Vyvanse makes me depressed

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  • SAMHSA’s National Helpline is a free, confidential, 24/7, 365-day-a-year treatment referral and information service (in English and Spanish) for individuals and families facing mental and/or substance use disorders.

    Also visit the online treatment locator.

SAMHSA’s National Helpline, 1-800-662-HELP (4357) (also known as the Treatment Referral Routing Service), or TTY: 1-800-487-4889 is a confidential, free, 24-hour-a-day, 365-day-a-year, information service, in English and Spanish, for individuals and family members facing mental and/or substance use disorders. This service provides referrals to local treatment facilities, support groups, and community-based organizations.

Also visit the online treatment locator, or send your zip code via text message: 435748 (HELP4U) to find help near you. Read more about the HELP4U text messaging service.

The service is open 24/7, 365 days a year.

English and Spanish are available if you select the option to speak with a national representative. Currently, the 435748 (HELP4U) text messaging service is only available in English.

In 2020, the Helpline received 833,598 calls. This is a 27 percent increase from 2019, when the Helpline received a total of 656,953 calls for the year.

The referral service is free of charge. If you have no insurance or are underinsured, we will refer you to your state office, which is responsible for state-funded treatment programs. In addition, we can often refer you to facilities that charge on a sliding fee scale or accept Medicare or Medicaid. If you have health insurance, you are encouraged to contact your insurer for a list of participating health care providers and facilities.

The service is confidential. We will not ask you for any personal information. We may ask for your zip code or other pertinent geographic information in order to track calls being routed to other offices or to accurately identify the local resources appropriate to your needs.

No, we do not provide counseling. Trained information specialists answer calls, transfer callers to state services or other appropriate intake centers in their states, and connect them with local assistance and support.

  • Suggested Resources

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    It's Not Your Fault (NACoA) (PDF | 12 KB)
    Assures teens with parents who abuse alcohol or drugs that, "It's not your fault!" and that they are not alone. Encourages teens to seek emotional support from other adults, school counselors, and youth support groups such as Alateen, and provides a resource list.

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    Aids family members in coping with the aftermath of a relative's suicide attempt. Describes the emergency department treatment process, lists questions to ask about follow-up treatment, and describes how to reduce risk and ensure safety at home.

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    For additional resources, please visit the SAMHSA Store.

Last Updated: 08/30/2022

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How depression affects the human body

March 6, 2018, 2:47 pm


The British scientific journal The Lancet Psychiatry published an article about an eight-year study of patients with severe clinical depression. This work reinforced the idea that the disease is associated with inflammatory processes in the brain.

Researchers from the University of Toronto divided the participants into three groups: some had depression for less than ten years, others for longer, and still others who were healthy. Each was checked on a CT scan to see if their gray matter differed. nine0003

Read also

"Psychiatrists should treat depression": three signs of illness and how to avoid it

It turned out that those who had not been treated for depression for ten years or more had elevated levels of a specific inflammatory protein. The same protein is found in Alzheimer's and Parkinson's diseases, which gradually destroy the brain.

Depression is not classified as a degenerative disease, but a study of Canadians showed that it also goes through several stages. This explains why depressive episodes become more frequent and last longer over time. But there's a bright side: Those who took antidepressants didn't see their inflammatory protein increase over the years. nine0003

A study by Canadian scientists once again confirmed that depression is not only a mental disorder, but also actively affects physical health. Previously, other studies have confirmed its association with diseases such as migraine, arthritis, and the impact of depression in pregnant women on infant brain development.


Migraine is like a regular headache, like an uppercut is like a flick. During an attack, it seems as if a nail was stuck in the eye, hair grows into the head with needles, any sound and light become unbearable. Not surprisingly, one in four people with migraines have depression - a reaction of the psyche to suffering. But apparently, the connection between the two diseases is much more complicated. nine0003

Back in 1994, American scientists calculated that depression more than triples the risk of a first migraine. By the age of 33, almost one in two people with clinical depression have a migraine. It turns out that two diseases mutually increase the risks of each other.

True, this does not mean that depression causes migraines. Perhaps they just have a common nature. A 2010 study of distant relatives in the Netherlands points to a possible genetic link between the two diseases. It has also been noticed that migraine sufferers have a low level of serotonin, and one of the causes of depression is just a lack of serotonin. But unlike the statistical association between migraine and depression, these explanations are mere guesswork. nine0003

Broken connections in the brain of babies

Depression undermines health, but even worse, it can change the body of a person who has not even been born yet. This has come to light in several studies of pregnant women with depression and their children after birth.

Read also

Ivanka Trump admitted to suffering from depression after giving birth

It turned out that the amygdala of babies - the area responsible for memory, emotions and decision-making - is connected to other parts of the brain in the same way as in adolescents and adults with depression. nine0003

Someone will object to this that the brain of babies could change due to care and upbringing in the first six months of life. But at the end of 2013, another work was published with the results of a survey of children 6-14 days old. Scientists have also found abnormalities in the amygdala that make babies prone to depression. Most likely, genetics affected, but the depression of mothers during pregnancy also played a role. Therefore, expectant mothers need to monitor their mental health and, if necessary, be treated. nine0003


Recent laboratory studies show that inflammation in depression extends throughout the body, not just the brain. Knowing this, scientists from the University of Calgary decided to test whether depression is to blame for the fact that about one in 12 patients with psoriasis develops arthritis.

Psoriasis is a disease in which the skin becomes covered with raised, red, scaly patches. This is due to the fact that the immune system mistakenly attacks skin cells and inflammation begins. But the nature of psoriasis is not fully understood, and one of the mysteries is why inflammation sometimes spreads to the joints and psoriatic arthritis develops. nine0003

To test whether there is a link between the diseases, scientists have processed more than 73 thousand medical records of people with psoriasis. It turned out that those who also had depression had arthritis 37% more often. Two guesses follow from this. Perhaps psoriatic arthritis can be treated with psychotherapy and antidepressants. It is also possible that depression can provoke other inflammatory diseases.

Read also

Scientists: stress and depression make people addicted to smartphones

All these effects of depression show how important it is to listen to yourself. By 2015, depression was the leading cause of disability, according to the World Health Organization. At that time, more than 300 million people around the world suffered from it, that is, every 25th, and their number is growing from year to year. In Russia, there are even more patients with depression - every 18th inhabitant of the country, and these are only diagnosed cases. Therefore, if the blues do not let go for more than two weeks, be sure to consult a doctor: perhaps this is not just a breakdown and a bad mood. A specialist will help you deal with this. nine0003

Marat Kuzaev

Beware of depression! Should I tell my boss about my illness?

The difference between a depressed person and a healthy person is very simple: in the case of depression, it is almost impossible to enjoy life, be active and experience positive emotions. This mental disorder brings bad mood, fatigue, mental retardation and lack of desire to do anything. It is extremely difficult to work in such a state. Recognizing depression and explaining your condition to others is even more difficult. We share with you the stories of people who have gone through this. nine0003

A year ago, I was diagnosed with an anxiety disorder by a neurologist. By autumn, it seemed that the anxiety had gone into remission - I was calm. But on New Year's Eve there was a short and very stressful project. The working chat in Telegram was bursting with messages. They came constantly - both at 3 am and at 8 am. I dreamed that this chat would just stay in 2020 and never appear again. Then I took sedatives because it was impossible to sleep, but I did not think that I was depressed.

The January holidays passed calmly and routinely. After returning to work, everything started spinning again - and the stress returned.

In the spring, I found out that I had health problems that required an operation. The blues and melancholy continued, but now I thought that the reason was in the diagnosis. In addition, the first priority was urgent medical matters - preparation for the operation. It seemed that as soon as everything ended well, I would become a happy person.

Before the hospitalization, I decided to ask for a week's vacation in order to take all the tests and have some rest. Colleagues picked up communication with clients. But as the guys kept writing and asking questions, I kept doing a lot of work. Now I understand that I overdid it. Colleagues could manage on their own. nine0003

After the sick leave, when I went to work, it turned out that I had a new client in addition to the existing ones - a colleague quit for family reasons, and her project was transferred to me. In the office, this girl was condemned for dropping her business and leaving. She was not understood. It also made me angry at the time. As a human being, I sympathized with her, but I got her projects in poor condition, and this made me angry.

The first week, when I was waiting for the results of the operation and was in touch with the doctors, I was constantly shaking. I thought about taking a break and telling my superiors about my condition. I consulted with one of my colleagues. He replied: “You can only say that it’s hard for you if you are ready to say goodbye to this job.” At the same time, he himself had problems, because of which he was depressed, but also did not say anything to his superiors and did not take a break. nine0003

Depression interferes with work. Any work task causes panic. The body gives out a constant physical reaction - trembling or heat, tension presses on the temples. Super inefficient. Realistically do only something very simple or work with familiar projects. It is difficult to take on large clients, conduct large deals and launches.

There are flashes. Suddenly you become very efficient, like performing well or doing a lot of tasks on your way up. In this state, it is dangerous, for example, to subscribe to KPIs with clients - the view of things is not entirely realistic, and then the depressive mood returns anyway. nine0003

It becomes hard not only to work, but also to hang out. There is stiffness, and alcohol does not help to relax. Probably 70% of jokes are impossible to understand and you just have to smile when everyone laughs. The feeling that all the good that is in me, in my head, is hidden under a layer of darkness and it is impossible to break through it.

I often compare myself with other people who are also in a difficult situation and cope with it. It seems that it is not possible to export only from me alone. It seems that I am afraid to face not only external stigma, I blame myself internally for what is happening. nine0003

Now I have changed my psychotherapist, I am taking antidepressants and waiting for the result. At work, I never said that I had a depressive-anxiety disorder.

* The heroine's name has been changed

In total, my depression has lasted 16 years. Exacerbations happen quite often and take several months. I worked in the office for about 6 years. I did not tell the employer, I was shy. The official hospital with a diagnosis of "depression" did not ask the doctors and just drank the medicine. Therefore, when exacerbations occurred, she often lied that she was poisoned or something else happened. Or came home from work, overeat, drank wine and slept until the morning. Then it was necessary to suffer for 8 hours at work and you can sleep again. But, in general, this is a so-so strategy. Because of this, she left the office for project work and freelance work. nine0003

Freelancing is easier: in remission, I try to earn a financial cushion and do not take long-term projects. If all of a sudden I am running a long-term project and an aggravation begins, I finish everything on moral and strong-willed efforts and do not start anything new. It was difficult to accept that my resource is limited and sometimes I can’t work at all, but only stare at the wall. There are signs by which I already understand when the battery is running out and it is necessary to complete current obligations and look for something that will give a resource. Or, if there is no strength for this, the doctor corrects the therapy - and I'm waiting for improvement lying down. nine0003

The employer, with whom I constantly do projects, knows about my depression - I told him everything honestly when it came to transferring me to a permanent salary instead of project work. He does not always understand, but he accepts and for some reason still works with me. Although he himself adheres to the position "in the army it becomes easier for everyone." I keep stubbornly refusing the constant so as not to let him down and drive myself into a corner with guilt.

In terms of money, of course, it comes out less and not so stable. But my life is dearer to me, and in general, for 5 years now I have been able to balance and twist. nine0003

When the depression started, I was 18 and in college. Then there were more episodes. One happened when I was working in a publishing house. Due to the fact that we had a friendly team, I was able to transfer most of the processes, push everything away from me to just lie down. But even then I had to work, just less. It was terrible anyway. Each action - such as opening the mail - already required enormous efforts, it seemed unbearable, and even writing a letter ... I told the authorities about depression in general terms, it didn’t really bother anyone and didn’t affect the attitude towards me. nine0003

Depression was difficult, I had to overcome myself. Managed with the support of family and friends. I tried to relax, put off work, contact people.

To minimize the risk of depression, I try to listen to the slightest bells, and it is even better not to bring them to my attention. I try to make my life varied and fulfilling. Quite simple things help: food, sleep, walks, people, books, sports.

If you don't have the strength for it, you have to lie down. It's so hard to work, I can't do much in this state and therefore I try not to take projects. As soon as strength appears, I try to invest it in something useful - try to cook something balanced (vegetables, cereals) or walk, go out, maybe even swim in the pool - in general, do something that will fill me up later and let it last for a while. I try to do something simple - wash my face or wipe the table - and be sure to praise myself for it. It is important not to devalue your condition. nine0003

I took antidepressants for a long time, but I have already stopped them. I'm lucky that I can somehow manage without them, but for many without the support of pills, it's completely impossible, and this is also normal.

I have been diagnosed with a depressive disorder. At that time I was already in psychotherapy, and my therapist referred me to a doctor who prescribed antidepressants.

At work I didn't say anything, didn't consider it necessary. Actually, the work saved me: I had to go to it, and then one question appeared, another - you look, and already got involved. It was rather scary to go home, where I was alone and everything could worsen. Here, probably, the key point is that I like what I do, and my company is very humane. Elsewhere, the situation could only get worse. nine0003

In a state of depression, sometimes it took a lot of strength to get together to do something. Especially new and incomprehensible. The illness lasted for about a year. I took medication and continued to go to therapy. I hope that this material will help other people, I think this is an important topic.

In world practice, more and more people openly talk about depression and adjust their professional plans because of this disease. For example, Japanese tennis player Naomi Osaka recently refused to participate in Roland Garros, and the youngest British MP, Nadia Wittom, went on vacation due to post-traumatic stress disorder and tweeted about it. nine0003

In Russia, the disease is still surrounded by stigma and guilt. Usually it is not customary to talk about it at work, where the employee is expected to effectively fulfill contractual obligations. The problem is that an employee with depression needs the help and support that the company can provide, and ignoring the problem affects not only the person's personal life, but often also business performance.

“It is impossible to give a definitive answer as to whether or not to tell management that you have clinical depression. It all depends on the culture of the company and how it relates to human health, says Marina Lvova, Director of Organizational Development HeadHunter .

Marina Lvova, Director of Organizational Development HeadHunter

If the company culture allows you to explain what is happening to you, and you trust your manager, you definitely need to talk about it and get support. Perhaps the company has access to psychologists or the HR department knows where to turn.

If you work in an organization with a fairly rigid structure and understand that you will be pressured after such a recognition or that you may lose your job, I would recommend not to speak, but to think about why you are in such an environment at all. nine0003

In any case, first of all, you need to take care of your health, because depression requires treatment. Only a doctor can diagnose it. If you are at the stage where you can combine treatment and work, keep working. If it’s hard for you and you can’t get out of bed, take sick leave or write an application for leave without pay - in this case, your condition is primary. ”

If you decide to take a breather, it is important to know that an official sick leave with a diagnosis of depression can only be issued by a neuropsychiatric dispensary or a psychiatric hospital. In other cases, sick leave may be issued for another reason. nine0002 In the fall of 2020, the State Duma proposed giving paid days off with a doctor's report on depression. The initiative is based on data from the Organization for Economic Co-operation and Development, according to which the productivity of an employee who is in a state of depression is reduced by four times. Whether this proposal will be accepted is not yet known, but it is a good step to help employees of companies experiencing this problem.

Being depressed and having to keep working is, of course, difficult. This is confirmed by the stories of our heroes. If you find yourself in this situation, the most important thing is to take care of yourself as much as you can now. nine0003

Talks about how you can support yourself Maria Shumikhina, psychologist, executive coach, member of the board of the International Association for the Psychoanalysis of Business and Organizations :

Maria Shumikhina, psychologist

“If you find symptoms of depression in yourself, try to seek professional help as soon as possible. Of course, you will be told stories about how depression was cured by meditation and douches, but it’s not a fact that you have enough time to try all the random recommendations. Unfortunately, very often depression, which is not treated, ends with a loss of working capacity. nine0003

Once diagnosed, it is important to understand that depression is a long marathon and how you take care of yourself and your ability to keep running will determine your destiny. You are the author of the most important part in the recovery process. A psychiatrist selects medicines, and your part of the job is not only to drink them, but also to be aware of the process of change, learn to listen to yourself.

Psychotherapy will help process traumatic experiences and teach sensitivity to one's condition. Often people, especially those most prone to burnout, lack self-compassion, and without self-support, we can rarely handle high overload. nine0003

In the process of psychotherapy, among other things, we learn not to succumb to the cognitive distortions that we find ourselves in during depression. They are quite easy to identify if you understand this mechanism: depression makes a person think in a certain way, gives him a specific view of reality.

This “voice of depression” says:

  1. “You are the problem” (guilt and shame come to the fore during depression).
  2. "Everything makes no sense, there is no solution, everything is already useless." nine0150

In a healthy person, such experiences are balanced by a more complete picture of the world and oneself. If the drugs are chosen effectively, these cognitive distortions disappear, “tunnel thinking” goes away, and the ability to look for new solutions appears.

If you need to look for new solutions in your work, healing will allow you to keep this skill. But, if depression is not treated, you can lose the ability to make any decisions.

The state of depression is a period when the body's resources are depleted, and this determines life strategies. Time to invest wisely everything you have: energy and physical strength, money and social connections. The restoration of the body is no less important than the restoration of the psyche. In some countries, recovery through regular physical activity is a prerequisite for receiving insurance-based psychotherapy. A good doctor will also give advice on improving sleep and nutrition. There is, for example, a high correlation between depression, neuroinflammation processes and an increased amount of carbohydrates in the diet. The microbiome (yes, the one that lives in the gut and prefers greens) is on your side in the fight against depression. nine0003

Process optimization is required to be able to stay operational. It's hard to do it alone when you're depressed. Is it possible to discuss at work how tasks will be temporarily redistributed? If yes, this will help you a lot. And a supportive atmosphere at work provides much more loyalty to all employees than forced sick leave or dismissal because it was not possible to redistribute tasks.

If you suspect depression and are unsure whether to see a doctor, the first step may be to complete a questionnaire. We recommend not to delay and if there are signs of the disease, immediately contact a specialist.

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