. In patients with impaired liver function, dose adjustment is not required. Elderly patients over 65 years of age may require a dose reduction of pregabalin due to decreased renal function. If a dose of pregabalin is missed, the next dose should be taken as soon as possible, but the missed dose should not be taken if the next dose is about to be taken. Side effects From the side of the psyche: often - euphoria, confusion, decreased libido, irritability, insomnia, disorientation; infrequently - depersonalization, anorgasmia, anxiety, depression, agitation, mood lability, depressed mood, difficulty in choosing words, hallucinations, unusual dreams, increased libido, panic attacks, apathy, increased insomnia; rarely - disinhibition, high spirits. From the side of the nervous system: very often - dizziness, drowsiness; often - ataxia, impaired attention, impaired coordination, memory impairment, tremor, dysarthria, paresthesia, imbalance, amnesia, sedation, lethargy; infrequently - cognitive disorders, hypesthesia, nystagmus, speech disturbance, myoclonic convulsions, weakening of reflexes, dyskinesia, psychomotor agitation, postural dizziness, hyperesthesia, loss of taste sensations, burning sensation on the mucous membranes and skin, intentional tremor, stupor, fainting; rarely - hypokinesia, parosmia, dysgraphia; frequency unknown - headache. From the senses: often - dizziness, blurred vision, diplopia; infrequently - hyperacusis, narrowing of the visual fields, decreased visual acuity, eye pain, asthenopia, dry eyes, swelling of the eyes, increased lacrimation; rarely - flashing sparks before the eyes, eye irritation, mydriasis, oscillopsia (subjective sensation of fluctuations in the objects under consideration), impaired perception of depth of vision, loss of peripheral vision, strabismus, increased brightness of visual perception; frequency unknown - keratitis. From the side of metabolism: often - increased appetite, weight gain; infrequently - anorexia, hypoglycemia; rarely - weight loss. From the side of the cardiovascular system: infrequently - tachycardia, AV block I degree, hot flashes, lowering blood pressure, cold extremities, increased blood pressure; rarely - sinus tachycardia, sinus arrhythmia, sinus bradycardia; the frequency is unknown - chronic heart failure, prolongation of the QT interval. From the respiratory system: infrequently - shortness of breath, cough, dryness of the nasal mucosa, nasopharyngitis; rarely - nasal congestion, nosebleeds, rhinitis, snoring, tightness in the throat; infrequently - pulmonary edema. From the digestive system: often - dry mouth, constipation, vomiting, flatulence, bloating; infrequently - increased salivation, gastroesophageal reflux, hypoesthesia of the oral mucosa; rarely - ascites, dysphagia, pancreatitis; frequency unknown - swelling of the tongue, nausea, diarrhea. From the musculoskeletal system: infrequently - muscle twitching, joint swelling, muscle spasms, myalgia, arthralgia, back pain, pain in the extremities, muscle stiffness; rarely - spasm of the cervical muscles, neck pain, rhabdomyolysis. From the urinary system: infrequently - dysuria, urinary incontinence; rarely - oliguria, renal failure. From the reproductive system: often - erectile dysfunction; infrequently - delayed ejaculation, sexual dysfunction; rarely - amenorrhea, pain in the mammary glands, discharge from the mammary glands, dysmenorrhea, enlargement of the mammary glands in volume. From the side of the hematopoietic system: rarely - neutropenia. Dermatological reactions: infrequently - skin flushing, sweating, papular rash; rarely - cold sweat; frequency unknown - pruritus, Stevens-Johnson syndrome. Allergic reactions: rarely - urticaria; frequency unknown - angioedema, hypersensitivity. From the side of laboratory parameters: infrequently - increased activity of ALT, AST, CPK, a decrease in the number of platelets; rarely - an increase in the content of glucose and creatinine in the blood, a decrease in the level of potassium in the blood, a decrease in the number of leukocytes in the blood. Other: often - fatigue, peripheral edema, feeling of intoxication, gait disturbance; infrequently - asthenia, falls, thirst, chest tightness, generalized edema, chills, pain; rarely - hyperthermia. Contraindications for use Children and adolescents up to 17 years of age, hypersensitivity to pregabalin. Use in pregnancy and lactation There are no adequate, well-controlled studies on the safety of pregabalin during pregnancy. Women of reproductive age should use adequate methods of contraception when using pregabalin. It is not known if pregabalin is excreted in human breast milk. If it is necessary to use pregabalin during lactation, the issue of stopping breastfeeding should be considered. In animal studies , pregabalin produced reproductive toxicity. Pregabalin has been found to be excreted in breast milk in rats. Special instructions Use with caution in renal failure, in heart failure. In connection with the reported isolated cases of uncontrolled use of pregabalin, it must be used with caution in patients with a history of drug dependence (during the treatment period, strict medical supervision is required in such cases). In patients with diabetes mellitus, in case of weight gain during treatment with pregabalin, dose adjustment of hypoglycemic drugs may be required. Pregabalin should be discontinued if symptoms of angioedema develop (such as swelling of the face, perioral edema, or swelling of the tissues of the upper respiratory tract). Pregabalin, like other anticonvulsants, may increase the risk of suicidal thoughts or behavior. Therefore, during the period of treatment, patients require careful medical monitoring for the occurrence or worsening of depression, the appearance of suicidal thoughts or behavior. Treatment with pregabalin has been associated with dizziness and drowsiness, which increase the risk of accidental injury (falls) in the elderly. During post-marketing use, there have also been cases of loss of consciousness, confusion and cognitive impairment. Therefore, until patients appreciate the possible effects of pregabalin, they should exercise caution. Data on the possibility of withdrawal of other anticonvulsants in the suppression of seizures with pregabalin and the advisability of monotherapy with pregabalin are insufficient. There are reports of the development of seizures, incl. epileptic status and small seizures, against the background of the use of pregabalin or immediately after the end of therapy. There have also been cases of renal failure, in some cases, after discontinuation of pregabalin, renal function was restored. The following adverse events have been observed with discontinuation of pregabalin after long-term or short-term therapy: insomnia, headache, nausea, diarrhea, flu-like syndrome, depression, sweating, dizziness, convulsions and anxiety. Information on the frequency and severity of manifestations of pregabalin withdrawal syndrome depending on the duration of therapy with the latter and its dose is not available. Post-marketing experience with pregabalin has reported the development of chronic heart failure during pregabalin therapy, predominantly in elderly patients with impaired cardiac function and receiving the drug for neuropathy. Therefore, pregabalin should be used with caution in this category of patients. After the abolition of pregabalin, the manifestations of such reactions may disappear. The frequency of adverse reactions from the CNS, especially such as drowsiness, is increased in the treatment of central neuropathic pain due to spinal cord injury, which, however, may be due to the summation of the effects of pregabalin and other concomitantly taken drugs (for example, antispastic). This circumstance should be taken into account when pregabalin is prescribed for this indication. Dependence has been reported with pregabalin. Patients with a history of drug dependence need careful medical monitoring for symptoms of pregabalin dependence. Cases of encephalopathy have been reported, especially in patients with concomitant diseases that can lead to the development of encephalopathy. Influence on the ability to drive vehicles and mechanisms Pregabalin can cause dizziness and drowsiness and, accordingly, affect the ability to drive vehicles and use complex equipment. Patients should not drive vehicles, use sophisticated machinery, or engage in other potentially hazardous activities until an individual response to pregabalin has been established. Drug Interactions Cases of respiratory distress and coma have been reported with concomitant use of pregabalin with other CNS depressants. Negative effects of pregabalin on the activity of the gastrointestinal tract (including the development of intestinal obstruction, paralytic ileus, constipation) have also been reported when used simultaneously with drugs that cause constipation (such as non-narcotic analgesics). Learn more How to give the silent treatment How does bipolar person act Why do i laugh when people get hurt Self validation quotes Questions to ask an introvert Does birth control cause depression Best child counselors near me Why am i always stressed How to feel comforted Are chest pains a symptom of anxiety How to deal with miscommunication in a relationship Copyright © · The Wright Initiative · Articles · Site Map