Can i take ibuprofen with flonase

Fluticasone and ibuprofen do not add to the effect of salmeterol on organic dust-induced airway inflammation and bronchial hyper-responsiveness

Randomized Controlled Trial

. 2008 Jul;264(1):83-94.

doi: 10.1111/j.1365-2796.2008.01928.x. Epub 2008 Feb 21.

K Strandberg¹, A Ek, L Palmberg, K Larsson

Affiliations

Affiliation

¹ Lung and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. [email protected]

PMID: 18298484
DOI: 10. 1111/j.1365-2796.2008.01928.x

Free article

Randomized Controlled Trial

K Strandberg et al. J Intern Med. 2008 Jul.

Free article

. 2008 Jul;264(1):83-94.

doi: 10.1111/j.1365-2796.2008.01928.x. Epub 2008 Feb 21.

Authors

K Strandberg¹, A Ek, L Palmberg, K Larsson

Affiliation

¹ Lung and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. karin.strandberg@ki. se

PMID: 18298484
DOI: 10.1111/j.1365-2796.2008.01928.x

Abstract

Background: Exposure in a pig house causes airway inflammation and bronchial hyper-responsiveness which are not influenced by anti-asthma drugs, including a beta(2)-agonist (salmeterol).

Objectives: We hypothesized that a glucocorticoid or a cyclo-oxygenase-inhibitor synergistically interacts with salmeterol offering a protection against dust-induced increased bronchial responsiveness and airway inflammation. As data did not confirm previous results a retrospective analysis of pooled data on dust-induced bronchial hyper-responsiveness from four other studies was performed.

Design: Fluticasone or ibuprofen was administered for 1 week and salmeterol or placebo was inhaled 1 h prior to a 3-h exposure in a pig barn in a double-blind, placebo-controlled, cross-over design (2-3 weeks apart) in 12 healthy subjects. Lung function, bronchial responsiveness to methacholine and inflammatory markers were evaluated before and after exposure. Pre- and postexposure bronchial responsiveness in nontreated subjects was retrospectively evaluated from four previous studies.

Subjects: Twelve healthy, nonatopic nonsmokers.

Results: Salmeterol partially protected against bronchial hyper-responsiveness but did not influence inflammatory markers. Fluticasone and ibuprofen did not add to these effects. The retrospective analysis showed that PD(20)FEV(1) after exposure in a pig barn is almost totally independent of pre-exposure PD(20)FEV(1)-level; all subjects end up at the same low postexposure PD(20)FEV(1).

Conclusion: Contradictory to our previous results, salmeterol offered partial protection against enhanced bronchial responsiveness induced by exposure in a pig barn. This effect was not modified by fluticasone or ibuprofen. Our data clearly demonstrate that interventions altering bronchial responsiveness must be compared between groups with similar prechallenge bronchial responsiveness or in a cross-over design.

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Alzheimer’s Disease and Intranasal Fluticasone Propionate in the FDA MedWatch Adverse Events Database

Abstract

Background:

Studies of Alzheimer’s disease suggest that neuroinflammation or deranged brain wound healing may be a cause of some cases. But a placebo controlled study showed no effect at all on Alzheimer’s disease of low dose oral prednisone after one year. Introducing the steroid directly into the hippocampus and rhinencephalon via the nose, as happens in hay fever subjects, could be more effective.

Objective:

In the present study, we analyzed FDA MedWatch data for intranasal fluticasone propionate (Flonase) to determine the frequency of Alzheimer’s disease as an adverse event reported after use of the medication.

Methods:

Machine-readable data from MedWatch, including adverse drug reaction reports from manufacturers, are part of a public database. We used the online tool eHealthMe to query the database.

Results:

By September 20, 2017, 35,221 people reported side effects to MedWatch after taking Flonase. Among them, 9 people (0.03%) had Dementia Alzheimer’s type. By October 3, 2017, 185,636 people reported side effects after taking Lipitor. Among them, 243 people (0.13%) had Dementia Alzheimer’s type. The lower incidence of Alzheimer’s dementia in the Flonase group compared to the Lipitor group was significant (p < 0.001, Fisher exact test, two tailed).

Conclusion:

Long term use of oral non-steroidal anti-inflammatory drugs (NSAIDs) is linked with reduced risk of developing Alzheimer’s disease. Data from MedWatch suggest that fluticasone propionate administered intranasally might have a similar preventive effect to ibuprofen. Perhaps combining ibuprofen and Flonase could be therapeutic. Further studies would be desirable.

Studies of Alzheimer’s disease suggest that neuroinflammation [1] or deranged brain wound healing [2] may be responsible for some cases. Injury to the brain from trauma or irradiation may initiate the process [3]. The characteristic pathologic plaques and tangles are a non-specific result of the disease process, not a cause [4].

Biochemical and neuropathological studies of brains from individuals with Alzheimer’s disease provide clear evidence for an activation of inflammatory pathways and glial inflammation [5]. If part of the neuroinflammation is autoimmune, the predominance of Alzheimer’s disease in women could be explained, since autoimmune diseases are much more common in women than men.

However, there is no beneficial effect of non-steroidal anti-inflammatory drugs (NSAIDs), such as naproxen, rofecoxib, or ibuprofen, on cognition or overall Alzheimer’s disease severity. Oral NSAIDs have no value as an Alzheimer’s disease treatment [6].

Chou et al. showed a reduction in risk of Alzheimer’s disease in rheumatoid arthritis patients on prednisone [7]; unadjusted the effect is almost significant (p = 0.1). The reduction is quite remarkable, given the tiny amounts of prednisone that reach the brain after an oral dose due to tight plasma protein binding. Balis et al. found that the cerebrospinal fluid/plasma ratio of dexamethasone is 0.15, of prednisolone 0.079 [8]. Such minute amounts of steroid in the brain presumably have a tiny or negligible effect. Indeed, another placebo controlled study showed no effect at all on Alzheimer’s disease of low dose oral prednisone after one year [9].

Introducing the steroid directly into the hippocampus and rhinencephalon via the nose, as happens in hay fever subjects, could be more effective. In the present study, we analyzed FDA MedWatch data for intranasal fluticasone propionate (Flonase) to determine the frequency of Alzheimer’s disease as an adverse event reported after use of the medication.

METHODS

We used data from MedWatch, the Food and Drug Administration (FDA) Safety Information and Adverse Event Reporting Program [10]. MedWatch was organized in 1993 to collect data regarding adverse events in healthcare. An adverse event is any undesirable experience associated with the use of a medical product. The MedWatch system collects reports of adverse reactions and quality problems, primarily due to drugs and medical devices, but also for other FDA-regulated products (e.g., dietary supplements, cosmetics, medical foods, and infant formulas).

MedWatch offers a choice between a voluntary reporting form, designed primarily for health care professionals and the general public, and a mandatory adverse event reporting service (AERS) form, available to manufacturers, importers, and medical product user facilities that manage and store medical products. The latter group is required by law to submit the mandatory form immediately upon discovery of a product malfunction. Printable mail-in forms are available as an alternative to the online submission system [11].

A MedWatch report of an adverse event does not establish causation. For any given report, there is no certainty that the drug in question caused the reaction. The adverse event may have been related to the underlying disease being treated, perhaps caused by another drug being taken concurrently, or something else.

Machine-readable data from MedWatch, including adverse drug reaction reports from manufacturers, are part of a public database. We used the online tool eHealthMe to query the database [12, 13]. Data are exclusively from MedWatch, not from social media [14].

RESULTS

By September 20, 2017, 35,221 people reported side effects to FDA after taking Flonase (intranasal fluticasone propionate). Among them, 9 people (0.03%) had Dementia Alzheimer’s type (Fig. 1).

By October 3, 2017, 185,636 people reported side effects after taking Lipitor (atorvastatin). Among them, 243 people (0.13%) had Dementia Alzheimer’s type (Fig. 1). In a large-scale randomized controlled trial evaluating statin therapy as a treatment for mild to moderate Alzheimer disease, atorvastatin was not associated with significant clinical benefit over 72 weeks [15].

Fig.1

MedWatch Alzheimer’s disease reports in patients using Flonase, Lipitor (atorvastatin), and ibuprofen by year. Number of reports is above the corresponding bar.

By October 8, 2017, 102,006 people reported side effects when taking Ibuprofen. Among them, 34 people (0.03%) had Dementia Alzheimer’s type, a proportion identical to Flonase (Fig. 1). Ibuprofen reduces the risk of Alzheimer’s disease, although, as was mentioned, it is not a treatment [16].

The lower incidence of Alzheimer’s dementia in the Flonase group compared to the Lipitor group was significant (p < 0. 001, Fisher exact test, two tailed).

80% of the people taking Flonase were over 60; 93% of the people taking Lipitor were over 60; 89% of the people taking ibuprofen were over 60 (Table 1). 89% of the patients using Flonase were female, versus 56% of the patients taking Lipitor and 82% of the patients taking ibuprofen. The most common other conditions in patients who reported Alzheimer’s disease are listed in Table 2. Drugs most often used by patients who reported Alzheimer’s disease are listed in Table 3. Additional side effects in patients who reported Alzheimer’s disease are listed in Table 4.

Table 1

Age distribution of patients using Flonase, Lipitor, or ibuprofen

Age	Flonase	Lipitor	Ibuprofen
10–19	0	0. 63%	3.70%
20–29	0	0.00%	0.00%
30–39	0	0.63%	3.70%
40–49	0	0.00%	0.00%
50–59	20%	5.70%	3.70%
60+	80%	93.04%	88.89%

Table 2

Most common other conditions in patients who reported Alzheimer’s disease

Flonase	Lipitor	Ibuprofen
Trigeminal Neuralgia (1 person, 11.11%)	Sleep Disorder (13 people, 5.35%)	Rheumatoid Arthritis (7 people, 20.59%)
Sinus Disorder (1 person, 11.11%)	Depression (9 people, 3.70%)	Preventive Health Care (6 people, 17.65%)
Metastases To Spine (1 person, 11.11%)	Diabetes (8 people, 3.29%)	Osteoporosis (4 people, 11.76%)
High Blood Pressure (1 person, 11. 11%)	Osteoporosis (7 people, 2.88%)	Multiple Myeloma (4 people, 11.76%)
Depression (1 person, 11.11%)	Ill-Defined Disorder (7 people, 2.88%)	Chronic Obstructive Pulmonary Disease (4 people, 11.76%)

Table 3

Other drugs most commonly used by patients who reported Alzheimer’s disease

Flonase	Lipitor	Ibuprofen
Aspirin (4 people, 44.44%)	Aricept (47 people, 19. 34%)	Aspirin (14 people, 41.18%)
Zometa (3 people, 33.33%)	Aspirin (21 people, 8.64%)	Lorazepam (10 people, 29.41%)
Lasix (3 people, 33.33%)	Namenda (20 people, 8.23%)	Humira (9 people, 26.47%)
Calcium (3 people, 33.33%)	Plavix (14 people, 5.76%)	Norvasc (8 people, 23.53%)
Albuterol (3 people, 33.33%)	Nexium (13 people, 5.35%)	Cymbalta (7 people, 20.59%)

Table 4

Other common side effects in patients who reported Alzheimer’s disease

Flonase	Lipitor	Ibuprofen
Pneumonia (5 people, 55.56%)	Memory Loss (55 people, 22.63%)	Fall (9 people, 26.47%)
Pain (5 people, 55.56%)	Stroke (24 people, 9.88%)	Breathing Difficulty (8 people, 23.53%)
Headache (5 people, 55.56%)	Depression (21 people, 8.64%)	Memory Loss (7 people, 20.59%)
Gastroesophageal Reflux Disease (5 people, 55. 56%)	Diarrhea (20 people, 8.23%)	Drug Ineffective (7 people, 20.59%)
Fall (5 people, 55.56%)	Pneumonia (18 people, 7.41%)	Injury (6 people, 17.65%)

DISCUSSION

One case control study demonstrated that hay fever and other allergies were associated with diminished risk of Alzheimer’s disease (odds ratio 0.6) [17]. Hay fever patients’ use of nasal glucocorticoids might be lessening their risk of Alzheimer’s disease and functioning as a treatment in early cases. Another analysis found no effect of hay fever [18], but subjects’ use of anti-allergy anticholinergics, such as diphenhydramine, may have confused the results by raising risk of Alzheimer’s disease [19].

Both pregnenolone and progesterone arrive in the brain after nasal administration [20]. Intranasal regular insulin improves cognition in Alzheimer’s disease, probably because of its brain effects [21]; and the kinetics of intranasal ACTH suggest that it gets into the brain [22]. Therefore, intranasal fluticasone probably gets into the brain via the nose, as well.

The rodent hippocampus is particularly sensitive to glucocorticoids. While glucocorticoids are essential for an effective stress response, their oversecretion was originally hypothesized to contribute to age-related hippocampal degeneration. However, conflicting findings were reported on whether prolonged exposure to elevated glucocorticoids endangered the hippocampus; and whether the primate hippocampus, where Alzheimer’s disease originates, even responds to glucocorticoids as the rodent hippocampus does [23].

Our use of adverse event drug reports has distinct problems. One problem is that the analysis does not include all those taking Flonase, ibuprofen or Lipitor who did not have any adverse reaction (including Alzheimer’s disease) to any drug they were taking. This problem might be addressed by prescription records (or company sales records) indicating how many took the drug. A big data approach could involve a large national database sample from Taiwan or South Korea, tracking medication usage and later medical diagnoses.

Another problem in our analysis is that those who reported adverse effects were likely also taking other medications, which may be associated with Alzheimer’s disease, either increasing or decreasing the risk (some because they treat a disease that is a risk factor for Alzheimer’s disease). This problem might be addressed more systematically by a big data analysis of MedWatch to seek drugs negatively associated with Alzheimer’s disease. However, it is implausible that the patterns of other medications in our analysis were the same for those taking Flonase, ibuprofen, and Lipitor.

In a previous study, Lerner et al. found that delirium is an initial symptom in about 3% of patients diagnosed with Alzheimer’s disease [24]. Medications are one of the biggest causes of delirium, especially benzodiazepines [25], which were common in patients taking atorvastatin as a concurrent medication. Dementia has been listed as a side effect of atorvastatin (and other statins), but might represent the confluence of two common disorders: hypercholesterolemia and dementia (which is not the same as Alzheimer’s disease).

It is possible that individuals already suffering some degree of dementia would be less bothered by seasonal rhinitis or have less access to over the counter drugs such as fluticasone nasal spray. These phenomena could account for part of the observed lower incidence of Dementia Alzheimer’s type reports in patients using Flonase^®.

Nevertheless, long term use of oral non-steroidal anti-inflammatory drugs is linked with reduced risk of developing Alzheimer’s disease [26]. These drugs also potentially inhibit brain wound healing [2]. We posit that NSAIDS and steroids both inhibit wound healing in the brain (a well-known fact in the periphery). We further suggest that the lower incidence of AD due to NSAIDS and steroids may be through inhibiting brain wound healing. That is, there is an initial event, and the brain response is what causes the dementia which we call “Alzheimer’s disease.” NSAIDS and steroids may be preventive through a wound healing inhibition mechanism. Our hypothesis is consistent with the idea that amyloid and tau and their cascade of pathology are both a brain response linked to the genesis of the problem [4].

In summary, data from MedWatch presented here suggest that fluticasone propionate administered intranasally might have a similar preventive effect to ibuprofen. Glucocorticoids, moreover, inhibit wound healing. Perhaps combining ibuprofen and Flonase could be therapeutic. Further studies would be desirable.

CONFLICT OF INTEREST

The authors have no conflict of interest to report.

REFERENCES

[1]	McManus RM , Heneka MT (2017) Role of neuroinflammation in neurodegeneration: New insights. Alzheimers Res Ther 9, 14.
[2]	Lehrer S , Rheinstein PH (2016) A derangement of the brain wound healing process may cause some cases of Alzheimer’s disease. Discov Med 22, 43–46.
[3]	Lehrer S , Rheinstein PH , Rosenzweig KE (2017) Association of radon background and total background ionizing radiation with Alzheimer’s disease deaths in U. S. states. J Alzheimers Dis 59, 737–741.
[4]	Castellani RJ , Perry G (2014) The complexities of the pathology-pathogenesis relationship in Alzheimer disease. Biochem Pharmacol 88, 671–676.
[5]	D’Andrea MR , Cole GM , Ard MD (2004) The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol Aging 25, 675–683.
[6]	Miguel-Alvarez M , Santos-Lozano A , Sanchis-Gomar F , Fiuza-Luces C , Pareja-Galeano H , Garatachea N , Lucia A (2015) Non-steroidal anti-inflammatory drugs as a treatment for Alzheimer’s disease: A systematic review and meta-analysis of treatment effect. Drugs Aging 32, 139–147.
[7]	Chou RC , Kane M , Ghimire S , Gautam S , Gui J (2016) Treatment for rheumatoid arthritis and risk of Alzheimer’s disease: A nested case-control analysis. CNS Drugs 30, 1111–1120.
[8]	Balis FM , Lester CM , Chrousos GP , Heideman RL , Poplack DG (1987) Differences in cerebrospinal fluid penetration of corticosteroids: Possible relationship to the prevention of meningeal leukemia. J Clin Oncol 5, 202–207.
[9]	Aisen PS , Davis KL , Berg JD , Schafer K , Campbell K , Thomas RG , Weiner MF , Farlow MR , Sano M , Grundman M , Thal LJ (2000) A randomized controlled trial of prednisone in Alzheimer’s disease. Alzheimer’s Disease Cooperative Study. Neurology 54, 588–593.
[10]	Kessler DA (1993) Introducing MEDWatch. A new approach to reporting medication and device adverse effects and product problems. JAMA 269, 2765–2768.
[11]	Craigle V (2007) MedWatch: The FDA safety information and adverse event reporting program. J Med Libr Assoc 95, 224.
[12]	US Department of Health and Human Services eHealthMe study from FDA and social media reports [electronic source]. http://www.ehealthme.com/print/ds15829624
[13]	Salihoglu M , Turhan V , Onem Y , Ulcay A , Uzun G , Ay H (2013) Sudden hearing loss in a patient receiving piperacillin/tazobactam and daptomycin for diabetic foot infection. Scand J Infect Dis 45, 239–240.
[14]	Coloma PM , Becker B , Sturkenboom MC , van Mulligen EM , Kors JA (2015) Evaluating social media networks in medicines safety surveillance: Two case studies. Drug Saf 38, 921–930.
[15]	Feldman HH , Doody RS , Kivipelto M , Sparks DL , Waters DD , Jones RW , Schwam E , Schindler R , Hey-Hadavi J , DeMicco DA , Breazna A (2010) Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe. Neurology 74, 956–964.
[16]	Vlad SC , Miller DR , Kowall NW , Felson DT (2008) Protective effects of NSAIDs on the development of Alzheimer disease. Neurology 70, 1672–1677.
[17]	Shalat SL , Seltzer B , Pidcock C , Baker EL Jr (1987) Risk factors for Alzheimer’s disease: A case-control study. Neurology 37, 1630–1633.
[18]	Breteler MM , van Duijn CM , Chandra V , Fratiglioni L , Graves AB , Heyman A , Jorm AF , Kokmen E , Kondo K , Mortimer JA , et al. (1991) Medical history and the risk of Alzheimer’s disease: A collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int J Epidemiol 20(Suppl 2), S36–S42.
[19]	Risacher SL , McDonald BC , Tallman EF , West JD , Farlow MR , Unverzagt FW , Gao S , Boustani M , Crane PK , Petersen RC , Jack CR Jr , Jagust WJ , Aisen PS , Weiner MW , Saykin AJ , Alzheimer’s Disease Neuroimaging Initiative (2016) Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults. JAMA Neurol 73, 721–732.
[20]	Ducharme N , Banks WA , Morley JE , Robinson SM , Niehoff ML , Mattern C , Farr SA (2010) Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol 641, 128–134.
[21]	Craft S , Claxton A , Baker LD , Hanson AJ , Cholerton B , Trittschuh EH , Dahl D , Caulder E , Neth B , Montine TJ , Jung Y , Maldjian J , Whitlow C , Friedman S (2017) Effects of regular and long-acting insulin on cognition and Alzheimer’s disease biomarkers: A pilot clinical trial. J Alzheimers Dis 57, 1325–1334.
[22]	Lehrer S , Rheinstein P (2015) Two compartment model of MSH/ACTH may be a surrogate for intranasal insulin central nervous system kinetic. https://www.j-alz.com/content/two-compartment-model-mshacth-may-be-surrogate-intranasal-insulin-central-nervous-system
[23]	Conrad CD (2008) Chronic stress-induced hippocampal vulnerability: The glucocorticoid vulnerability hypothesis. Rev Neurosci 19, 395–411.
[24]	Lerner AJ , Hedera P , Koss E , Stuckey J , Friedland RP (1997) Delirium in Alzheimer disease. Alzheimer Dis Assoc Disord 11, 16–20.
[25]	Clegg A , Young JB (2011) Which medications to avoid in people at risk of delirium: A systematic review. Age Ageing 40, 23–29.
[26]	Wyss-Coray T , Rogers J (2012) Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med 2, a006346.

Can ibuprofen be taken with antibiotics? Frequently Asked Questions on Medicine and Health: Doctors' Answers

Ibuprofen is a world-famous drug in the NSAID category, that is, a non-steroidal anti-inflammatory drug, which also has moderate analgesic and antipyretic activity. It is used in various inflammatory processes, often combined with other drugs. But can ibuprofen be taken along with antibiotics?

The best way to determine if you can take any medications together is to consult with your healthcare provider and get tested for drug interactions to avoid risks. nine0003

Some antibiotics can react with ibuprofen to cause serious stomach and kidney damage. In some cases, there may also be a risk of bleeding. That is why it is extremely important before using ibuprofen with antibiotics, be sure to check with your doctor: how justified and safe will it be in your particular case?

Please note!

Ibuprofen should not be used with quinolone antibiotics because they can react with each other and cause severe convulsions in a person. nine0003

Quinolones are a large group of medicines that contain fluoroquinolones (synthetic antibiotics). These include:

pipemidic, oxolinic and nalidixic acids;
ofloxacin, norfloxacin, ciprofloxacin, lomefloxacin, pefloxacin;
sparfloxacin, levofloxacin, marbofloxacin;
gemifloxacin, gatifloxacin, moxifloxacin, delafloxacin, sitafloxacin and trovafloxacin.

Do not combine ibuprofen with the above substances, as this can be life threatening! nine0003

Fluoroquinolones are extremely powerful drugs that can have serious effects on the central nervous system. Ibuprofen also affects the central nervous system, so when combined, there may be unpredictable reactions. It is also important to know that each fluoroquinolone-containing drug has an individual reaction with each type of non-steroidal anti-inflammatory drug (NSAID), which makes the problem even more obscure and dangerous. Therefore, there is a general ban on the use of ibuprofen along with any form of quinolone antibiotics. nine0003

Do not use antibiotics without first consulting a doctor about this topic, as self-medication can have a negative impact on your health and exacerbate the healing process.

Sources

Can you take ibuprofen with antibiotics? / Drugs.com (English)

Effects of anti-inflammatory drugs on convulsant activity of quinolones: a comparative study of drug interaction between quinolones and anti-inflammatory drugs / PubMed (English)

Quinolone antibiotics / NCBI (English) ) nine0003

Medical specialties / National Medical University named after O.O. Bogomoltsya (Ukrainian)

Safety of ibuprofen instillation in pediatric practice / Ukrainian Medical Chronicle (English)

Online: 08:00 - 21:00, seven days a week

What ibuprofen is for

Ibuprofen is used for the symptomatic treatment of pain of various etiologies, reduction of fever and mild inflammation. How to take ibuprofen is decided by the doctor on an individual basis. nine0003

Is ibuprofen an antipyretic?

Yes, the drug reduces the temperature during fever, and also has analgesic and anti-inflammatory effects.

Indications for the use of ibuprofen

Ibuprofen is indicated for:

high fever in adults and children;
headache;
toothache;
migraine;
dysmenorrhea;
neuralgia;
muscle pain;
joint pains; nine0016
arthrosis;
menstrual pain;
mild forms of arthritis;
symptoms of colds and flu;
soft tissue inflammation;
bruises, injuries.

For more information about what helps and how to take ibuprofen, you can additionally ask your doctor.

What ibuprofen tablets are for

Ibuprofen tablets are used to reduce body temperature, relieve headaches and various inflammations (ibuprofen is used for muscle pain, joint inflammation). nine0003

What ibuprofen ointment is for

Ibuprofen in the form of ointments and creams is used topically for joint and muscle pain.

What ibuprofen injections are for

Injectable ibuprofen is not available on the Ukrainian market.

Does ibuprofen help with fever

Yes, ibuprofen helps with fever, but it only reduces it without affecting the cause of hyperthermia.

How to use ibuprofen

Your doctor will tell you what ibuprofen helps and how to drink it correctly. If it is not possible to contact a specialist, you should carefully study the instructions for a specific drug with ibuprofen in the composition. nine0003

How to take ibuprofen for adults

An adult is given an initial dose of ibuprofen of 200-400 mg, if necessary, then the same dosage is given every 4-6 hours. As an antipyretic and pain reliever, ibuprofen is very effective. Cream and ointment with ibuprofen are applied 3-4 times a day. They should be applied in a thin layer to the affected area, gently rubbing into the skin with light massaging movements.

How long does it take for ibuprofen to work in adults

On average, ibuprofen starts working 30 minutes after ingestion. In adults, the maximum concentration of the substance in the blood is reached 1-2 hours after oral administration. nine0003

When ibuprofen starts to work in children

Many parents wonder how quickly ibuprofen reduces fever in children. The hypothermic effect of the drug occurs on average one hour after the drug is taken orally, and the maximum concentration of the drug in the blood occurs after 2-4 hours. The duration of action of ibuprofen is individual and depends on many factors.

How long does it take for ibuprofen to act on inflammation? When ibuprofen starts to act is a purely individual question, which depends on the characteristics of the body and the severity of the inflammatory process. It is important how to drink ibuprofen (follow the rules of admission) and follow other doctor's recommendations, for example, immobilize the inflamed limb as much as possible. nine0003

Ibuprofen - pain reliever or not?

Yes, this drug has analgesic properties.

How long can I take ibuprofen

The maximum amount of the drug that can be taken per day is 1.2 g. It is not recommended to take a second dose of the drug earlier than 4 hours after the first use. The duration of the drug without a doctor's prescription should not exceed 5 days.

How fast ibuprofen works

The medicinal effect of the use of ibuprofen occurs very quickly, in comparison with other non-steroidal anti-inflammatory drugs. After oral administration of the drug, ibuprofen shows an analgesic effect in about half an hour, and a hypothermic effect in an average of an hour.

Does ibuprofen help with colds

It is not uncommon for people to take ibuprofen at the first sign of a cold, believing that it will stop the disease from progressing. This is a delusion that can hurt. Ibuprofen for colds does not have a curative effect, but only eliminates certain symptoms without affecting the cause of the disease (headache, fever). That is why taking ibuprofen for a cold without a temperature is not recommended - the remedy simply will not have a therapeutic effect and can even harm. Your therapist or pediatrician will tell you how to take ibuprofen for a cold and choose the right dosage. If it is not possible to consult a doctor, the use of ibuprofen tablets for colds should not exceed 1200 mg per day and last more than 5 days. nine0003

Is it possible to drink ibuprofen at a temperature

Yes, you can, but you should lower the temperature if it is 38.5 degrees and above.

Ibuprofen for children with fever

The daily dose of ibuprofen for children varies depending on their age and weight.
Ibuprofen for a child over 12 years of age is prescribed in the amount of 150-300 mg up to three times a day. Further, the dosage can be reduced to 100 mg three times a day.

Oral suspension calculation: 5-20 mg per 1 kilogram of body weight. This dosage can be given up to three times a day. nine0003

Correspondingly:

Children 3-12 months on average 50 mg up to four times a day.
Children 1-3 years old - 100 mg up to three times a day.
Children 4-6 years old average 150 mg up to three times a day.
Children 7-9 years old, 200 mg up to three times a day.
Children 10-12 years old - 300 mg up to three times a day.

Ibuprofen at a temperature of 39 degrees is prescribed at a dose of 10 mg/kg per day, if the temperature is below 39.2 degrees - 5 mg/kg per day. nine0003

Ibuprofen lowers the temperature in febrile syndrome after immunization at a dosage of 50 mg, after six hours, if necessary, you can repeat the application at the same dosage, without exceeding the maximum daily dose (100 mg).

How long ibuprofen works

When taken orally, ibuprofen begins to show medicinal activity on average half an hour after ingestion and lasts 4-6 hours. The drug is completely eliminated from the body after 24 hours.

How to take ibuprofen at

Ibuprofen brings down body temperature, therefore it is often prescribed for hyperthermia. Adults are advised to use the drug at a dosage of 200-400 mg up to four times a day, not exceeding a daily dose of 1200 mg. Depending on the individual characteristics of the organism, the rate of onset of the therapeutic effect also changes: the dosage of ibuprofen at a temperature of 400-600 mg per day can eliminate hyperthermia. In acute cases, the highest daily dose of ibuprofen at a high temperature may be exceeded up to 2400 mg as directed by a doctor. nine0003

For children under 12 years of age, ibuprofen in suspension can be used.

Retard forms are prescribed 1-2 times a day, as they are long-acting drugs.

Is it possible to drink ibuprofen at a temperature of 37°

It is possible, but not necessary. An increase in body temperature indicates the body's struggle with the pathogen, in addition, such a temperature does not threaten human life. If you bring down the already low temperature, you can prevent the immune system from fighting the pathogen. nine0003

At what temperature to drink ibuprofen

Taking ibuprofen at a temperature of 37 degrees does not make sense, since an increase in body temperature means that the body is fighting the pathogen. Drinking ibuprofen tablets is necessary if the body temperature exceeds 38.5 degrees, or is accompanied by an unbearable headache and convulsions.

Is it possible to drink ibuprofen if there is no temperature

The drug is used not only to reduce body temperature, but also to relieve pain. Therefore, if you are worried about headache, toothache, menstrual and other types of pain, this is an indication for the use of ibuprofen. nine0003

How to take ibuprofen when you have a high temperature

It is important to calculate the correct dose before use. The maximum dosage of ibuprofen at a temperature for an adult is 1200 mg, divided into 2-3 doses. How to take ibuprofen for children is prescribed by a pediatrician, as a rule, at the rate of 20 mg / kg of body weight, divided into 3-4 doses. The drug should be washed down with a small amount of clean water.

Why ibuprofen doesn't bring down the temperature

If ibuprofen does not bring down the temperature well, the drug or its dosage may have been incorrectly selected. If everything is chosen correctly, and the temperature does not drop (especially high values \u200b\u200bare kept for more than a few days), you should immediately consult a doctor. nine0003

Ibuprofen for newborns

Ibuprofen for babies is prescribed exclusively by a doctor. It is not recommended to give ibuprofen to infants weighing less than seven kilograms.

How often can ibuprofen be given to a child

The drug can be given to a child up to four times a day, observing a six-hour interval. It is important not to exceed the maximum daily dose calculated individually for the baby, depending on his age and weight. It is not recommended to use the drug for more than five days in a row. nine0003

If ibuprofen does not bring down the temperature

If ibuprofen does not bring down the temperature, it is important to check the correctness of the calculated dose, and also take into account how much time has passed since taking the drug. In the case of correct dosing and a sufficient amount of time after the use of the drug, you can try to supplement therapy with drugs based on paracetamol. If all else fails, it is recommended to call your doctor. If ibuprofen does not bring down the high temperature in the child, and the situation is critical, call an ambulance. nine0003

How long does it take for ibuprofen to bring down the temperature

When taking the drug, few people know how long it takes ibuprofen to bring down the temperature, and they start to panic if this does not happen after 5-10 minutes. If the dosage has been calculated correctly, the drug will show a hypothermic effect in about an hour. Based on the characteristics of the patient's body, this time may vary slightly.

Which is better for temperature: ibuprofen or paracetamol

The answer to this question depends on several factors. Ibuprofen and paracetamol tablets have an antipyretic effect, however, unlike paracetamol, ibuprofen has an anti-inflammatory effect. Ibuprofen and paracetamol are prescribed to reduce fever, as well as eliminate pain of various etiologies - dental, menstrual, headache, muscle and articular. The advantage of paracetamol is the possibility of its use during pregnancy, lactation, in childhood and old age due to safety and low incidence of side effects. In addition, the drug can be used in combination with other medicines. Ibuprofen is advisable to use if you need not only to reduce the temperature, but also to relieve inflammation and pain. Paracetamol is less effective in severe pain syndrome. nine0003

Which is better for headaches paracetamol or ibuprofen

When choosing which is better to drink for headaches - ibuprofen or paracetamol, it is important to consider the following factors:

paracetamol is approved for use during pregnancy and lactation;
ibuprofen has a more pronounced analgesic effect, while relieving inflammation;
both drugs are approved for use in children;
paracetamol has a less pronounced effect on pain; nine0016
ibuprofen is not recommended for use during the third trimester of pregnancy.

How much ibuprofen to drink at a temperature

The maximum daily dose of ibuprofen is 1200 mg, in severe cases it can be increased according to the doctor's prescription. The medicine should be drunk with a time interval of six hours, preferably in 3-4 doses. Retard forms (drugs with a slow, modified release) are prescribed 1-2 times a day.

Can ibuprofen be used during pregnancy

In the 1st and 2nd trimester of pregnancy, ibuprofen is used only on prescription. This is due to an increased risk of developing genital disorders in male newborns (cryptorchism), and in girls - a decrease in ovarian reserve. The use of several non-narcotic painkillers (paracetamol, aspirin and ibuprofen) at the same time during childbearing significantly increases the likelihood of developing pathologies in the fetus and side effects in the mother.

The use of ibuprofen during pregnancy in the 3rd trimester is contraindicated as it may cause premature closure of the ductus arteriosus in the fetus. Like any other drug, ibuprofen should only be prescribed to pregnant women by the attending physician, taking into account the potential risk and expected benefit. nine0003

Ibuprofen when planning a pregnancy

Non-steroidal anti-inflammatory drugs such as ibuprofen can potentially affect fertility and should be used with caution when planning a pregnancy.

Ibuprofen ointment during pregnancy

According to the instructions, ibuprofen in external preparations (ointments, gels) is not recommended for use in the third trimester of pregnancy. Ibuprofen can be used externally in the first and second trimester only on prescription. nine0003

Is it possible to breastfeed ibuprofen

As a result of studies, it was found that ibuprofen passes into breast milk, but in such small quantities that it does not cause any negative consequences for the health of nursing mothers and the child. However, ibuprofen for HB is recommended for short-term use.

Therefore, to the question “Is it possible to breastfeed ibuprofen?” you can answer yes, but it is advisable to consult a doctor before that. Ibuprofen is one of the drugs of choice as an analgesic during lactation. nine0003

Ibuprofen ointment for breastfeeding

Ibuprofen for lactating mothers can be used externally in the form of an ointment, gel or cream. Even when taken orally, the drug passes into breast milk in small quantities, and even more so when taken locally. If you need long-term use of the drug (in any dosage form), you should consult your doctor.

Does ibuprofen help with menstruation

Yes, it is widely used as a pain reliever for painful periods. Ibuprofen helps with period pain by blocking the production of both forms of the cyclooxygenase enzyme, and by acting on the hypothalamus, it reduces inflammation. For abdominal pain, ibuprofen can be taken at 200-400 mg every 6 hours, not exceeding 1.2 g per day. Ibuprofen for painful periods is the drug of choice along with paracetamol. nine0003

Does ibuprofen help with toothache

Ibuprofen is used quite often for toothache, as it quickly relieves pain and reduces inflammation. Ibuprofen is also prescribed for children with toothache. However, it should be borne in mind that this remedy only eliminates the pain, and not the problem, so you can take it to endure until the dentist. Ibuprofen helps with toothache for an average of 4-6 hours, after which it can be taken again. It is undesirable to exceed the daily dosage of 1200 mg. nine0003

Ibuprofen for concussion

The drug may be prescribed for concussion as a symptomatic remedy for severe headache. However, the remedy can only be used as part of complex drug therapy, including the gradual return of physical and social activity.

Does ibuprofen help with headaches

Yes, ibuprofen is great for headaches and migraines, relieving pain by blocking the production of cyclooxygenases “responsible” for feeling pain. However, if the drug does not have an analgesic effect, or the head does not stop hurting for a long time, you should consult a doctor for professional diagnosis. nine0003

Ibuprofen for headaches in children

Many parents wonder if ibuprofen will help with headaches in children and if it is safe. Yes, the drug is prescribed for children from infancy, if the child's body weight exceeds 7 kilograms. It is important to consider that if a child complains of a headache for a long time, an urgent need to contact a pediatrician, as this may be a symptom of some disease.

Ibuprofen for kidney pain

Ibuprofen for kidney pain can be used as an analgesic that will relieve acute pain before the arrival of an ambulance (renal colic). With renal colic, pyelonephritis may develop, accompanied by an increase in temperature, which can be reduced by ibuprofen. nine0003

Important! The drug does not treat the kidneys, and renal failure is a direct contraindication to use, therefore ibuprofen should be used with great caution in case of inflammation of the kidneys.

Ibuprofen for acute respiratory viral infections and influenza

Ibuprofen is used for influenza and acute respiratory viral infections as a means that effectively and quickly reduces fever and relieves headaches. It must be remembered that ibuprofen does not cure influenza and SARS, but only eliminates their symptoms. In addition, the drug is not recommended for use at body temperatures below 38.5 degrees. This temperature is a normal reaction of the body to the pathogen, its increase means that the body is fighting the pathogen. nine0003

Ibuprofen for neuralgia

According to the manufacturer's instructions, ibuprofen is used for various neuralgias (including intercostal neuralgia and trigeminal neuralgia). The drug reduces acute pain, but does not cure pathology. It is used in combination with other drugs: for example, for primary neuralgia, B vitamins are prescribed, and for trigeminal neuralgia, anticonvulsants (which also have an analgesic effect). Secondary neuralgia requires mandatory therapy for the underlying disease. nine0003

Ibuprofen for hemorrhoids

The drug can be used for inflammation of hemorrhoids and anal fissures as an analgesic. The drug has an anti-inflammatory effect, and also quickly reduces the temperature that can occur with the above pathologies. Important! The remedy relieves the symptoms of the disease, but does not cure the disease - local healing ointments and oral capillary-stabilizing drugs are recommended for full therapy. In severe cases, surgical treatment is indicated. nine0003

Does ibuprofen help with cystitis

Ibuprofen for cystitis is used by many people who suffer from acute pain. If you drink the remedy on an empty stomach, the pain will subside after 30 minutes, if after eating - after an hour and a half. It should be understood that ibuprofen does not cure cystitis - it can temporarily anesthetize and reduce low-grade fever, which periodically occurs with cystitis. In addition, the use of a drug can blur the clinical picture and make it difficult for a specialist to diagnose the pathology. Therefore, it is undesirable to take the remedy before consulting a doctor. nine0003

Post-abortion ibuprofen

Can be used after a miscarriage as prescribed by a physician as a pain reliever for mild to moderate pain.

Ibuprofen for angina

The drug is used to reduce body temperature in acute tonsillitis. Depending on the type of sore throat, symptoms differ, for example, the presence of body aches and the degree of fever. Severe hyperthermia (39-40 degrees), headache, joint and muscle pain are characteristic of follicular and catarrhal tonsillitis. The use of ibuprofen for pain in the joints, muscles and headache in this case is relevant, because the temperature rises above 38.5 degrees. nine0003

Catarrhal angina is accompanied by a slight temperature (usually subfebrile) and less pronounced symptoms. In this case, the use of ibuprofen is impractical and may even be harmful.

Ibuprofen for back pain

Ibuprofen for back pain is given as a tablet, ointment or cream. Since it is a non-steroidal anti-inflammatory drug, it temporarily relieves pain and reduces inflammation. For pathologies of moderate severity, ibuprofen tablets for back pain and ointment in combination are prescribed for pain relief. Ibuprofen ointment is also relevant for back bruises. Important! The drug will not cope with severe pathologies, in this case, complex treatment is necessary. nine0003

Ibuprofen for ARVI

The use of ibuprofen is advisable only if the body temperature reaches 38.5 and above. Accordingly, if the course of SARS is mild, then there is no need to take ibuprofen.

Ibuprofen for hangovers

Hangovers are often accompanied by unpleasant symptoms, including severe headaches. To the question “Is it possible to drink ibuprofen for a hangover headache?” can be answered positively, because the remedy shows a very fast analgesic effect. The drug does not relieve alcohol intoxication, but it helps to cope with a headache. You can take up to 1200 mg per day with breaks between doses of 4-6 hours, depending on the dosage. nine0003

Why you shouldn't use ibuprofen for chickenpox

Chickenpox is often accompanied by fever. Many people wonder if it is possible to drink ibuprofen with chickenpox to eliminate the fever. According to studies, the use of ibuprofen for chickenpox can lead to the development of serious side effects, such as severe skin infections.

The risk of developing necrotizing fasciitis due to bacterial skin lesions is low, but ibuprofen should not be risked for the treatment of chickenpox fever. It is recommended to opt for paracetamol. nine0003

Ibuprofen for prostatitis

The drug is used in the treatment of prostatitis in combination with other drugs (antibiotics, zinc preparations, enzymes, immunomodulators) and physiotherapy. Before long-term use of NSAIDs, it is recommended to consult a doctor.

Ibuprofen for arthritis

The drug is widely used in the treatment of inflammatory and degenerative diseases of the musculoskeletal system. Ibuprofen is used for rheumatoid arthritis, spondylitis, ankylosing arthritis. It is also included in the complex of drugs that are used for these types of arthritis:

juvenile chronic;
psoriatic;
arthritis in SLE;
gouty.

The drug helps to eliminate the pain syndrome that accompanies the pathology, but the disease does not cure and does not affect the progression of the disease.

Ibuprofen for sore throat

Ibuprofen for sore throat does not help, but can be taken to relieve symptoms that may accompany it (for example, fever with SARS or headache)

Ibuprofen for stomach pain

Ibuprofen for stomach pain is not used. On the contrary, contraindications to the drug include pathologies of the gastrointestinal tract, accompanied by pain:

peptic ulcer of the stomach and duodenum;
ulcerative colitis (Crohn's disease).

In addition, ibuprofen has ulcerogenic activity and can cause heartburn, nausea, vomiting, diarrhoea, flatulence and increase stomach pain. With caution, ibuprofen is used for gastritis. nine0003

Ibuprofen for back pain

Topical use of ibuprofen for back pain caused by bruising, as well as myalgia, arthralgia, neuralgia and sciatica. The remedy temporarily relieves pain and inflammation, but should not be used as monotherapy, but only in combination with other drugs. In case of severe back pain, a doctor's consultation is necessary.

Ibuprofen for pancreatitis

It is recommended to take the remedy for pancreatitis only if the patient has previously taken enzymes, but they did not have the necessary effect on the body. It is necessary to resort to the use of NSAIDs as needed and to abandon long-term use without medical supervision. nine0003

Ibuprofen for sinusitis

Ibuprofen for inflammation of the maxillary sinuses is used for significant hyperthermia. It is recommended to use the drug if the temperature exceeds 38.5 degrees. In addition, the medicine temporarily reduces the pain caused by sinusitis. Ibuprofen with a cold without pain and fever is not used.

Ibuprofen high blood pressure

Ibuprofen high blood pressure should be used with caution. The drug is not used to influence blood pressure, however, one of the possible side effects of ibuprofen is an increase in pressure. Hypertensive patients who regularly take antihypertensive drugs should drink ibuprofen in the smallest possible quantities, as it can reduce the effectiveness of antihypertensive drugs. nine0003

Ibuprofen for osteochondrosis

Ibuprofen for cervical osteochondrosis and spinal osteochondrosis is used as part of complex therapy as an anti-inflammatory and analgesic agent. You can use oral and external forms of the drug for treatment. With exacerbation of osteochondrosis, ibuprofen is used at 200-400 mg 2-3 times a day. Do not forget that medication should be combined with bed rest, physiotherapy and the use of special corsets when moving. nine0003

How many days to drink ibuprofen for osteochondrosis

It is recommended to take ibuprofen for osteochondrosis and osteoarthritis no longer than five days, not exceeding the dosage of 1200 mg per day. Further use of the drug should be agreed with the doctor.

Ibuprofen for otitis media

The use of the drug in case of an inflammatory process in the ear is advisable only if the pathology is accompanied by severe pain. Ibuprofen for ear pain helps relieve the condition, but does not affect the cause of otitis media. For the purpose of complex treatment, it is recommended to contact an otolaryngologist. nine0003

Ibuprofen for gout

The severe pain associated with gout can significantly impair quality of life. It occurs due to the accumulation of uric acid in the joints, impairing their functionality. Ibuprofen preparations temporarily relieve the pain and inflammation that accompanies gout. It is important to understand that ibuprofen does not cure the disease, but only facilitates its course, so it is important to take it as part of complex therapy and follow a diet.

Ibuprofen for muscle pain

Ibuprofen is often used for muscle pain (myalgia) and myositis. It helps with pain of various etiologies and localizations (in the knees, in the neck, etc.). Tablets and capsules of the drug for adults are used 3-4 times a day, the maximum recommended dosage is 1200 mg. To improve the effectiveness of treatment, ibuprofen can be applied externally in the form of an ointment.

Ibuprofen for abdominal pain

If pain occurs in the abdomen, the cause of which is unknown, do not rashly drink painkillers. For example, ibuprofen for abdominal pain in a child can be harmful if the baby has a history of a stomach or duodenal ulcer, colitis or gastritis. The use of NSAIDs can “blur” the clinical picture and make it difficult for the doctor to diagnose, as well as cause side effects in the form of flatulence, nausea, vomiting, diarrhea, and increased pain. nine0003

Ibuprofen for allergies

The drug is a non-steroidal anti-inflammatory drug and is not indicated for allergies, as it does not have antihistamine properties. However, in some cases, he himself can lead to allergic skin reactions associated with intolerance to the components of the drug. In case of allergy to ibuprofen, the drug should be discontinued.

Ibuprofen for bronchitis

Bronchitis usually causes low-grade fever caused by viruses or bacteria. She doesn't need to be knocked down. However, if it rises above 38.5 degrees, then the use of ibuprofen as an antipyretic drug is advisable. Ibuprofen does not cure cough and bronchitis, so it is important to see a doctor to prescribe an individual complex treatment. nine0003

Ibuprofen for varicose veins

The drug is used in varicose veins to relieve pain and relieve inflammation. It does not treat the cause of varicose veins, therefore it is prescribed in combination with phlebo- and venotonics, anticoagulants, antiplatelet agents, fibrinolytics and antioxidants. The drug without consulting a doctor is recommended to take no longer than five days.

Ibuprofen for viral infection

Recommended for use if body temperature rises above 38.5°C during viral infection. Otherwise, its use may prevent the body from fighting the virus. The drug does not cure a viral infection, but only facilitates the course of the disease. nine0003

Ibuprofen for swollen lymph nodes

This medicine can be used for severe lymphadenopathy accompanied by fever and pain. The drug is a non-steroidal anti-inflammatory drug that alleviates the symptoms of pathology, but does not treat its cause. Lymph nodes can become inflamed due to many reasons, so it is very important to diagnose the disease in time and start complex treatment.

Ibuprofen for inflammation of the appendages

Inflammation of the appendages (adnexitis, salpingo-oophoritis) in the acute phase is manifested by fever up to 38-38.5 degrees, pain in the lower abdomen and malaise. Ibuprofen preparations are prescribed to reduce fever and relieve pain, but the cause of the inflammation must be treated. For this, antibiotics, immunomodulators and physiotherapy are prescribed. nine0003

Ibuprofen for sciatica

Ibuprofen for sciatica (sciatica) is used in conservative medical therapy. The drug relieves pain and relieves inflammation when a nerve is pinched. If non-steroidal anti-inflammatory drugs do not show the expected effect, the doctor may replace them with steroid drugs.

Ibuprofen for herpes

Ibuprofen, unlike acyclovir and valaciclovir, does not have an antiviral effect, therefore it can only be used to relieve pain in herpes. The drug should not be taken longer than 5 days. nine0003

Ibuprofen for lactostasis

In case of lactostasis (stagnation of milk during breastfeeding), the temperature can rise to subfebrile values, the mammary glands hurt during feeding, pumping, and sometimes even at rest. Ibuprofen can be used for pain relief during breastfeeding, as it practically does not penetrate into breast milk and is safe for the baby.

Ibuprofen for mastopathy

Mastopathy is periodically accompanied by soreness and coarsening of the mammary glands, especially in the second phase of the menstrual cycle. Ibuprofen does not cure mastopathy, and there is no such indication for use in the manufacturer's instructions. When using the drug for pain, do not forget about the need for consultation with a doctor and the full treatment of pathology. nine0003

Ibuprofen for heavy periods

The drug does not reduce the amount of blood loss during menstruation, but has an analgesic effect. Therefore, with women's pain, ibuprofen can be used for no longer than five days without a break.

Ibuprofen in oncology

Pain therapy in oncology involves the use of a three-step pain management system (“WHO ladder”). Ibuprofen in the treatment of cancer patients is one of the first-line drugs that are used for mild pain. They also include paracetamol, ketoprofen and diclofenac. In this case, NSAIDs are combined with adjuvant and symptomatic treatment using corticosteroids, antispasmodics and antihistamines. nine0003

Ibuprofen for poisoning

Food poisoning is accompanied by many unpleasant symptoms, one of which is fever and abdominal pain. To the question “Is it possible to drink ibuprofen with abdominal pain if it is caused by poisoning?” you can answer like this: if the temperature is above 38.5 and does not go astray, then you can.

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Can ibuprofen be taken with antibiotics? Frequently Asked Questions on Medicine and Health: Doctors' Answers

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