Medical treatment for depression


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SAMHSA’s National Helpline, 1-800-662-HELP (4357) (also known as the Treatment Referral Routing Service), or TTY: 1-800-487-4889 is a confidential, free, 24-hour-a-day, 365-day-a-year, information service, in English and Spanish, for individuals and family members facing mental and/or substance use disorders. This service provides referrals to local treatment facilities, support groups, and community-based organizations.

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Last Updated: 08/30/2022

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Fighting depression: 10 modern drugs

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Fighting depression: 10 modern drugs

Depression is an urgent problem, the number of visits to doctors is growing every year. It can be solved by contacting a psychotherapist and taking antidepressants . These are drugs that regulate the production of hormones and biochemical processes in the body. It is strictly forbidden to prescribe them to oneself , as these are complex drugs with certain restrictions, side effects effects . The doctor must authorize their appointment and control the intake. We will tell you which of them are the most effective and common in medicine, how many they have pluses and minuses.

What is meant by

depression

Doctors have known it since ancient Greece and Egypt. Hippocrates described it as melancholy - a condition that is accompanied by anxiety, despondency, insomnia, refusal of food, irritability. Most often, the cause is childhood trauma or severe, frequent stress in adulthood. There are many provoking factors: the death of a loved one, deterioration of living conditions, alcoholism, brain diseases. Such cases are referred to as psychogenic depression.

The second type is endogenous. The problem appears not from large external shocks, but because of internal causes. A person is constantly dissatisfied with himself, subjecting himself to criticism. Many patients have panic attacks , haunted by a feeling of fear, anxiety.

How long the period of depression lasts

Many people mistake ordinary periods of low mood for depression. If they do not last long and are quickly replaced by periods of recovery, then we are not talking about a depressive state. The problem is obvious when the symptoms persist for months and dramatically change a person's life. Then you need to see a doctor.

What happens to the body

The most common theory is that there is a malfunction of neurotransmitters located in the brain. These substances transmit signals from neuron to neuron and are responsible for a person's mood. Dysfunction leads to a slowdown in the rate of this transmission and a decrease in the number of neurotransmitters themselves. Serotonin, which is called the "hormone of happiness", suffers the most. For clarity, this biochemical process can be compared, for example, with a drop in blood sugar levels in diabetes mellitus.

How is

treated depression

Depression has been treated in different ways. In the ancient world - emetics and laxatives. In the Renaissance - wine and sunbathing. In the Age of Enlightenment - external stimuli, for example, insects. The 19th century brought new recipes - in particular, a solution of camphor in tartaric acid. The treatment also included the use of drugs, which are now no longer allowed for sale, and some are recognized as narcotic.

Obviously, all these drugs had no effect on increasing the amount of serotonin. And the treatment is precisely to normalize its production. This was done after creating modern antidepressants , which have a minimum of side effects, are safe for the body and are not addictive. These are medicines, whose action is aimed specifically at balancing the disturbed balance of neurotransmitters: serotonin, norepinephrine, dopamine.

Prescription

If a healthy person takes antidepressants , there will be no effect . For a depressed patient, taking them will help:

  • improve psychological state;
  • get rid of irritability;
  • panic fear;
  • increase mental and physical activity;
  • overcome the dreary mood.

Psychiatrists prescribe antidepressants for chronic back pain, headaches. And also with irritable bowel syndrome, incontinence and other cases when the body stops producing its own painkillers. Medication helps restore pain suppression mechanisms.

These drugs can only be taken with a doctor's prescription, as many of them are strong stimulants. Self-administration may cost dearly - the condition may worsen. Only a doctor will correctly calculate how many medicines to take per day. In parallel with the treatment by a psychiatrist, a neurologist, a consultation of a psychotherapist is required.

Precautions

  • Prescribed drug start drinking from a small dose - the first couple of days they take a quarter of a tablet. Gradually increase the dose to normal. So the body adapts better. Finish the course by reducing the dose.
  • The first effect of appears only 2 weeks after the start of administration. Sustained action - after six months. All this time, you need to take remedy, without making passes, breaks.
  • Products are not combined with melatonin, St. John's wort, products and dietary supplements based on sibutramine, 5-HTP. Their combination can raise serotonin to dangerous levels. Also, you can not combine them with monoamine oxidase inhibitors, for example, Cipralex. When writing a prescription, the doctor takes these points into account.

  • Drinking antidepressants is better in parallel with visits to a psychotherapist. If the drugs normalize the biochemical processes in the body, then this doctor will help normalize the psychological state after depression.

The best antidepressants

In medicine, they have long argued that some drugs give only a placebo effect. The purpose of the study was to find out which of them are the most effective and valid . The project involved 116 thousand patients, and its results were published by the authoritative edition of the Lancet. We offer a list of the best.

1. Agomelatine

New generation drug. Agomelatine is used for severe depressive disorders, high levels of anxiety. Enhances the release of dopamine and norepinephrine, stimulates melatonin receptors. The standard therapeutic dose is 25-50 mg 1 time / day. Helps to restore the normal structure of sleep, get rid of anxiety and panic attacks attacks

Pros

+ Does not adversely affect attention and memory.

+ No lethargy during the day.

+ No sexual deviations.

+ No relation to blood pressure.

+ Do not reduce dosage upon discontinuation.

Cons

— In 1-10% of cases, increased sweating, diarrhea, constipation.

- Possible increased fatigue, drowsiness.

- There are no evidence-based safety studies in people with renal or hepatic insufficiency, therefore, such patients are advised to refrain from taking drugs with active ingredient agomelatine.

2. Amitriptyline

Tricyclic antidepressant. Moreover, the World Health Organization considers Amitriptyline the most reliable in this group. The standard dose is 200-250 mg / day. The action is to block the reuptake of neurotransmitters. A good remedy for moderate to severe disorders of the endogenous type. Additionally, it has a sedative and hypnotic effect. Effective in the treatment of neuropathic pain, for the prevention of migraine.

Pluses

+ Preparations with active ingredient amitriptyline are inexpensive.

+ High reliability, minimum side effects.

+ Relatively safe during breastfeeding.

Cons

- Possible side effect in the form of blurred vision, dry mouth.

- Lowering blood pressure.

- Some patients experience constipation.

- Drowsiness.

3. Escitalopram

It belongs to the group of modern serotonin reuptake inhibitors (SSRIs). Most often, it is recommended to take for anxiety, panic attacks. It is taken once, the standard dose is 10 mg per day. Escitalopram has a milder effect and is prescribed to patients for whom tricyclic drugs are contraindicated.

Pluses

+ Lasting effect comes after 3 months.

+ Indicated for patients with disorders of the cardiovascular system.

+ Soft action.

Cons

- In some patients, the functions of the gastrointestinal tract are disturbed, which is most often expressed in diarrhea.

- Anxiety may increase during the first 2 weeks, therefore it is recommended to start treatment with low doses and gradually increase them.

- Contraindicated in pregnancy and lactation.

4. Mirtazapine

A drug of the tetracyclic group. Mirtazapine - good stimulant for anxious depressions, has a moderate sedative effect. The average amount is 30 mg / day, it must be consumed once. Usually it is prescribed to patients who lose interest in life, cease to experience joy, pleasure. Effective in the correction of sleep, in particular, early awakenings.

Pros

+ Earlier onset of action than SSRIs (1 week).

+ Works well with most general medicines.

+ Full effect in 4 weeks.

+ Does not affect sexual function.

Cons

- The active substance mirtazapine is contraindicated in diabetes mellitus, arterial hypotension, increased intraocular pressure.

— During the appointment, you must drive carefully and engage in potentially hazardous types of work.

- 18% of patients experience drowsiness, 15% dry mouth, 5% weight loss. Other side effects occur in 1-3% of cases.

5. Paroxetine

Belongs to the SSRI group, is used most often for severe anxiety, panic, social phobia, nightmares, stress after trauma. Paroxetine can resolve the problems of anxious depression, anxiety-phobic disorders. Take once a day at a dose of 20 mg.

Pros

+ The most powerful stimulant among SSRIs.

+ Anxiety and insomnia pass quickly.

+ Minimal side effects in the form of vomiting, diarrhea.

+ Suitable for patients with cardiovascular problems.

Cons

— Not suitable for patients with severe motor, mental inhibition.

- Reduces libido.

- Harmful to the fetus when taken during pregnancy.

6. Fluoxetine

One of the most commonly used antidepressants in the SSRI group. Known as Prozac. Fluoxetine is also known as a good mood stimulant. Patients have a feeling of fear, tension, anxiety, gloomy dislike for others. Depending on the indications, the average daily dose is 20-60 mg.

Pluses

+ There is practically no effect on the work of the heart.

+ Does not cause sedation.

+ Effective for patients with motor retardation and excessive daytime sleepiness.

Cons

- May cause weight loss.

— Hypoglycemia is possible in diabetes mellitus.

- Contraindicated in severe renal impairment.

7. Fluvoxamine

Another SSRI drug. Fluvoxamine is similar to Prozac Fluoxetine but is fast acting and may cost cheaper. The effect is in a more active slowing down of the reuptake of serotonin by neurons. It is indicated for depression of various origins, as well as obsessive-compulsive disorders. The average daily dose is 100 mg.

Pros

+ Lower price than traditional Prozac.

+ Faster action than him.

+ Relatively minor side effects (diarrhea, dry mouth, drowsiness).

Cons

- Contraindicated in diabetes.

- Pregnant women - with caution, lactation - prohibited.

- Causes nausea in some patients.

8. Sertraline

One of the widely used and universal drugs of the SSRI group. They treat almost any depressive condition, panic disorder, social phobia. However, in severe clinical cases, sertraline may not be effective enough. The standard dose is 50 mg/day.

Pros

+ No cardiotoxicity.

+ The patient's psychomotor activity does not change.

+ Does not increase body weight.

+ Combines well with other groups of antidepressants.

Cons

— In the first 2 weeks there may be problems with sleep, diarrhea.

- Side effects of a sexual nature.

- Contraindicated in pregnant women.

9. Escitalopram

The drug is classified as an SSRI. Its difference is in its effectiveness in depression, which is accompanied by involuntary movements (tic, tremor, chewing, smacking). Escitalopram is prescribed to patients with panic, anxiety, phobias, obsessive thoughts or actions. The daily dose is 20 mg.

Pluses

+ Effective in tardive dyskinesia.

+ One of the most powerful SSRIs.

+ More pronounced thymoleptic effect (improvement of mood) compared to many antidepressants of the same group.

Cons

- In some patients, anxiety increases within 2 weeks after starting treatment.

— Gastrointestinal disorders, insomnia, agitation are possible.

— Use during pregnancy only in extreme cases, incompatible with feeding.

10. Venlafaxine

Belongs to the SNRI group. In addition to blocking the reuptake of serotonin, venlafaxine has a similar effect on another neurotransmitter, norepinephrine. The medicine is prescribed for depressive conditions of various origins, social phobias, anxiety, panic. Usually take 150 mg per day.

Pros

+ Better tolerated by patients than most tricyclics.

+ More pronounced effect than classic SSRIs.

+ Fewer contraindications.

Cons

- Traditional side effects of most antidepressants: nausea, drowsiness, dry mouth, diarrhea or constipation.

- May increase eye pressure.

- The most severe withdrawal syndrome among antidepressant drugs.

This list is not to be used as a recommendation. In any case, consult your doctor before purchasing. Be healthy!

Fighting depression 10 modern drugs

Depression is a real problem and the number of doctors is growing year by year. Contact psychosomatic medicine and solve it by taking antidepressants. These are drugs that regulate the production of hormones and biochemical processes in the body. It is strictly forbidden to prescribe yourself because it is a complex drug and has certain limitations and side effects. Physicians must authorize bookings and manage appointments. Here are some of the most effective and most common, how many advantages and disadvantages.

What is meant by depression

Doctors knew from ancient Greece and Egypt. Hipocrates describes restlessness, despair, insomnia, anorexia, and frustration as "melancholy". In many cases trauma in childhood and intense frequent stress since they become adults. There are various factors such as the death of an important person, deterioration of the living environment, alcoholism and brain disease. Such cases are called psychogenic depression.

The second type is internal. The problem is not a big shock from the outside, but from an internal cause. People are always dissatisfied with themselves and are criticized. Many patients experience a panic attack associated with fear and anxiety.

How long does a depressed period last?

Many people confuse normal mood depression with depression. If this state does not last long and is immediately restored, it is not a state of depression. Symptoms continue for several months, and when a person's life has changed dramatically, the problem becomes clear. Then you should see a doctor.

What happens to the body

The most common theory is that the neurotransmitters in the brain are malfunctioning. These substances transmit signals from neurons to neurons, affecting the human mood. Functional impairments cause this decrease in transmission rate and decrease in the irotransmitter itself. Serotonin, called the happy hormone, is the most affected. To make it easier to understand, this biochemical process can be compared to the drop in blood sugar in diabetes.

How depression is treated

There have been various treatments for depression. In ancient times a-vomiting and laxatives. In the Renaissance, wine and sunbathing. Age of Enlightenment - External stimuli, such as insects. In the 19th century, a piece of camphor was dissolved in tabular acid. At present, medicines that are prohibited from being sold and those that are recognized as medicines have been used for treatment.

Obviously, these drugs did not affect the increase in serotonin. And treatment only normalizes its production. This is after a modern antidepressant that has few side effects and does not become safe and becomes dependent on the body. It is a drug that targets a precise balance of a neurotransmitter such as serotonin, noruepinfrin, and dopamine.

Prescription

Even a healthy person takes an antidepressant, it will not be effective. For patients with depression, acceptance can be effective.

  • Improve psychological status.
  • Eliminate disappointment
  • Increased mental and physical activity
  • overcome sadness

Psychiatrists prescribe ant and depid agents for chronic back pain and headaches. Also, even if the painkillers are not produced in the body, such as irritable bowel syndrome and incontinence. Drug therapy helps restore the mechanism that suppresses pain.

These products can only be consumed according to a doctor's prescription because it is a strong stimulus. Independent goals are expensive o-conditions can get worse. Only doctors calculate the amount of medicine to be taken per day. It is necessary to consult with a psychotherapist in parallel with the treatment of psychiatrists and neurologists.

Precautions

  • Start your prescribed medicine at a low dose and take 1/4 tablet for the first two days. Gradually increase and use the normal amount. Thus, the body adapts better. Not enough to complete the course.
  • The first effect appears only two weeks after the start of hospitalization. Sustained effect-After six months, you need to continue taking the medication without interruption, without rest.

Remedies do not combine with Melatonin, St. Jung's Stars, Remedies, Cybbtramin and 5-ADR. These combinations can increase serotonin to dangerous levels. It should not be used in combination with monoamine oxidate inhibitors such as Cypralex. When writing a prescription, the doctor considers these points.

The best antidepressants

In 2017, an international team of scientists conducted a large-scale study on the effects of modern antidepressants. In the medical world, some drugs have long been claimed to be given only as a placebo. The goal is to find out what is the most efficient and active. The project monitored 116,000 patients, resulting in the authoritative Lancet journals. We provide.

1. Latin Island

This medicine is a new generation. Ectylatine is used for severe depression and severe anxiety. Promotes the release of dopamine and noruepinephrine and stimulates melatonin receptors. The standard treatment is e-25-50 mg 1 hour/day. It helps to restore the normal structure of sleep and eliminate anxiety and panic attacks.

+ Does not adversely affect attention or memory.

+ Do not suppress during the day.

+ No sexual deviation.

There is no relationship with blood pressure.

+Don't lose weight as soon as you stop taking it.

In case e-1-10% sweating, diarrhea and constipation increased.

-It may increase fatigue and drowsiness.

-There is no evidence-based validation for the safety of patients with renal and hepatic dysfunction, therefore it is recommended that medicines containing the active substances agoline be avoided in these patients. Increase.

2. Amitripsis

Pe l-Antidepressant. Among the groups, amitripine is said to be the most reliable in the World Health Organization. Standard doses are 200-250 mg/day. Its effect is to suppress the reverse side of neurotransmitters. A good remedy for severe endogenous disorders. In addition, it contains sedative and hypnosis. It is effective in the treatment of neuropathic pain and the prevention of migraine.

+ Products containing amitripline are inexpensive.

+ High reliability, few side effects.

+ It is relatively safe even when breastfeeding.

-There is a possibility of visual dysfunction and side effects of dry mouth.

- High blood pressure

- Patients are constipated.

3. ESSITARO SLUMA

It is staggering, belonging to the group of modern drugs that delay the reversal of serotonin (SIOS). Most often it is recommended to shoot with anxiety and panic attacks. Take 10mg per day once, once. Escitalopram is effective and indicated for patients who are contraindicated for the use of the triple county drugs.

+ Long-term effects occur after 3 months.

+ It is adapted to patients with cardiovascular diseases.

- Abnormal function of the gastrointestinal tract in each patient, which is most pronounced as diarrhea.

-B, during the first two weeks it is recommended to start treatment with a low dose and gradually increase.

-Mated pregnancy and breastfeeding are contraindicated.

4. Mirta Zapin

Tetra-a-cycline based on the preparation. Mirazapine is an anxiety-suppressing stimulant with a mild sedative effect. The average amount is 30 mg/day, after use. It is usually given to patients who have lost interest in life and no longer feel joy or pleasure. Effective for sleep, especially for early growth.

+ Expression effect is faster than Shiore (one week).

+ Good compatibility with most drugs in general groups.

+ Full effect can be obtained after 4 weeks.

+ Do not affect sexual function.

- Mirasapin, the active substance, is contraindicated in diabetes, arterial hypotension and ascending.

- At the reception, you need to pay attention to driving cars and engage in dangerous work.

-18% of patients had drowsiness, 15% dropped out, and 5% lost weight. Other side effects are allowed at the level of 1-3%.

5. Paroxetine

It belongs to the SIOS group, most often used for severe anxiety, panic, social phobia, nightmares and stress after trauma. Paroxetine can solve the problem of anxiety depression, anxiety and phobia. Take 20 mg once a day.

+ The most powerful stimulant in SIO.

+ Excitement and insomnia will heal quickly.

+ There are several side effects such as vomiting and diarrhea.

+ Suitable for patients with cardiovascular problems.

- Impossible for patients with strong exercise inhibition and mental suppression.

- Pager for pregnant fetus.

6. Fluoxetine

One of the representative antidepressants of the SIOS group. Known as Prozac. Fluoxetine is also known as a stimulant that improves your mood. Patients have feelings of dread, tension, restlessness, and a grim hostility towards others. Depending on adaptation, an average of 20 to 60 mg per day is administered.

+ The impact on the work of the mind is significant.

+ There is no sedative work.

+ A tool that is effective for patients with exercise inhibition and excessive sleepiness during the day.

-On may cause weight loss.

-D diabetes can cause hypoglycemia.

- Not contraindicated if renal function is severely reduced.

7. Fluvaffosamine

Another SIOS drug. Fullbucamine is similar to fluo-exetin in spills, but has an immediate effect and can be reduced at low cost. The effect is to make the neuron's serotonin reuptake more active. There are various causes of depression and obsessive-compulsive disorder. The average dose per day is 100 mg.

+ Realizes lower prices than conventional projectors.

+ Compared to this, faster operation is possible.

+ Relatively mild side effects (diarrhea, dry mouth, drowsiness).

- Contraindicated in diabetes mellitus.

- Pregnant women - with caution, lactating women - prohibited.

- Nausea in some patients.

8. Thirteen

This is one of the widely used universal drugs of the SIOS group. Treatment of almost all depressions, panic disorders and social phobias. However, in severe clinical cases, teralen may not be effective enough. The usual dose is 50 mg per day.

+ No cardiotoxicity.

+ The psychomotor potential of the patient is not changed.

+ does not add weight.

+ Good compatibility with other antidepressants.

- Sleep disturbances and diarrhea may occur during the first two weeks.

- side effects of a sexual nature

9. Escitalopram

This tool is attributed to Siox. The difference lies in the effect of pressing with involuntary movements (ticking, shaking, biting, tapping). Escitalopram is prescribed to patients with panic, anxiety, phobias, obsessions and behaviors. The daily dose is 20 mg.

+ Effective against life delays.

+ One of the most powerful Saiox.

+ More pronounced thymotropic (improving mood) effect compared to many antidepressants of the same family.

- Some patients experience increased anxiety within 2 weeks of admission.

- May cause gastrointestinal disturbances, insomnia and agitation.

- Used during pregnancy only in extreme cases when breastfeeding is not possible.

10. Venlafaxine

It belongs to the group of schiosins. In addition to inhibiting the reacquisition of serotonin, venlafaxine is also effective against another neurotransmitter, norepinephrine. It is prescribed for various causes of depression, social phobias, anxiety, panic. The usual dose is 150 mg per day.

+ Better tolerated by patients than most tricyclics.

+ More pronounced effect compared to the classic Syoks.

+ Fewer contraindications.

— Common side effects of most antidepressants are nausea, drowsiness, dry mouth, diarrhea, or constipation.

- May increase intraocular pressure.

- Withdrawal syndrome, the most severe of the antidepressants.

This list should not be used as a recommendation. In any case, before buying, consult your doctor. Stay healthy!

The placebo effect was experienced by most people with high suggestibility. There are many examples of how a simple "vitamin" relieved a headache or how a drop of salt water improved the patient's condition literally before our eyes. Make a reservation. If you do not suspect that you have been given a "dummy", then a "miracle" has happened. It's a "cure" so it should work.

Well, what is a placebo, is it really possible to be cured by the power of thought alone, and what is the mechanism of action of the drug "placebo" on the body - I will tell in the article.

Placebo effect in psychology

Derived from the Latin word "placebo", which translates as "think". A placebo is a substance used as a drug without an apparent therapeutic effect. The therapeutic effect is achieved when the patient believes that "this medicine works. " Placebo can be found in the treatment of a number of mental disorders, pain syndromes, asthma, Parkinson's disease, bowel disease, ischemia and hypertension. Placebo is more effective, the higher the degree of obedience of a person.

Here is an example from a long time ago. In the 18th century, TB patients were tested on placebo in a German clinic. At first he was said to be "a new drug to cure disease", brought his own medicine and prescribed the sick. With one month of treatment, 80% of people recovered. As I found out later, this "magic medicine" was normal aspirin, which did not affect the severity of tuberculosis, such as tuberculosis.

Much later, the "ignorance" of the placebo effect was scientifically proven. The scientists found that this was based on unconscious brain function. In other words, the brain determines how a drug affects people before it perceives drug information.

The placebo effect is associated with mental and emotional. A person who wants to be healed believes in the effects of prescribed drugs and thinks that this is the hand of salvation. Currently, vitality is mobilized, the recovery process begins, and the patient's physical and mental state returns to normal.

By the way, the price and appearance of the drug play an important role in the placebo. In other words, the higher the placebo price, the better. Speaking of color, for example, yellow drugs in depression, green medicine relieves anxiety, and white drugs have the effect of "hardening" stomach ulcers.

A disease that can be best treated with a placebo has also been found to be the best treatment. These are the following.

  • Headache … 62%.
  • Depression … 59%.
  • Cold … 45%, 59%.
  • Nausea: 58%.
  • Intestinal disease: 58%.

Placebo - what is it in simple words

The placebo effect was first announced by the American doctor Henry Villa in 1955. He found that taking a placebo (a pill without a drug component) would heal about one-third of the patient. However, the "dummy" has been known for a long time. It was mentioned in the 18th century. At that time, a placebo was called a drug that contains indifferent substances.

Matovay Mudrov, a famous doctor who played an active role at the end of the 18th century to the beginning of the 19th century, used three kinds of powder, plain, gold and silver for treatment. With this remedy, the patient's pain is miraculously relieved. Then, when Moodle died, it turned out that the main ingredient in the "magic" powder was normal crayon.

Another historical example of the Plasbo phenomenon dates back to World War II. During the absence of a cure, he administered physiological saline to shocked soldiers, faking morphine. And the pain has been reduced.

In the late 1970s, scientists proved that Plasbo promoted the production of endorphins, known as hormones of joy and pleasure, and worked in the same way as drugs. Dr. John Levin Medical Science did an experiment. The patient appears to have improved the physical condition of the patient who gave the pacifier to 40 patients with teeth who were extracting wisdom teeth instead of painkillers. And after the introduction of the antidote morphine, people began to experience pain. Hence, the placebo was found to give a sense of security as well as the patient's head, but the body was also suggested.

Placebo effect in medicine and psychology

Placebos are often used in medicine. It is used to relieve pain in a patient when there are no effective drugs, or to improve the patient's condition when there is doubt about the effectiveness of existing drugs. Also, because of impotence, the doctor may prescribe a "placebo" in the hope that the medicine will work, but in reality it turns out to be a useless substance.

Sometimes a placebo is the only way to avoid conflict between doctors and patients. There are patients who are convinced that they need to take some kind of medication, even if they do not have a medical indication. Therefore, the doctor prescribes a neutral treatment to help the person calm down.

  • Positive (most common). Increases the effectiveness of drugs and treatments.
  • Negative. Neutralize the therapeutic effect of the drug or aggravate the condition.
  • Neutral (very rare). As the name suggests, there is no placebo effect here.
  • Medical clearance required. If the patient does not trust the doctor, the placebo effect will work negatively.
  • drug prices. Inexpensive drugs for severe disease also have a negative placebo effect.
  • Availability of medicines The placebo effect increases exponentially if you take medicines delivered from far away.

Placebos are also used in new drug trials. As a rule, the subjects are divided into two groups: one receives the active drug, and the other receives a "double" dummy. The participants in the experiment did not know what was a placebo and what was a real medicine. The researchers then analyze the results and evaluate the effectiveness of the new drug.

In psychology, the placebo effect is the effect that results from contact with our subconscious. As mentioned earlier, the more suggestive it is, the greater its effect.

Placebos give good results in the treatment of psychosomatic disorders. For example, if the patient himself invents a disease, it should be influenced psychologically, and not with the help of drugs. In this case, the task of the specialist is to convince the patient that the prescribed drug is not a dummy, but a miracle cure for a 100% recovery.

The nocebo effect: the other side of the coin

The placebo effect can also work negatively. This is when the patient expects side effects or worsening of well-being from the "placebo". This effect is called nocebo. Negative expectations are one of the main reasons for this phenomenon. After all, thoughts can have a very strong influence on emotions. The brain creates false sensations that are indistinguishable from real sensations. For example, the fear of pain leads to its intensity.

  • prone to anxiety and depression.
  • have a chronic disease;
  • I have a history of treatment failure.

Overview In many cases, the placebo effect speeds up recovery. However, it is less reliable than the effects of real drugs. Placebos provide a subjective improvement in symptoms but rarely cure the disease. In any case, it must be clearly understood that the placebo effect will work only if the person has a firm belief in recovery, a positive attitude and confidence in the success of the treatment.

Can antidepressants be bought without a prescription? What mood-enhancing drugs work best if you need a milder or stronger one, how they affect your body, and whether they can be taken alone. When choosing a drug, it is important not to harm your health.

I'm depressed!

Often heard from a friend or read on a bulletin board. However, those who make such remarks are fundamentally wrong. After all, what does “depression” mean in conversation? It usually refers to deterioration, frustration and fatigue in the short term and due to the consequences of the situation. Sometimes some people call it depression just because "I have something bad" or "I'm sick."

Modern people are always tense. The overflow of work, the intensity of life, the high demands on oneself and the vast information that flows everywhere. Many people cannot cope with many stressors, so it is not surprising that various symptoms will appear.

  • anxiety?
  • get annoyed?
  • Tired?
  • Sleeping disorder
  • Obsession
  • panic disorder

Do not panic if these symptoms naturally disappear in a short period of time. In most cases, only a good rest is useful for their victory. However, sometimes vacation alone is unsatisfactory and requires little help in the body. To do this, it is very important to choose the right tool.

What depression really is

This is accompanied by many additional symptoms, such as prolonged (two weeks or more) mood, reduced activity, decreased mental activity and lack of enjoyment of life. In other words, if you are not touching your usual joys such as hobbies, family and friends, then you need to take this opportunity, observe your condition and ask a doctor to get to you.

If you do not touch your usual joy, this is an opportunity to think, and in some cases you will need to consult.

This depression is often severe and the psychiatrist needs to be forcibly treated with a specific drug.

What medications are used to treat depression?

There is a common name called antidepressant. It should be noted that the adaptation of antidepressants has increased significantly in recent years. There have been a number of studies not only for depression, but also that antidepressants are effective for anxiety, sleep disorders (insomnia), neurosis, and neurophyllic pain. Today, psychiatrists, neurologists, and even therapists widely prescribe antidepressants of various groups.

The most commonly used medicines of the two groups.

Min based antidepressant

These are the oldest drugs that are the most powerful.

    - a drug with a strong sedative effect and a strong antidepressant effect. A large administration is used to treat severe depression, while a small administration is used for mild disability. There are also sleeping pills, relieving anxiety. -Balanced drugs are usually more familiar than amitripine and relieve anxiety. He has excitement and is designated as Trump's card for depression.

Selected serotonin inverse inhibitor (SIOS)

This is a more modern drug group. The advantage is that they are good at resisting, have few or no side effects.

Often assigned by this group.

    -Sodetsya analgesic effect and a good antidepressant. By using it for a long time, broken dreams are normalized.

    - The antidepressant is quite strong during the day. Relieves anxiety and obsession without the need for sleep. - to the degree of awakening and is often prescribed for the treatment of panic disorder.

Most modern antidepressants have few side effects and are well tolerated.

However, strong antidepressants cannot be sold without a prescription. They can only be prescribed by doctors, such as psychiatrists, neurologists, and sometimes therapists.

Why can't I take antidepressants without a prescription?

  • Only a doctor can assess the risk of side effects for a particular patient.
  • Different types of antidepressants have different nuances in their therapeutic effects. If you choose the wrong medicine, at best it will do you no good, and at worst it will harm you.
  • The choice of dosage is made individually. A rapid increase in dosage on your own can have many unpleasant consequences.
  • Also, elimination should be carried out gradually under the guidance of a physician. Otherwise, you risk getting a withdrawal syndrome.

What to do?

Many medicines are sold without a prescription. It does not work for clinical depression, but it helps with stress, short-term sleep disturbances and irritability. With their help, I try to alleviate my state of mind.

    - one of the most popular means. The most popular dish. May be useful for mild sleep disturbances. It has an anti-anxiety effect and eliminates fear, tearfulness and irritability. It is used to treat phytovascular dystonia, and in alcoholics to relieve withdrawal symptoms. You will not become addicted. It should be borne in mind that it is contraindicated in children under 18 years of age. It has a rather strong sedative effect, causes nervousness and irritability. Effective for concentration, memory and reducing fatigue. Helps restore the nervous system during times of stress.
    Better understanding, relieves frustration and anxiety, improves sleep. During treatment, it is not recommended to engage in activities that require concentration, such as driving a car. Contains extracts of valerian, lemon balm and mint. It has a sedative and anti-anxiety effect. It works well for symptoms such as excitability, emotional instability, and tearfulness. It can be used in the complex treatment of mild restless depression, facilitating the withdrawal of potent drugs. • Increases the body's resistance to stress. Lack of magnesium can lead to nervous system imbalance, irritability and sleep disturbances, so Magne B6 can help in these situations too. It has calming, sedative and anti-anxiety properties and helps treat anxiety, mental and emotional stress. Relieves irritation and tension. It can also be used for neurotic symptoms.

When should I see a doctor?

  • If mood deterioration persists for more than 2 weeks and initial therapeutic efforts have failed.
  • If you have lifeless or suicidal thoughts.
  • Depression significantly impairs normal life, such as being unable to work, being unable to communicate well with family members, and being unable to enjoy the things that used to make you happy.

You can consult a psychiatrist in confidence. Information related to the complaint, not to mention diagnosis and treatment, is considered confidential medical information and will not be shared or disclosed in the workplace. It is better to diagnose depression early and start treatment than to bring it to a neglected state.

According to WHO, more than 40% of people on earth suffer from allergies. And this number is increasing every year. Doctors and scientists have never been able to figure out why such diseases occur. Lack of knowledge prevents us from developing a way to permanently get rid of allergies.

However, in connection with the development of science, today many drugs are produced for strong suppression of expression. Allergically proven tablets eliminate most allergic reactions and help to forget about unpleasant symptoms for a long time.

What is this disease

Allergy is a very strange disease. Since it is not caused by microorganisms, it is not contagious. Allergic reactions are “caused” by our own immune system, which reacts very aggressively to completely harmless substances. Main allergens: house dust, animal hair, plant pollen, product ingredients. As a result of pathological changes in the immune system, the body reacts to these substances and begins to produce antibodies that trigger an inflammatory response.

  • sneeze
  • cough
  • shortness of breath
  • Appearance of itching in the nose and discharge
  • Pimples
  • skin rash

A bright type of disease has less pronounced symptoms. However, symptoms can get worse for a variety of reasons.

If you have symptoms of an allergy, you should consult an allergist. Your doctor will order tests that will allow you to "detect" the allergen. By doing so, you can avoid contact and prevent an aggravation. However, complete separation from allergens can not always be avoided. In this case, drug therapy is carried out to eliminate or reduce the severity of the reaction.

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Allergy remedy

These drugs belong to the group of antihistamines. Prevents the production of histamine. This substance normally participates in many physiological processes. However, if the immune system is disrupted, histamine is actively produced as allergens enter the body. When ingested in large quantities, an inflammatory reaction occurs and allergic symptoms appear. There are currently three generations of antihistamines in medicine.

First generation drug

Relieve unpleasant symptoms quickly, but don't overdo it. And this long-term use is addictive. There seem to be side effects.

  • drowsiness
  • weakness
  • reaction suppression
  • Headache

But where there are disadvantages, drugs have advantages. These inexpensive drugs are available not only in the form of tablets, but also in the form of solutions, and are also used for emergency care.

The most popular among them. Not all are suitable for children, so be sure to consult a pediatrician before use.

second generation drugs

It is more effective, causes little to no drowsiness and has fewer side effects. Work up to 8-12 hours. Some of its features can cause heart rhythm disturbances. The most popular antiallergic agent.

third generation drugs

The drug is not yet officially developed. However, unofficially, advanced second-generation drugs include drugs of newer generations. They are characterized by high efficiency, instant effect and a small number of side effects. It is non-addictive and can be used for a long time.

One of the most popular allergy sufferers is Elios. Available in the form of tablets and syrup. Other Modern Remedies

Today's Best Allergy Remedy

Corticosteroids and histiocytic membrane stabilizers are used in addition to antihistamines for severe allergic symptoms. Food supplements can also be used as an allergy countermeasure. However, its use requires the consent of the doctor.

How to get rid of allergies forever

Antihistamines, even the most modern ones, only relieve the symptoms, they do not cure the disease. Currently, the most reliable way to eliminate allergies is immunotherapy (ASIT), in which substances that cause allergic reactions are introduced. With a gradual increase in dosage, symptoms of intoxication of the body with an allergen are formed.

AIS can significantly reduce allergies, reduce the duration of exacerbations, and often cure the disease. The disadvantage of immunotherapy is its duration (3-5 years).

  • Wash your hair and shower every night before bed to wash pollen from your skin and hair.
  • Rinse your nose daily. Even rinsing with plain water can help soften harmful particles that have settled on the mucous membranes of the respiratory tract.
  • Washing clothes in hot water at 30-40°C does not kill bed bugs, which are among the most common allergens.
  • It is also important to use a vacuum cleaner to remove dust from carpets and upholstered furniture.

Unfortunately, there is no universal approach to allergies. In addition, it often takes a long time to find the right fund. If you have any allergic symptoms, consult your doctor and let him choose a treatment method in accordance with the characteristics of your body.

There are contraindications. Need to see a specialist

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Buying good blood pressure medicine is not easy. The pharmacist at the pharmacy is rarely helpful and will send you to a doctor immediately. Is it really so difficult to recommend a reliable drug at an affordable price? Try to understand the types of drugs and the principle of administration.

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Hypertension

Most people today have never heard of the term "hypertension". It is not surprising that in today's society, one in three faces this problem and is forced to look for a solution.

Blood pressure 140/90 mmHg Art. defined as hypertension. Art and above, regardless of age. In many cases, increased pressure is an independent disease called hypertension. However, high blood pressure can also be a symptom of other conditions (such as kidney, thyroid, or adrenal problems). In this case, it is necessary not only to reduce the figure, but also to treat the underlying disease.

Symptoms

Symptoms of high blood pressure include:

  • Headache
  • headache, headache, dizziness, dizziness, headache, headache, dizziness
  • Dizziness; pre-fainting state; "warmth" before the eyes.
  • In such cases, it is recommended to check the blood pressure. If the threshold is exceeded, care should be taken to lower it.

Can your blood pressure go up even if you're not worried about anything? Unfortunately, such cases are not rare. That's why it's so important to keep your blood pressure under control, even if it seems normal. It seems that many people misunderstand that if there are no symptoms, then there is no need to lower the barometric pressure. Indeed, why take medication when you are in good physical shape? Unfortunately, the rate of complications of high blood pressure is not determined by whether you feel it or not.

High blood pressure can lead to serious complications.

Terrible complications.

Myocardial infarction?

  • Stroke?
  • renal failure.
  • The higher the pressure, the higher the risk of its development.

Most people with high blood pressure need medication to lower their blood pressure. In the early stages, when blood pressure is slightly elevated, lifestyle changes (diet, weight loss, stress relief, exercise) can bring the values ​​back to normal. However, most patients still require ongoing treatment. If treatment is interrupted, high blood pressure and associated discomfort and risk of complications reappear. During treatment, it is very important to control the level of pressure and keep a diary, recording the patient's performance. This allows you to choose the optimal treatment and accurately evaluate its effectiveness.

Treatment

There are many drugs available today to lower blood pressure. Consider the main groups of these drugs.

ACE inhibitor

This medicine inhibits (blocks) one of the enzymes involved in hypertension and is often used as the first line of treatment for hypertension.

Advantages of this group

Does not affect the heart rate (possible prescription by index).

  • Does not increase cholesterol and blood sugar levels.
  • In diabetes and chronic kidney disease, it can not only lower blood pressure, but also prevent the development of kidney failure.
  • These drugs are also effective in chronic heart failure.
  • But for pregnant (or planning to become pregnant) women, this group is not suitable - it can adversely affect the fetus. Also, taking these medicines can sometimes cause a dry cough. If the patient's anxiety is great, it should be replaced with drugs from other groups.

ACE inhibitors are not suitable for pregnant women as they may harm the fetus.

Angiotensin receptor blockers (ARBs).

The mechanism of action is similar to the previous group of drugs, but blocks the process at a different level. In general, they have properties similar to those of ACE inhibitors. If you develop a dry cough while taking an ACE inhibitor, this group is often prescribed because it does not have these side effects.

beta-blockers

Reduces the pressure that acts on the β-adrenaline receptor in the heart and blood vessels.

These drugs not only lower blood pressure, but also increase the pulse rate. It is preferable when the heartbeat is frequent, but it is better not to take it if the pulse is irregular. When choosing doses and treatments, pulse monitoring is required (preferably 50 or more per minute).

It is also recommended for high blood pressure, coronary artery disease and chronic heart failure. In addition, when used in combination with bronchial asthma or chronic obstructive pulmonary disease (COPD), caution must be taken as convulsive bronchodilation may be exacerbated.

Calcium antagonist

Lowers blood pressure by acting on calcium cells in cells. It can be used along with hypertension such as asthma, COPD, diabetes, and kidney disease.

Dirtiazem, Bella Pamil, Isoptine (extended type) - impulse-lowering effect can be used as a substitute for β-blockers.

It does not create Corda Flex, Normodipine, Lelkame n-pulse and has vasodilatation. In particular, it is effective for increasing the expansion of blood pressure (descent blood pressure).

Diuretics

Indpamid Leviard

    ; ; ;
  • Additional water and sodium are discharged outside the body. In particular, it is associated with people who have signs of edema and heart failure. Although the diuretic effect is not the strongest in the Indian pamid and has few side effects, it has a good blood pressure stabilizing effect.

Diuretics are suitable for people with signs of heart failure.

This group should be used with caution to increase blood sugar and uric acid levels.

Central nervous system

Reduces the pressure that acts on the brain receptor. In principle, if the desired effects cannot be obtained, it is added in combination with other drugs.

Complicated instrument

In the treatment of high blood pressure, several combinations of active substances are often used. According to studies, the combination is more effective than increasing the number of drugs and has fewer side effects.

Many co-administered drugs complement each other's effects and improve each other. As a result, many agents containing two agents in one tablet, and sometimes three agents at the same time, are produced. The technology is efficient and very convenient.

2. combined use

ACE inhibitor + Diuretic: ANAP N, Codlon, Noryprel.

  • Angiotensin receptor antagonist + diuretics: Rosla Plus, Balsacall N, Ederby KL.
  • Angiotensin receptor antagonist + calcium antagonist: LOL Tenza, Veroset, ex.
  • Beta blocker + calcium antagonist: Concole AM, Logimax.
  • 3 combined use
  • ACE blocker + diuretic + calcium antagonist: KO DARNEF, Trick LAX.

Angiotensin receptor antagonist + diuretics + calcium antagonist: co-vamloset, Coxford.