Botox depression treatment
SAMHSA’s National Helpline | SAMHSA
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SAMHSA’s National Helpline is a free, confidential, 24/7, 365-day-a-year treatment referral and information service (in English and Spanish) for individuals and families facing mental and/or substance use disorders.
Also visit the online treatment locator.
SAMHSA’s National Helpline, 1-800-662-HELP (4357) (also known as the Treatment Referral Routing Service), or TTY: 1-800-487-4889 is a confidential, free, 24-hour-a-day, 365-day-a-year, information service, in English and Spanish, for individuals and family members facing mental and/or substance use disorders.
This service provides referrals to local treatment facilities, support groups, and community-based organizations.
Also visit the online treatment locator, or send your zip code via text message: 435748 (HELP4U) to find help near you. Read more about the HELP4U text messaging service.
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English and Spanish are available if you select the option to speak with a national representative. Currently, the 435748 (HELP4U) text messaging service is only available in English.
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No, we do not provide counseling. Trained information specialists answer calls, transfer callers to state services or other appropriate intake centers in their states, and connect them with local assistance and support.
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Suggested Resources
What Is Substance Abuse Treatment? A Booklet for Families
Created for family members of people with alcohol abuse or drug abuse problems. Answers questions about substance abuse, its symptoms, different types of treatment, and recovery.
Addresses concerns of children of parents with substance use/abuse problems.It's Not Your Fault (NACoA) (PDF | 12 KB)
Assures teens with parents who abuse alcohol or drugs that, "It's not your fault!" and that they are not alone. Encourages teens to seek emotional support from other adults, school counselors, and youth support groups such as Alateen, and provides a resource list.After an Attempt: A Guide for Taking Care of Your Family Member After Treatment in the Emergency Department
Aids family members in coping with the aftermath of a relative's suicide attempt. Describes the emergency department treatment process, lists questions to ask about follow-up treatment, and describes how to reduce risk and ensure safety at home.Family Therapy Can Help: For People in Recovery From Mental Illness or Addiction
Explores the role of family therapy in recovery from mental illness or substance abuse. Explains how family therapy sessions are run and who conducts them, describes a typical session, and provides information on its effectiveness in recovery.
For additional resources, please visit the SAMHSA Store.
Last Updated: 08/30/2022
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Botox was assigned an antidepressant effect
American researchers have found that Botox injections are accompanied by a significant antidepressant effect - and regardless of the injection site and indications for its use. To do this, they analyzed the manifestation of side effects in more than 45 thousand patients who were injected with Botox - both for cosmetic and medical purposes. So far, the exact mechanism of manifestation of such an effect is unclear: as options, the authors of the article in Scientific Reports suggest the effects of Botox at high doses on the central nervous system, as well as the relief of certain symptoms of depression.
The main active ingredients of Botox are part of the group of botulinum toxins - neurotoxins of a protein nature that block signal transmission between neurons and muscle tissue, due to which the latter ceases (partially or completely) to contract. Botox was originally developed to treat facial muscle spasms (or tics), but in the last few years the drug has become very popular in cosmetology: it is used both to smooth wrinkles and to treat excessive sweating.
In cosmetology, Botox is most often injected into the muscles that cover the glabella - the area of the skull between the eyebrows above the nose: smoothing these muscles reduces the number of visible facial wrinkles that appear, for example, when a person frowns (angry or upset). The use of Botox in this case also leads to a curious side effect: some studies conducted in the last ten years indicate a mild antidepressant property of the drug.
As an explanation for this effect, scientists suggest a rather simple mechanism: the smoothing of wrinkles that appear as a result of the manifestation of negative emotions leads to the so-called mimic feedback, according to which a person who does not express negative emotions feels them less often.
This hypothesis, however, is highly speculative: for example, a meta-analysis conducted last year indicated that smiling has little effect on mood.
At the same time, the antidepressant effect of Botox still remains, and if the mimic feedback hypothesis is eliminated, another explanation must be found for it. For this Tigran Makunts (Tigran Makunts) from the University of California at San Diego and his colleagues decided to test whether the antidepressant properties of Botox depend on the injection site.
In total, scientists analyzed data on the side effects of more than 45 thousand patients who were injected with Botox for cosmetic purposes, for the treatment of muscle spasms (in addition to tics, increased salivation and pain in the neck were also indications), as well as for the treatment of, for example, urinary incontinence. The participants, depending on the indications for the use of Botox, were selected as a control group - with the same indications, but with a different treatment.
The analysis showed that participants who received Botox were diagnosed with depression and depressive symptoms 40-88 percent less often than control groups, and this effect did not depend on the injection site: depression and its symptoms were less common than in people who received Botox was administered for cosmetic purposes, and in those who underwent therapy for muscle spasms and pain. In the treatment group for increased salivation and urinary incontinence, however, no effect was found: in the first case, due to a small sample, and in the second, the difference simply turned out to be insignificant (although in both cases there were depressive symptoms when using Botox, albeit and insignificant, but still lower).
Since the antidepressant effect of Botox persists regardless of the injection site, facial feedback is really an unlikely explanation for its existence. As an alternative, the researchers offer several options. First, at high doses, Botox can actually affect the central nervous system: in this case, it directly affects the parts of the brain responsible for regulating mood.
Secondly, the reduction of depressive symptoms may be due to the fact that Botox reduces muscle tension, which is also often associated with depression. Thirdly, in some cases, Botox can act on the root cause of depression - a chronic disease: by relieving the symptoms of the latter, the drug reduces the symptoms of a contributing affective disorder. However, to establish the exact causes, according to the authors, more research is needed.
A 2016 study found that Botox injections were better than conventional electrical sacral nerve stimulation for urinary incontinence.
Elizaveta Ivtushok
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Botox injections save from depression
July 31, 2020 10:46 Julia Rudy
Scientists suggest that injections of the drug break the feedback loop.
Photo by Pexels.
An analysis of the US Food and Drug Administration database, which collects information on side effects of drugs, showed that the effect can be maintained regardless of where Botox is injected.
Botox is a world famous drug based on a bacterial toxin, usually administered to smooth wrinkles, relieve a person from migraines and muscle spasms, as well as excessive sweating and urinary incontinence.
Clinical trials are currently underway to confirm or disprove that injecting the drug into forehead tissue can save many people from depression. By the way, according to the World Health Organization, today in the world more than 264 million people suffer from this condition.
Researchers at the UC San Diego School of Pharmacy and Pharmaceutical Sciences examined the US Food and Drug Administration's (FAERS) Adverse Effects Reporting System database.
The scientists wanted to know that about 40 thousand people reported their condition after Botox treatment, regardless of the reasons for which they chose this particular method of treatment.
In a study published publicly in the journal Scientific Reports, the team found that people who received Botox (in six different locations, not just forehead tissue) reported improved symptoms of depression more often than patients who received Botox. other treatments under the same conditions.
"For many years, clinicians have noted that Botox injections given for cosmetic reasons seem to alleviate depression in their patients," says Ruben Abagyan, co-author of the new paper. forehead breaks the feedback loop that reinforces negative emotions, but we found that the mechanism can be more complex because it doesn't really matter where Botox is injected."
The FAERS database contains more than 13 million volunteer reports of side effects that people have experienced while taking medication.
After selecting 40,000 reports against a number of criteria, the team applied a mathematical algorithm to find statistically significant differences between those who received Botox injections and patients who received other treatments for the same conditions. In the end, the researchers found that depression was 40 to 88 percent less common in patients treated with Botox for six of the eight conditions and eight injection sites.
"This discovery […] supports a new treatment for influencing mood and combating depression, one of the most common and dangerous mental illnesses. It is also based on a very large body of statistical data," said co-author Tigran Makunts (Tigran Makunts).
As a reminder, an ongoing clinical study is investigating the effects of Botox injections in forehead tissue. Abagyan also suggests that in the future it will be necessary to conduct additional clinical trials. They will help determine the best place and dose to administer the medication specifically in terms of treating depression.
