Latuda for adhd
The Dopamine Dilemma - PMC
1. Olfson M, Gameroff M, Marcus S, Jensen P. National trends in the treatment of attention deficit hyperactivity disorder. Am J Psychiatry. 2003;160:1071–1077. [PubMed] [Google Scholar]
2. Cooper WO, Arbogast PG, Ding H, et al. Trends in prescribing of antipsychotic medications for US children. Ambul Pediatr. 2006;6(2):79–83. [PubMed] [Google Scholar]
3. Zuvekas SH, Vitiello B, Norquist GS. Recent trends in stimulant medication use among US children. Am J Psychiatry. 2006;1(3):579–585. [PubMed] [Google Scholar]
4. Bhatara V, Feil M, Hoagwood K, Vitiello B, Zima B. National trends in concomitant psychotropic medication with stimulants in pediatric visits: practice versus knowledge. J Atten Disord. 2004;7(4):217–26. [PubMed] [Google Scholar]
5. Wonodi I, Reeves G, Carmichael D, et al. Tardive dyskinesia in children treated with atypical antipsychotic medications. Mov Disord. 2007;22:1777–1782. [PubMed] [Google Scholar]
6. Olfson M, Blanco C, Liu L, et al. National trends in the outpatient treatment of children and adolescents with antipsychotic drugs. Arch Gen Psychiatry. 2006;63(6):679–685. [PubMed] [Google Scholar]
7. Zito JM, Safer DJ, dosReis S, et al. Trends in the prescribing of psychotropic medications to preschoolers. JAMA. 2008;283(8):1025–1030. 23. [PubMed] [Google Scholar]
8. Kutcher S, Aman M, Brooks SJ, et al. International consensus statement on attention-deficit/hyperactivity disorder (ADHD) and disruptive behaviour disorders (DBDs): clinical implications and treatment practice suggestions. Eur Neuropsychopharmacol. 2004;4(1):11–28. [PubMed] [Google Scholar]
9. Pliszka S, Crimson M, Hughes C, et al. The Texas Children's Medication Algorithm Project: revision of the algorithm for pharmacotherapy of attention-deficit/hyperactivity disorder. ACAP. 2006;45(6):642–657. [PubMed] [Google Scholar]
10. Stahl SM. Stahl's Essential Psychopharmacology. New York, NY: Cambridge University Press; 2008.
pp. 878–879. [Google Scholar]
11. Moore KE. The actions of amphetamine on neurotransmitters: a brief review. Biol Psychiatry. 1977;12(3):451–462. [PubMed] [Google Scholar]
12. Pehek AE. Comparison of effects of Haloperidol administration on amphetamine-stimulated dopamine release in the rat medial prefrontal cortex and dorsal striatum. J Pharmacol Exp Therapeut. 1999;289(1):14–23. [PubMed] [Google Scholar]
13. Nakahra T, Kurokit, Hashimoto K, et al. Effect of atypical antipsychotics on phencyclidine-induced expression of arc in rat brain. Neuroreport. 2000;11(3):551–555. [PubMed] [Google Scholar]
14. Kargieman L, Santana N, Mengod G, et al. NMDA antagonist and antipsychotic actions in cortico-subcortical circuits. Neurotox Res. 2008;14(2-3):129–140. [PubMed] [Google Scholar]
15. Volkow ND, Wang G-J, Fowler JS, et al. Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors. Am J Psychiatry. 1997;154:50–55.
[PubMed] [Google Scholar]
16. Botly L, Burton CL, Rizos Z, Fletcher PJ. Characterization of methylphenidate self-adminstration and reinstatement in the rat. Psychopharmacology. 2008;199:55–56. [PubMed] [Google Scholar]
17. Owen R, Owen F, Poulter M, Crow TJ. Dopamine D2 receptors in substantia nigra in schizophrenia. Brain Res. 1994;299(1):152–154. [PubMed] [Google Scholar]
18. Fehr C, Yakushev I, Hohmann N, et al. Association of low striatal dopamine D2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse. Am J Psychiatry. 2008;165:507–514. [PubMed] [Google Scholar]
19. Laurelle M, Abi-Dargham A, van Dyck H, et al. SPECT imaging of striatal dopamine release after amphetamine challenge. J Nucl Med. 1995;36:1182–1190. [PubMed] [Google Scholar]
20. Leite JV, Guimarães FS, Moreira FA. Aripiprazole, an atypical antipsychotic, prevents the motor hyperactivity induced by psychotomimetics and psychostimulants in mice.
Eur J Pharmacol. 2008;578(2-3):222–227. [PubMed] [Google Scholar]
21. Rappley M. Attention deficit-hyperactivity disorder. N Engl J Med. 2005;352:2. [PubMed] [Google Scholar]
22. Cheng-Shannon J, McGough JJ, Pataki C, McCracken JT. Second-generation antipsychotic medications in children and adolescents. J Child Adolesc Psychopharmacol. 2004;14(3):372–394. [PubMed] [Google Scholar]
23. Werry JS, Aman MG. Methylphenidate and haloperidol in children. Effects on attention, memory, and activity. Arch Gen Psychiatry. 1975;32(6):790–795. [PubMed] [Google Scholar]
24. Gittelman-Klein R, Klein DF, Katz S, et al. Comparative effects of methylphenidate and thioridazine in hyperkinetic children. Arch Gen Psychiatry. 1976;33(10):1217–1231. [PubMed] [Google Scholar]
25. Greenberg LM, Deem MA, McMahon S. Effects of dextroamphetamine, chlorpromazine, and hydroxyzine on behavior and performance in hyperactive children. Am J Psychiatry. 1972;129(5):532–539. [PubMed] [Google Scholar]
26.
Biederman J, Hammerness P, Doyle R. Risperidone treatment for ADHD in children and adolescents with bipolar disorder. Neuropsychiatr Dis Treat. 2008;4(1):203–207. [PMC free article] [PubMed] [Google Scholar]
27. Findling RL, Short EJ, Leskovec T, et al. Aripiprazole in children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2008;18(4):347–354. [PubMed] [Google Scholar]
28. Gualtieri CT, Hicks RE. Stimulants and neuroleptics in hyperactive children (letter) J Am Acad Child Psychiatry. 1985;24:363–364. [PubMed] [Google Scholar]
29. Weizman A, Weitz R, Szekely GA, et al. Combination of neuroleptic and stimulant treatment in attention deficit disorder with hyperactivity. J Am Acad Child Psychiatry. 1984;23(3):295–298. [PubMed] [Google Scholar]
30. Pliszka S. Practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2007;46(7):894–921.
[PubMed] [Google Scholar]
31. Findling RL. Atypical antipsychotic treatment of disruptive behavior disorders in children and adolescents. J Clin Psychiatry. 2008;69(Suppl 4):9–14. [PubMed] [Google Scholar]
32. Pandina GJ, Aman MG, Findling RL. Risperidone in the management of disruptive behavior disorders. J Child Adolesc Psychopharmacol. 2006;16(4):379–392. [PubMed] [Google Scholar]
33. Gadow KD, Nolan EE, Sverd J, et al. Methylphenidate in aggressive-hyperactive boys: effects on peer aggression in public school settings. J Am Acad Child Adolesc Psychiatry. 1990;29(5):710–718. [PubMed] [Google Scholar]
34. Connor DF, Glatt SJ, Lopez ID, et al. Psychopharmacology and aggression: A meta-analysis of stimulant effects on overt/covert aggression-related behaviors in ADHD. J Am Acad Child Adolesc Psychiatry. 2002;41:253–261. [PubMed] [Google Scholar]
35. Allen RP, Safer D, Covi L. Effects of psychostimulants on aggression. J Nerv Ment Dis. 1975;160:138–145. [PubMed] [Google Scholar]
36.
Sharp B. CMAP ADHD and comorbid aggression algorithm: letter to the editor. ACAP. 2007;46(1):1–3. [PubMed] [Google Scholar]
37. Beller B, Zimerman B, Williams M, et al. DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J Am Acad Child Adolesc Psychiatry. 2002;12(1):11–25. [PubMed] [Google Scholar]
38. Trivedi MH, Thase ME, Fava M, et al. Adjunctive aripiprazole in major depressive disorder: analysis of efficacy and safety in patients with anxious and atypical features. J Clin Psychiatry. 2008;69(12):1928–1936. [PubMed] [Google Scholar]
39. Shajahan P, Taylor M. The uses and outcomes of quetiapine in depressive and bipolar mood disorders in clinical practice. J Psychopharmacol. 2010;24(4):565–572. Epub 2009 Jan 22. [PubMed] [Google Scholar]
40. Sajatovic M. Treatment for mood and anxiety disorders: quetiapine and aripiprazole. Curr Psychiatry Rep. 2003;5:320–326. [PubMed] [Google Scholar]
41.
Hardy SE. Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults. Am J Geriatr Pharmacother. 2009;7(1):34–59. [PMC free article] [PubMed] [Google Scholar]
42. Huang CC, Shiah IS, Chen HK, et al. Adjunctive use of methylphenidate in the treatment of psychotic unipolar depression. Clin Neuropharmacol. 2008;31(4):245–247. [PubMed] [Google Scholar]
43. Nandagopal JJ, DelBello MP, Kowatch R. Pharmacologic treatment of pediatric bipolar disorder. Child Adolesc Psychiatr Clin N Am. 2009;18(2):455–469. [PubMed] [Google Scholar]
44. Chang KD. The use of atypical antipsychotics in pediatric bipolar disorder. J Clin Psychiatry. 2008;69(Suppl 4):4–8. [PubMed] [Google Scholar]
45. Levin A. Kids with bipolar + ADHD respond to added stimulant. Psychiatr News. 2005;40(2):42. [Google Scholar]
46. Wingo AP, Ghaemi SN. Frequency of stimulant treatment and of stimulant-associated mania/hypomania in bipolar disorder patients.
Psychopharmacol Bull. 2008;41(4):37–47. [PubMed] [Google Scholar]
47. Carlson PJ, Merlock MC, Suppes T. Adjunctive stimulant use in patients with bipolar disorder: treatment of residual depression and sedation. Bipolar Disord. 2004;6(5):416–420. [PubMed] [Google Scholar]
48. Ross RG. Psychotic and manic-like symptoms during stimulant treatment of attention deficit hyperactivity disorder. Am J Psychiatry. 2006;163(7):1149–1152. [PubMed] [Google Scholar]
49. Curran C, Byrappa N, McBride A. Stimulant psychosis: systematic review. Br J Psychiatry. 2004;185:196–204. [PubMed] [Google Scholar]
50. Aman MG, Binder C, Turgay A. Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ. J Child Adolesc Psychopharmacol. 2004;14(2):243–254. [PubMed] [Google Scholar]
51. Hollis CP, Thompson A. Acute dyskinesia on starting methylphenidate after risperidone withdrawal. Pediatr Neurol.
2007;37(4):287–288. [PubMed] [Google Scholar]
52. Connor DF, Benjamin S, Ozbayrak KR. Case study: neuroleptic withdrawal dyskinesia exacerbated by ongoing stimulant treatment. J Am Acad Child Adolesc Psychiatry. 1995;34(11):1490–1494. [PubMed] [Google Scholar]
53. Benjamin E, Salek S. Stimulant-atypical antipsychotic interaction and acute dystonia. J Am Acad Child Adolesc Psychiatry. 2005;44(6):510–512. [PubMed] [Google Scholar]
54. Sabuncuoglu O. Risperidone-to-methylphenidate switch reaction in children: three cases. J Psychopharmacol. 2009;22(6):699. [PubMed] [Google Scholar]
55. Seeman P, Niznik HB, Guan H-C, et al. Link between D1 and D2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain. Proc Nat Acad Sci USA. 1989;86:10156–10160. [PMC free article] [PubMed] [Google Scholar]
56. Volkow N, Swanson J. Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD. Am J Psychiatry. 2003;160:1909–1918.
[PubMed] [Google Scholar]
57. Sikström S, Söderlund G. Stimulus-dependent dopamine release in attention-deficit/hyperactivity disorder. Psychol Rev. 2007;114(4):1047–1075. [PubMed] [Google Scholar]
58. Goto Y, Otani S, Grace AA. The yin and yang of dopamine release: a new perspective. Neuropharmacology. 2007;53(5):583–587. [PMC free article] [PubMed] [Google Scholar]
59. Grace AA. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience. 1991;41(1):1–24. [PubMed] [Google Scholar]
60. Braun AR, Laruelle M, Mouradian MM. Interactions between D1 and D2 dopamine receptor family agonists and antagonists: the effects of chronic exposure on behavior and receptor binding in rats and their clinical implications. J Neur Transmis. 1997;104:4–5. [PubMed] [Google Scholar]
61. Gianutsos G, Drawbaugh RB, Hynes MD, Lal H. Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol.
Life Sci. 1974;14:887–898. [PubMed] [Google Scholar]
62. Samaha A, Seeman P, Steward J, et al. “Breakthrough” dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time. J Neurosci. 2007;27(11):2979–2986. [PMC free article] [PubMed] [Google Scholar]
How Lurasidone Works For ADHD, Anxiety, and Other Mental Disorders
How Lurasidone Works For ADHD, Anxiety, and Other Mental Disorders
- Post author:MedicaPharma Team
- Post published:June 27, 2022
- Post category:Product Guide
Lurasidone, also known as lurasidone hydrochloride, is a prescription drug administered for numerous mental disorders, including anxiety, bipolar disease, depression, sleep disorders, and schizophrenia.
Sold under the brand name Latuda, lurasidone is available in the US, Canada, Switzerland, Denmark, Norway, the U.
K., the Netherlands, Finland, Australia, Sweden, Thailand, Hong Kong, and Singapore. The drug is also available in India under numerous brand names, including Lurasid, Alsiva, Emsidon, Lurakem, Luratrend, Tablura, Lurastar, Atlura, Lurace, Lurafic, Luramax, Latuda, Lurata, and Unison.
Table of Contents
What is Lurasidone?
Sold under numerous brand names worldwide, Lurasidone is an antipsychotic drug prescribed and administered for various mental disorders, including anxiety, depression, bipolar, schizophrenia, and sleep disorders. For bipolar conditions, it is typically prescribed along with a mood-stabilizing drug such as valproate or lithium.
Search for:
Lurasidone Regulatory Approval
United StatesFDA approval of lurasidone in the US is indicated for the treatment of:
- Schizophrenia in adults and children/adolescents aged 13-17 years
- Depression with bipolar disorder in adults and children aged 10-17 years
- Depression associated with bipolar disorder in adults, in combination with valproate or lithium
Lurasidone is approved in the EU to treat schizophrenia in adults aged 18 years and over.
The drug is not approved for bipolar disorder.
Lurasidone Pharmacology
Researchers are unclear on Lurasidone’s mechanism of action, however it is believed to have an effect on the production of serotonin and dopamine in the brain.
PharmacodynamicsLurasidone acts as a brain receptor antagonist of the dopamine receptors (D2 and D3), α2C-adrenergic receptor, and serotonin 5-HT2A and 5-HT7 receptors. The drug is also a partial agonist of the serotonin 5-HT1A receptor.
Studies suggest that lurasidone has a low and likely clinical affinity for serotonin 5-HT2C receptors. According to research, this may explain the drug’s low propensity to stimulate appetite and affect weight gain. In addition, the drug also has negligible affinity for muscarinic acetylcholine receptors and histamine h2 receptors and therefore has no anticholinergic effects or antihistamine effects.
PharmacokineticsThe main active metabolite in Lurasidone is ID-14283 and norbornane ring hydroxylation is highlighted.
Lurasidone’s other active metabolite is ID-14326, and it has the OH group in the endo position. Metabolites ID-11614 and ID-20219 are produced via the main inactivation step by oxidative N-dealkylation.
When taken by mouth, Lurasidone has an estimated 9-19% absorption rate. Researchers found that absorption increases approximately twofold when lurasidone is taken with food and peak blood plasma concentrations are reached after 1-3 hours. Approximately 99% of the circulating substance is bound to plasma proteins.
Lurasidone is predominantly metabolized via the enzyme CYP3A4 in the liver. The drug has a minimal affinity to other P450 cytochrome enzymes. It is transported by ABCG2 and P-glycoprotein, and additionally inhibits these carrier proteins in vitro while inhibiting solute carrier protein SLC22A1 without other relevant transporters.
The biological half-life of Lurasidone is 18 hours and 20-40 hours depending on the source. Nine to 19% is recovered from the urine, and 80% or 67% (of a radiolabelled dose) is recovered from the feces.
Search for:
Lurasidone Dosages
Lurasidone doses depend on the condition being treated. Some lurasidone treatment dosages include:
Lurasidone for AnxietyThere is no standard lurasidone for anxiety. The average prescription according to online sources is 20-120 mg per day.
Lurasidone for Bipolar Depression- Monotherapy: 20 mg per day not to exceed 120 mg/day
- Adjunctive therapy: 20 mg per day not to exceed 120 mg/day
- Monotherapy: 20 mg per day not to exceed 120 mg/day
- Adjunctive therapy: 20 mg per day not to exceed 120 mg/day
- 40 mg per day initially, not to exceed 160 mg/day
Lurasidone vs. Risperidone
Risperdal (risperidone) is thought to help control thoughts and mood while lurasidone (Latuda) is indicated for depression and schizophrenia-related to bipolar disorder.
According to one study, lurasidone increased total sleep time by an average of 28.4 minutes in the laboratory when compared to a placebo. In addition, the drug was found to decrease wake time after sleep onset, and after the final awakening. Researchers also believe it increases sleep efficiency.
Lurasidone for PTSDLurasidone is rarely prescribed for PTSD. However a randomized, double-blind study by Monelly, et al. suggests that 0.5 to 2mg of the alternative risperidone reduces intrusive thoughts and irritability in combat-related PTSD.
Lurasidone Side Effects
Latuda/Lurasidone side effects include:
- Weight gain
- Lipid-related adverse effects
- Increased risk for a stroke
- Increased risk of transient ischemic attack
- Increased mortality
- Drowsiness
- Dizziness
- Lightheadedness
- Nausea
- Shaking
- Mask-like facial expressions
- Inability to keep still
- Agitation
Lurasidone may cause facial muscle twitching in addition to tardive dyskinesia – a condition characterized by uncontrollable movements such as mouth puckering, lip-smacking, tongue thrusting, mouth chewing, and other unusual arm and leg movements.
This condition may be permanent in some cases.
Lurasidone InteractionsLurasidone increases blood plasma concentrations when used with CYP3A4 inhibitors. This may lead to additional side effects, and has been verified for ketoconazole and other 3A4 inhibitors such as grapefruit juice.
Frequently asked questions:
How does lurasidone work?
Lurasidone works by antagonizing specific receptors in the brain. Research suggests that the drug acts as an antagonist of the α2C-adrenergic receptor, dopamine receptors (D3 and D2), and serotonin 5-HT2A and 5-HT7 receptors. In addition, it is also a partial agonist of the serotonin 5-HT1A receptor.
What is lurasidone used for?
Lurasidone or lurasidone hydrochloride is an atypical antipsychotic prescribed to treat several mental illnesses and disorders such as anxiety, sleep disorders, bipolar, depression, schizophrenia, and post-traumatic stress disorder.
What drug class does lurasidone belong to?
Lurasidone belongs to a class of medications called atypical antipsychotics.
Atypical antipsychotics work by altering the activity of certain substances or hormones in the brain responsible for mood, such as dopamine and serotonin.
How does lurasidone affect dopamine and serotonin?
Lurasidone works by acting as an antagonist of the dopamine receptors (D3 and D2), α2C-adrenergic receptor, and serotonin 5-HT2A and 5-HT7 receptors. The drug also acts on the serotonin 5-HT1A receptor as a partial antagonist.
How long does it take for lurasidone to work?
Lurasidone (or Latuda) results vary substantially between patients depending on their height, weight, and the condition being treated. Generally, the drug works for most patients within 6 weeks and possibly sooner depending on the dose.
Special Active Pharmaceutical Ingredients (GMP)
Full GMP API Product List
Download
Latuda - indications, analogs, reviews
Brief information about the drug
The active ingredient of the drug is lurasidone.
In 2010, the FDA approved this substance. In our country, Latuda was patented in 2006.
Lurasidone has affinity for receptors:
- 5-HT7- and 5-HT1a-serotonin
- 5-HT2A- and D2-dopamine
- α2a- and α2c-adrenergic
At the same time, the substance does not bind to muscarinic and histamine receptors.
The drug is available in the form of tablets for oral administration.
Use: when to prescribe
Clinical studies have shown the effectiveness of the drug in:
- Schizophrenia (a mental disorder characterized by the breakdown of thought processes and emotional reactions)
- Depressive episodes in bipolar I disorder (mental pathology in which phases of mania alternate with phases of depression)
Contraindications
The drug is not prescribed for patients under 18 years of age, as well as for:
- Simultaneous therapy with strong inducers of the CYP3A4 isoenzyme (including phenobarbital), strong inhibitors of the CYP3A4 isoenzyme (including ketoconazole, saquinavir), perforated, rifampicin
- Pregnancy and lactation
- Individual intolerance to the components of the drug
There are diseases in which the use of Latuda requires special care.
For example, cardiovascular pathologies, Parkinson's disease, kidney and liver failure, seizures, etc.
Antipsychotics increase mortality in older people with dementia, according to some studies. The use of lurasidone in this category of patients has not been studied.
Side effects
Most common adverse reactions:
- Drowsiness
- Restlessness, anxiety
- Sleep problems
- Dizziness
- Nausea and vomiting
- Stomach discomfort, upper abdominal pain
- Weight increase
- Excessive salivation or dry mouth
- Agitation (restlessness, which is usually accompanied by strong emotional arousal, anxiety and fear)
- Akathisia (internal restlessness, which is manifested by the inability to remain in one position)
- Parkinsonism (neurological syndrome, in which there is hypertonicity of the muscles, slowness of movement, trembling of the limbs at rest)
- Increased skeletal muscle tone
- Dystonia (abnormal contractions of muscle groups)
- Increased blood levels of creatine phosphokinase and creatinine
Infrequently and rarely, the following side effects may occur:
- Pain in the muscles, back and neck
- Pressure increase or decrease
- "Hot flashes" (feeling of intense warmth over the upper body and face)
- Nasopharyngitis (inflammation of the mucous membranes of the nose and throat)
- Nightmares
- Catatonia (syndrome, the main manifestation of which is a movement disorder - stupor or agitation)
- Decreased appetite
- Flatulence (gas formation)
- Lethargy (painful condition similar to prolonged sleep)
- Dysarthria (distortion, difficulty pronouncing certain sounds or words)
- Excessive sweating
- Blurred vision
- Increase in heart rate or, conversely, slow heart rate
- Malignant neuroleptic syndrome (fever, muscle hypertonicity, impaired consciousness, instability of autonomic functions (respiration, digestion, heartbeat, bladder function, etc.
), increased activity of creatine phosphokinase in the blood) - Anemia (decrease in red blood cells and hemoglobin)
- Leukopenia (decrease in the number of leukocytes)
- Neutropenia (decreased content of a special type of white blood cells - neutrophils)
- Increased blood sugar
- Sodium reduction
- Increase in alanine aminotransferase
- Panic attacks (severe attacks of anxiety accompanied by increased heart rate, respiratory failure and other autonomic manifestations)
- Suicidal behavior
- Convulsions
- Angina
- Joint stiffness
- Urinary disorders
- Erectile dysfunction
- Missing periods or painful periods
- Rhabdomyolysis (destruction of muscle tissue, which is also accompanied by kidney failure)
- Dysphagia (swallowing disorder)
- Gastritis (inflammatory or inflammatory-dystrophic changes in the gastric mucosa)
- Allergic reactions
- Renal failure
- Breast pain
- Extrapyramidal disorders (tremor, rigidity, mask-like face, gait and posture disturbances, dystonia, excessive salivation)
Analogues
Latuda is the only officially registered drug in Russia containing lurasidone as an active ingredient.
Only a doctor can select another antipsychotic after a thorough diagnosis of the patient.
Latuda and alcohol
Simultaneous use of the drug with alcohol is unacceptable - both substances affect the central nervous system, so the consequences are unpredictable.
Latuda and transport
The drug has little effect on the ability to drive a car. But if it is not reliably confirmed that the patient has no adverse reactions, the doctor should warn him about the dangers of driving a car and working with other mechanisms.
As a rule, people who are prescribed the drug do not have a driver's license for medical reasons.
Is Latuda addictive?
At the same time, there are no systematic studies that would reliably refute such a possibility. Therefore, patients with a history of addiction require particularly careful medical supervision during treatment with lurasidone.
Reviews
Source: https://ru.braggcreekanihosp.com/65695-latudal-81 80%D0%B0%D0%B7%D0%B8%D0%B4%D0%BE%D0%BD-%D0%BB%D0%B0%D1%82%D1%83%D0%B4%D0%B0 /Source: https://psy-ru.
org/viewtopic.php?f=31&t=6325 Answers to frequently asked questions
Why can't I drink grapefruit juice while taking the drug?
According to the official instructions, grapefruit juice increases blood levels of lurasidone. Therefore, during therapy it is recommended not to consume this food product.
How long after starting treatment will the patient's condition improve?
As with other antipsychotics, improvement is most often seen within a few days to a few weeks.
Can the drug be used in Parkinson's disease?
Patients with this condition are more sensitive to antipsychotics and the risk of exacerbation of symptoms is increased. Therefore, Latuda is prescribed with caution and provided that the potential benefit to a person outweighs the possible harm.
Is it true that the drug can cause suicidal ideation?
Patients with psychoses are prone to suicidal thoughts and behavior.
Cases have been recorded when such reactions occurred at the beginning of therapy and when changing the antipsychotic drug. Therefore, treatment is always carried out under continuous medical supervision.
Get consultation
Sign up for an appointment
Call a doctor at home
Leave a review
Calculate the cost of treatment
Leave your phone number and we will call you back
8 (800) 301-90-04 Write to WhatsApp Write to Viber
Sign up
Medication | Beacon PCP Toolkit
| Depression | Brand name | Generic | Additional information |
| SSRIs | Z oloft | Sertraline | – https://medlineplus.gov/druginfo/meds/a697048.html |
| Prozac | Fluoxetine | – https://medlineplus. gov/druginfo/meds/a689006.html | |
| Celexa | Citalopram | – https://medlineplus.gov/druginfo/meds/a699001.html | |
| Paxil, CR | Paroxetine | – https://medlineplus.gov/druginfo/meds/a698032.html | |
| Lexapro | Escitalopram | – https://medlineplus.gov/druginfo/meds/a603005.html | |
| IONI | Effexor, XR | Venlafaxine | – https://medlineplus.gov/druginfo/meds/a694020.html – https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/venlafaxine-marketed-effexor-information |
| Cymbalta | Duloxetine | – https://medlineplus.gov/druginfo/meds/a604030.html – https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/duloxetine-marketed-cymbalta -information | |
| Other atypical antidepressants | Wellbutrin, SR, XL | Bupropion | – https://medlineplus. gov/druginfo/meds/a695033.html |
| Alarm | Brand name | Generic | Additional information |
| Benzodiazepines | Klonopin | Clonazepam | – https://medlineplus.gov/druginfo/meds/a682279.html |
| Xanax | Alprazolam | – https://medlineplus.gov/druginfo/meds/a684001.html | |
| Ativan | Lorazepam | – https://medlineplus.gov/druginfo/meds/a682053.html | |
| Other anxiolytics | Buspar | Buspirone | – https://medlineplus.gov/druginfo/meds/a688005.html |
| ADHD | Brand name | Generic | Additional information |
| Methylphenidate | Concert | Methylphenidate | – https://medlineplus. gov/druginfo/meds/a682188.html |
| Daitrana | Methylphenidate patch | ||
| Focalin, XR D | Methylphenidate | ||
| Metadata CD, ER | Methylphenidate | ||
| Ritalin, LA, SR | Methylphenidate | ||
| Amphetamine | Adderall ; Adderall XR | Mixed amphetamine salts | – https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/adderall-and-adderall-xr-amphetamines-information |
| Dexedrine | Dexamphetamine | – https://medlineplus.gov/druginfo/meds/a601234.html | |
| DextroStat | Dexamphetamine | ||
| Vyvanse | Lisdexamphetamine | ||
| Other | Catapres | Clonidine | – https://medlineplus. gov/druginfo/meds/a682243.html |
| Intuniv (Tenex) | Guanfacine | – https://medlineplus.gov/druginfo/meds/a601059.html | |
| Antipsychotics | Brand name | Generic | Additional information |
| Typical / First generation | Thorazine | Chlorpromazine | – https://medlineplus.gov/druginfo/meds/a682040.html |
| Haldol | Haloperidol | – https://medlineplus.gov/druginfo/meds/a682180.html | |
| Trilafon | Perphenazine | – https://medlineplus.gov/druginfo/meds/a682165.html | |
| Prolixin | Fluphenazine | – https://medlineplus.gov/druginfo/meds/a682172.html | |
| Antipsychotics | Brand name | Generic | Additional information |
| Atypical / Second generation | Abilify, Disc Melt | Aripiprazole | – https://medlineplus. gov/druginfo/meds/a603012.html |
| Abilify Maintena | Aripiprazole IM | ||
| Geodon | Ziprasidone | – https://medlineplus.gov/druginfo/meds/a699062.html | |
| Invega | Paliperidone | – https://medlineplus.gov/druginfo/meds/a607005.html | |
| Latuda | Lurasidone | – https://medlineplus.gov/druginfo/meds/a611016.html | |
| Risperdal, M | Risperidone | – https://medlineplus.gov/druginfo/meds/a694015.html | |
| Seroquel XR | Quetiapine | – https://medlineplus.gov/druginfo/meds/a698019.html | |
| Zyprexa, Zidis | Olanzapine | – https://medlineplus.gov/druginfo/meds/a601213.html | |
| Mood stabilizers | Brand name | Generic | Additional information |
| Depakote, ER | Valproic acid | – https://medlineplus.    Copyright © · The Wright Initiative · Articles · Site Map 
|
