Maximum dosage of magnesium

How Much Should You Take per Day?

Magnesium is a mineral that you need to stay healthy.

It’s crucial for many functions in your body, including energy metabolism and protein synthesis. It also contributes to proper brain function, bone health, and heart and muscle activity (1).

Magnesium is found naturally in foods like nuts, leafy green vegetables, and milk products (2).

Supplementing with this vital nutrient has been linked to many benefits, including constipation relief and improved blood sugar regulation and sleep.

This article reviews different types of magnesium supplements and how to determine the best daily dosage for your needs.

Magnesium is essential for maintaining proper health.

However, low magnesium intake is relatively common.

It’s primarily found in people who follow a typical Western diet, which contains processed foods and refined grains and can lack foods like leafy green vegetables and legumes, which provide magnesium and other important nutrients (3, 4).

The table below shows the recommended daily allowance (RDA) or adequate intake (AI) of magnesium for adults, infants, and children (2).

For pregnant women 18 or older, the requirements are increased to 350–360 mg per day (2).

Certain diseases and conditions are associated with magnesium deficiency, including high blood pressure, type 2 diabetes, and alcoholism (5, 6, 7).

Taking a magnesium supplement may help increase magnesium levels in those who have a higher risk of deficiency or don’t consume enough through their diet.

Summary
The recommended daily allowance (RDA) for magnesium for adults is 310–420 mg depending on age and gender.

Many forms of magnesium supplements are available.

The most important thing to consider before deciding on a supplement is its absorption rate, or how well the supplement is absorbed by your body.

Here are brief descriptions of the most common magnesium supplements.

Magnesium gluconate

Magnesium gluconate comes from the magnesium salt of gluconic acid. In rats, it has been shown to have the highest absorption rate among other types of magnesium supplements (8).

Magnesium oxide

Magnesium oxide has the highest amount of elemental, or actual, magnesium per weight. However, it’s poorly absorbed. Studies have found that magnesium oxide is essentially insoluble in water, making absorption rates low (9, 10).

Magnesium citrate

In magnesium citrate, magnesium in salt form is combined with citric acid. Magnesium citrate is absorbed relatively well by the body and has high solubility in water, meaning it mixes well with liquid (10).

Magnesium citrate is found in pill form and commonly used as a saline laxative before a colonoscopy or major surgery.

Magnesium chloride

Like magnesium gluconate and citrate, magnesium chloride has been observed to be well absorbed by the body (2).

It’s also available as an oil that can be applied topically, but further studies are needed to fully understand how well magnesium in this form is absorbed through the skin (11).

Magnesium hydroxide

Magnesium hydroxide, also known as milk of magnesia, is commonly used as a laxative to treat constipation and in some antacids to treat heartburn (2, 12).

Magnesium aspartate

Magnesium aspartate is another common magnesium supplement that is highly absorbable by the human body (13, 14).

Magnesium glycinate

Magnesium glycinate has been shown to have a relatively good absorption rate with less of a laxative effect.

This is likely because it’s absorbed in a different area of your intestine, compared with many other forms of magnesium supplements (15).

Summary
Many types of magnesium supplements are available. It’s important to consider the absorption rate of supplements before making a purchase.

Whether you struggle with acute or chronic constipation, it can be uncomfortable.

Magnesium citrate and magnesium hydroxide are two magnesium compounds commonly used to promote bowel movements (16).

Magnesium hydroxide, or milk of magnesia, works as a laxative by pulling water into your intestines, which helps soften your stool and ease its passage.

The recommended dose depends on the product. Always follow the dosage instructions (17).

Exceeding the recommended intake could cause watery diarrhea or electrolyte imbalances.

Due to its laxative effect, milk of magnesia is generally used to treat acute constipation and not usually recommended for chronic cases.

Magnesium citrate is another magnesium supplement used to treat constipation.

It’s better absorbed and has a gentler laxative effect than magnesium hydroxide (18).

The standard dose for magnesium citrate is 240 ml per day, which can be mixed with water and taken orally.

Summary
Magnesium citrate and magnesium hydroxide are common magnesium compounds used to treat constipation. For best results, always follow standard dosage recommendations on the label.

Adequate magnesium levels are important for a good night’s sleep. Magnesium can help your mind relax and your body achieve deep, restorative sleep.

In fact, studies in rats have shown that suboptimal magnesium levels led to poor sleep quality (19).

Currently, a limited number of studies have studied the effects of magnesium supplements on sleep quality, making it difficult to recommend a specific daily dose.

However, in one study, older adults who received 414 mg of magnesium oxide twice daily (500 mg of magnesium per day) had better sleep quality, compared with adults who received a placebo (20).

Summary
Based on limited research, taking 500 mg of magnesium daily may improve sleep quality.

People with diabetes may be more likely to have low magnesium levels (21, 22).

High blood sugar levels can increase magnesium loss through urine, causing low magnesium levels in your blood.

Studies have shown that magnesium supplements may help regulate blood sugar by managing insulin action (23).

Insulin is a hormone that helps control blood sugar levels by signaling your cells to take in sugar from your blood.

One study found that supplementing with 2,500 mg of magnesium in a magnesium chloride solution daily improved insulin sensitivity and fasting blood sugar levels in people with type 2 diabetes and low magnesium levels at baseline (24).

However, another study found that people who received a daily total of 20.7 mmol of magnesium oxide daily showed no improvements in blood glucose regulation.

That said, those who received a higher dosage of magnesium oxide (41.4 mmol daily) showed a decrease in fructosamine, an average measurement of a person’s blood sugar over about 2–3 weeks (25).

The researchers concluded that prolonged magnesium supplementation at higher than usual doses could benefit blood glucose control, but further studies are needed (25).

Summary
Very high doses of 2,500 mg of magnesium supplements daily have been shown to improve blood glucose levels in patients with diabetes, but more research is needed.

Many conditions can cause muscle cramps.

Since magnesium is key to muscle function, a deficiency may cause painful muscle contractions.

Magnesium supplements are often marketed to prevent or improve muscle cramping.

Though research on magnesium supplements for muscle cramping is mixed, one study found that participants who received 300 mg of magnesium daily for 6 weeks reported fewer muscle cramps, compared with those who received a placebo (26).

Another study noted the ability of magnesium supplements to reduce the frequency of leg cramps during pregnancy. Women who took 300 mg of magnesium daily experienced less frequent and less intense leg cramps, compared with women who took a placebo (27).

Summary
Although further research is needed on magnesium and muscle cramps, taking 300 mg of magnesium daily has been shown to decrease symptoms.

Studies have shown that magnesium deficiency may increase your risk of depression (28).

In fact, taking a magnesium supplement may improve depressive symptoms in some people.

One study found that taking 248 mg of magnesium chloride improved depressive symptoms in those with mild to moderate depression (29).

Moreover, another study found that taking 450 mg of magnesium chloride was as effective as an antidepressant at improving depressive symptoms (30).

While magnesium supplements may improve depression in those with magnesium deficiency, further research is needed to know if they can alleviate depression in those with normal magnesium levels.

Summary
Supplementing with 248–450 mg of magnesium per day has been shown to improve mood in patients with depression and low magnesium levels.

Various studies on magnesium supplements’ effects on exercise performance have shown that the improvement potential is largely based on dosage.

For example, two studies that used doses of 126–250 mg of magnesium daily showed no significant change in exercise performance or muscle gain.

Researchers concluded that any benefits from supplementing with magnesium at these doses were not strong enough to be detected (31, 32).

However, another study found that volleyball players who took 350 mg of magnesium per day showed improved athletic performance, compared with the control group (33).

Summary
Supplementing with magnesium at doses of 350 mg or higher per day may boost exercise performance.

Premenstrual syndrome (PMS) is a group of symptoms, including water retention, agitation, and headaches, that many women experience about 1–2 weeks before their period.

Supplementing with magnesium has been shown to improve PMS symptoms.

One study found that taking 200 mg of magnesium oxide daily improved water retention associated with PMS (34).

Another study determined that taking 360 mg of magnesium daily improved PMS symptoms associated with mood and mood changes (35).

Summary
Magnesium doses of 200–360 mg daily have been shown to improve PMS symptoms in women, including mood and water retention.

People who experience migraines may be at risk of magnesium deficiency due to several factors, including a genetic inability to absorb magnesium efficiently or increased excretion of magnesium due to stress (36).

One study found that supplementing with 600 mg of magnesium citrate helped reduce the frequency and severity of migraines (37).

Another study showed that the same dose daily tended to decrease the frequency of migraine attacks (38).

Summary
Supplementing with 600 mg of magnesium daily has been shown to prevent and possibly decrease the intensity and duration of migraines.

The National Academy of Medicine recommends not exceeding 350 mg of supplemental magnesium per day (2).

However, several studies have involved higher daily dosages.

It’s recommended to only take a daily magnesium supplement that provides more than 350 mg while under medical supervision.

Though magnesium toxicity is rare, taking certain magnesium supplements at high doses may cause diarrhea, nausea, and abdominal cramping.

Magnesium supplements may also interact with some medications, including antibiotics and diuretics (2).

Summary
Magnesium toxicity is rare, but be sure to speak with your healthcare provider before beginning to supplement with more than 350 mg daily.

Magnesium is involved in more than 300 biochemical reactions in your body and crucial for maintaining good health.

The RDA for magnesium is 310–420 mg for adults depending on age and gender.

If you require a supplement, dosage recommendations can vary depending on your needs, such as to improve constipation, sleep, muscle cramps, or depression.

Most studies found positive effects with daily doses of 125–2,500 mg.

However, it’s best to consult your healthcare provider before taking a supplement, especially at higher doses.

How Much Should You Take per Day?

Magnesium is a mineral that you need to stay healthy.

It’s crucial for many functions in your body, including energy metabolism and protein synthesis. It also contributes to proper brain function, bone health, and heart and muscle activity (1).

Magnesium is found naturally in foods like nuts, leafy green vegetables, and milk products (2).

Supplementing with this vital nutrient has been linked to many benefits, including constipation relief and improved blood sugar regulation and sleep.

This article reviews different types of magnesium supplements and how to determine the best daily dosage for your needs.

Magnesium is essential for maintaining proper health.

However, low magnesium intake is relatively common.

The table below shows the recommended daily allowance (RDA) or adequate intake (AI) of magnesium for adults, infants, and children (2).

For pregnant women 18 or older, the requirements are increased to 350–360 mg per day (2).

Certain diseases and conditions are associated with magnesium deficiency, including high blood pressure, type 2 diabetes, and alcoholism (5, 6, 7).

Taking a magnesium supplement may help increase magnesium levels in those who have a higher risk of deficiency or don’t consume enough through their diet.

Summary
The recommended daily allowance (RDA) for magnesium for adults is 310–420 mg depending on age and gender.

Many forms of magnesium supplements are available.

The most important thing to consider before deciding on a supplement is its absorption rate, or how well the supplement is absorbed by your body.

Here are brief descriptions of the most common magnesium supplements.

Magnesium gluconate

Magnesium gluconate comes from the magnesium salt of gluconic acid. In rats, it has been shown to have the highest absorption rate among other types of magnesium supplements (8).

Magnesium oxide

Magnesium citrate

Magnesium citrate is found in pill form and commonly used as a saline laxative before a colonoscopy or major surgery.

Magnesium chloride

Like magnesium gluconate and citrate, magnesium chloride has been observed to be well absorbed by the body (2).

It’s also available as an oil that can be applied topically, but further studies are needed to fully understand how well magnesium in this form is absorbed through the skin (11).

Magnesium hydroxide

Magnesium hydroxide, also known as milk of magnesia, is commonly used as a laxative to treat constipation and in some antacids to treat heartburn (2, 12).

Magnesium aspartate

Magnesium aspartate is another common magnesium supplement that is highly absorbable by the human body (13, 14).

Magnesium glycinate

Magnesium glycinate has been shown to have a relatively good absorption rate with less of a laxative effect.

This is likely because it’s absorbed in a different area of your intestine, compared with many other forms of magnesium supplements (15).

Summary
Many types of magnesium supplements are available. It’s important to consider the absorption rate of supplements before making a purchase.

Whether you struggle with acute or chronic constipation, it can be uncomfortable.

Magnesium citrate and magnesium hydroxide are two magnesium compounds commonly used to promote bowel movements (16).

Magnesium hydroxide, or milk of magnesia, works as a laxative by pulling water into your intestines, which helps soften your stool and ease its passage.

The recommended dose depends on the product. Always follow the dosage instructions (17).

Exceeding the recommended intake could cause watery diarrhea or electrolyte imbalances.

Due to its laxative effect, milk of magnesia is generally used to treat acute constipation and not usually recommended for chronic cases.

Magnesium citrate is another magnesium supplement used to treat constipation.

It’s better absorbed and has a gentler laxative effect than magnesium hydroxide (18).

The standard dose for magnesium citrate is 240 ml per day, which can be mixed with water and taken orally.

Summary
Magnesium citrate and magnesium hydroxide are common magnesium compounds used to treat constipation. For best results, always follow standard dosage recommendations on the label.

Adequate magnesium levels are important for a good night’s sleep. Magnesium can help your mind relax and your body achieve deep, restorative sleep.

In fact, studies in rats have shown that suboptimal magnesium levels led to poor sleep quality (19).

Currently, a limited number of studies have studied the effects of magnesium supplements on sleep quality, making it difficult to recommend a specific daily dose.

However, in one study, older adults who received 414 mg of magnesium oxide twice daily (500 mg of magnesium per day) had better sleep quality, compared with adults who received a placebo (20).

Summary
Based on limited research, taking 500 mg of magnesium daily may improve sleep quality.

People with diabetes may be more likely to have low magnesium levels (21, 22).

High blood sugar levels can increase magnesium loss through urine, causing low magnesium levels in your blood.

Studies have shown that magnesium supplements may help regulate blood sugar by managing insulin action (23).

Insulin is a hormone that helps control blood sugar levels by signaling your cells to take in sugar from your blood.

However, another study found that people who received a daily total of 20.7 mmol of magnesium oxide daily showed no improvements in blood glucose regulation.

That said, those who received a higher dosage of magnesium oxide (41.4 mmol daily) showed a decrease in fructosamine, an average measurement of a person’s blood sugar over about 2–3 weeks (25).

The researchers concluded that prolonged magnesium supplementation at higher than usual doses could benefit blood glucose control, but further studies are needed (25).

Summary
Very high doses of 2,500 mg of magnesium supplements daily have been shown to improve blood glucose levels in patients with diabetes, but more research is needed.

Many conditions can cause muscle cramps.

Since magnesium is key to muscle function, a deficiency may cause painful muscle contractions.

Magnesium supplements are often marketed to prevent or improve muscle cramping.

Summary
Although further research is needed on magnesium and muscle cramps, taking 300 mg of magnesium daily has been shown to decrease symptoms.

Studies have shown that magnesium deficiency may increase your risk of depression (28).

In fact, taking a magnesium supplement may improve depressive symptoms in some people.

One study found that taking 248 mg of magnesium chloride improved depressive symptoms in those with mild to moderate depression (29).

Moreover, another study found that taking 450 mg of magnesium chloride was as effective as an antidepressant at improving depressive symptoms (30).

While magnesium supplements may improve depression in those with magnesium deficiency, further research is needed to know if they can alleviate depression in those with normal magnesium levels.

Summary
Supplementing with 248–450 mg of magnesium per day has been shown to improve mood in patients with depression and low magnesium levels.

Various studies on magnesium supplements’ effects on exercise performance have shown that the improvement potential is largely based on dosage.

For example, two studies that used doses of 126–250 mg of magnesium daily showed no significant change in exercise performance or muscle gain.

Researchers concluded that any benefits from supplementing with magnesium at these doses were not strong enough to be detected (31, 32).

However, another study found that volleyball players who took 350 mg of magnesium per day showed improved athletic performance, compared with the control group (33).

Summary
Supplementing with magnesium at doses of 350 mg or higher per day may boost exercise performance.

Premenstrual syndrome (PMS) is a group of symptoms, including water retention, agitation, and headaches, that many women experience about 1–2 weeks before their period.

Supplementing with magnesium has been shown to improve PMS symptoms.

One study found that taking 200 mg of magnesium oxide daily improved water retention associated with PMS (34).

Another study determined that taking 360 mg of magnesium daily improved PMS symptoms associated with mood and mood changes (35).

Summary
Magnesium doses of 200–360 mg daily have been shown to improve PMS symptoms in women, including mood and water retention.

One study found that supplementing with 600 mg of magnesium citrate helped reduce the frequency and severity of migraines (37).

Another study showed that the same dose daily tended to decrease the frequency of migraine attacks (38).

Summary
Supplementing with 600 mg of magnesium daily has been shown to prevent and possibly decrease the intensity and duration of migraines.

The National Academy of Medicine recommends not exceeding 350 mg of supplemental magnesium per day (2).

However, several studies have involved higher daily dosages.

It’s recommended to only take a daily magnesium supplement that provides more than 350 mg while under medical supervision.

Though magnesium toxicity is rare, taking certain magnesium supplements at high doses may cause diarrhea, nausea, and abdominal cramping.

Magnesium supplements may also interact with some medications, including antibiotics and diuretics (2).

Summary
Magnesium toxicity is rare, but be sure to speak with your healthcare provider before beginning to supplement with more than 350 mg daily.

Magnesium is involved in more than 300 biochemical reactions in your body and crucial for maintaining good health.

The RDA for magnesium is 310–420 mg for adults depending on age and gender.

If you require a supplement, dosage recommendations can vary depending on your needs, such as to improve constipation, sleep, muscle cramps, or depression.

Most studies found positive effects with daily doses of 125–2,500 mg.

However, it’s best to consult your healthcare provider before taking a supplement, especially at higher doses.

When to determine magnesium deficiency and how to take it?

December 1, 2019

July 6, 2020

3 minutes

75266

ProWellness

Contents

Do you need magnesium?
Daily intake of magnesium
How to take?

Disclaimer

Please note that all information posted on the site Prowellness is provided for informational purposes only and is not a personal program, a direct recommendation for action, or medical advice. Do not use these materials for diagnosis, treatment, or any medical procedure. Consult your physician before using any technique or using any product. This site is not a specialized medical portal and does not replace the professional advice of a specialist. The Site Owner is not liable to any party who has suffered indirect or direct damage as a result of misuse of materials posted on this resource.

When is magnesium deficiency diagnosed and how should I take it?

Magnesium is important for the proper functioning of all systems and organs. He is involved in more than 500 reactions that occur in the human body. Without it, it is impossible to maintain the health of the cardiovascular system. A macronutrient deficiency threatens with hypertension, stroke, heart attack.

Many people do not get enough magnesium. It is found in grains and legumes, vegetables, nuts. However, soil depletion leads to a decrease in the concentration of the substance in plant products. In addition, it may not be absorbed due to digestive disorders, the use of antibiotics and certain other drugs, the use of large doses of vitamin D, K ₂ .

Every day, the human body spends magnesium on the synthesis of hormones, muscle contraction and heartbeat. Therefore, it is imperative to make up for its costs. A great way to do this is to take magnesium supplements.

Do you need magnesium?

It is almost impossible to determine magnesium deficiency by taking a blood test for vitamins. Almost 99% of the element is concentrated in muscle cells, bones and other tissues. And only 1% floats in plasma and extracellular fluid.

Attention! Even if the body spends 80% of the total accumulated magnesium, its level in the serum will not be shaken.

A good alternative to a blood test is a hair or nail test. But most cannot afford such a diagnosis. Therefore, there is only one option for detecting a lack of magnesium - symptomatic. The condition may be accompanied by:

high cholesterol;
atherosclerosis;
stone formation;
migraine;
deficiency of calcium and potassium with sufficient consumption of foods rich in them;
spasm of the calf muscles;
overly pronounced PMS;
mood swings;
depression;
caries;
edema due to fluid retention in the body;
muscle cramps;
weakness.

Daily intake of magnesium

Attention! To find out how much magnesium you need to consume, calculate its amount using the formula: 5, mg x weight, kg. The maximum daily dosage is 800 mg.

The average intake of magnesium is shown in the table:

Age, gender	Daily intake of magnesium, mg
Infant up to 6 months	thirty
Infant up to 3 years	78
Child under 8	125
Children under 13	235
Adolescents under 18, women	370
Adolescents under 18, male.	420
grown men	400–420
adult women	320
Pregnant and lactating	360

How to take?

Magnesium supplements come in the form of tablets or capsules. You need to drink them with meals. It is important not to drink dietary supplements with milk and not to take them together with iron, calcium. The best combination - magnesium and B ₆ . These substances improve the absorption of each other.

Attention! The degree of digestibility of the element depends on the type of sodium salt from which the drug is made. Magnesium citrate is best absorbed. In second place are lactate, asparaginate, pidolate. On the last - oxide, sulfate.

The dosage of different drugs is different. Read the instructions for use carefully. Overdose is not terrible, since the element does not accumulate in the body. Its excess is excreted naturally. But still, it is not worth taking risks and drinking the drug in large quantities, as the balance of other nutrients may be disturbed.

Disclaimer

Expert: Ekaterina Podvalenchuk Nutrition and health expert

Reviewer: Ekaterina Vorobieva Adept of a healthy and active lifestyle

Read other related articles

magnesium take magnesium supplements magnesium deficiency magnesium deficiency

(29 votes, average 5)

Magnesium through the eyes of a neurologist

Home » The science » Science articles » Magnesium through the eyes of a neurologist

Science

A.S. Kadykov
professor
S. N. Busheneva
doctor

The name "magnesia" is already found in the Leiden Papyrus X (3rd century AD). It probably comes from the name of the city of Magnesia in the mountainous region of Thessaly. Magnesian stone in ancient times was called magnetic iron oxide, and magnes - a magnet. It is interesting that the original name "magnesium" was preserved only in Russian thanks to Hess's textbook, and at the beginning of the 19th century, other names were proposed in a number of manuals - magnesia, magnesia, bitter earth.

The total content of magnesium in the human body is about 25 grams. It plays an important role in the formation of more than three hundred enzymes. Magnesium takes part in energy and electrolyte metabolism, acts as a regulator of cell growth, and is necessary at all stages of the synthesis of protein molecules. The role of magnesium in the processes of membrane transport is especially important. Magnesium helps to relax muscle fibers (musculature of blood vessels and internal organs). The most important value of magnesium is that it serves as a natural anti-stress factor, inhibits the processes of excitation in the central nervous system and reduces the body's sensitivity to external influences.

It is believed that 25-30% of the population does not get enough magnesium from food. This may be due to modern processing technologies and the use of mineral fertilizers in growing vegetables, leading to a deficiency of magnesium in the soil.

Chronic magnesium deficiency is often observed in patients with diabetes mellitus, arterial hypertension, atherosclerosis, epilepsy, osteoporosis, etc. A number of physiological conditions are known that are accompanied by an increased need for magnesium: pregnancy, breastfeeding, a period of intensive growth and maturation, elderly and senile age, heavy physical labor and physical activity in athletes, emotional stress, frequent and prolonged (more than 30-40 minutes per day). session) stay in the sauna, insufficient sleep, air travel and crossing time zones. Magnesium deficiency occurs when taking caffeine, alcohol, drugs, and certain drugs, such as diuretics, which help remove magnesium in the urine.

Our nervous system is sensitive to the level of magnesium in the body. Its reduced content can cause anxiety, nervousness, fear, as well as insomnia and fatigue, decreased attention and memory, in some cases, seizures, tremors and other symptoms. Often people complain of "causeless" headaches.

Magnesium (especially in combination with vitamin B6) has a normalizing effect on the state of the higher parts of the nervous system during emotional stress, depression, neurosis. This is no coincidence. Stress (physical, mental) increases the need for magnesium, which causes intracellular magnesium deficiency.

Magnesium deficiency worsens with age, reaching a maximum in people over 70 years of age. According to the European Epidemiological Study of Cardiovascular Diseases, plasma magnesium levels below 0.76 mmol / l are considered as an additional (for example, arterial hypertension) risk factor for stroke and heart attack. Imbalance of Ca2+ and Mg2+ ions is one of the serious reasons for the formation of blood clots in the vessels. The use of magnesium preparations helps to reduce the tendency to form a blood clot. Magnesium, for example, enhances the antithrombotic effect of aspirin.

Magnesium is believed to play a positive role by inhibiting the process of atherosclerosis.
Taking into account the latest data on the prevalence of magnesium deficiency in residents of large cities, its content in the blood is determined in neurological patients with chronic fatigue syndrome, vegetative-vascular dystonia, as well as depression and asthenia. Normally, the content of magnesium in the blood serum in children varies from 0.66 to 1.03 mmol / l, in adults from 0.7 to 1.05 mmol / l.

In healthy people, the daily requirement for magnesium is 350-800 mg. With magnesium deficiency, its additional administration is required at the rate of 10-30 mg per kilogram of body weight per day. In addition to dietary correction, medicinal preparations are also used. The saturation time of tissue depots during magnesium therapy is 2 months or more. The choice of preparations for correction is well known - these are inorganic and organic magnesium salts. The first generation of magnesium preparations included inorganic salts. However, in this form, magnesium is absorbed by no more than 5%, stimulates intestinal motility, which often leads to diarrhea. Magnesium absorption in the gastrointestinal tract is increased by lactic, pidolic and orotic acids, vitamin B6 (pyridoxine), and some amino acids.

The second generation of magnesium-containing preparations is much better absorbed and does not cause dyspepsia and diarrhea. Modern combined preparations include Magne-B6.

The anti-anxiety effect of Magne-B6 allows it to be included in the complex therapy of depression (together with antidepressants), convulsive conditions (in combination with anticonvulsants), sleep disorders (together with sleeping pills), and also to use the drug as an additional tool for prevention and leveling mild excitatory effects of brain metabolism activators.

Learn more