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Side effects of hydroxyzine pamoate


Hydroxyzine Pamoate Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Hydroxyzine is used to treat itching caused by allergies. It is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Hydroxyzine may also be used short-term to treat anxiety or to help you feel sleepy/relaxed before and after surgery.

How to use Hydroxyzine Pamoate

Take this medication by mouth with or without food as directed by your doctor, usually three or four times daily.

The dosage is based on your age, medical condition, and response to treatment. In children, the dosage may also be based on weight. Do not increase your dose or take this medication more often than directed.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Drowsiness, dizziness, blurred vision, constipation, or dry mouth may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as restlessness, confusion, hallucinations), shaking (tremor), difficulty urinating.

Get medical help right away if you have any very serious side effects, including: seizures, fast/irregular heartbeat, severe dizziness, fainting.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking hydroxyzine, tell your doctor or pharmacist if you are allergic to it; or to cetirizine; or to levocetirizine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as emphysema, asthma), high pressure in the eye (glaucoma), high blood pressure, kidney problems, liver problems, seizures, stomach/intestine problems (such as ulcer, blockage), overactive thyroid (hyperthyroidism), difficulty urinating (for example, due to enlarged prostate).

Hydroxyzine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before taking hydroxyzine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about taking hydroxyzine safely.

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Children may be more sensitive to the side effects of this drug. This drug can often cause excitement in young children instead of drowsiness.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, trouble urinating or QT prolongation (see above). Drowsiness and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as diphenhydramine, promethazine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

Hydroxyzine is very similar to cetirizine and levocetirizine. Do not use these medications while using hydroxyzine.

This medication may interfere with certain laboratory tests (including allergy skin testing, urine corticosteroids level), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Does Hydroxyzine Pamoate interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness, seizures. In children, mental/mood changes (such as restlessness, irritability) may occur before drowsiness.

Do not share this medication with others.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Mental Health Medications | NAMI: National Alliance on Mental Illness

Brand names:

  • Vistaril®
    • Capsule: 25 mg, 50 mg
    • Liquid: 25 mg/5 ml suspension
  • Atarax®
    • Tablet: 10 mg, 25 mg, 50 mg
    • Liquid: 10 mg/5 ml
    • Injection: 25 mg/ml, 50 mg/ml

Generic name: hydroxyzine (hye DROKS i zeen)

All FDA black box warnings are at the end of this fact sheet. Please review before taking this medication.

What Is Hydroxyzine And What Does It Treat?

Hydroxyzine is an antihistamine. It is approved for the treatment of anxiety. However, hydroxyzine is also used to treat difficulty sleeping, nausea, vomiting, itching, skin rash, and allergies.

Symptoms of anxiety include:

  • Feeling nervous
  • Feeling fearful
  • Excessive worrying
  • Difficulty sleeping
  • Difficulty concentrating
  • Irritability

What Is The Most Important Information I Should Know About Hydroxyzine?

Do not drive a car or operate machinery until you know how this medication affects you because you may notice that you feel tired or dizzy.

Hydroxyzine is not a controlled substance. It does not have the risk of addiction like some other medications used to treat anxiety e.g., lorazepam (Ativan®), alprazolam (Xanax®), clonazepam (Klonopin®), and other benzodiazepines.

Are There Specific Concerns About Hydroxyzine And Pregnancy?

If you are planning on becoming pregnant, notify your healthcare provider to best manage your medications. People living with anxiety disorders who wish to become pregnant face important decisions. It is important to discuss this with your doctor and caregivers.

Hydroxyzine should not be used in the first trimester of pregnancy. Studies that were done with mice and rats found an increased risk of birth defects. The risk to humans in the first trimester is unclear due to lack of well-controlled studies in humans. Hydroxyzine may be used in the second and third trimesters of pregnancy, but it should not be used during or just prior to labor. Use of hydroxyzine during labor may increase seizure risk in infants, decrease fetal heart rate, and increase side effects when combined with narcotics.

Regarding breastfeeding, use is not recommended since hydroxyzine does pass into breast milk. Infants who have received other antihistamines have experienced drowsiness, irritability, or unusual excitement. In addition, it may lower milk production in the mother.

What Should I Discuss With My Healthcare Provider Before Taking Hydroxyzine?

  • Symptoms of your condition that bother you the most
  • If you have thoughts of suicide or harming yourself
  • Medications you have taken in the past for your condition, whether they were effective or caused any adverse effects
  • If you experience side effects from your medications, discuss them with your healthcare provider. Some side effects may pass with time, but others may require changes in the medication.
  • Any other psychiatric or medical problems you have, including obstructive sleep apnea
  • All other medications you are currently taking (including over the counter products and herbal and nutritional supplements) and any medication allergies you have, including allergies to cetirizine (Zyrtec®) or levocetirizine (Xyzal®)
  • Other non-medication treatment you are receiving, such as talk therapy or substance abuse treatment. Your provider can explain how these different treatments work with the medication
  • If you are elderly or are prone to falls
  • If you are pregnant, plan to become pregnant, or are breast-feeding
  • If you drink alcohol or use drugs
  • If you have a heart condition known as a prolonged QT interval

How Should I Take Hydroxyzine?

Hydroxyzine may be taken with or without food. Take with food if you experience an upset stomach.

Hydroxyzine may be taken every day at regular times or on an as needed (“PRN”) basis. Typically, your healthcare provider will limit the number of doses you should take in one day.

Your health care provider will determine the dose and method of taking the medication that is right for you based upon your response.

If you take the medication every day (instead of ‘as needed’), use a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take it. You may also ask a family member or a friend to remind you or check in with you to be sure you are taking your medication.

What Happens If I Miss A Dose Of Hydroxyzine?

If you miss a dose of hydroxyzine, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your healthcare provider. Do not double your next dose or take more than what is prescribed.

What Should I Avoid While Taking Hydroxyzine?

Avoid drinking alcohol and using illegal drugs while you are taking hydroxyzine. They may decrease the benefits (e.g., worsen your condition) and increase the adverse effects (e.g., sedation) of the medication.

What Happens If I Overdose With Hydroxyzine?

If an overdose occurs call your doctor or 911. You may need urgent medical care. You may also contact the poison control center at 1-800-222-1222.

Symptoms of overdose include severe drowsiness, dry mouth, difficulty urinating, headache, rapid heartbeat, confusion, impaired coordination, slow reflexes, seizures, or coma.

A specific treatment to reverse the effects of hydroxyzine does not exist.

What Are Possible Side Effects Of Hydroxyzine?

Common side effects

  • Dizziness, drowsiness, fatigue, dry mouth
  • Urinary retention, blurred vision, confusion, irritability
  • Headache

Rare/serious side effects

  • Allergic reaction (difficulty breathing; hives; swelling of your lips, tongue or face)
  • Increased heart rate, unsafe heart beat (long QT on ECG), confusion, hallucinations
  • Priapism (an erection in males that does not go away after 4 hours)
  • Skin rash known as acute generalized exanthematous pustulosis (AGEP)

Are There Any Risks For Taking Hydroxyzine For Long Periods Of Time?

To date, there are no known problems associated with the long-term use of hydroxyzine. It is a safe and effective medication when used as directed.

Physician should reassess periodically the usefulness of the drug for the individual patient.

What Other Medications May Interact With Hydroxyzine?

The following medications may increase the levels and effects of hydroxyzine:

  • Other antihistamines, such as diphenhydramine (Benadryl®) and cetirizine (Zyrtec®)
  • Other medications with anticholinergic effects, such as benztropine (Cogentin®)
  • Other medications that can cause drowsiness, such as zolpidem (Ambien®)
  • Other medications that increase the heart’s QT interval such as amitriptyline (Elavil®), citalopram (Celexa®), and methadone.

How Long Does It Take For Hydroxyzine To Work?

Symptoms of anxiety or insomnia may improve within hours of the first dose of medication.

Summary of FDA Black Box Warnings

Hydroxizine does not have any black box warnings. 

 

Provided by

(September 2021)

©2021 The College of Psychiatric and Neurologic Pharmacists (CPNP) and the National Alliance on Mental Illness (NAMI). CPNP and NAMI make this document available under the Creative Commons Attribution-No Derivatives 4.0 International License. Last Updated: January 2016.

This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists. This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein.

Canon Hydroxyzine instructions for use: indications, contraindications, side effects - description of Hydroxyzine Canon Film-coated tablets (43070)

📜 Instructions for use Hydroxysin Canon

💊 Composition of the drug Hydroxysin Canon

✅ Use of the drug Hydroxyzine Canon

📅 Storage conditions Hydroxyzine Canon

⏳ Expiration date Hydroxyzine Canon


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Product description Hydroxyzine Canon (Hydroxyzine Canon)

Based on the approved prescribing information and prepared for the 2014 Vidal E-Manual, updated on 2021. 10.25

Marketing authorization holder:

CANONPHARMA PRODUCTION CJSC (Russia)

ATX code: N05BB01 (Hydroxyzine)

Active substance: hydroxyzine (hydroxyzine)

Rec.INN WHO registered

Dosage form


Hydroxyzine Canon

Tab., coated film coated, 25 mg: 20, 25, 30 or 50 pcs.

reg. No.: LP-002566 dated 06.08.14 - Indefinitely

Release form, packaging and composition drug Hydroxysin Canon


Film-coated tablets white, round, biconvex, scored; almost white in cross section.

1 tab.
hydroxyzine hydrochloride 25 mg

Excipients : pregelatinized corn starch - 30 mg, colloidal silicon dioxide - 0.7 mg, magnesium stearate - 1 mg, mannitol - 40 mg, microcrystalline cellulose - 33.3 mg.

10 pcs. - cellular contour packings (2) - packs of cardboard.
10 pcs. - cellular contour packings (3) - packs of cardboard.
10 pcs. - cellular contour packings (5) - packs of cardboard.
25 pcs. - cellular contour packings (1) - packs of cardboard.
25 pcs. - cellular contour packings (2) - packs of cardboard.

Clinical and pharmacological group: Anxiolytic (tranquilizer)

Pharmacotherapeutic group: Anxiolytic agent (tranquilizer)

Pharmacological action

Hydroxyzine is a blocker of H 1 -histamine receptors of the first generation, a derivative of phenothiazine with antimuscarinic and sedative properties and diphenylmethane, promotes inhibition of the activity of certain subcortical zones.

H 1 has a histamine blocking, bronchodilating and antiemetic effect, has a moderate inhibitory effect on gastric secretion. Hydroxyzine significantly reduces itching in patients with urticaria, eczema, and dermatitis.

Hydroxyzine has a positive effect on cognitive abilities, improves attention and memory. Hydroxyzine does not cause addiction and psychological dependence, with prolonged use of the withdrawal syndrome was not observed.
Hydroxyzine is able to depress the central nervous system, also has anticholinergic, antihistamine, antispasmodic, local anesthetic, sympatholytic effects, and has muscle relaxant activity.

In liver failure H 1 - histamine-blocking effect may be prolonged up to 96 hours after a single dose. It has moderate anxiolytic activity.

Polysomnography in patients with insomnia and anxiety demonstrates an increase in sleep duration, a decrease in the frequency of nocturnal awakenings after taking a single or repeated dose of hydroxyzine at a dose of 50 mg. A decrease in muscle tension in patients with anxiety was noted when taking the drug at a dose of 50 mg 3 times a day.

H 1 - histamine-blocking effect occurs approximately 1 hour after oral administration of the tablets. The sedative effect appears after 30-45 minutes.

Pharmacokinetics

Absorption

High absorption. TC max after oral administration - 2 hours. After taking an average dose of 50 mg, TC max in adults is 70 mg / ml.

Distribution

The distribution coefficient is 7-16 l/kg in adults. Hydroxyzine crosses the blood-brain barrier and the placenta, concentrating more in fetal than maternal tissues. After oral administration, hydroxyzine penetrates the skin well, while the concentration of hydroxyzine in the skin is much higher than the concentration in the blood serum, both after single and after multiple doses. The plasma concentration of hydroxyzine does not necessarily reflect its binding to tissues or distribution to skin receptors. It has an effect on skin inflammation depending on the serum concentration.

Metabolism

Hydroxyzine is metabolized in the liver. Cetirizine - the main metabolite (45%) is a blocker of H 1 -histamine receptors. Metabolites are found in breast milk.

Elimination

T 1/2 in adults - 14 hours (range: 7-20 hours). The total clearance of hydroxyzine is 13 ml / min / kg. About 0.8% of hydroxyzine is excreted unchanged through the kidneys. The main metabolite cetirizine is excreted mainly in the urine, also unchanged (25% of the dose of hydroxyzine taken).

Pharmacokinetics in special groups of patients

In elderly patients

In elderly patients T 1/2 was 29 hours. The volume of distribution is 22.5 l/kg. It is recommended to reduce the daily dose of hydroxyzine when administered to elderly patients.

Children under 1 year

In children, the total clearance is 2. 5 times higher than in adults. The dose must be adjusted. T 1/2 4 hours.

Children aged 1 to 14

T 1/2 11 o'clock.

In patients with hepatic insufficiency

In patients with secondary liver dysfunction due to primary biliary cirrhosis, the total clearance was approximately 66% of the value recorded in healthy volunteers. In patients with liver disease, T 1/2 increased up to 37 hours, the concentration of metabolites in the blood serum is higher than in young patients with normal liver function. Patients with hepatic insufficiency are advised to reduce the daily dose or frequency of administration.

In patients with renal insufficiency

The pharmacokinetics of hydroxyzine was studied in 8 patients with severe renal insufficiency (creatinine clearance 24+7 ml/min). The duration of exposure to hydroxyzine did not change significantly, while the duration of exposure to cetirizine was increased. To avoid any significant accumulation of the cetirizine metabolite after repeated use of hydroxyzine in patients with impaired renal function, the daily dose of hydroxyzine should be reduced.

Indications of the drug Hydroxyzine Canon

  • symptomatic treatment of anxiety in adults;
  • as a sedative during premedication;
  • symptomatic treatment of itching of allergic origin.

Open list of ICD-10 codes

F41.9 Anxiety disorder, unspecified
L29 Itching
Z51.4 Preparatory procedures for subsequent treatment or examination, not elsewhere classified

Dosage regimen

The drug is used orally.

Children:

For the symptomatic treatment of itching of allergic origin:

From 3 to 6 years of age: 1.0 mg/kg/day to 2.5 mg/kg/day in divided doses.

Ages 6 years and older: 1.0 mg/kg/day to 2.0 mg/kg/day in divided doses.

For premedication: 1 mg/kg at night before anesthesia.

The dosage is calculated by the doctor individually depending on the body weight of the child in accordance with the recommended doses, it should be noted that the minimum dosage received, after dividing the tablet, is 12.5 mg.

Adults:

For symptomatic treatment of anxiety: standard dose of 50 mg per day divided into 3 doses (1/2 tablet (12.5 mg) in the morning, 1/2 tablet (12.5 mg) in the afternoon and 1 tablet (25 mg at night) For anxiety in severe cases, the drug is used at a dose of 50-100 mg 4 times a day. if necessary, the dose may be increased to 1 tablet (25 mg) 3-4 times daily. 0006

For premedication in surgical practice: 2-8 tablets (50-200 mg) at night before anesthesia.

A single maximum adult dose should not exceed 8 tablets (200 mg), the maximum daily dose is not more than 12 tablets (300 mg).

Use in special groups of patients:

When used in the elderly, the dose is selected individually, taking into account concomitant diseases in the recommended dose range (see section Pharmacokinetics).

Use in patients with renal insufficiency and impaired liver function:

Patients with severe and moderate renal insufficiency, as well as with hepatic insufficiency, a dose reduction is necessary. In patients with hepatic insufficiency, it is recommended to reduce the daily dose by 33%. In patients with severe and moderate renal insufficiency, the drug is used in half the dose due to a decrease in the excretion of the main metabolite of hydroxyzine - cetirizine.

Side effects

Possible side effects are listed below by body system and frequency of occurrence.

WHO classification of side effects:

very common - ≥1/10 prescriptions (>10%)

common - ≥1/100 to <1/10 prescriptions (>1% and <10%)

infrequently - from ≥ 1/1000 to <1/100 appointments (>0.1% and <1%)

rarely - from ≥ 1/10000 to <1/1000 appointments (>0.01% and <0.1%)

very rare - <1/10000 prescriptions (<0.01%)

The most common adverse reactions were drowsiness, headache, lethargy, dry mouth and fatigue.

Immune system disorders:

rare: hypersensitivity;

very rare: anaphylactic shock.

Nervous system disorders:

infrequently: dizziness, insomnia, tremor;

rarely: convulsions, dyskinesia.

infrequently: agitation, confusion;

rare: hallucinations, disorientation.

Violations of the organ of vision:

rare: disturbance of accommodation, visual impairment.

Cardiac disorders:

rare: tachycardia;

frequency unknown: prolongation of the QT interval on the electrocardiogram, ventricular tachycardia of the "pirouette" type.

Vascular disorder:

rare: decrease in blood pressure.

Respiratory, thoracic and mediastinal disorders:

very rare: bronchospasm.

Gastrointestinal disorders:

infrequently: nausea; rarely: vomiting, constipation.

Liver and biliary disorders:

rare: abnormal liver function tests;

frequency unknown: hepatitis.

Renal and urinary disorders:

rare: urinary retention.

Rut and subcutaneous tissue disorders:

rare: pruritus, rash (erythematous, maculo-papular), urticaria, dermatitis;

very rare: angioedema, increased sweating, acute generalized exanthematous-pustular rash, erythema multiforme, Stevens-Johnson syndrome.

General disorders:

rare: hyperthermia, malaise.

The following side effects have been observed with cetirizine, the main metabolite of hydroxyzine: thrombocytopenia, aggression, depression, tic, dystonia, paresthesia, oculogeric crisis, diarrhea, dysuria, enuresis, asthenia, edema, weight gain and may occur with hydroxyzine.

Contraindications for use

  • hypersensitivity to any of the components of the drug, cetirizine and other piperazine derivatives, aminophylline or ethylenediamine;
  • porphyria;
  • children under 3 years of age;
  • pregnancy, childbirth and breastfeeding.

With caution: in myasthenia gravis, prostatic hyperplasia with clinical manifestations, difficulty urinating, constipation, glaucoma, dementia, convulsive disorders, including epilepsy, with a tendency to arrhythmia, including electrolyte imbalance (hypokalemia, hypomagnesemia), in patients with a history of heart disease (with heart failure and arterial hypertension) or with the use of drugs that can cause arrhythmia, with hyperthyroidism. Hydroxyzine contributes to a decrease in gastrointestinal motility, the development of a stenosing peptic ulcer, and respiratory failure.

Use during pregnancy and lactation

Hydroxysin Canon is contraindicated during pregnancy, childbirth and breastfeeding.

Use in hepatic impairment

Patients with hepatic impairment require dose reduction. In patients with hepatic insufficiency, it is recommended to reduce the daily dose by 33%.

Use for impaired renal function

Patients with severe and moderate renal insufficiency require a dose reduction. In patients with severe and moderate renal insufficiency, the drug is used in half the dose due to a decrease in the excretion of the main metabolite of hydroxyzine - cetirizine.

Use in children

Contraindicated in children under 3 years of age.

Use in the elderly

When used in the elderly, the dose is selected individually, taking into account concomitant diseases in the recommended dose range (see section Pharmacokinetics).

Special instructions

When used simultaneously with drugs with m-anticholinergic properties and drugs that depress the central nervous system, the dose of hydroxyzine must be reduced.

Hydroxyzine can lead to prolongation of the QT interval on the electrocardiogram, so concomitant use with other drugs that can interfere with cardiac activity may increase the risk of arrhythmias. It is suggested that other drugs that cause changes in the electrocardiogram (atropine, antiparkinsonian drugs, lithium carbonate, quinidine, phenothiazines, procainamide, tricyclic antidepressants, thioridazine) may exacerbate and exacerbate the changes that can be caused by hydroxyzine and increase the risk of sudden death. The simultaneous use of two or more drugs that prolong the QT interval should be avoided because of the risk of additive effects that can lead to the development of potentially life-threatening and severe cardiac arrhythmias.

In renal and/or hepatic insufficiency, doses should be reduced.

In the elderly, the dosage should be adjusted individually, starting with half the minimum dose, and adjusting in the range of recommended doses. If it is necessary to set up allergic tests or conduct a methacholine test, taking the drug Hydroxysin Canon should be discontinued 5 days before the study to prevent obtaining distorted data.

Alcohol should be avoided during treatment with Hydroxysin Canon.

Influence on the ability to drive vehicles and mechanisms

Hydroxyzine Canon may impair the ability to concentrate and the speed of psychomotor reactions. Taking other sedative medicines may increase this effect. Therefore, one should refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Overdose

Symptoms of CNS toxicity are associated with excessive m-anticholinergic action, suppression or paradoxical stimulation of the CNS. These symptoms include nausea, vomiting, tachycardia, pyrexia, drowsiness, impaired pupillary reflex, tremors, confusion, or hallucinations. Subsequently, depression of consciousness, respiration, convulsions, lowering blood pressure, and arrhythmia may develop. Possible aggravation of coma and cardiopulmonary collapse.

Treatment: It is necessary to control the state of the respiratory tract, the state of respiration and circulation using Electrocardiographic (ECG) monitoring, to ensure adequate oxygenation. Heart activity and blood pressure should be monitored within 24 hours after the symptoms disappear.

At high doses, hydroxyzine can lead to QT interval prolongation and marked electrocardiogram changes.

In case of mental status disorder, other drugs or alcohol should be avoided, if necessary, the patient should be given oxygen inhalation, naloxone, dextrose (glucose) and thiamine. The use of analeptics is not allowed.

If a vasopressor effect is needed, norepinephrine or metaraminol is given. Epinephrine should not be used. In case of ingestion of a significant amount of the drug, it is possible to perform gastric lavage with previous endotracheal intubation. Activated charcoal may be used, but there is insufficient evidence to support its effectiveness. There is no specific antidote. Hemodialysis is not effective.

Literature data indicate that in the case of the development of severe, life-threatening, intractable m-anticholinergic effects that are not stopped by other drugs, it is possible to use a therapeutic dose of physostigmine. Physostigmine should not be used solely to bring the patient to consciousness. If the patient was taking tricyclic antidepressants, the use of physostigmine can provoke seizures and irreversible cardiac arrest. The use of physostigmine should also be avoided in patients with cardiac conduction disorders.

Drug interactions

The potentiating effect of hydroxyzine should be taken into account when used together with drugs that depress the central nervous system (CNS), such as narcotic analgesics, barbiturates, tranquilizers, hypnotics, alcohol. In this case, their doses should be selected individually. Simultaneous use with MAO inhibitors (MAO) and anticholinergics should be avoided. The drug interferes with the pressor action of epinephrine and the anticonvulsant activity of phenytoin, and also interferes with the action of betahistine and drugs - cholinesterase inhibitors.

Cimetidine 600 mg twice daily has been found to increase serum hydroxyzine concentration by 36% and decrease the maximum concentration of cetirizine metabolite by 20%.

The effect of atropine, belladonna alkaloids, cardiac glycosides, antihypertensive drugs, blockers of H 2 -histamine receptors do not change under the action of hydroxyzine. Hydroxyzine is an inhibitor of the CYP2D6 isoenzyme and in high doses can cause drug interactions with CYP2D6 substrates. Since hydroxyzine is metabolized in the liver, an increase in its plasma concentration can be expected when used simultaneously with inhibitors of microsomal liver enzymes. Since hydroxyzine is metabolized by alcohol dehydrogenase and the CYP3A4 / 5 isoenzyme, it is possible to increase the concentration of hydroxyzine in plasma when used simultaneously with drugs that potentially inhibit the CYP3A4 / 5 isoenzyme (telithromycin, clarithromycin, delavirdine, styripentol, ketoconazole, voriconazole, itraconazole, posaconazole and some HIV protease inhibitors including atazanavir, indinavir, nelfinavir, ritonavir, saquinarine, lopinavir/ritonavir, saquinarine/ritonavir, and tipranavir/ritonavir). However, the inhibition of one metabolic pathway can be partially compensated by the work of another. The concomitant use of hydroxyzine with medicinal products that have the potential to cause arrhythmia may increase the risk of QT interval prolongation and torsades de pointes.

Co-administration with ototoxic agents such as gentamicin may mask symptoms of ototoxicity such as dizziness. The drug should be canceled 3 days before the planned skin tests with allergens.

Storage conditions of the drug Hydroxysin Canon

In a dry, dark place at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life of the drug Hydroxysin Canon

Shelf life - 2 years.

Terms of sale

By prescription.


Keep

Hydroxyzine Pamoate in English - Product

Hydroxyzine Pamoate in English - Product - TabletWise. com

About Us

Detailed information on uses, side effects, interactions, contraindications and reviews for Hydroxyzine Pamoate is provided below:

Benefits

Hydroxyzine Pamoate is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

  • Anxiety
  • Tension associated with psychoneurosis
  • Chronic urticaria
  • Atopic dermatitis
  • Contact dermatitis
  • Histamine-mediated pruritus

Learn more: Benefits

Side effects

The following is a list of possible side effects that may be caused by medicines that contain Pamoate hydroxyzine / Hydroxyza. This list is not final. These side effects have been recorded previously, but are not always recorded when using the drug. Some of these side effects may be extremely rare, but have incredibly severe consequences. If you notice any side effects, contact your doctor immediately. Especially in the case of observing side effects for a long time.

  • Dry mouth
  • Tremor
  • Seizures

If you experience side effects not listed above, contact your healthcare provider for advice. In addition, you can report side effects to your local Food and Drug Administration.

Precautions

Before taking this drug, tell your doctor about any medications you are taking, dietary supplements (such as vitamins, natural supplements, etc.), allergies, existing medical conditions, and current health conditions (such as pregnancy, upcoming surgery, and etc.). The side effects of the drug may be more pronounced depending on the state of your body. Take this medicine as directed by your doctor, or follow the directions for use that come with your medicine. The dosage of the drug depends on your condition. Tell your doctor if there is no change or if your condition worsens. Important points to discuss with your healthcare provider are listed below.

  • Elderly patients
  • Care should be taken when driving or operating heavy machinery

For this information, please consult your physician, pharmacist or read the information on the product packaging.

Hypersensitivity to Hydroxyzine Pamoate is a contraindication. In addition, Hydroxyzine Pamoate should not be used if you have the following conditions:

  • hypersensitivity

FAQ

  • Is it safe to drive or operate heavy machinery while using this product?

    If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Pamoate Pamoate medicine then it may not be safe to drive a vehicle or operate heavy machinery. You should stop driving if taking this medicine makes you drowsy, dizzy, or hypotensive. Doctors recommend that you stop drinking alcohol with such drugs, because. alcohol greatly increases the side effects and drowsiness. Please check for these effects on your body when using Hydroxyzine Pamoate. Be sure to consult your doctor for advice based on the characteristics of your body and general health.

  • Is this drug (product) addictive or addictive?

    Most drugs are not habit-forming or addictive. In most cases, the state classifies drugs that can be addictive as controlled dispensing drugs. For example, schedule H or X in India and schedule II-V in the USA. Please check the information on the drug packaging to make sure that this drug is not in the controlled category. Also, do not self-medicate or accustom your body to medications without consulting your doctor.

  • Can I stop using this product immediately or do I need to slowly stop using it?

    Some medications need to be stopped gradually due to a rebound effect. Be sure to consult your healthcare provider for advice based on your body, general health, and other medications you may be taking.

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Hydroxyzine Pamoate

APA Style Citation (n.d.). Retrieved October 21, 2022, from https://www.tabletwise.com/medicine-ru/hydroxyzine-pamoate
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  • "Hydroxyzine Pamoate in Russian - Product - TabletWise.com" Tabletwise.com . N.p., n.d. Web. 21 Oct. 2022.
Chicago Style Citation
  • "Hydroxyzine Pamoate in English - Product - TabletWise.com" Tabletwise. Accessed October 21, 2022. https://www.tabletwise.com/medicine-en/hydroxyzine-pamoate.

More information about Pamoate Pamoate

  • Uses of
  • Reviews
  • What are the uses of Pamoate Hydroxyzine?
  • What are the side effects of Hydroxyzine Pamoate?
  • What other medicines does Hydroxyzine Pamoate interact with?
  • When should you not use Hydroxyzine Pamoate?
  • What precautions should you take while using Hydroxyzine Pamoate?

Last updated date

This page was updated on 9/29/2020.

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